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Marine Drugs, Volume 17, Issue 3

March 2019 - 57 articles

Cover Story: Though in many cases bioactive metabolites have been attributed to marine sponges and other invertebrates, due to the extraction of both animal and associated symbiotic microorganisms for the isolation of the metabolites, the true origin often remains unclear. An increasing number of reports highlight the production of metabolites, originally assigned to the animal, by associated microorganisms. Now, studies on the sea anemone Gyractis sesere at Easter Island (Chile) add a new example to this topic. The two cytotoxic anthraquinones Lupinacidin A and Galvaquinone B present in extracts of the sea anemone were ultimately found to be products of an actinobacterium associated with this animal and were identified in extracts of a Verrucosispora species, an isolate from this sea anemone. View this paper
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Articles (57)

  • Article
  • Open Access
24 Citations
4,512 Views
16 Pages

High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing

  • Ge Yao,
  • Chao Peng,
  • Yabing Zhu,
  • Chongxu Fan,
  • Hui Jiang,
  • Jisheng Chen,
  • Ying Cao and
  • Qiong Shi

26 March 2019

The venom of each Conus species consists of a diverse array of neurophysiologically active peptides, which are mostly unique to the examined species. In this study, we performed high-throughput transcriptome sequencing to extract and analyze putative...

  • Article
  • Open Access
32 Citations
5,188 Views
11 Pages

25 March 2019

Plastid proteins are one of the main components in red algae. In order to clarify the angiotensin I converting enzyme (ACE) inhibitory peptides from red alga Palmaria sp. (Japan), we determined the plastid genome sequence. The genome possesses 205 pr...

  • Review
  • Open Access
44 Citations
8,061 Views
28 Pages

25 March 2019

Saline environments, such as marine and hypersaline habitats, are widely distributed around the world. They include sea waters, saline lakes, solar salterns, or hypersaline soils. The bacteria that live in these habitats produce and develop unique bi...

  • Article
  • Open Access
23 Citations
4,378 Views
11 Pages

Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga Dictyota spiralis

  • Olfa Chiboub,
  • Ines Sifaoui,
  • Jacob Lorenzo-Morales,
  • Manef Abderrabba,
  • Mondher Mejri,
  • José Javier Fernández,
  • José E. Piñero and
  • Ana R. Díaz-Marrero

25 March 2019

Bioassay-guided fractionation of the antikinetoplastid extract of the brown alga Dictyota spiralis has led to the isolation of spiralyde A (1), a new dolabellane aldehyde, along with other five known related diterpenes (2–6). Their structures w...

  • Article
  • Open Access
24 Citations
6,026 Views
17 Pages

23 March 2019

Stress, protein aggregation, and loss of functional properties of cells have been shown to contribute to several deleterious pathologies including cancer and neurodegeneration. The incidence of these pathologies has also been shown to increase with a...

  • Article
  • Open Access
20 Citations
6,220 Views
16 Pages

Phytoene Accumulation in the Novel Microalga Chlorococcum sp. Using the Pigment Synthesis Inhibitor Fluridone

  • Kelly Laje,
  • Mark Seger,
  • Barry Dungan,
  • Peter Cooke,
  • Juergen Polle and
  • F. Omar Holguin

22 March 2019

Carotenoids are lipophilic pigments found in plants and algae, as well as some bacteria, archaea, and fungi that serve two functions—(1) as light harvesting molecules—primary carotenoids, and (2) as antioxidants, acting against reactive o...

  • Article
  • Open Access
17 Citations
4,964 Views
12 Pages

Structure and Neuroprotective Effect of Polysaccharide from Viscera Autolysates of Squid Ommastrephes bartrami

  • Peng Ye,
  • Peipei Li,
  • Wenge Yang,
  • Yue Zhao,
  • Yuqin Zhao,
  • Kunlai Sun,
  • Bin Wang and
  • Yin Chen

22 March 2019

To explore bioactive polysaccharides from the byproducts of squid processing, a heteropolysaccharide, named SV2-1, was isolated from the viscera of squid Ommastrephes bartrami by autolysis, anion-exchange and gel-permeation chromatography and measure...

  • Article
  • Open Access
12 Citations
4,456 Views
7 Pages

Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636

  • Xiuli Xu,
  • Jiahui Han,
  • Rui Lin,
  • Steven W. Polyak and
  • Fuhang Song

21 March 2019

Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomyc...

  • Article
  • Open Access
16 Citations
4,284 Views
12 Pages

Chromone-Derived Polyketides from the Deep-Sea Fungus Diaporthe phaseolorum FS431

  • Heng Guo,
  • Zhao-Ming Liu,
  • Yu-Chan Chen,
  • Hai-Bo Tan,
  • Sai-Ni Li,
  • Hao-Hua Li,
  • Xiao-Xia Gao,
  • Hong-Xin Liu and
  • Wei-Min Zhang

20 March 2019

Five new chromone-derived polyketides phaseolorins A-F (1–5), together with nine known compounds, were isolated from the deep-sea derived fungus Diaporthe phaseolorum FS431. The structures of new compounds were determined by analysis of their N...

  • Review
  • Open Access
418 Citations
21,651 Views
18 Pages

20 March 2019

The marine acid polysaccharide fucoidan has attracted attention from both the food and pharmaceutical industries due to its promising therapeutic effects. Fucoidan is a polysaccharide that mainly consists of L-fucose and sulphate groups. Its excellen...

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Mar. Drugs - ISSN 1660-3397Creative Common CC BY license