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485 Results Found

  • Editorial
  • Open Access
5 Citations
3,724 Views
5 Pages

What Do We Know about Transcranial Direct Current Stimulation for Major Depression?

  • Derrick Matthew Buchanan,
  • Philippe Robaey and
  • Amedeo D’Angiulli

The interest in using non-invasive brain stimulation (NIBS) for the treatment of major depression (MD), including treatment resistant depression, is growing rapidly. The paper by Bennabi and Haffen (Brain Sci. 2018, 8) was an important step towards t...

  • Review
  • Open Access
1,995 Views
34 Pages

Background: In recent years, there has been increasing interest in the application of repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct-Current Stimulation (tDCS) to enhance and rehabilitate the language abilities in individ...

  • Article
  • Open Access
15 Citations
4,210 Views
14 Pages

Focality-Oriented Selection of Current Dose for Transcranial Direct Current Stimulation

  • Rajan Kashyap,
  • Sagarika Bhattacharjee,
  • Ramaswamy Arumugam,
  • Rose Dawn Bharath,
  • Kaviraja Udupa,
  • Kenichi Oishi,
  • John E. Desmond,
  • S. H. Annabel Chen and
  • Cuntai Guan

21 September 2021

Background: In transcranial direct current stimulation (tDCS), the injected current becomes distributed across the brain areas. The objective is to stimulate the target region of interest (ROI) while minimizing the current in non-target ROIs (the ‘fo...

  • Article
  • Open Access
3 Citations
5,740 Views
9 Pages

18 December 2020

Obsessive-compulsive disorder (OCD) is a debilitating disorder with an approximate lifetime prevalence of 1–3%. Despite advances in leading treatment modalities, including pharmacotherapy and psychotherapy, some cases remain treatment resistant. Non-...

  • Review
  • Open Access
8 Citations
7,328 Views
23 Pages

Post-stroke cognitive impairment is a common and disabling condition with few effective therapeutic options. After stroke, neural reorganization and other neuroplastic processes occur in response to ischemic injury, which can result in clinical impro...

  • Article
  • Open Access
1 Citations
2,134 Views
9 Pages

To further understand how consciousness emerges, certain paradigms inducing distractor-induced perceptual impairments are promising. Neuro-computational models explain the inhibition of conscious perception of targets with suppression of distractor i...

  • Review
  • Open Access
7 Citations
2,092 Views
11 Pages

Transcranial Direct Current Stimulation in the Treatment of Chronic Knee Pain: A Scoping Review

  • Roberto Tedeschi,
  • Maria Grazia Benedetti,
  • Lisa Berti,
  • Danilo Donati and
  • Daniela Platano

13 August 2024

Background: Chronic knee pain in older adults is a prevalent condition that significantly impacts quality of life. Transcranial Direct Current Stimulation (tDCS) has emerged as a potential non-invasive treatment option. This scoping review aims to ev...

  • Article
  • Open Access
1 Citations
1,621 Views
17 Pages

Non-Dominant Hemisphere Excitability Is Unaffected during and after Transcranial Direct Current Stimulation of the Dominant Hemisphere

  • Erik W. Wilkins,
  • Richard J. Young,
  • Daniel Houston,
  • Eric Kawana,
  • Edgar Lopez Mora,
  • Meghana S. Sunkara,
  • Zachary A. Riley and
  • Brach Poston

Transcranial direct current stimulation (tDCS) increases primary motor cortex (M1) excitability and improves motor performance when applied unilaterally to the dominant hemisphere. However, the influence of tDCS on contralateral M1 excitability both...

  • Article
  • Open Access
7 Citations
2,886 Views
10 Pages

A New Approach to Assess Blinding for Transcranial Direct Current Stimulation Treatment in Patients with Fibromyalgia. A Randomized Clinical Trial

  • Rubén Arroyo-Fernández,
  • Juan Avendaño-Coy,
  • Rafael Velasco-Velasco,
  • Rocío Palomo-Carrión,
  • Elisabeth Bravo-Esteban and
  • Asunción Ferri-Morales

11 October 2021

Correct blinding is essential for preventing potential biases. The aim of this study was to assess the blinding of participants and a therapist following treatment with transcranial direct current stimulation in subjects with fibromyalgia using James...

