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Structural Diversity, Characterization and Toxicology of Microcystins
Open AccessArticle

Metabolome Variation between Strains of Microcystis aeruginosa by Untargeted Mass Spectrometry

1
Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada
2
Current address: Environment and Climate Change Canada, Canada Centre for Inland Waters, Burlington, ON L7S 1A1, Canada
*
Author to whom correspondence should be addressed.
Toxins 2019, 11(12), 723; https://doi.org/10.3390/toxins11120723
Received: 16 October 2019 / Revised: 1 December 2019 / Accepted: 4 December 2019 / Published: 11 December 2019
Cyanobacteria are notorious for their potential to produce hepatotoxic microcystins (MCs), but other bioactive compounds synthesized in the cells could be as toxic, and thus present interest for characterization. Ultra performance liquid chromatography and high-resolution accurate mass spectrometry (UPLC-QTOF-MS/MS) combined with untargeted analysis was used to compare the metabolomes of five different strains of the common bloom-forming cyanobacterium, Microcystis aeruginosa. Even in microcystin-producing strains, other classes of oligopeptides including cyanopeptolins, aeruginosins, and aerucyclamides, were often the more dominant compounds. The distinct and large variation between strains of the same widespread species highlights the need to characterize the metabolome of a larger number of cyanobacteria, especially as several metabolites other than microcystins can affect ecological and human health. View Full-Text
Keywords: Cyanobacteria; Microcystis aeruginosa; metabolome; microcystins; oligopeptides; HRMS (UPLC-QTOF) Cyanobacteria; Microcystis aeruginosa; metabolome; microcystins; oligopeptides; HRMS (UPLC-QTOF)
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MDPI and ACS Style

Racine, M.; Saleem, A.; Pick, F.R. Metabolome Variation between Strains of Microcystis aeruginosa by Untargeted Mass Spectrometry. Toxins 2019, 11, 723.

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