Special Issue "Quorum Quenching Agents: Exploring Quorum Sensing Interfering Strategies in Marine Bacteria for the Development of Novel Therapeutics"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (15 November 2019).
Interests: isolation and stereostructural elucidation of new leads compounds in anti-inflammatory and anti-cancer drug discovery; exploration of the QQ and the QS system in bacteria symbiotic with sponges with the goal to create novel leads in antibacterial drug discovery; cyanobacteria as source of novel lead compounds and toxins
Special Issues and Collections in MDPI journals
Special Issue in Marine Drugs: Marine Secondary Metabolite II, 2017
Topical Collection in Marine Drugs: International Summer School on Natural Products: The Contribution of Young Researchers to Marine Inspired Products
Special Issue in Molecules: Sea-Inspired Molecules
Special Issue in Molecules: Selected Papers from the 7th European Chemical Biology Symposium 2021 (ECBS/LS EuCHEMS)
It is well recognized that bacteria are able to communicate with each other using a cell-signaling system, known as “quorum sensing” (QS). The “language” that bacteria use to communicate is the use of small signaling molecules, enabling them to activate a variety of processes, including the biosynthesis of virulence factors, and biofilm formation in a synchronized, population-density-dependent manner. The discovery that QS controls the production of virulence factors and biofilm formation in many common nosocomial pathogens has opened the way for research looking at novel agents able to interfere with the QS mechanism, with the idea of developing novel ways to fight and/or control bacterial infections, other than by using antibiotics.
In recent years, the need to find alternatives to antibiotics has raised the level of emergency, due to the increasing occurrence of resistant strains that have enormous consequences for human lives and economic impact. The marine world represents an excellent source to isolate bioactive compounds that are able to interfere with the QS system, i.e. quorum quenching (QQ) agents, and, at the same time, to identify novel chemical tools to develop studies on QS mechanisms and their regulation.
This Special Issue of Marine Drugs will cover the entire field of marine QS and QQ agents. In particular, studies on the molecular mechanisms of these compounds are especially encouraged.
Prof. Valeria Costantino
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Quorum sensing
- Quorum quenching agents
- N-acyl homoserine lactones
- Marine bacteria
- Antivirulance lead compounds
- LuxR homologues
- LuxI homologues
- Peptide signalling molecules