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Open AccessArticle

Phenalenones from a Marine-Derived Fungus Penicillium sp.

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
2
School of Pharmacy, Bandung Institute of Technology, Jl. Ganesha 10, Bandung 40132, Indonesia
3
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(3), 176; https://doi.org/10.3390/md17030176
Received: 26 February 2019 / Revised: 14 March 2019 / Accepted: 14 March 2019 / Published: 18 March 2019
(This article belongs to the Special Issue Natural Products from Marine Fungi)
Six new phenalenone derivatives (16), along with five known compounds (711) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity. View Full-Text
Keywords: herqueinones; phenalenones; Penicillium sp.; marine-derived fungi; adipogenesis; anti-angiogenesis; anti-inflammatory herqueinones; phenalenones; Penicillium sp.; marine-derived fungi; adipogenesis; anti-angiogenesis; anti-inflammatory
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Park, S.C.; Julianti, E.; Ahn, S.; Kim, D.; Lee, S.K.; Noh, M.; Oh, D.-C.; Oh, K.-B.; Shin, J. Phenalenones from a Marine-Derived Fungus Penicillium sp.. Mar. Drugs 2019, 17, 176.

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