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Mar. Drugs 2019, 17(3), 176; https://doi.org/10.3390/md17030176

Phenalenones from a Marine-Derived Fungus Penicillium sp.

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
2
School of Pharmacy, Bandung Institute of Technology, Jl. Ganesha 10, Bandung 40132, Indonesia
3
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
*
Authors to whom correspondence should be addressed.
Received: 26 February 2019 / Revised: 14 March 2019 / Accepted: 14 March 2019 / Published: 18 March 2019
(This article belongs to the Special Issue Natural Products from Marine Fungi)
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Abstract

Six new phenalenone derivatives (16), along with five known compounds (711) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity. View Full-Text
Keywords: herqueinones; phenalenones; Penicillium sp.; marine-derived fungi; adipogenesis; anti-angiogenesis; anti-inflammatory herqueinones; phenalenones; Penicillium sp.; marine-derived fungi; adipogenesis; anti-angiogenesis; anti-inflammatory
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Park, S.C.; Julianti, E.; Ahn, S.; Kim, D.; Lee, S.K.; Noh, M.; Oh, D.-C.; Oh, K.-B.; Shin, J. Phenalenones from a Marine-Derived Fungus Penicillium sp.. Mar. Drugs 2019, 17, 176.

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