Special Issue "Characterization and Quantitative Analysis of Botulinum Neurotoxin"
Deadline for manuscript submissions: closed (31 July 2019) | Viewed by 59149
Botulism is caused by exposure to Botulinum neurotoxins (BoNTs), protein toxins produced by Clostridium botulinum and related Clostridia. With seven confirmed serotypes and over 40 subtypes, the diversity of these neurotoxins is both fascinating and challenging. Characterization of the varied BoNTs through qualitative analysis is critical for understanding toxicity/mechanism of action, and structure/function relationships, designing medical countermeasures to treat or prevent botulism, and development of assays to detect the neurotoxin. A quantitiative analysis of the neurotoxin assists in medical countermeasure development as well as toxicity assessments. This Special Issue will focus on qualitative and/or quantitative analysis of BoNTs as it applies to mechanism of action, toxicity assessment, structure/function relationships, medical countermeasure development, and assay development.
Dr. Suzanne R. Kalb
Manuscript Submission Information
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- Botulinum neurotoxin
- Mechanism of action
- Toxicity assessment
- Structure/function relationship
- Quantitative analysis