Next Article in Journal
Effects of Modification of Light Parameters on the Production of Cryptophycin, Cyanotoxin with Potent Anticancer Activity, in Nostoc sp.
Next Article in Special Issue
Intestinal Chelators, Sorbants, and Gut-Derived Uremic Toxins
Previous Article in Journal
Tolerability and Efficacy of Customized IncobotulinumtoxinA Injections for Essential Tremor: A Randomized, Double-Blind, Placebo-Controlled Study
Previous Article in Special Issue
Varying Protein Levels Influence Metabolomics and the Gut Microbiome in Healthy Adult Dogs
Open AccessReview

Targeting Uremic Toxins to Prevent Peripheral Vascular Complications in Chronic Kidney Disease

by 1,2,3 and 2,4,5,6,7,*
1
Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan
2
Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan
3
Translational Research Laboratory, Changhua Christian Hospital, Changhua 500, Taiwan
4
Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
5
Department and Institute of Physiology, National Yang-Ming University, Taipei 112, Taiwan
6
Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), Hsinchu 300, Taiwan
7
Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan
*
Author to whom correspondence should be addressed.
Toxins 2020, 12(12), 808; https://doi.org/10.3390/toxins12120808
Received: 18 November 2020 / Revised: 14 December 2020 / Accepted: 16 December 2020 / Published: 20 December 2020
(This article belongs to the Special Issue New Strategies for the Reduction of Uremic Toxins)
Chronic kidney disease (CKD) exhibits progressive kidney dysfunction and leads to disturbed homeostasis, including accumulation of uremic toxins, activated renin-angiotensin system, and increased oxidative stress and proinflammatory cytokines. Patients with CKD are prone to developing the peripheral vascular disease (PVD), leading to poorer outcomes than those without CKD. Cumulative evidence has showed that the synergy of uremic milieu and PVD could exaggerate vascular complications such as limb ischemia, amputation, stenosis, or thrombosis of a dialysis vascular access, and increase mortality risk. The role of uremic toxins in the pathogenesis of vascular dysfunction in CKD has been investigated. Moreover, growing evidence has shown the promising role of uremic toxins as a therapeutic target for PVD in CKD. This review focused on uremic toxins in the pathophysiology, in vitro and animal models, and current novel clinical approaches in reducing the uremic toxin to prevent peripheral vascular complications in CKD patients. View Full-Text
Keywords: AST-120; chronic kidney disease; indoxyl sulfate; peripheral vascular disease; phosphorus; uremic toxins AST-120; chronic kidney disease; indoxyl sulfate; peripheral vascular disease; phosphorus; uremic toxins
MDPI and ACS Style

Wu, C.-L.; Tarng, D.-C. Targeting Uremic Toxins to Prevent Peripheral Vascular Complications in Chronic Kidney Disease. Toxins 2020, 12, 808. https://doi.org/10.3390/toxins12120808

AMA Style

Wu C-L, Tarng D-C. Targeting Uremic Toxins to Prevent Peripheral Vascular Complications in Chronic Kidney Disease. Toxins. 2020; 12(12):808. https://doi.org/10.3390/toxins12120808

Chicago/Turabian Style

Wu, Chia-Lin; Tarng, Der-Cherng. 2020. "Targeting Uremic Toxins to Prevent Peripheral Vascular Complications in Chronic Kidney Disease" Toxins 12, no. 12: 808. https://doi.org/10.3390/toxins12120808

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop