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  • Review
  • Open Access
842 Views
20 Pages

Spinal Cord Ischemia After Thoracoabdominal Aortic Aneurysm Repair: Pathophysiology, Detection, and Management

  • Janak Patel,
  • Stephanie Liang,
  • Mirza Bulic,
  • May Kim-Tenser,
  • Tatsuhiro Fuji,
  • Sukgu Han,
  • Benjamin Emanuel and
  • Fawaz Philip Tarzi

Thoracoabdominal aortic aneurysm (TAAA) is a complex vascular disorder involving both thoracic and abdominal segments of the aorta and remains associated with substantial morbidity and mortality. One of the most serious complications after thoracoabd...

(This article belongs to the Special Issue Spinal Cord Injury: Emerging Therapeutics and Neurorehabilitation)
  • Case Report
  • Open Access
2,892 Views
15 Pages

17 December 2024

Background: Stent-graft implantation is a widely recognized method for endovascular treatment of aortic aneurysms. In cases where the aneurysm involves the thoracic and abdominal aorta, repair including fenestrated and branched stent grafts provides...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
923 Views
16 Pages

Pulmonary Risk Stratification in Open Thoracoabdominal Aortic Aneurysm Repair

  • Jelle Frankort,
  • Mohammed Al-Falahi,
  • Andras Keszei,
  • Bernhard Hruschka,
  • Quentin Cappel,
  • Christian Uhl and
  • Alexander Gombert

30 March 2026

Background/Objectives: The aim of this study was to assess whether preoperative pulmonary function testing (PFT) is related to postoperative complications after open thoracoabdominal aortic aneurysm (TAAA) repair. Methods: This study was conducted as...

(This article belongs to the Special Issue Aortic Diseases: Modern Strategies in Diagnosis, Management, and Prevention of Complications)
  • Review
  • Open Access
824 Views
13 Pages

Spinal Cord Ischemia Following Thoracoabdominal Aortic Aneurysm Repair: Translational Insights from Stroke and Traumatic Injury for Biomarker Development

  • James A. Kelly,
  • Miranda Witheford,
  • Kong Teng Tan,
  • Tiam Feridooni,
  • Daniyal Mahmood,
  • Carmen Garcia-Mere and
  • Thomas F. Lindsay

Background: Spinal cord ischemia (SCI) is a severe complication of thoracoabdominal aortic aneurysm (TAAA) repair, associated with substantial morbidity and mortality. Despite advances in operative techniques, its pathophysiology remains incompletely...

(This article belongs to the Special Issue Aortic Aneurysm: Mechanisms, Biomarkers, and Therapeutic Strategy)
  • Article
  • Open Access
3 Citations
1,053 Views
13 Pages

Shift in Patient Demographics of Open Thoracoabdominal Aortic Aneurysm Repair Patients in the Endovascular Era

  • Jelle Frankort,
  • Siebe Frankort,
  • Panagiotis Doukas,
  • Christian Uhl,
  • Moustafa Elfeky,
  • Barend M. E. Mees,
  • Alexander Gombert and
  • Michael J. Jacobs

8 October 2025

Background/Objectives: Open thoracoabdominal aortic aneurysm (TAAA) repair remains essential despite expanded endovascular options, yet the contemporary open-surgery case-mix has shifted as minimally invasive therapies became widespread. The objectiv...

(This article belongs to the Special Issue Current Trends in Vascular and Endovascular Surgery)
  • Review
  • Open Access
959 Views
16 Pages

Open Repair of Thoracoabdominal Aortic Aneurysms in the Endovascular Era: When and for Whom

  • Lucas Ribé,
  • Luis E. Guilarte,
  • Eanas S. Yassa,
  • Anthony L. Estrera and
  • Rana O. Afifi

22 May 2026

Open surgical repair continues to play an essential role in the contemporary management of thoracoabdominal aortic aneurysms, despite the dramatic advances and growing adoption of endovascular aortic techniques, which include the combination of thora...

(This article belongs to the Special Issue State of the Art in Management of Aortic Aneurysm in Vascular Surgery)
  • Article
  • Open Access
5 Citations
2,714 Views
13 Pages

The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair

  • Elisabeth Zechendorf,
  • Alexander Gombert,
  • Tanja Bülow,
  • Nadine Frank,
  • Christian Beckers,
  • Arne Peine,
  • Drosos Kotelis,
  • Michael J. Jacobs,
  • Gernot Marx and
  • Lukas Martin

14 October 2020

Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the grou...

