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Mar. Drugs 2019, 17(3), 186; https://doi.org/10.3390/md17030186

Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636

1
School of Ocean Sciences, China University of Geosciences, Beijing 100083, China
2
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
3
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, Australia
*
Author to whom correspondence should be addressed.
Received: 28 February 2019 / Revised: 14 March 2019 / Accepted: 19 March 2019 / Published: 21 March 2019
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
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Abstract

Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compound 4 exhibited moderate antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) with Minimum Inhibitory Concentration (MIC) values of 12.5 and 25 μg/mL, respectively. Compound 6 displayed significant antibacterial activities against S. aureus, MRSA and Bacillus Calmette-Guérin (BCG) with MIC values of 0.78, 0.78 and 1.25 μg/mL, respectively. View Full-Text
Keywords: marine-derived Streptomycetes; piperazine-trione; antibacterial; MRSA marine-derived Streptomycetes; piperazine-trione; antibacterial; MRSA
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Xu, X.; Han, J.; Lin, R.; Polyak, S.W.; Song, F. Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636. Mar. Drugs 2019, 17, 186.

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