Human Papillomavirus (HPV) and Related Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Infectious Agents and Cancer".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 928

Special Issue Editor


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Guest Editor
Maria Skłodowska-Curie National Research Institute of Oncology, Cracow Branch, Cracow, Poland
Interests: HPV infections; cancer
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Special Issue Information

Dear Colleagues,

Currently, infection with high-risk human papillomavirus (HR-HPV) is estimated to be the primary etiological factor for approximately 5% of all malignant tumors. HR-HPV infection is a well-established risk factor in the development of certain anogenital cancers, including cervical, vulvar, penile, and anal cancers. Recently, increasing attention has been directed toward the role of this infection in the development of other types of malignant tumors. Understanding the prevalence of HPV infection across various malignant tumor types may enhance our comprehension of the carcinogenesis process and assist in identifying novel prognostic and/or predictive factors in non-anogenital cancers. Although HPV infection is a recognized risk factor in the aforementioned cancers, its significance in the development of many other malignant tumors remains under investigation. Additionally, methods for detecting transcriptionally active infection, in particular, require further research. Therefore, we warmly invite you to submit your publication to the Special Issue of Cancers entitled “Human Papillomavirus (HPV) and Related Cancer”.

Prof. Dr. Beata Biesaga
Guest Editor

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Keywords

  • HPV
  • carcinogenesis
  • methods of virus identification diagnostics
  • prognostification

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Published Papers (1 paper)

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Review

18 pages, 4098 KiB  
Review
Human Papillomavirus-Related Cutaneous Squamous Cell Carcinoma
by Alejandra Sandoval-Clavijo, Ignasí Martí-Martí, Carla Ferrándiz-Pulido, Júlia Verdaguer-Faja, Ane Jaka and Agustí Toll
Cancers 2025, 17(5), 897; https://doi.org/10.3390/cancers17050897 - 5 Mar 2025
Viewed by 692
Abstract
The human papillomavirus (HPV) has been associated with the carcinogenesis of cutaneous squamous cell carcinoma (cSCC), especially in immunosuppressed patients. This article reviews the microbiology of HPV and its role in tissue tropism, invasion, and oncogenesis. It also describes possible HPV oncogenic ability [...] Read more.
The human papillomavirus (HPV) has been associated with the carcinogenesis of cutaneous squamous cell carcinoma (cSCC), especially in immunosuppressed patients. This article reviews the microbiology of HPV and its role in tissue tropism, invasion, and oncogenesis. It also describes possible HPV oncogenic ability due to the inactivation of the host p53 and retinoblastoma protein (pRb) by HPV oncoproteins E6 and E7, producing a suppression of cell cycle checkpoints and uncontrolled cell proliferation that may eventually result in invasive carcinoma. We will focus on β-HPV types and their role in epidermodysplasia verruciformis (EV), as well as α types and their ability to cause cutaneous and mucosal pathology. We also intend to examine the clinical characteristics of cSCC related to HPV and host immunosuppression conditions such as solid organ transplant in order to provide management guidelines for patients with cSCC associated with HPV based on available data. Other topics addressed in this article include particular locations of cSCC, such as nails; the prognosis; the recurrence; therapeutic modalities; and the role of HPV vaccines. Full article
(This article belongs to the Special Issue Human Papillomavirus (HPV) and Related Cancer)
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