Special Issue "Global Impact of Ergot Alkaloids"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 30 October 2020.

Special Issue Editor

Dr. James L. Klotz
Website
Guest Editor
USDA-ARS Forage-Animal Production Research Unit Lexington, KY 40546, USA
Interests: ergot alkaloids, livestock, forages, toxicology pharmacology vascular physiology, systems biology

Special Issue Information

Dear Colleagues,

For many years ergot alkaloids have been identified and studied as both problems or toxins to be mitagated and also as potential medical solutions or cures. These comounds have been primarily studied in the medical/pharmaceutical and agricultural fields. Depending on one’s perspective, the impact that ergot alkaloids have had on the progress of human medicine and livestock production can be either positive or negative. The dose or concentration of ergot alkaloid exposure is paramount. This can make the difference from these compounds being implicated in the morbidity and mortality of individuals with St. Anthony’s Fire to being used to treat migraines and post-partum bleeding or being used to maximize plant resistance and persistence and being framed as an animal welfare concern for grazing the livestock. The ethics of ergot alkaloid use is debated to this day, but there is no debating their impacts. Many of the positive and negative issues associated with ergot alkaloids have specific conditions with regional implications, but that does not diminsh the magnitude of impact that these compounds have had on humans, livestock, and plants globally. The focus of this special issue will include original research and review articles that highlight benefits and detriments and successes and failures involving ergot alkloids around the world with deference to regional distinctions. What role have ergot alkaloids played and continue to play in your country, your region, and on your research? 

We all focus on how ergot alkaloids influence (positive or negative) our individual situation. There is a benefit to this shared interest even if the issues with ergot alkaloids don’t directly overlap.

Dr. James L. Klotz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Ergot alkaloids
  • Toxin
  • Drug development
  • Medicine
  • Livestock
  • Endophyte

Published Papers (1 paper)

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Research

Open AccessArticle
Novel Ergot Alkaloids Production from Penicillium citrinum Employing Response Surface Methodology Technique
Toxins 2020, 12(7), 427; https://doi.org/10.3390/toxins12070427 - 29 Jun 2020
Abstract
Ergot alkaloids are novel pharmaceutical and therapeutic agents synthesized in this study using fungal species Penicillium citrinum. To get the maximum yield of ergot alkaloids a statistical process of response surface methodology was employed using surface culture fermentation technique. Initially, the strain of [...] Read more.
Ergot alkaloids are novel pharmaceutical and therapeutic agents synthesized in this study using fungal species Penicillium citrinum. To get the maximum yield of ergot alkaloids a statistical process of response surface methodology was employed using surface culture fermentation technique. Initially, the strain of Penicillium was improved using physical (ultraviolet (UV) and chemical (ethyl methane sulfonate (EMS) treatments to get the maximum yield of ergot alkaloids through surface culture fermentation technique. After improving the strain, survival rate of colonies of Penicillium citrinum treated with UV and EMS was observed. Only 2.04% living colonies were observed after 150 min of exposure of Penicillium citrinum in UV light and 3.2% living colonies were observed after 20 min of the exposure in EMS. The mutated strains of Penicillium citrinum were screened for their production of ergot alkaloids and after fermentation experiments, maximum yield was obtained from PCUV-4 and PCEMS-1 strains. After strain improvement, Plackett–Burman design (PBD) and Box–Behnken design (BBD) of RSM were employed and 10-fold yield enhancement (35.60 mg/100 mL) of ergot alkaloids was achieved. This enhancement in yield of ergot alkaloids proved the positive impacts of RSM and UV on the yield of ergot alkaloids. The study provides a cost effective, economical and sustainable process to produce medically important ergot alkaloids which can be used in various pharmaceutical formulations to treat human diseases. Full article
(This article belongs to the Special Issue Global Impact of Ergot Alkaloids)
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