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Special Issue "Staphylococcus aureus Toxins: Promoter or Handicap during Infection"
Deadline for manuscript submissions: 30 June 2020.
S. aureus is an opportunistic and versatile pathogen that can cause several diseases ranging from acute and invasive to chronic and difficult-to-treat infections. S. aureus can colonize the nasopharynx of many individuals but also causes infections that vary from superficial mild skin infections to severe necrotizing diseases, such as bacteremia, infective endocarditis, osteomyelitis, and device-related infections. Many staphylococcal infections are associated with significant morbidity and mortality. The ability of S. aureus to trigger different types of infection is due to its wide repertoire of virulence factors and strategies that can evade the host immune system. To start the infection, S. aureus uses different surface-bound proteins that facilitate the pathogen to attach to host tissue and invade host cells. After internalization, S. aureus can express a multitude of molecules that destroy host cells in order to enter deep tissue structures and get the nutrition necessary for its growth or to defend against elements of the immune system, such as superantigens. However, for bacterial persistence, many of these toxins need to be downregulated. In this way, the bacteria can avoid clearance by the immune defense and can silently persist within host cells/tissue for long time periods.
Taken together, virulence factors, in particular toxins, need to be regulated precisely during the course of infection by global regulators which act as a feedback to the surrounding microenvironment. Even though staphylococcal toxins have been studied in depth, the question still remains as to whether a “virulent” strain which expresses a lot of secreted toxins or a “silent” persisting strain is the real danger for the host.
The purpose of this Special Issue is to publish original research work related to the role of toxins in immune escape and host–pathogen interaction, regulation of toxins during infection, relation between expression of virulence factors and clinical outcome, toxins as activators or inhibitors of host clearance machine, toxins as targets for vaccine development, and the impact of agr-negative strains in the clinic.
Dr. Lorena Tuchscherr
Prof. Bettina Löffler
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- S. aureus
- host–pathogen interaction
- immune escape
- host clearance evasion