  • Systematic Review
  • Open Access
1 Citations
2,416 Views
20 Pages

The Effects of Transcranial Direct Current Stimulation (tDCS) in HIV Patients—A Review

  • James Chmiel,
  • Donata Kurpas,
  • Filip Rybakowski and
  • Jerzy Leszek

3 June 2024

Introduction: HIV is a severe and incurable disease that has a devastating impact worldwide. It affects the immune system and negatively affects the nervous system, leading to various cognitive and behavioral problems. Scientists are actively explori...

  • Review
  • Open Access
1 Citations
1,922 Views
37 Pages

12 May 2025

Introduction: Basketball performance requires not only intermittent high-intensity movements—such as sprinting, jumping, and rapid directional changes—but also rapid decision-making under cognitive and psychological stress. Transcranial d...

  • Systematic Review
  • Open Access
12 Citations
4,965 Views
23 Pages

Determining the Effects of Transcranial Direct Current Stimulation on Tinnitus, Depression, and Anxiety: A Systematic Review

  • Bas Labree,
  • Derek J. Hoare,
  • Lauren E. Gascoyne,
  • Polly Scutt,
  • Cinzia Del Giovane and
  • Magdalena Sereda

(1) Background: Tinnitus is the awareness of a sound in the absence of an external source. It affects around 10–15% of people, a significant proportion of whom also experience symptoms such as depression or anxiety that negatively affect their...

  • Article
  • Open Access
2 Citations
2,209 Views
10 Pages

Influence of Transcranial Direct Current Stimulation on Psychomotor Symptoms in Major Depression

  • Djamila Bennabi,
  • Nicolas Carvalho,
  • Ambra Bisio,
  • Juliana Teti Mayer,
  • Thierry Pozzo and
  • Emmanuel Haffen

29 October 2020

Background: Transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (dlPFC) might be a promising treatment strategy for depression. As disturbances in psychomotor activity are one of the key features of unipo...

  • Review
  • Open Access
1 Citations
3,535 Views
19 Pages

13 October 2023

Cocaine addiction is a significant problem worldwide. The development of addiction involves a reward system, which consists of certain brain regions like the ventral tegmental area, nucleus accumbens, and prefrontal cortex. Currently, there are no ap...

  • Review
  • Open Access
100 Citations
13,777 Views
10 Pages

Background: Transcranial direct current stimulation (tDCS) opens new perspectives in the treatment of major depressive disorder (MDD), because of its ability to modulate cortical excitability and induce long-lasting effects. The aim of this review is...

  • Article
  • Open Access
29 Citations
9,390 Views
7 Pages

The 10/20 electroencephalogram (EEG) measurements system often guides electrode placement for transcranial direct current stimulation (tDCS), a form of non-invasive brain stimulation. One targeted region of the brain is the primary motor cortex (M1)...

  • Review
  • Open Access
5 Citations
5,390 Views
20 Pages

The Effects of Transcranial Direct Current Stimulation in Patients with Mild Cognitive Impairment

  • Matei Palimariciuc,
  • Dan Cătălin Oprea,
  • Ana Caterina Cristofor,
  • Tudor Florea,
  • Romeo Petru Dobrin,
  • Irina Dobrin,
  • Bogdan Gireadă,
  • Radu Gavril,
  • Iasmin Mawas and
  • Andreea Cristina Bejenariu
  • + 3 authors

29 November 2023

Transcranial direct current stimulation (tDCS) came into consideration in recent years as a promising, non-invasive form of neuromodulation for individuals suffering from mild cognitive impairment (MCI). MCI represents a transitional stage between no...

  • Review
  • Open Access
24 Citations
6,477 Views
14 Pages

Effects of Transcranial Direct Current Stimulation Combined with Physiotherapy on Gait Pattern, Balance, and Functionality in Stroke Patients. A Systematic Review

  • Víctor Navarro-López,
  • Francisco Molina-Rueda,
  • Samuel Jiménez-Jiménez,
  • Isabel M Alguacil-Diego and
  • María Carratalá-Tejada

Background: The effectiveness of transcranial direct current stimulation (tDCS) together with conventional physiotherapy in motor rehabilitation after stroke has been widely studied. Despite this, few studies have focused on its application in gait a...