(This article belongs to the Special Issue New Diagnostic and Therapeutic Approaches for the Care of the Severely Injured Patient)
  • Article
  • Open Access
2 Citations
1,499 Views
10 Pages

Outcome Following Open Repair of Hereditary and Non-Hereditary Thoracoabdominal Aortic Aneurysm in Patients Under 60 Years Old—A Multicenter Study

  • Jelle Frankort,
  • Siebe Frankort,
  • Panagiotis Doukas,
  • Christian Uhl,
  • Michael J. Jacobs,
  • Barend M. E. Mees and
  • Alexander Gombert

7 April 2025

Objective: This multicenter study compares outcomes of open thoracoabdominal aortic aneurysm (TAAA) repair in patients < 60 years with (n = 106), versus without (n = 167), hereditary aortopathy. Methods: We conducted a retrospective analysis of 27...

(This article belongs to the Special Issue Aortic Pathologies: Aneurysm, Atherosclerosis and More)
  • Article
  • Open Access
579 Views
11 Pages

Impact of Previous Thoracotomy on Outcomes of Open Thoracoabdominal Aortic Aneurysm Repair: A Retrospective Propensity Score-Matched Analysis

  • Muhyung Heo,
  • Siwon Oh,
  • Suryeun Chung,
  • Dong Seop Jeong,
  • Wook Sung Kim,
  • Yang Hyun Cho and
  • Kiick Sung

25 January 2026

Objectives: Open repair remains widely used for TAAA (Thoracoabdominal Aortic Aneurysm), but disease progression may require reoperation via repeat thoracotomy, which is technically challenging. These procedures involve increased risks due to adhesio...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
6 Citations
1,901 Views
10 Pages

Determinants of Neurological Outcome Following Elective and Emergency Open Thoracoabdominal Aortic Aneurysm Repair—A Retrospective Multi-Center Study

  • Jelle Frankort,
  • Panagiotis Doukas,
  • Christian Uhl,
  • Nelly Otte,
  • Julia Krabbe,
  • Barend Mees,
  • Michael J. Jacobs and
  • Alexander Gombert

14 September 2024

Background/Objectives: This study aimed to evaluate and establish the incidence of all types of neurological complications at our high-volume reference center for open TAAA repair in the Netherlands and Germany. Additionally, we sought to identify pr...

(This article belongs to the Section Cardiovascular Medicine)
  • Systematic Review
  • Open Access
8 Citations
2,179 Views
10 Pages

29 February 2024

Background: Minimally Invasive Staged Segmental Artery Coil Embolization (MIS2ACE) is a novel technique of spinal cord preconditioning used to reduce the risk of paraplegia in thoracoabdominal aortic aneurysm (TAAA) repair. In this study, we report o...

(This article belongs to the Special Issue Vascular Surgery: Current Challenges and New Perspectives)
  • Article
  • Open Access
19 Citations
2,849 Views
15 Pages

Postoperative Outcomes and Reinterventions Following Fenestrated/Branched Endovascular Aortic Repair in Post-Dissection and Complex Degenerative Abdominal and Thoraco-Abdominal Aortic Aneurysms

  • Bright Benfor,
  • Julia Högl,
  • Ryan Gouveia e Melo,
  • Jan Stana,
  • Carlota Fernandez Prendes,
  • Maximilian Pichlmaier,
  • Barbara Rantner and
  • Nikolaos Tsilimparis

16 August 2022

Background: The outcome of FBEVAR in post-dissection thoracoabdominal aortic aneurysms has not been well established in the literature. The aim of this study was to compare midterm outcomes following FBEVAR in post-dissection aneurysms to degenerativ...

