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Volume 14
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Article

Home-Based Transcranial Direct Current Stimulation in Primary Progressive Aphasia: A Pilot Study

by
Kyriaki Neophytou
1,
Kelly Williamson
1,
Olivia Herrmann
1,
Alexandros Afthinos
1,2,
Jessica Gallegos
1,
Nadine Martin
3,
Donna C. Tippett
1,4,5 and
Kyrana Tsapkini
1,6,*
1
Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Phipps 488, Baltimore, MD 21287, USA
2
Cooper Medical School of Rowan University, Rowan University, 401 Broadway, Camden, NJ 08103, USA
3
Department of Communication Sciences and Disorders, Temple University, 1701 N. 13th Street, Philadelphia, PA 19122, USA
4
Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Phipps 174, Baltimore, MD 21287, USA
5
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 N. Caroline Street, Baltimore, MD 21287, USA
6
Department of Cognitive Science, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2024, 14(4), 391; https://doi.org/10.3390/brainsci14040391
Submission received: 18 January 2024 / Revised: 12 April 2024 / Accepted: 13 April 2024 / Published: 17 April 2024
(This article belongs to the Special Issue Recent Development of Cognitive and Neuropsychological Assessment)
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Abstract

Background: This study aims to determine (a) if home-based anodal transcranial direct current stimulation (a-tDCS) delivered to the left supramarginal gyrus (SMG) coupled with verbal short-term memory/working memory (vSTM/WM) treatment (“RAM”, short for “Repeat After Me”) is more effective than sham-tDCS in improving vSTM/WM in patients with primary progressive aphasia (PPA), and (b) whether tDCS effects generalize to other language and cognitive abilities. Methods: Seven PPA participants received home-based a-tDCS and sham-tDCS coupled with RAM treatment in separate conditions in a double-blind design. The treatment task required participants to repeat word spans comprising semantically and phonologically unrelated words in the same and reverse order. The evaluation of treatment effects was carried out using the same tasks as in the treatment but with different items (near-transfer effects) and tasks that were not directly related to the treatment (far-transfer effects). Results: A-tDCS showed (a) a significant effect in improving vSTM abilities, measured by word span backward, and (b) a generalization of this effect to other language abilities, namely, spelling (both real words and pseudowords) and learning (retention and delayed recall). Conclusions: These preliminary results indicate that vSTM/WM intervention can improve performance in trained vSTM/WM tasks in patients with PPA, especially when augmented with home-based tDCS over the left SMG.
Keywords: primary progressive aphasia; verbal short-term memory; working memory; transcranial direct current stimulation; home-based tDCS primary progressive aphasia; verbal short-term memory; working memory; transcranial direct current stimulation; home-based tDCS

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MDPI and ACS Style

Neophytou, K.; Williamson, K.; Herrmann, O.; Afthinos, A.; Gallegos, J.; Martin, N.; Tippett, D.C.; Tsapkini, K. Home-Based Transcranial Direct Current Stimulation in Primary Progressive Aphasia: A Pilot Study. Brain Sci. 2024, 14, 391. https://doi.org/10.3390/brainsci14040391

AMA Style

Neophytou K, Williamson K, Herrmann O, Afthinos A, Gallegos J, Martin N, Tippett DC, Tsapkini K. Home-Based Transcranial Direct Current Stimulation in Primary Progressive Aphasia: A Pilot Study. Brain Sciences. 2024; 14(4):391. https://doi.org/10.3390/brainsci14040391

Chicago/Turabian Style

Neophytou, Kyriaki, Kelly Williamson, Olivia Herrmann, Alexandros Afthinos, Jessica Gallegos, Nadine Martin, Donna C. Tippett, and Kyrana Tsapkini. 2024. "Home-Based Transcranial Direct Current Stimulation in Primary Progressive Aphasia: A Pilot Study" Brain Sciences 14, no. 4: 391. https://doi.org/10.3390/brainsci14040391

APA Style

Neophytou, K., Williamson, K., Herrmann, O., Afthinos, A., Gallegos, J., Martin, N., Tippett, D. C., & Tsapkini, K. (2024). Home-Based Transcranial Direct Current Stimulation in Primary Progressive Aphasia: A Pilot Study. Brain Sciences, 14(4), 391. https://doi.org/10.3390/brainsci14040391

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