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Mar. Drugs 2019, 17(3), 182; https://doi.org/10.3390/md17030182

Chromone-Derived Polyketides from the Deep-Sea Fungus Diaporthe phaseolorum FS431

1
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China
2
College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
3
Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
*
Authors to whom correspondence should be addressed.
Received: 28 February 2019 / Revised: 13 March 2019 / Accepted: 15 March 2019 / Published: 20 March 2019
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Abstract

Five new chromone-derived polyketides phaseolorins A-F (15), together with nine known compounds, were isolated from the deep-sea derived fungus Diaporthe phaseolorum FS431. The structures of new compounds were determined by analysis of their NMR and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectroscopic data. The absolute configurations were confirmed by chemical transformations, extensively experimental electron capture detection (ECD) calculations, or X-ray crystallography. Among them, compound 2 represented the first example for a new family of chromone derivative possessing an unprecedented recombined five-member γ-lactone ring. Moreover, the new compounds (15) were evaluated for in vitro cytotoxic activities against a panel of human cancer cell lines. View Full-Text
Keywords: Diaporthe phaseolorum; deep-sea derived fungus; chromone-derived polyketides; phaseolorins A-F Diaporthe phaseolorum; deep-sea derived fungus; chromone-derived polyketides; phaseolorins A-F
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Guo, H.; Liu, Z.-M.; Chen, Y.-C.; Tan, H.-B.; Li, S.-N.; Li, H.-H.; Gao, X.-X.; Liu, H.-X.; Zhang, W.-M. Chromone-Derived Polyketides from the Deep-Sea Fungus Diaporthe phaseolorum FS431. Mar. Drugs 2019, 17, 182.

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