  • Review
  • Open Access
7 Citations
3,853 Views
12 Pages

Can Transcranial Direct Current Stimulation Enhance Functionality in Older Adults? A Systematic Review

  • Andrés Pino-Esteban,
  • Álvaro Megía-García,
  • David Martín-Caro Álvarez,
  • Hector Beltran-Alacreu,
  • Juan Avendaño-Coy,
  • Julio Gómez-Soriano and
  • Diego Serrano-Muñoz

3 July 2021

Transcranial direct current stimulation (tDCS) is a non-invasive, easy to administer, well-tolerated, and safe technique capable of affecting brain excitability, both at the cortical and cerebellum levels. However, its effectiveness has not been suff...

  • Review
  • Open Access
2 Citations
2,162 Views
13 Pages

The Effect of Transcranial Direct Current Stimulation on Lower-Limb Endurance Performance: A Systematic Review

  • Zhen Xu,
  • Bin Shen,
  • Songlin Xiao,
  • Chuyi Zhang,
  • Jianglong Zhan,
  • Jingjing Li,
  • Weijie Fu and
  • Jing Jin

This study systematically reviews the literature on transcranial direct current stimulation (tDCS) interventions for lower-limb endurance performance in healthy adults and provides a summary of the effects and underlying mechanisms of tDCS on lower-l...

  • Review
  • Open Access
5 Citations
3,760 Views
18 Pages

20 October 2023

(1) Introduction: Anorexia nervosa (AN) is a severe, debilitating disease with high incidence and high mortality. The methods of treatment used so far are moderately effective. Evidence from neuroimaging studies helps to design modern methods of ther...

  • Article
  • Open Access
13 Citations
4,426 Views
13 Pages

Effect of Transcranial Direct Current Stimulation versus Virtual Reality on Gait for Children with Bilateral Spastic Cerebral Palsy: A Randomized Clinical Trial

  • Asmaa Radwan,
  • Hoda A. Eltalawy,
  • Faten Hassan Abdelziem,
  • Rebecca Macaluso,
  • Megan K. O’Brien and
  • Arun Jayaraman

27 January 2023

Impaired gait is a common sequela in bilateral spastic cerebral palsy. We compared the effects of two novel research interventions—transcranial direct current stimulation and virtual reality—on spatiotemporal and kinetic gait impairments...

  • Protocol
  • Open Access
5 Citations
5,026 Views
8 Pages

Effects of Transcranial Direct Current Stimulation on Sleep in Athletes: A Protocol of a Randomized Controlled Trial

  • Mohammad Etoom,
  • Mohammad Alwardat,
  • Alia Alghwiri,
  • Francesco Lena and
  • Andrea Romigi

5 October 2022

Background: Sleep disturbances are common among athletes. There is recently a growing interest in improving sleep quality by using noninvasive brain stimulation techniques such as transcranial direct current stimulation (tDCS). We hypothesized that b...

  • Review
  • Open Access
8 Citations
5,581 Views
16 Pages

25 January 2024

Introduction: Depression is the most prevalent comorbid neuropsychiatric condition in individuals with Parkinson’s disease (PD), and its underlying mechanisms are not yet fully understood. Current treatment methods are characterised by moderate...

  • Article
  • Open Access
3 Citations
3,142 Views
13 Pages

Role of Catechol-O-methyltransferase Val158Met Polymorphism on Transcranial Direct Current Stimulation in Swallowing

  • Hyemi Hwang,
  • Yeonjae Han,
  • Geun-Young Park,
  • Soohwan Lee,
  • Hae-Yeon Park and
  • Sun Im

17 March 2022

Transcranial direct current stimulation (tDCS) is one of the latest post-stroke dysphagia treatment modalities, and the effect of tDCS is known to be affected by various factors including genetic polymorphisms. However, the role of catechol-O-methylt...

  • Review
  • Open Access
1,004 Views
13 Pages

Background: Chronic shoulder pain is a prevalent musculoskeletal disorder often associated with central sensitisation, which limits the effectiveness of conventional therapies. Transcranial direct current stimulation (tDCS) has emerged as a non-invas...

