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32 Results Found

  • Article
  • Open Access
1 Citations
1,861 Views
13 Pages

16 May 2023

Tectonic coal, an aggregate of coal particles formed by compacting pulverized coal, has been developed extensively in China. Currently, reconstituted coal specimens are widely adopted to investigate the mechanical properties of tectonic coal, but the...

  • Article
  • Open Access
8 Citations
4,075 Views
16 Pages

12 May 2020

Changes in the reactor pressure vessel (RPV) material properties due to neutron irradiation are monitored by means of surveillance specimen programs, which are used for realistic evaluation of the RPVs’ lifetime. Due to a limited number of surv...

  • Article
  • Open Access
492 Views
27 Pages

This study investigates the behaviour of dense silty sands with kaolinite clay under static drained/undrained conditions at low confining stress. Conventional laboratory tests assessed the mixtures’ physical properties, but standard void ratio...

  • Article
  • Open Access
1,330 Views
11 Pages

30 September 2024

The understanding of naturally occurring materials such as clay, sand, hard and soft rocks under a common theoretical framework has been a topic of persistent research interest. Over the past few decades, various sample reconstitution techniques have...

  • Article
  • Open Access
6 Citations
4,221 Views
17 Pages

Influence of Abaca Fiber Inclusion on the Unconfined Compressive Strength of Reconstituted Sandy Silts

  • Jorge Albuja-Sánchez,
  • Eduardo Alcívar,
  • Daniela Escobar,
  • Juan Montero,
  • Guillermo Realpe,
  • Andrés Muñoz and
  • Mateo Peñaherrera-Aguirre

12 November 2022

The present investigation determines the influence of abaca (Musa textilis) fiber inclusion on the simple compressive strength of reconstituted sandy silt specimens. For this purpose, fibers of different lengths (5, 10 and 15 mm) and quantities (0.5,...

  • Article
  • Open Access
4 Citations
2,207 Views
22 Pages

12 July 2023

To investigate the effects of the properties of plastic fines on the pore water pressure generation characteristics of fine-grained soils during cyclic loadings, we used 29 sets of test data from the literature and prepared another 21 reconstituted s...

  • Article
  • Open Access
3,330 Views
19 Pages

Large Shear Strength Parameters for Landslide Analyses on Highly Weathered Flysch

  • Sofia Anagnostopoulou,
  • Nikolaos Depountis,
  • Nikolaos Sabatakakis and
  • Panagiotis Pelekis

19 August 2022

Many significant landslide movements are often observed in the upper weathering zone of flysch, which constitutes the most critical landslide-prone geological formation in Western Greece. In this article, a laboratory approach is adopted to investiga...

  • Case Report
  • Open Access
8 Citations
3,189 Views
4 Pages

Persistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?

  • Maria Antonia De Francesco,
  • Giovanni Ianiro,
  • Marina Monini,
  • Cesare Vezzoli,
  • Richard Fabian Schumacher,
  • Silvia Giliani,
  • Giovanni Lorenzin,
  • Francesca Gurrieri and
  • Arnaldo Caruso

16 November 2019

We report the first case, to our knowledge, in Italy, of a severe combined immunodeficiency patient with a persistent rotavirus infection due to a vaccine derived strain. Rotavirus was detected by enzyme immunoassays and RT-PCR in stool specimens for...

  • Article
  • Open Access
14 Citations
6,295 Views
15 Pages

A Procedure to Prepare Sand–Clay Mixture Samples for Soil–Structure Interface Direct Shear Tests

  • Kexin Yin,
  • Jiangxin Liu,
  • Andreea-Roxana Vasilescu,
  • Eugenia Di Filippo and
  • Khaoula Othmani

8 June 2021

A large number of experimental studies on sand–clay mixtures are well documented in the literature; however, the preparation protocol is rarely clearly detailed or varies a lot according to the authors. Variations in the preparation technique obvious...

  • Case Report
  • Open Access
1,029 Views
7 Pages

Background: Thymoma-associated pure white cell aplasia (PWCA), characterized by agranulocytosis with absent myeloid precursors in the bone marrow in the setting of preserved erythropoiesis and megakaryopoiesis, is exceedingly rare, with only a few ca...

  • Article
  • Open Access
3,487 Views
19 Pages

3 November 2020

Liquefaction risk assessment is critical for the safety and economics of structures. As the soil strata of Ramsar area in north Iran is mostly composed of poorly graded clean sand and the ground water table is found at shallow depths, it is highly su...

  • Article
  • Open Access
3 Citations
2,963 Views
15 Pages

The Influence of Abaca Fiber Treated with Sodium Hydroxide on the Deformation Coefficients Cc, Cs, and Cv of Organic Soils

  • Carlos Contreras,
  • Jorge Albuja-Sánchez,
  • Oswaldo Proaño,
  • Carlos Ávila,
  • Andreina Damián-Chalán and
  • Mateo Peñaherrera-Aguirre

15 October 2024

This study shows the influence of the inclusion of abaca fiber (Musa Textilis) on the coefficients of consolidation, expansion, and compression for normally consolidated clayey silt organic soil specimens using reconstituted samples. For this purpose...