(This article belongs to the Special Issue Abdominal Aortic Aneurysm: Clinical Updates and Perspectives)
  • Article
  • Open Access
6 Citations
3,353 Views
12 Pages

Distribution and Maturity of Medial Collagen Fibers in Thoracoabdominal Post-Dissection Aortic Aneurysms: A Comparative Study of Marfan and Non-Marfan Patients

  • Panagiotis Doukas,
  • Bernhard Hruschka,
  • Cathryn Bassett,
  • Eva Miriam Buhl,
  • Florian Simon,
  • Pepijn Saraber,
  • Michael Johan Jacobs,
  • Christian Uhl,
  • Leon J. Schurgers and
  • Alexander Gombert

Thoracoabdominal aortic aneurysms (TAAAs) are rare but serious conditions characterized by dilation of the aorta characterized by remodeling of the vessel wall, with changes in the elastin and collagen content. Individuals with Marfan syndrome have a...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
12 Citations
1,939 Views
11 Pages

Early Experience with Inner Branch Stent–Graft System for Endovascular Repair of Thoraco-Abdominal and Pararenal Abdominal Aortic Aneurysm

  • Simone Cuozzo,
  • Antonio Marzano,
  • Ombretta Martinelli,
  • Jihad Jabbour,
  • Andrea Molinari,
  • Vincenzo Brizzi and
  • Enrico Sbarigia

21 November 2024

Objectives: This study aims to evaluate the technical and clinical outcomes of the E-nside stent graft for thoraco-abdominal aortic aneurysm (TAAA) and pararenal abdominal aortic aneurysm (PAAA) endovascular treatment at our University Hospital Cente...

(This article belongs to the Special Issue New Advances in Thoracic Surgery: Clinical Diagnosis, Treatment, and Prognosis)
  • Article
  • Open Access
2 Citations
771 Views
11 Pages

Plasma Desmosine Is Elevated in Thoracoabdominal Aortic Aneurysms and Is Associated with Intramural Proteolytic Activity

  • Panagiotis Doukas,
  • Cathryn Bassett,
  • Bernhard Hruschka,
  • Elena Kuzmanova,
  • Inga Wessels,
  • Hannes J. Klump,
  • Leon J. Schurgers,
  • Michael J. Jacobs,
  • Christian Uhl and
  • Jeffrey T. J. Huang
  • + 1 author

26 January 2026

Thoracoabdominal aortic aneurysms (TAAAs) are rare and often remain asymptomatic until rupture, leading to high morbidity and mortality. Elastin degradation, largely mediated by matrix metalloproteinases (MMPs), plays a central role in their pathogen...

(This article belongs to the Special Issue Molecular Research in Cardiovascular Disease, 3rd Edition)
  • Review
  • Open Access
11 Citations
2,441 Views
14 Pages

21 November 2023

The optimal surgical treatment for extended thoracoabdominal aortic aneurysms (TAAAs) is still a matter of debate. The historical treatment is open repair (OR), but over the past fifteen years, endovascular strategies have gained widespread acceptanc...

(This article belongs to the Special Issue Open and Endovascular Management of Complex Aortic Aneurysms)
  • Article
  • Open Access
1 Citations
2,061 Views
7 Pages

Aneurysm Sac Pressure during Branched Endovascular Aneurysm Repair versus Multilayer Flow Modulator Implantation in Patients with Thoracoabdominal Aortic Aneurysm

  • Maciej Antkiewicz,
  • Wiktor Kuliczkowski,
  • Marcin Protasiewicz,
  • Tomasz Zubilewicz,
  • Piotr Terlecki,
  • Magdalena Kobielarz and
  • Dariusz Janczak

Open thoracoabdominal repair is the gold standard in the TAAA treatment. However, there are endovascular techniques, that sometimes may be an alternative, such as branched endovascular aneurysm repair (BEVAR) or implantation of the multilayer flow mo...

(This article belongs to the Section Health Care Sciences & Services)
  • Article
  • Open Access
2 Citations
1,285 Views
10 Pages

Evaluation of Coagulation Factors and Platelet Activation in Patients Undergoing Complex Endovascular Para-Renal and Thoraco-Abdominal Aneurysm Repair: The Protocol of a Prospective Observational Study

  • Maria P. Ntalouka,
  • Konstantinos Spanos,
  • Paraskevi Kotsi,
  • Aikaterini Bouzia,
  • Georgios Kouvelos,
  • Diamanto Aretha,
  • Efthymia Petinaki,
  • Athanasios Giannnoukas,
  • Miltiadis Matsagkas and
  • Eleni M. Arnaoutoglou

30 April 2025

Background/Objectives: Endovascular aneurysm repair (EVAR) of the aorta may trigger an inflammatory response that affects coagulation. In the EVAR of para-renal and thoraco-abdominal aortic aneurysms, the implants are more complex and the duration of...

