Table of Contents
Mar. Drugs, Volume 17, Issue 3 (March 2019)
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Cover Story (view full-size image) Though in many cases bioactive metabolites have been attributed to marine sponges and other [...] Read more. Though in many cases bioactive metabolites have been attributed to marine sponges and other invertebrates, due to the extraction of both animal and associated symbiotic microorganisms for the isolation of the metabolites, the true origin often remains unclear. An increasing number of reports highlight the production of metabolites, originally assigned to the animal, by associated microorganisms. Now, studies on the sea anemone Gyractis sesere at Easter Island (Chile) add a new example to this topic. The two cytotoxic anthraquinones Lupinacidin A and Galvaquinone B present in extracts of the sea anemone were ultimately found to be products of an actinobacterium associated with this animal and were identified in extracts of a Verrucosispora species, an isolate from this sea anemone. View this paper