Aortic Aneurysm: Mechanisms, Biomarkers, and Therapeutic Strategy
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 49
Special Issue Editors
2. College of Medicine Phoenix, University of Arizona, Phoenix, AZ 85004, USA
Interests: vascular biology; aneurysms; endothelial function; angiotensin signaling; genetic aortic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aortic aneurysm remains a life-threatening vascular disease that can lead to high morbidity and mortality, despite significant progress in diagnostic imaging, surgical techniques, and pharmacological interventions. The complexity of its pathogenesis—encompassing genetic predisposition, inflammatory processes, extracellular matrix remodeling, endothelial dysfunction, and altered smooth muscle cell signaling—necessitates multidisciplinary investigation to uncover novel mechanisms and therapeutic strategies.
This Special Issue of Biomedicines, titled “Aortic Aneurysm: Mechanisms, Biomarkers, and Therapeutic Strategy”, aims to showcase cutting-edge basic, translational, and clinical research that advances our understanding of the molecular, cellular, and biomechanical underpinnings of aortic aneurysm. In addition, it will highlight innovations in diagnosis, risk stratification, and therapeutics. We welcome contributions from diverse fields, including vascular biology, genetics, molecular medicine, biomechanics, pharmacology, and surgery. We emphasize the importance of an integrative approach to this complex disease utilizing in vitro, ex vivo, and in vivo experimental models.
Topics of interest include, but are not limited to, the following:
- Molecular and cellular mechanisms driving aortic aneurysm initiation and progression;
- Role of smooth muscle cells, endothelial cells, and immune cells in aneurysm pathology;
- Genetic and epigenetic determinants of syndromic and non-syndromic aneurysms;
- Sex differences and hormonal influences on aneurysm development and rupture risk;
- Oxidative stress, nitric oxide signaling, and vascular inflammation;
- Advanced imaging techniques and biomarkers for early detection and risk assessment;
- Biomechanical modeling and wall stress analysis in aneurysm growth and rupture prediction;
- Experimental pharmacological approaches and repurposing of existing drugs;
- Crosstalk between aortic aneurysm and systemic metabolic or cardiovascular disorders;
- Insights from animal models, organ-on-chip, and tissue-engineered vascular models;
- Translational studies using animal models;
- Clinical trials of novel interventions.
This Special Issue strives to convene a global community of researchers and clinicians dedicated to unraveling the complexities of aortic aneurysm disease and paving the way toward innovative, patient-centered care. We cordially invite you to contribute your latest findings and insights to this Special Issue and help shape the future of aortic aneurysm research and treatment.
Dr. Mitra Esfandiarei
Dr. Seda Selamet Tierney
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aortic aneurysms
- genetic aortic diseases
- endothelial dysfunction
- extracellular matrix
- aortic wall
- aortic smooth muscle
- angiotensin system
- aortic wall elasticity
- matrix metalloproteinases
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