(This article belongs to the Section Anesthesiology)
  • Review
  • Open Access
2 Citations
1,315 Views
14 Pages

Staging Strategies During Complex Endovascular Aortic Procedures to Minimize Spinal Cord Ischemia Rates: A Narrative Review

  • Alessandro Grandi,
  • Andrea Melloni,
  • Pietro Dioni,
  • Stefano Bonardelli and
  • Luca Bertoglio

3 October 2025

Endovascular repair of thoracoabdominal aortic aneurysms (TAAAs) requires multidisciplinary expertise to minimize mortality and disabling complications. Despite satisfactory outcomes with this approach being common knowledge, extensive aortic coverag...

(This article belongs to the Special Issue Clinical Advances and Challenges in Vascular and Endovascular Medicine)
  • Interesting Images
  • Open Access
3 Citations
2,069 Views
4 Pages

High-Grade Infection after Branched Endovascular Aortic Repair in Patient with Recent COVID-19 Hospitalization

  • Alireza Mohseni,
  • Alessia Di Girolamo,
  • Rocco Cangiano,
  • Marta Ascione,
  • Luca di Marzo and
  • Wassim Mansour

In the context of the COVID-19 pandemic, the global healthcare landscape has undergone significant transformations, particularly impacting the management of complex medical conditions such as aortic aneurysms. This study focuses on a 76-year-old fema...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
4 Citations
2,747 Views
14 Pages

Complex endovascular aortic repair (coEVAR) of thoracoabdominal aortic aneurysms (TAAA) has greatly evolved in the past decades. Despite substantial improvements of postoperative care, spinal cord injury (SCI) remains the most devastating complicatio...

(This article belongs to the Section Molecular and Translational Medicine)
  • Article
  • Open Access
904 Views
10 Pages

Hybrid Repair of Thoraco-Abdominal Aortic Disease with Complex Renal and Hypogastric Anatomy

  • Fabrizio Minelli,
  • Simona Sica,
  • Francesco Sposato,
  • Antonino Marzullo,
  • Laura Rascio,
  • Ottavia Borghese,
  • Giovanni Tinelli and
  • Yamume Tshomba

23 October 2025

Background: The treatment of thoraco-abdominal aortic aneurysms (TAAAs) and chronic type B aortic dissections (TAAD), is technically challenging. Traditional open surgery repair carries high morbidity and mortality rates, while endovascular repair is...

(This article belongs to the Special Issue State of the Art in Management of Aortic Aneurysm in Vascular Surgery)
  • Article
  • Open Access
20 Citations
2,676 Views
13 Pages

Outcomes following Management of Complex Thoracoabdominal Aneurysm by an Open Approach

  • Roberto Chiesa,
  • Enrico Rinaldi,
  • Andrea Kahlberg,
  • Sarah Tinaglia,
  • Annarita Santoro,
  • Giovanni Colacchio and
  • Germano Melissano

29 April 2023

Background: In the last decade, advances in surgical techniques, and the introduction of adjuncts for organ protection, have modified the approach for thoracoabdominal aortic aneurysm (TAAA) surgical repair. The aim of this study is to determine whet...

(This article belongs to the Special Issue Open and Endovascular Management of Complex Aortic Aneurysms)
  • Review
  • Open Access
17 Citations
6,270 Views
11 Pages

Prevention of Spinal Cord Injury during Thoracoabdominal Aortic Aneurysms Repair: What the Anaesthesiologist Should Know

  • Federico Marturano,
  • Fulvio Nisi,
  • Enrico Giustiniano,
  • Francesco Benedetto,
  • Federico Piccioni and
  • Umberto Ripani

1 October 2022

Thoraco-abdominal aortic repair is a high-risk surgery for both mortality and morbidity. A major complication is paraplegia-paralysis due to spinal cord injury. Modern thoracic and abdominal aortic aneurysm repair techniques involve multiple strategi...

