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Toxins, Volume 17, Issue 12

December 2025 - 42 articles

Cover Story: Amanita muscaria (fly agaric) remains an uncommon but clinically significant cause of acute mushroom poisoning, with highly variable toxic effects. This article presents a literature review of this mushroom’s biochemical makeup, toxicodynamics, and clinical manifestations—focusing on the principal toxins ibotenic acid and muscimol—and illustrates these findings through two severe intoxication cases in elderly spouses following home preparation. The cases underscore rapid-onset gastrointestinal symptoms, profound central nervous system depression, and autonomic disturbances, highlighting diagnostic and management challenges. This work emphasizes the need for heightened clinical awareness and improved toxicological preparedness. View this paper
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Articles (42)

  • Review
  • Open Access
484 Views
20 Pages

18 December 2025

Toxic Shock Syndrome Toxin-1 (TSST-1) is produced by Staphylococcus aureus strains encoded by the tst gene. Toxic shock syndrome (TSS) is a severe disease caused by TSST-1 toxin and associated with staphylococcal food poisoning (SFP). The aim of the...

  • Case Report
  • Open Access
261 Views
7 Pages

Venom-Induced Recurrent Thrombocytopenia: A Model of Intervention-Driven Platelet Modulation

  • Mojca Dobaja Borak,
  • Katarina Reberšek,
  • Tihana Kurtović,
  • Adrijana Leonardi,
  • Igor Križaj and
  • Miran Brvar

17 December 2025

We present the case of a Vipera ammodytes ammodytes (Vaa, nose-horned viper)-bitten patient with recurrent thrombocytopenia. A 53-year-old patient envenomated by Vaa experienced three episodes of venom-dependent thrombocytopenia (4, 57 and 11 ×...

  • Review
  • Open Access
336 Views
25 Pages

Microorganism-Based Strategies for the Control of Cyanobacterial Blooms: A Review of Recent Progress

  • Wangle Zhang,
  • Shiyuan Meng,
  • Xiaoxu Wu,
  • Hong Shen,
  • Dongqin Wang,
  • Tong Qiu,
  • Weijie Li,
  • Jiping Chen,
  • Ling Li and
  • Bingbing Liang
  • + 3 authors

17 December 2025

Cyanobacterial blooms, which are increasingly exacerbated by eutrophication and climate change, pose threats to ecosystems and public health. This paper systematically reviews recent advances in microbial intervention strategies for controlling cyano...

  • Article
  • Open Access
869 Views
13 Pages

Why, When, and How to Treat Dynamic Forehead Lines with Botulinum Toxin Type A

  • Carla de Sanctis Pecora,
  • Martina Kerscher,
  • Mariana Muniz and
  • Ada Trindade de Almeida

17 December 2025

Recent advances in the understanding of facial anatomy have contributed significantly to the refinement of injection techniques for the treatment of dynamic forehead lines. A comprehensive assessment of eyebrow shape, position, and the aging process...

  • Review
  • Open Access
387 Views
19 Pages

16 December 2025

Bacteria encode a broad range of survival and defence systems, including CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas systems, restriction-modification systems, and toxin–antitoxin (TA) systems, which are involved in b...

  • Article
  • Open Access
304 Views
13 Pages

Characterization of Alpha-Bungarotoxin Antibodies Prepared by Different Strategies

  • Huijuan Lu,
  • Guowen Zhang,
  • Lin Zhao,
  • Ying Yuan,
  • Bing Gong,
  • Bin Han and
  • Wen-Hui Lee

16 December 2025

The preparation of an antibody to treat snake envenomation requires a large amount of snake venom. In China, only four types of anti-snake venom sera are clinically available, and the production and immunization strategies for clinically approved ant...

  • Article
  • Open Access
345 Views
15 Pages

16 December 2025

Parasitoid wasp venoms represent highly specialized biochemical arsenals that evolved to manipulate host physiology and ensure successful development of the parasitoid offspring. However, the molecular targets and mechanisms underlying this complex h...

  • Review
  • Open Access
588 Views
21 Pages

15 December 2025

The interaction between gut microbiota dysbiosis and CKD progression via the “gut–kidney axis” is increasingly recognized. Gut-derived uremic toxins (e.g., indoxyl sulfate and p-cresyl sulfate) accumulate systemically, while benefic...

  • Review
  • Open Access
453 Views
16 Pages

Immunological Considerations of Polysorbate as an Excipient in Botulinum Neurotoxin Type A Formulations: A Narrative Review

  • Michael Uwe Martin,
  • Jürgen Frevert,
  • Je-Young Park,
  • Haiyan Cui,
  • Andy Curry and
  • Wei Qi Loh

15 December 2025

Recent botulinum neurotoxin type A (BoNT/A) formulations have shifted towards the use of polysorbate 20 (PS20) and polysorbate 80 (PS80) as a non-human-derived excipient to enhance product stability. Polysorbates are a distinct class of synthetic non...

  • Article
  • Open Access
427 Views
12 Pages

Artificial Intelligence Analysis of Symmetry and Emotions in Facial Palsy Patients After Botulinum Toxin A Injections

  • Seraina L. C. Müller,
  • Chantal Zeier,
  • Pablo Pfister,
  • Nadia Menzi,
  • Bita Tafrishi,
  • Dirk J. Schaefer,
  • Jan A. Plock,
  • Tarek Ismail and
  • Holger J. Klein

15 December 2025

Facial palsy affects millions worldwide. Botulinum toxin Type A (BoNT-A) is an established treatment for non-flaccid facial palsy, yet objective evidence remains limited. This study evaluates the effects of BoNT-A using AI-based tools and patient-rep...

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Toxins - ISSN 2072-6651