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Mar. Drugs 2019, 17(3), 188;

Structure and Neuroprotective Effect of Polysaccharide from Viscera Autolysates of Squid Ommastrephes bartrami

College of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316000, China
Marine School, Ningbo University, Ningbo 315000, China
Zhejiang Mariculture Research Institute, Zhoushan 316000, China
Author to whom correspondence should be addressed.
Received: 6 February 2019 / Revised: 5 March 2019 / Accepted: 15 March 2019 / Published: 22 March 2019
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To explore bioactive polysaccharides from the byproducts of squid processing, a heteropolysaccharide, named SV2-1, was isolated from the viscera of squid Ommastrephes bartrami by autolysis, anion-exchange and gel-permeation chromatography and measured for its neuroprotective activity. It was a homogeneous polysaccharide with a molecular weight of 2.3 kDa by HPSEC analysis. SV2-1 contained glucuronic acid, galactosamine and fucose in the ratio of 1.0:1.1:1.2. Its structural characteristics were elucidated by methylation analysis, gas chromatography-mass spectrometry (GC-MS), and nuclear magnetic resonance (NMR). The backbone of SV2-1 was composed of alternant →4)-α-l-Fucp-(1→ and →3)-β-d-GlcUA-(1→ Most of →4)-α-l-Fucp-(1→ (90%) was substituted by single α-d-GlcNAc as the branches. SV2-1 can protect against the death of PC12 induced by 6-OHDA, and effectively improves cell viability and reduces extracellular LDH release in PC12 cells after injury. Moreover, SV2-1 significantly increases SOD activity but decreases MDA levels. View Full-Text
Keywords: polysaccharide; squid autolysate; structure; neuroprotective polysaccharide; squid autolysate; structure; neuroprotective

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Ye, P.; Li, P.; Yang, W.; Zhao, Y.; Zhao, Y.; Sun, K.; Wang, B.; Chen, Y. Structure and Neuroprotective Effect of Polysaccharide from Viscera Autolysates of Squid Ommastrephes bartrami. Mar. Drugs 2019, 17, 188.

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