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Special Issue "Animal Venoms and Their Components: Molecular Mechanisms of Action"
Deadline for manuscript submissions: 31 May 2020.
Interests: Isolation of proteins with new structural and pharmacological properties from animal venoms. Investigation of chemical and spatial structures of biologically active peptides and proteins, in particular animal toxins. Studying the mechanism of the ligand-receptor interaction. Elucidation of the general principles of protein recognition for particular cases of the neuroreceptor interactions with neuropeptides and neurotoxins. Characterization of ligand-binding sites in neuroreceptors as a prerequisite for rational drug design.
Animal venoms comprise numerous toxins, which, in turn, comprise peptides and proteins. In prey, these toxins affect various vitally important systems that may result in severe illness or death. During evolution, toxins acquired the ability to bind selectively and with high affinity to biological targets in organisms. However, at present, not all toxin targets have been identified, and not all the molecular mechanisms underlying the effects of toxins are understood. This understanding is very important for the efficient treatment of envenomation, which still continues to be a significant problem. On the other hand, their high selectivity and efficiency make toxins valuable molecular tools for fundamental research. Moreover, toxins with known mechanisms of action may serve as templates for drug development. All this suggests that studying the molecular mechanisms of action of animal venoms and their toxins is a very challenging but important task. The aim of this Special Issue of Toxins is to present a modern understanding of the various aspects of the molecular mechanisms underlying the action of animal venoms and their components.
Prof. Yuri N. Utkin
- marine snail
- jelly fish
- sea anemone
- biological target
- molecular mechanism