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Toxins, Volume 11, Issue 12

December 2019 - 58 articles

Cover Story: The evaluation of biological activity for conotoxins isolated from the venom of predatory marine snails of the genus Conus is difficult and prohibitive in many research environments. A common component of cone snail venom is α-conotoxins that act on nicotinic acetylcholine receptors. A qualitative screening method employing PC12 cells for the rapid detection of dopamine release from ligand activation or suppression of α7, α3β2, or α3β4-nicotinic acetylcholine receptor subtypes was evaluated. This PC12 cell-based assay proved useful as a screening tool for toxin-influenced receptor activity. View this paper.
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Articles (58)

  • Article
  • Open Access
24 Citations
6,644 Views
13 Pages

Staphylococcus aureus Pneumonia: Preceding Influenza Infection Paves the Way for Low-Virulent Strains

  • Stefanie Deinhardt-Emmer,
  • Karoline Frieda Haupt,
  • Marina Garcia-Moreno,
  • Jennifer Geraci,
  • Christina Forstner,
  • Mathias Pletz,
  • Christina Ehrhardt and
  • Bettina Löffler

17 December 2019

Staphylococcus aureus is a facultative pathogenic bacterium that colonizes the nasopharyngeal area of healthy individuals, but can also induce severe infection, such as pneumonia. Pneumonia caused by mono- or superinfected S. aureus leads to high mor...

  • Article
  • Open Access
48 Citations
5,679 Views
23 Pages

Intraspecific Variability in the Toxin Production and Toxin Profiles of In Vitro Cultures of Gambierdiscus polynesiensis (Dinophyceae) from French Polynesia

  • Sébastien Longo,
  • Manoella Sibat,
  • Jérôme Viallon,
  • Hélène Taiana Darius,
  • Philipp Hess and
  • Mireille Chinain

17 December 2019

Ciguatera poisoning (CP) is a foodborne disease caused by the consumption of seafood contaminated with ciguatoxins (CTXs) produced by dinoflagellates in the genera Gambierdiscus and Fukuyoa. The toxin production and toxin profiles were explored in fo...

  • Article
  • Open Access
39 Citations
4,963 Views
13 Pages

Deoxynivalenol Induces Inflammatory Injury in IPEC-J2 Cells via NF-κB Signaling Pathway

  • Xichun Wang,
  • Yafei Zhang,
  • Jie Zhao,
  • Li Cao,
  • Lei Zhu,
  • Yingying Huang,
  • Xiaofang Chen,
  • Sajid Ur Rahman,
  • Shibin Feng and
  • Yu Li
  • + 1 author

16 December 2019

The aim of this study was to investigate the effects of deoxynivalenol (DON) exposure on the inflammatory injury nuclear factor kappa-B (NF-κB) pathway in intestinal epithelial cells (IPEC-J2 cells) of pig. The different concentrations of DON (...

  • Article
  • Open Access
14 Citations
6,144 Views
14 Pages

The Peptide Venom Composition of the Fierce Stinging Ant Tetraponera aethiops (Formicidae: Pseudomyrmecinae)

  • Valentine Barassé,
  • Axel Touchard,
  • Nathan Téné,
  • Maurice Tindo,
  • Martin Kenne,
  • Christophe Klopp,
  • Alain Dejean,
  • Elsa Bonnafé and
  • Michel Treilhou

14 December 2019

In the mutualisms involving certain pseudomyrmicine ants and different myrmecophytes (i.e., plants sheltering colonies of specialized “plant-ant” species in hollow structures), the ant venom contributes to the host plant biotic defenses b...

  • Review
  • Open Access
28 Citations
4,789 Views
17 Pages

13 December 2019

Neurogenic and non-neurogenic urethral sphincter dysfunction are common causes of voiding dysfunction. Injections of botulinum toxin A (BoNT-A) into the urethral sphincter have been used to treat urethral sphincter dysfunction (USD) refractory to con...

  • Article
  • Open Access
23 Citations
9,548 Views
12 Pages

Measurement of Microcystin and Nodularin Activity in Human Urine by Immunocapture-Protein Phosphatase 2A Assay

  • Rebekah E. Wharton,
  • Brady R. Cunningham,
  • Adam M. Schaefer,
  • Sophia M. Guldberg,
  • Elizabeth I. Hamelin and
  • Rudolph C. Johnson

13 December 2019

Microcystins (MC) and nodularin (NOD) are toxins released by cyanobacteria during harmful algal blooms. They are potent inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A) and cause a variety of adverse symptoms in humans and animals if ingest...

  • Article
  • Open Access
16 Citations
3,620 Views
14 Pages

AflSte20 Regulates Morphogenesis, Stress Response, and Aflatoxin Biosynthesis of Aspergillus flavus

  • Ding Li,
  • Ling Qin,
  • Yinchun Wang,
  • Qingchen Xie,
  • Na Li,
  • Shihua Wang and
  • Jun Yuan

13 December 2019

Various signaling pathways in filamentous fungi help cells receive and respond to environmental information. Previous studies have shown that the mitogen-activated protein kinase (MAPK) pathway is phosphorylation-dependent and activated by different...

  • Article
  • Open Access
169 Citations
15,546 Views
20 Pages

13 December 2019

Resveratrol, a natural polyterpenoid, can scavenge reactive oxygen species in vivo to carry out the functions of antioxidation and antiaging. Resveratrol’s anti-cancer capability has attracted widespread attention, but its molecular mechanism has not...

  • Article
  • Open Access
35 Citations
5,825 Views
20 Pages

Ciguatoxin Occurrence in Food-Web Components of a Cuban Coral Reef Ecosystem: Risk-Assessment Implications

  • Lisbet Díaz-Asencio,
  • Rachel J. Clausing,
  • Mark Vandersea,
  • Donaida Chamero-Lago,
  • Miguel Gómez-Batista,
  • Joan I. Hernández-Albernas,
  • Nicolas Chomérat,
  • Gabriel Rojas-Abrahantes,
  • R. Wayne Litaker and
  • Patricia Tester
  • + 3 authors

11 December 2019

In Cuba, ciguatera poisoning associated with fish consumption is the most commonly occurring non-bacterial seafood-borne illness. Risk management through fish market regulation has existed in Cuba for decades and consists of bans on selected species...

  • Article
  • Open Access
17 Citations
7,207 Views
11 Pages

11 December 2019

Amatoxins (AMAs) are lethal toxins found in a variety of mushroom species. Detection methods are needed to determine the occurrence of AMAs in mushroom species suspected in mushroom poisonings. In this manuscript, we report the generation of novel mo...

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Toxins - ISSN 2072-6651