Liquid Biopsy Technology Development and Clinical Applications in Cancer Research and Treatment
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 252
Special Issue Editors
Interests: cancer biomarkers; liquid biopsy; circulating cancer markers; circulating tumor cells; cancer early detection; precision cancer treatment; cancer genetics; prostate cancer; bladder cancer
Special Issue Information
Dear Colleagues,
Liquid biopsy refers to the sampling of body fluids, such as blood, urine, saliva, and cerebrospinal fluid; however, the blood is the mostly commonly used sample. Cancer liquid biopsy biomarkers include cancer cells (circulating tumor cells-CTCs, when using blood samples), nucleic acids (ctDNA and ctRNA when in blood samples), extracellular vesicles (EVs), proteins, and metabolites, which together offer a dynamic molecular snapshot of cancer status without invasive tissue sampling. Liquid biopsy is transforming static, invasive tissue biopsies to dynamic, minimally invasive cancer diagnostics.
Liquid biopsy technologies have rapidly evolved in recent years, driven by innovations in molecular biology and sequencing. Liquid biopsies are reshaping cancer care across the continuum, from cancer screening and early detection to treatment stratification, outcome prediction, real-time monitoring of treatment response, minimal residual disease and the emergence of resistance mutations. Ongoing clinical trials and approvals are expanding applications across multiple solid tumor types.
Despite major progress, sensitivity and specificity still require improvement, and assay standardization and validation across clinical settings remain challenging. AI-assisted interpretation of liquid biopsy data is expected to further enhance its clinical applications. This Specific Issue will highlight the role of liquid biopsy in cancer management, including cancer early detection, prognosis, personalized treatment selection ,and real-time monitoring, through technological innovation and clinical validation.
Prof. Dr. Yong-Jie Lu
Dr. Xia Yu
Guest Editors
Manuscript Submission Information
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Keywords
- liquid biopsy
- biomarkers
- circulating tumor cells
- circulating nucleic acids
- extracellular vesicles
- proteins
- cancer early detection
- prognosis
- personalized treatment
- real-time monitoring
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