(This article belongs to the Special Issue Individual Evaluation, Management and Outcome in Perioperative Medicine)
  • Article
  • Open Access
639 Views
13 Pages

The Impact of Operator’s Learning Curve on the Outcomes of an Off-the-Shelf Multi-Branched Endograft for Complex and Thoracoabdominal Aneurysms Repair

  • Enrico Gallitto,
  • Antonio Cappiello,
  • Gianluca Faggioli,
  • Andrea Vacirca,
  • Paolo Spath,
  • Stefania Caputo,
  • Chiara Mascoli,
  • Carmine Poliseno,
  • Marco Mattiacci and
  • Mauro Gargiulo
  • + 2 authors

11 May 2026

Objectives: The study objectives are to evaluate the impact of the operator’s learning curve on the outcomes of off-the-shelf branched endovascular aortic repair (OTS-BEVAR) in complex and thoracoabdominal (C/TAAAs) aneurysms. Methods: Patients...

(This article belongs to the Special Issue Aortic Diseases: Modern Strategies in Diagnosis, Management, and Prevention of Complications)
  • Article
  • Open Access
1 Citations
1,823 Views
13 Pages

Objectives: Image-based sarcopenia has been the subject of recent studies, hypothesized as a prognostic factor for patients with thoracoabdominal aortic aneurysms. Methods and Materials: We conducted a single-center retrospective analysis of patients...

(This article belongs to the Special Issue Recent Advances in the Diagnosis and Treatment of Vascular Diseases)
  • Article
  • Open Access
954 Views
13 Pages

Increased suPAR Plasma Levels May Indicate Postoperative Sepsis Following Open Thoracoabdominal Aortic Repair

  • Dragos Socol,
  • Cathryn Bassett,
  • Bernhard Hruschka,
  • Jelle Frankort,
  • Moustafa Elfeky,
  • Katja Heller,
  • Florian Kahles,
  • Berkan Kurt,
  • Christian Uhl and
  • Alexander Gombert
  • + 1 author

14 December 2025

Background/Objectives: Postoperative organ complications following open thoracoabdominal aortic aneurysm (TAAA) repair pose significant challenges during the early postoperative period, where prompt detection is crucial for improving patient outcomes...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
1,421 Views
14 Pages

Evaluation of Spinal Cord Blood Supply with Hyperspectral Imaging of the Paraspinous Musculature During Staged Endovascular Repair of Thoracoabdominal Aortic Aneurysm: A Sub-Study of the Prospective Multicenter PAPA-ARTiS Trial

  • Birte Winther,
  • Daniela Branzan,
  • Christian D. Etz,
  • Antonia Alina Geisler,
  • Sabine Steiner,
  • Hinrich Winther,
  • Raphael Meixner,
  • Marina Jiménez-Muñoz,
  • Hannes Köhler and
  • Andrej Schmidt
  • + 1 author

Background/Objectives: Our aim was to assess the feasibility of hyperspectral imaging (HSI) to detect changes in tissue oxygenation (StO2) of the back, as non-invasive spinal cord collateral network (CN) monitoring during staged endovascular repair (...

(This article belongs to the Special Issue Vascular and Endovascular Surgery: Current Progress and Future Challenges)
  • Article
  • Open Access
280 Views
13 Pages

30 August 2026

Background/Objectives: Not all patients with acute aortic dissection undergo endovascular repair at initial presentation, and surgical or endovascular interventions are often required for late aneurysmal degeneration. This study aims to report the mi...

(This article belongs to the Special Issue Advances in Treatment and Prognosis for Acute Type A and Type B Aortic Dissections)
  • Review
  • Open Access
21 Citations
8,306 Views
21 Pages

Peri-Operative Management of Patients Undergoing Fenestrated-Branched Endovascular Repair for Juxtarenal, Pararenal and Thoracoabdominal Aortic Aneurysms: Preventing, Recognizing and Treating Complications to Improve Clinical Outcomes

  • Andrea Xodo,
  • Mario D’Oria,
  • Bernardo Mendes,
  • Luca Bertoglio,
  • Kevin Mani,
  • Mauro Gargiulo,
  • Jacob Budtz-Lilly,
  • Michele Antonello,
  • Gian Franco Veraldi and
  • Randall DeMartino
  • + 12 authors

21 June 2022

The advent and refinement of complex endovascular techniques in the last two decades has revolutionized the field of vascular surgery. This has allowed an effective minimally invasive treatment of extensive disease involving the pararenal and the tho...

  • Article
  • Open Access
3 Citations
1,841 Views
15 Pages

10 August 2023

Despite the development of fenestrated and branched endovascular aortic repair (f/bEVAR), the surgical management of thoraco-abdominal aortic aneurysms (TAAAs) remains a major challenge. The aim of this study was to analyse the hospital incidence and...

