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Marine Drugs
Volume 17
Issue 3
10.3390/md17030175
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Article

Dietary Supplementation with Low-Molecular-Weight Fucoidan Enhances Innate and Adaptive Immune Responses and Protects against Mycoplasma pneumoniae Antigen Stimulation

by
Pai-An Hwang
1,*,†,
Hong-Ting Victor Lin
2,†,
Hsin-Yuan Lin
1 and
Szu-Kuan Lo
3
1
Department of Bioscience and Biotechnology, National Taiwan Ocean University, No. 2, Beining Road, Keelung 20246, Taiwan
2
Department of Food Science, National Taiwan Ocean University, Keelung 20246, Taiwan
3
Gi-Kang Clinic, No. 155, Yanping Rd., Zhongli Dist., Taoyuan 32043, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors equally contributed to this work.
Mar. Drugs 2019, 17(3), 175; https://doi.org/10.3390/md17030175
Received: 15 February 2019 / Revised: 14 March 2019 / Accepted: 14 March 2019 / Published: 18 March 2019
(This article belongs to the Special Issue Characterization of Bioactive Components in Edible Algae)
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Abstract

In this study, the low-molecular-weight (LMW) fucoidan, rich in fucose and sulfate, was extracted and purified from the edible brown seaweed, Laminaria japonica. In this study, we orally administered LMW fucoidan to mice for 6 weeks. We then examined fucoidan’s effects on innate immunity, adaptive immunity, and Mycoplasma pneumoniae (MP)-antigen-stimulated immune responses. Our data showed that LMW fucoidan stimulated the innate immune system by increasing splenocyte proliferation, natural killer (NK) cell activity, and phagocytic activity. LMW fucoidan also increased interleukin (IL)-2, IL-4, and interferon (IFN)-γ secretion by splenocytes and immunoglobulin (Ig)-G and IgA content in serum, which help regulate adaptive immune cell functions, and decreased allergen-specific IgE. In MP-antigen-stimulated immune responses, the IgM and IgG content in the serum were significantly higher in the LMW fucoidan group after MP-antigen stimulation. Our study provides further information about the immunomodulatory effects of LMW fucoidan and highlights a potential role in preventing M. pneumoniae infection. View Full-Text
Keywords: low molecular weight fucoidan; Mycoplasma pneumoniae; NK cell; antigen-specific antibody; adjuvant low molecular weight fucoidan; Mycoplasma pneumoniae; NK cell; antigen-specific antibody; adjuvant
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MDPI and ACS Style

Hwang, P.-A.; Lin, H.-T.V.; Lin, H.-Y.; Lo, S.-K. Dietary Supplementation with Low-Molecular-Weight Fucoidan Enhances Innate and Adaptive Immune Responses and Protects against Mycoplasma pneumoniae Antigen Stimulation. Mar. Drugs 2019, 17, 175. https://doi.org/10.3390/md17030175

AMA Style

Hwang P-A, Lin H-TV, Lin H-Y, Lo S-K. Dietary Supplementation with Low-Molecular-Weight Fucoidan Enhances Innate and Adaptive Immune Responses and Protects against Mycoplasma pneumoniae Antigen Stimulation. Marine Drugs. 2019; 17(3):175. https://doi.org/10.3390/md17030175

Chicago/Turabian Style

Hwang, Pai-An, Hong-Ting Victor Lin, Hsin-Yuan Lin, and Szu-Kuan Lo. 2019. "Dietary Supplementation with Low-Molecular-Weight Fucoidan Enhances Innate and Adaptive Immune Responses and Protects against Mycoplasma pneumoniae Antigen Stimulation" Marine Drugs 17, no. 3: 175. https://doi.org/10.3390/md17030175

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