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Open AccessArticle

Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636

School of Ocean Sciences, China University of Geosciences, Beijing 100083, China
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, Australia
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(3), 186;
Received: 28 February 2019 / Revised: 14 March 2019 / Accepted: 19 March 2019 / Published: 21 March 2019
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
PDF [608 KB, uploaded 21 March 2019]


Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compound 4 exhibited moderate antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) with Minimum Inhibitory Concentration (MIC) values of 12.5 and 25 μg/mL, respectively. Compound 6 displayed significant antibacterial activities against S. aureus, MRSA and Bacillus Calmette-Guérin (BCG) with MIC values of 0.78, 0.78 and 1.25 μg/mL, respectively. View Full-Text
Keywords: marine-derived Streptomycetes; piperazine-trione; antibacterial; MRSA marine-derived Streptomycetes; piperazine-trione; antibacterial; MRSA

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Xu, X.; Han, J.; Lin, R.; Polyak, S.W.; Song, F. Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636. Mar. Drugs 2019, 17, 186.

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