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Mar. Drugs 2019, 17(3), 192; https://doi.org/10.3390/md17030192

Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga Dictyota spiralis

1
Instituto Universitario de Bio-Orgánica Antonio González (IUBO AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna (ULL), Avda. Astrofísico F. Sánchez, 2, 38206 La Laguna, Tenerife, Spain
2
Instituto Universitario de Enfermedades Tropicales y Salud Pública de Islas Canarias, Universidad de La Laguna, Avda. Astrofísico F. Sánchez s/n, 38206 La Laguna, Tenerife, Spain
3
Laboratoire Matériaux-Molécules et Applications, IPEST, B.P 51, La Marsa, University of Carthage, Tunis 2070, Tunisia
4
Institut National d’Agronomie de Tunis, 43 Avenue Charles Nicolle, University of Carthage, Tunis 1082, Tunisia
5
Departamento de Química Orgánica, Universidad de La Laguna (ULL), Avda. Astrofísico F. Sánchez, 2, 38206 La Laguna, Tenerife, Spain
*
Authors to whom correspondence should be addressed.
Received: 4 March 2019 / Revised: 18 March 2019 / Accepted: 21 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Marine Natural Products with Antiprotozoal Activity)
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Abstract

Bioassay-guided fractionation of the antikinetoplastid extract of the brown alga Dictyota spiralis has led to the isolation of spiralyde A (1), a new dolabellane aldehyde, along with other five known related diterpenes (26). Their structures were determined by HRESIMS, 1D and 2D NMR spectroscopy, and comparison with data reported in the literature. The antiparasitic activity of all compounds was evaluated. Spiralyde A (1) and the known compound 3,4-epoxy-7,18-dolabelladiene (2) were the most active compounds against Leishmania amazonensis and Trypanosoma cruzi. Spiralyde A (1) was the most potent compound, comparable to benznidazole, the reference drug for trypanocidal activity. View Full-Text
Keywords: Spiralyde A; brown algae; antikinetoplastid; dolabellanes; Dictyota spiralis; Leishmania; Trypanosoma Spiralyde A; brown algae; antikinetoplastid; dolabellanes; Dictyota spiralis; Leishmania; Trypanosoma
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Chiboub, O.; Sifaoui, I.; Lorenzo-Morales, J.; Abderrabba, M.; Mejri, M.; Fernández, J.J.; Piñero, J.E.; Díaz-Marrero, A.R. Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga Dictyota spiralis. Mar. Drugs 2019, 17, 192.

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