(This article belongs to the Section Vascular Medicine)
  • Systematic Review
  • Open Access
12 Citations
3,534 Views
12 Pages

11 January 2024

The objective of this study is to present the current outcomes of fenestrated/branched endovascular repair (F/BEVAR) for post-dissection thoracoabdominal aortic aneurysms (PDTAAAs). A systematic review of the literature according to PRISMA guidelines...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
4 Citations
2,208 Views
13 Pages

Urgent or Emergent Endovascular Aortic Repair of Infective Aortitis

  • Bernardo Orellana Davila,
  • Carlotta Mancusi,
  • Carlo Coscarella,
  • Claudio Spataro,
  • Paolo Carfagna,
  • Arnaldo Ippoliti,
  • Rocco Giudice and
  • Ciro Ferrer

9 August 2024

Background: Aortitis is a rare inflammation of the aorta. It can be classified as infective, non-infective, or idiopathic. Infective aortitis can debut as an acute aortic syndrome that needs urgent or emergent treatment. Historically, these kinds of...

(This article belongs to the Section Vascular Medicine)
  • Review
  • Open Access
5 Citations
3,554 Views
14 Pages

Plug-Based Embolization Techniques of Aortic Side Branches during Standard and Complex Endovascular Aortic Repair

  • Andrea Melloni,
  • Mario D’Oria,
  • Pietro Dioni,
  • Deborah Ongaro,
  • Giovanni Badalamenti,
  • Sandro Lepidi,
  • Stefano Bonardelli and
  • Luca Bertoglio

3 April 2024

Vascular plugs are an evolving family of vessel occluders providing a single-device embolization system for large, high-flow arteries. Nitinol mesh plugs and polytetrafluoroethylene membrane plugs are available in different configurations and sizes t...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
3 Citations
2,617 Views
24 Pages

Anti-HMGB1 Antibody Therapy Ameliorates Spinal Cord Ischemia–Reperfusion Injury in Rabbits

  • Genya Muraoka,
  • Yasuhiro Fujii,
  • Keyue Liu,
  • Handong Qiao,
  • Dengli Wang,
  • Daiki Ousaka,
  • Susumu Oozawa,
  • Shingo Kasahara and
  • Masahiro Nishibori

5 September 2025

Spinal cord ischemia–reperfusion (SCI/R) injury remains a major clinical challenge with limited therapeutic options. High-mobility group box 1 (HMGB1), a proinflammatory mediator released during cellular stress, has been implicated in the patho...

(This article belongs to the Collection Advances in Cell and Molecular Biology)
  • Article
  • Open Access
7 Citations
4,350 Views
14 Pages

Macrophage Migration Inhibitory Factor Predicts Outcome in Complex Aortic Surgery

  • Alexander Gombert,
  • Christian Stoppe,
  • Ann Christina Foldenauer,
  • Tobias Schuerholz,
  • Lukas Martin,
  • Johannes Kalder,
  • Gereon Schälte,
  • Gernot Marx,
  • Michael Jacobs and
  • Jochen Grommes

9 November 2017

The perioperative inflammatory response is associated with outcome after complex aortic repair. Macrophage migration inhibitory factor (MIF) shows protective effects in ischemia-reperfusion (IR), but also adverse pro-inflammatory effects in acute inf...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
18 Citations
3,547 Views
15 Pages

Outcomes of Directional Branches of the T-Branch Off-the-Shelf Multi-Branched Stent-Graft

  • Konstantinos Spanos,
  • Tomasz Jakimowicz,
  • Petroula Nana,
  • Christian-Alexander Behrendt,
  • Giuseppe Panuccio,
  • George Kouvelos,
  • Katarzyna Jama,
  • Ahmed Eleshra,
  • Fiona Rohlffs and
  • Tilo Kölbel

2 November 2022

Background: A controversy on bridging covered stent (BCS) choice, between self-expanding (SECS) and balloon-expandable (BECS) stents, still exists in branched endovascular repair. This study aimed to determine the primary target vessel (TV) patency i...

