Toxins, Volume 12, Issue 12 (December 2020) – 78 articles
Cover Story (view full-size image): Current anticancer therapy suffers from several limitations, including lack of selectivity and multidrug resistance. Natural products represent an excellent opportunity for the identification of new therapeutic options due to their safety, low toxicity, and general availability. Piper nigrum is one of the most popular species in the world, with growing fame as a source of bioactive molecules with pharmacological properties. The present review provides a comprehensive overview of the anticancer potential of Piper nigrum and its main bioactive component piperine, with particular emphasis on their anticancer mechanisms, chemosensitizing effects, and pharmacokinetic and toxicological profile. View this paper
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