  • Article
  • Open Access
3 Citations
2,573 Views
14 Pages

Temporal Dynamics of Adverse Effects across Five Sessions of Transcranial Direct Current Stimulation

  • Miguel Delicado-Miralles,
  • Laura Flix-Diez,
  • Francisco Gurdiel-Álvarez,
  • Enrique Velasco,
  • María Galán-Calle and
  • Sergio Lerma Lara

(1) Background: Transcranial direct current stimulation (tDCS) is a safe intervention, only producing mild and transient adverse effects (AEs). However, there is no detailed analysis of the pattern of adverse effects in an application transferable to...

  • Article
  • Open Access
7 Citations
5,402 Views
11 Pages

Anodal Transcranial Direct Current Stimulation over the Vertex Enhances Leg Motor Cortex Excitability Bilaterally

  • Soumya Ghosh,
  • David Hathorn,
  • Jennifer Eisenhauer,
  • Jesse Dixon and
  • Ian D. Cooper

In many studies, anodal transcranial Direct Current Stimulation (tDCS) is applied near the vertex to simultaneously facilitate leg motor cortex (M1) of both hemispheres and enhance recovery of gait and balance in neurological disorders. However, its...

  • Article
  • Open Access
2 Citations
2,066 Views
16 Pages

23 April 2024

Remembering objects and their associated location (object–location memory; OLM), is a fundamental cognitive function, mediated by cortical and subcortical brain regions. Previously, the combination of OLM training and transcranial direct curren...

  • Article
  • Open Access
1 Citations
1,727 Views
10 Pages

26 October 2023

The temporoparietal junction (TPJ), which integrates visual, somatosensory, and vestibular information to form body schema, is involved in human postural control. We evaluated whether or not the transcranial direct current stimulation (tDCS) of the T...

  • Review
  • Open Access
17 Citations
8,373 Views
14 Pages

Stroke remains a global leading cause of disability. Novel treatment approaches are required to alleviate impairment and promote greater functional recovery. One potential candidate is transcranial direct current stimulation (tDCS), which is thought...

  • Article
  • Open Access
6 Citations
4,102 Views
8 Pages

7 February 2021

Repetitive transcranial magnetic stimulation (rTMS) and transcutaneous direct current stimulation (tDCS) are non-invasive treatments for chronic tinnitus based on neuromodulation of cortical activity. Both are considered effective, but with heterogen...

  • Article
  • Open Access
10 Citations
3,917 Views
13 Pages

Transcranial Direct Current Stimulation Modulates EEG Microstates in Low-Functioning Autism: A Pilot Study

  • Jiannan Kang,
  • Xiwang Fan,
  • Yiwen Zhong,
  • Manuel F. Casanova,
  • Estate M. Sokhadze,
  • Xiaoli Li,
  • Zikang Niu and
  • Xinling Geng

Autism spectrum disorder (ASD) is a heterogeneous disorder that affects several behavioral domains of neurodevelopment. Transcranial direct current stimulation (tDCS) is a new method that modulates motor and cognitive function and may have potential...

  • Feature Paper
  • Article
  • Open Access
13 Citations
3,812 Views
12 Pages

Feasibility and Safety of Transcranial Direct Current Stimulation in an Outpatient Rehabilitation Setting After Stroke

  • Brice T. Cleland,
  • Melissa Galick,
  • Amy Huckstep,
  • Laura Lenhart and
  • Sangeetha Madhavan

9 October 2020

Transcranial direct current stimulation (tDCS) has strong potential for outpatient clinical use, but feasibility and safety of tDCS has only been evaluated in laboratory and inpatient clinical settings. The objective of this study was to assess feasi...

  • Article
  • Open Access
1,969 Views
12 Pages

Treatment of Chronic Neck Pain with Transcranial Direct Current Stimulation: A Single-Blinded Randomized Clinical Trial

  • Manuel Rodríguez-Huguet,
  • Miguel Ángel Rosety-Rodríguez,
  • Daniel Rodríguez-Almagro,
  • Rocío Martín-Valero,
  • Maria Jesus Vinolo-Gil,
  • Jorge Bastos-Garcia and
  • Jorge Góngora-Rodríguez

Background/Objectives: Neck pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, affecting the cervical region. It represents one of the leading causes of disability, with a prevalence o...