(This article belongs to the Special Issue Abdominal Aortic Aneurysm: Clinical Updates and Perspectives)
  • Review
  • Open Access
1 Citations
10,766 Views
33 Pages

The Future of Cardiothoracic Surgical Critical Care Medicine as a Medical Science: A Call to Action

  • Rafal Kopanczyk,
  • Jesse Lester,
  • Micah T. Long,
  • Briana J. Kossbiel,
  • Aaron S. Hess,
  • Alan Rozycki,
  • David R. Nunley,
  • Alim Habib,
  • Ashley Taylor and
  • Amar M. Bhatt
  • + 1 author

27 December 2022

Cardiothoracic surgical critical care medicine (CT-CCM) is a medical discipline centered on the perioperative care of diverse groups of patients. With an aging demographic and an increase in burden of chronic diseases the utilization of cardiothoraci...

(This article belongs to the Special Issue Cardiothoracic Surgical Critical Care: A Future of Distinction)
  • Case Report
  • Open Access
1 Citations
2,103 Views
9 Pages

Background/Objectives: The management of patients with severe systemic comorbidities undergoing radiologic interventional procedures presents a significant challenge for anesthesiologists. Selecting an appropriate combination of anesthetic drugs is c...

  • Article
  • Open Access
4 Citations
2,007 Views
11 Pages

23 May 2024

Introduction: The aim of this paper is to propose a sequential deployment technique for the E-nside off-the-shelf endograft that could potentially enhance target visceral vessel (TVV) cannulation and overstenting in narrow aortic anatomies. Methods:...

(This article belongs to the Special Issue State of the Art in Invasive Vascular Interventions)
  • Review
  • Open Access
2 Citations
848 Views
9 Pages

Desmosine in Aortic Disease: Biology, Measurement, and Clinical Applications in Aortic Pathologies

  • Alexander Gombert,
  • Saurav Ranjan Mohapatra,
  • Jelle M. Frankort,
  • Christian Uhl and
  • Panagiotis Doukas

26 March 2026

Thoracoabdominal aortic aneurysms (TAAAs) are uncommon and usually silent until rupture, causing a substantial burden to the health care system. Aneurysm growth and rupture prediction is mainly based on aneurysm diameter measurement by imaging modali...

(This article belongs to the Special Issue Aortic Diseases: Modern Strategies in Diagnosis, Management, and Prevention of Complications)
  • Article
  • Open Access
2 Citations
1,183 Views
14 Pages

Mapping 18F-FDG Positron Emission Tomography Uptake in the Aortic Wall and Thrombus: Validation and Reproducibility

  • Mireia Bragulat-Arévalo,
  • Marta Ferrer-Cornet,
  • Lydia Dux-Santoy,
  • Ruper Oliveró-Soldevila,
  • Marvin Garcia-Reyes,
  • Gisela Teixidó-Turà,
  • Juan Garrido-Oliver,
  • Laura Galian-Gay,
  • Pere Lopez-Gutierrez and
  • Andrea Guala
  • + 7 authors

3 October 2025

18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) could be useful to assess inflammation of the aortic wall, a potential early indicator of aneurysm formation. Nonetheless, its current clinical assessment presents several limitation...

(This article belongs to the Special Issue Biomedical Imaging Technologies for Cardiovascular Disease, 4th Edition)
  • Article
  • Open Access
1 Citations
794 Views
9 Pages

Influence of Foehn on Aortic Aneurysm Ruptures in Southern Germany

  • Elena Streck,
  • Irena Kaspar-Ott,
  • Oksana Radu,
  • Stefan Schiele,
  • Hans-Henning Eckstein,
  • Gernot Müller,
  • Elke Hertig and
  • Alexander Hyhlik-Dürr

30 April 2025

Background/Objectives: Foehn, a warm, dry wind blowing down into the valleys of a mountain, is a typical weather condition in southern Germany. Until now, there have been no data regarding the impact of foehn on aortic aneurysm ruptures in the Alpine...

(This article belongs to the Section Vascular Medicine)
  • Review
  • Open Access
92 Citations
16,789 Views
25 Pages

Risk Factors for Thoracic Aortic Dissection

  • Zhen Zhou,
  • Alana C. Cecchi,
  • Siddharth K. Prakash and
  • Dianna M. Milewicz

7 October 2022

Thoracic aortic aneurysms involving the root and/or the ascending aorta enlarge over time until an acute tear in the intimal layer leads to a highly fatal condition, an acute aortic dissection (AAD). These Stanford type A AADs, in which the tear occu...

