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Open AccessReview

Botulinum Toxin in the Treatment of Headache

Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB T2N 2T9, Canada
Toxins 2020, 12(12), 803; https://doi.org/10.3390/toxins12120803
Received: 23 November 2020 / Revised: 8 December 2020 / Accepted: 11 December 2020 / Published: 17 December 2020
Botulinum toxin type A has been used in the treatment of chronic migraine for over a decade and has become established as a well-tolerated option for the preventive therapy of chronic migraine. Ongoing research is gradually shedding light on its mechanism of action in migraine prevention. Given that its mechanism of action is quite different from that of the new monoclonal antibodies directed against calcitonin gene-related peptide (CGRP) or its receptor, it is unlikely to be displaced to any major extent by them. Both will likely remain as important tools for patients with chronic migraine and the clinicians assisting them. New types of botulinum toxin selective for sensory pain neurons may well be discovered or produced by recombinant DNA techniques in the coming decade, and this may greatly enhance its therapeutic usefulness. This review summarizes the evolution of botulinum toxin use in headache management over the past several decades and its role in the preventive treatment of chronic migraine and other headache disorders. View Full-Text
Keywords: chronic migraine; migraine; botulinum toxin; onabotulinumtoxinA; erenumab; CGRP chronic migraine; migraine; botulinum toxin; onabotulinumtoxinA; erenumab; CGRP
MDPI and ACS Style

Becker, W.J. Botulinum Toxin in the Treatment of Headache. Toxins 2020, 12, 803. https://doi.org/10.3390/toxins12120803

AMA Style

Becker WJ. Botulinum Toxin in the Treatment of Headache. Toxins. 2020; 12(12):803. https://doi.org/10.3390/toxins12120803

Chicago/Turabian Style

Becker, Werner J. 2020. "Botulinum Toxin in the Treatment of Headache" Toxins 12, no. 12: 803. https://doi.org/10.3390/toxins12120803

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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