  • Review
  • Open Access
17 Citations
7,091 Views
15 Pages

2 October 2024

Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that applies a stable, low-intensity (1–2 mA) direct current to modulate neuronal activity in the cerebral cortex. This technique is effective, simple to...

  • Systematic Review
  • Open Access
8 Citations
3,929 Views
24 Pages

Is Transcranial Direct Current Stimulation Effective for Cognitive Dysfunction in Substance Use Disorders? A Systematic Review

  • Xinbi Zhang,
  • Mingming Huang,
  • Ying Yu,
  • Xiaoke Zhong,
  • Shengyu Dai,
  • Yuanfu Dai and
  • Changhao Jiang

Patients with substance use disorders (SUDs) often suffer from cognitive dysfunction (CD), affecting their quality of life and daily functioning. Current treatments, including pharmacotherapy and psychotherapy, have limited efficacy and notable side...

  • Feature Paper
  • Article
  • Open Access
29 Citations
6,401 Views
13 Pages

23 December 2019

Transcranial direct current stimulation (tDCS) modulates cortical excitability and affects a variety of outcomes. tDCS at intensities ≤2 mA is well-tolerated, but the tolerability and efficacy of tDCS at intensities >2 mA merits systematic investi...

  • Case Report
  • Open Access
3 Citations
2,654 Views
11 Pages

The Influence of Transcranial Direct Current Stimulation on Shooting Performance in Elite Deaflympic Athletes: A Case Series

  • Milan Pantovic,
  • Drazenka Macak,
  • Nebojsa Cokorilo,
  • Sheniz Moonie,
  • Zachary A. Riley,
  • Dejan M. Madic and
  • Brach Poston

Transcranial direct current stimulation (tDCS) has been shown to improve motor learning in numerous studies. However, only a few of these studies have been conducted on elite-level performers or in complex motor tasks that have been practiced extensi...

  • Article
  • Open Access
31 Citations
8,536 Views
13 Pages

The Role of Transcranial Direct Current Stimulation (tDCS) in Tourette Syndrome: A Review and Preliminary Findings

  • Valsamma Eapen,
  • Richard Baker,
  • Amelia Walter,
  • Veena Raghupathy,
  • Jordan J. Wehrman and
  • Paul F. Sowman

8 December 2017

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that is being investigated for a variety of neurological and psychiatric conditions. Preliminary evidence suggests that tDCS may be useful in the treatment o...

  • Article
  • Open Access
7 Citations
2,428 Views
12 Pages

Effect of Single Session of Anodal M1 Transcranial Direct Current Stimulation—TDCS—On Cortical Hemodynamic Activity: A Pilot Study in Fibromyalgia

  • Marianna La Rocca,
  • Livio Clemente,
  • Eleonora Gentile,
  • Katia Ricci,
  • Marianna Delussi and
  • Marina de Tommaso

18 November 2022

Transcranial direct current stimulation (TDCS) on the primary motor cortex (M1) has been reported to be effective in fibromyalgia (FM). Our previous works have shown hypometabolism of motor networks in FM using Functional Near Infrared Spectroscopy (...

  • Review
  • Open Access

9 November 2025

Transcranial direct current stimulation (tDCS) is being explored as an adjunct for diabetes-related symptoms grounded in diabetes-associated alterations in brain networks. We reviewed clinical trials of tDCS conducted in people with diabetes and summ...

  • Article
  • Open Access
17 Citations
3,380 Views
15 Pages

An Acute Application of Cerebellar Transcranial Direct Current Stimulation Does Not Improve Motor Performance in Parkinson’s Disease

  • Lidio Lima de Albuquerque,
  • Milan Pantovic,
  • Mitchel Clingo,
  • Katherine Fischer,
  • Sharon Jalene,
  • Merrill Landers,
  • Zoltan Mari and
  • Brach Poston

14 October 2020

Transcranial direct current stimulation of the cerebellum (c-tDCS) improves motor performance in young and old adults. Based on the cerebellar involvement in Parkinson’s disease (PD), c-tDCS could have potential to improve motor function in PD....