(This article belongs to the Special Issue Molecular Mechanisms of Vascular Disease)
  • Article
  • Open Access
2 Citations
2,252 Views
11 Pages

Increased Aortic Exclusion in Endovascular Treatment of Complex Aortic Aneurysms

  • Merel Verhagen,
  • Daniel Eefting,
  • Carla van Rijswijk,
  • Rutger van der Meer,
  • Jaap Hamming,
  • Joost van der Vorst and
  • Jan van Schaik

26 July 2023

Purpose: Perioperative risk assessments for complex aneurysms are based on the anatomical extent of the aneurysm and do not take the length of the aortic exclusion into account, as it was developed for open repair. Nevertheless, in the endovascular r...

(This article belongs to the Special Issue Endovascular Aortic Interventions and Aneurysm Repair: Recent Advances and Future Prospects)
  • Article
  • Open Access
487 Views
8 Pages

Experience of Alternative Technique for Branch Cannulation in Branched Endovascular Aneurysm Repair

  • Daniela Mazzaccaro,
  • Paolo C. Righini,
  • Fabiana Fancoli,
  • Alfredo Modafferi,
  • Giovanni Malacrida,
  • Marina Galligani and
  • Giovanni Nano

24 March 2026

Background/Objectives: To describe our experience of using an alternative technique for retrograde branch graft cannulation during Branched EndoVascular Aortic Repair (B-EVAR) of complex abdominal and thoraco-abdominal aortic aneurysm (TAAA) with bra...

(This article belongs to the Special Issue Clinical Advances in the Management of Abdominal and Thoracoabdominal Aortic Aneurysms)
  • Article
  • Open Access
2 Citations
2,287 Views
14 Pages

Prognostic Impact of Pulmonary Diseases in 952 Patients with Thoracic and/or Abdominal Aortic Aneurysm

  • Yoichi Kobayashi,
  • Takashi Ishiguro,
  • Naho Kagiyama,
  • Makoto Sumi and
  • Noboru Takayanagi

19 October 2024

Background/Objectives: Pulmonary diseases are common in patients with thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA). Although high prevalences of chronic obstructive pulmonary disease and lung cancer (LC) are known, the prevalenc...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
3 Citations
2,234 Views
10 Pages

Post-Operative and Mid-Term Renal Function Impairment Following Elective Fenestrated Endovascular Aortic Repair for Complex Aortic Aneurysms: Incidence and Risk Factors Analysis

  • Elda Chiara Colacchio,
  • Mariagiovanna Berton,
  • Franco Grego,
  • Michele Piazza,
  • Mirko Menegolo,
  • Francesco Squizzato and
  • Michele Antonello

Background. The aim of this study was to assess the incidence of two post-operative acute kidney injury (AKI) stages according to the Risk, Injury, Failure, Loss of function, End-stage (RIFLE) criteria in patients undergoing fenestrated endovascular...

(This article belongs to the Collection Vascular Diseases Diagnostics)
  • Article
  • Open Access
20 Citations
3,657 Views
13 Pages

Initial Experience with Fenestrated Physician-Modified Stent Grafts Using 3D Aortic Templates

  • Paweł Rynio,
  • Tomasz Jedrzejczak,
  • Anita Rybicka,
  • Ross Milner,
  • Piotr Gutowski and
  • Arkadiusz Kazimierczak

13 April 2022

The goal of this study was to describe the surgical results of physician-modified endografts (PMEG) utilizing a 3D aortic template in a center with no prior experience in complex endovascular aortic repairs. Forty-three patients underwent physician-m...

(This article belongs to the Section Cardiovascular Medicine)
  • Review
  • Open Access
16 Citations
4,679 Views
12 Pages

Physician-Modified Endografts for Repair of Complex Abdominal Aortic Aneurysms: Clinical Perspectives and Medico-Legal Profiles

  • Giovanna Ricci,
  • Filippo Gibelli,
  • Ascanio Sirignano,
  • Maurizio Taurino and
  • Pasqualino Sirignano

17 July 2024

Standard endovascular aortic repair (EVAR) has become the standard of care for treating infrarenal abdominal aortic aneurysms (AAAs) in patients with favorable anatomies, while patients with challenging AAA anatomies, and those with suprarenal or tho...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)

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