Special Issue "Study on the Uremic Toxin Targeting Mechanism"
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Uremic Toxins".
Deadline for manuscript submissions: 31 October 2021.
Special Issue Editor
Interests: chronic kidney disease; uremic toxins; kynurenine pathway; osteoblastogenesis; renal osteodystrophy
Special Issue Information
Uremic toxins are biologically active compounds accumulated in the body in the course of chronic kidney disease (CKD). Their accumulation can lead to damage to multiple organ systems, raising the risk of death in patients with CKD. The mechanisms of uremic toxicity are multifactorial and still incompletely understood. Available treatment options for end-stage renal disease are principally limited to dialysis and organ transplantation, as other treatment alternatives have proven insufficient. Renal dysfunction is a complex biological process that is mediated by genetics, epigenetics, a dysregulated form of matrix mineral metabolism, hormones, and the activation of cellular signaling pathways.
This Special Issue is specifically focused on publishing original research articles, reviews, and short communications toward discovering and understanding novel mechanisms for interaction between uremic toxins and biological systems. A better understanding of the uremic toxin targeting mechanism can prevent/reduced uremic toxin accumulation and improve management of CKD patients.
Prof. Dariusz Pawlak
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chronic kidney disease
- uremic toxins
- signaling and metabolic pathways
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Contribution of uremic toxins to mineralization of soft tissues and cardiovascular system
Authors: Prof. Tomasz Stompur
Affiliation: Clinic of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, Zolnierska 18 Str., 10-561 Olsztyn, Poland
Title: Indoxyl Sulfate And Diabetic Kidney Disease. The Chicken and The Egg Dilemma
Authors: Tomasz Kaminski
Affiliation: Vascular Medicine Institute, University of Pittsburgh School of Medicine, BST E1200 – 26B, 200 Lothrop Street Pittsburgh, PA 15261 USA
Title: Thrombolome and its emerging role in chronic kidney diseases
Authors: Prof. Beata Naumnik
Affiliation: Faculty of Medicine with Division of Dentistry of Medical Education in English, Head of Department of Nephrology with Dialysis Unit, Medical Univesity of Bialystok Zurawia 14 Str 15-540 Bialystok, Poland
Title: Uraemic toxins and bacterial endocarditis - cases and literature review
Authors: Prof. Beata Naumnik
Affiliation: Faculty of Medicine with Division of Dentistry of Medical Education in English, Head of Department of Nephrology with Dialysis Unit, Medical Univesity of Bialystok Zurawia 14 Str 15-540 Bialystok, Poland
Title: "The links between microbiome and uremic toxins in acute kidney injury: beyond gut feeling – a systematic review."
Authors: Alicja Rydzewska-Rosołowska; Natalia Sroka; Katarzyna Kakareko; Mariusz Rosołowski; Edyta Zbroch; Tomasz Hryszko
Affiliation: Medical University of Białystok, 2nd Department of Nephrology and Hypertension with Dialysis Unit
Abstract: Last years have brought an abundance of data on the existence of a gut-kidney axis and the importance of microbiome in kidney injury. Data on kidney-gut crosstalk suggest the possibility that microbiota alters renal inflammation, therefore we aimed to answer questions about the role of microbiome and gut-derived toxins in acute kidney injury. PubMed and Cochrane Library were searched from inception to October 10, 2020 for relevant studies with an additional search performed on ClinicalTrials.gov. We identified 31 eligible articles and 1 ongoing trial (19 original studies and 12 reviews/commentaries) and included in this systematic review. Experimental studies prove the existence of a kidney-gut axis, focus on the role of gut-derived uremic toxins and provide concepts that modification of the microbiota composition may result in better AKI outcomes. Small interventional studies in animal models and in humans show promising results, therefore microbiome-targeted therapy for AKI treatment might be a promising possibility.