  • Review
  • Open Access
5 Citations
5,034 Views
16 Pages

Transcranial Direct Current Stimulation for Chronic Stroke: Is Neuroimaging the Answer to the Next Leap Forward?

  • Claudia A. Salazar,
  • Wuwei Feng,
  • Leonardo Bonilha,
  • Steven Kautz,
  • Jens H. Jensen,
  • Mark S. George and
  • Nathan C. Rowland

30 March 2023

During rehabilitation, a large proportion of stroke patients either plateau or begin to lose motor skills. By priming the motor system, transcranial direct current stimulation (tDCS) is a promising clinical adjunct that could augment the gains acquir...

  • Review
  • Open Access
3 Citations
4,059 Views
15 Pages

Neural Mechanisms of Neuro-Rehabilitation Using Transcranial Direct Current Stimulation (tDCS) over the Front-Polar Area

  • Koji Ishikuro,
  • Noriaki Hattori,
  • Hironori Otomune,
  • Kohta Furuya,
  • Takeshi Nakada,
  • Kenichiro Miyahara,
  • Takashi Shibata,
  • Kyo Noguchi,
  • Satoshi Kuroda and
  • Yuji Nakatsuji
  • + 1 author

18 November 2023

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation (NIBS) technique that applies a weak current to the scalp to modulate neuronal excitability by stimulating the cerebral cortex. The technique can produce either somatic...

  • Article
  • Open Access
10 Citations
3,140 Views
16 Pages

Home-Based Transcranial Direct Current Stimulation in Primary Progressive Aphasia: A Pilot Study

  • Kyriaki Neophytou,
  • Kelly Williamson,
  • Olivia Herrmann,
  • Alexandros Afthinos,
  • Jessica Gallegos,
  • Nadine Martin,
  • Donna C. Tippett and
  • Kyrana Tsapkini

Background: This study aims to determine (a) if home-based anodal transcranial direct current stimulation (a-tDCS) delivered to the left supramarginal gyrus (SMG) coupled with verbal short-term memory/working memory (vSTM/WM) treatment (“RAM&rd...

  • Communication
  • Open Access
6 Citations
4,451 Views
8 Pages

The aim of this randomized sham-controlled study was to examine the impact of cathodal transcranial direct current stimulation (ctDCS) of the primary motor cortex (M1) during movement observation on subsequent execution-related motor cortex activity....

  • Review
  • Open Access
2 Citations
2,569 Views
35 Pages

25 July 2025

Transcranial direct current stimulation (tDCS) can modulate cortical excitability in a polarity-specific manner, yet identical protocols often produce inconsistent outcomes across sessions or individuals. This narrative review proposes that much of t...

  • Article
  • Open Access
12 Citations
3,317 Views
19 Pages

Transcranial Direct Current Stimulation of Primary Motor Cortex over Multiple Days Improves Motor Learning of a Complex Overhand Throwing Task

  • Milan Pantovic,
  • Lidio Lima de Albuquerque,
  • Sierra Mastrantonio,
  • Austin S. Pomerantz,
  • Erik W. Wilkins,
  • Zachary A. Riley,
  • Mark A. Guadagnoli and
  • Brach Poston

10 October 2023

Transcranial direct current stimulation (tDCS) applied to the primary motor cortex (M1) improves motor learning in relatively simple motor tasks performed with the hand and arm. However, it is unknown if tDCS can improve motor learning in complex mot...

  • Article
  • Open Access
3 Citations
2,944 Views
16 Pages

Development of a Clinical Prediction Rule for Treatment Success with Transcranial Direct Current Stimulation for Knee Osteoarthritis Pain: A Secondary Analysis of a Double-Blind Randomized Controlled Trial

  • Paulo E. P. Teixeira,
  • Daniela R. B. Tavares,
  • Kevin Pacheco-Barrios,
  • Luis Castelo Branco,
  • Eric Slawka,
  • Julie Keysor,
  • Virginia F. M. Trevisani,
  • Doug K Gross and
  • Felipe Fregni

The study’s objective was to develop a clinical prediction rule that predicts a clinically significant analgesic effect on chronic knee osteoarthritis pain after transcranial direct current stimulation treatment. This is a secondary analysis fr...

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