  • Article
  • Open Access
10 Citations
2,402 Views
18 Pages

20 June 2020

To study the mechanical properties of argillaceous weakly cemented rock under dynamic loading, a sample reconstituted and graded loading scheme is firstly designed, and then the reorganization rock sample is used as the research object. Using a Hopki...

  • Article
  • Open Access
2 Citations
2,051 Views
14 Pages

Modification of a Constitutive Model for Gassy Clay

  • Tao An,
  • Dong Wang and
  • Xiurong Yang

Gassy clays containing large, discrete gas bubbles are widely spread in deposits in shallow waters. The existence of gas bubbles may impair the original soil structure, resulting in the instability of offshore foundations and the occurrence of submar...

  • Article
  • Open Access
19 Citations
4,900 Views
22 Pages

The study of the strength of reconstituted and stabilised soft soils is very important in geotechnical engineering. The soil particles, such as clay, sand, and silt play important roles in determining the behaviour of soils. The behaviour of clay and...

  • Article
  • Open Access
1 Citations
2,696 Views
10 Pages

Study of Ion Adsorption and Shear Strength of Red Clay under Leaching Action

  • Yu Song,
  • Hui Li,
  • Yukun Geng,
  • Lulu Xia and
  • Rongtao Yan

4 January 2023

To study the soil-water effect of red clay, a leaching test is conducted by loading red clay into a soil column and collecting the leaching waste liquid periodically for analysis of the ion content and conductivity changes in the leaching waste liqui...

  • Article
  • Open Access
4 Citations
3,749 Views
18 Pages

Behavior of Offshore Pile in Calcareous Sand—Case Study

  • Tarek N. Salem,
  • Nadia M. Elkhawas and
  • Ahmed M. Elnady

The erosion of limestone and calcarenite ridges that existed parallel to the Mediterranean shoreline forms the calcareous sand (CS) formation at the surface layer of Egypt’s northern coast. The CS is often combined with broken shells which are consid...

  • Feature Paper
  • Article
  • Open Access
5 Citations
2,834 Views
17 Pages

18 March 2021

This paper presents the findings of a laboratory study of the shear strength and yielding behavior of two glacial till soil deposits from the area of Heiligenhafen, northern Germany. The tests were conducted on reconstituted forms of the soils using...

  • Article
  • Open Access
1 Citations
2,484 Views
37 Pages

Stress–Strain–Time Description and Analysis of Frozen–Thawed Silty Clay under Low Stress Level

  • Haigang Qu,
  • Dianrui Mu,
  • Zhenlu Ren,
  • Ziyuan Huang,
  • Yang Huang and
  • Aiping Tang

24 October 2022

The construction of high-speed railways in cold regions needs to consider the effects of freeze–thaw cycles (FTHs) on the long-term deformation of subgrades. However, at present, research on the creep characteristics of frozen–thawed rock...

  • Article
  • Open Access
42 Citations
5,870 Views
15 Pages

To investigate the geotechnical soil properties of Emilia Romagna Region, a large series of in situ tests, laboratory tests and geophysical tests have been performed, particularly at the damaged city of Scortichino—Bondeno. Deep site investigations h...

  • Article
  • Open Access
5 Citations
2,776 Views
18 Pages

30 August 2022

It has long been known that the hysteresis loops of sand under cyclic loading gradually become asymmetric with the increase of strain amplitudes, but a symmetrical hysteresis loop is widely assumed in current practice. Despite several methods which h...

  • Article
  • Open Access
3,492 Views
14 Pages

A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues

  • Alessandra Manca,
  • Amedeo De Nicolò,
  • Elisa Delia De Vivo,
  • Micol Ferrara,
  • Sharon Oh,
  • Sahar Khalili,
  • Niamh Higgins,
  • Robert G. Deiss,
  • Stefano Bonora and
  • Antonio D’Avolio
  • + 4 authors

Background: Opioids are considered the cornerstone of pain management: they show good efficacy as a first-line therapy for moderate to severe cancer pain. Since pharmacokinetic/pharmacodynamic information about the tissue-specific effect and toxicity...

  • Article
  • Open Access
2 Citations
1,952 Views
24 Pages

17 October 2024

The formation of layering during the sedimentation process of tailings makes it of great significance to investigate tailings and to analyze their susceptibility to flow liquefaction. In this study, homogeneous iron ore tailings (IOTs) specimens were...

  • Article
  • Open Access
13 Citations
3,751 Views
17 Pages

miR-1272 Exerts Tumor-Suppressive Functions in Prostate Cancer via HIP1 Suppression

  • Federica Rotundo,
  • Denis Cominetti,
  • Rihan El Bezawy,
  • Stefano Percio,
  • Valentina Doldi,
  • Monica Tortoreto,
  • Valentina Zuco,
  • Riccardo Valdagni,
  • Nadia Zaffaroni and
  • Paolo Gandellini

13 February 2020

The development of novel therapies or the improvement of currently used approaches to treat prostate cancer (PCa), the most frequently diagnosed male tumor in developed countries, is an urgent need. In this regard, the functional characterization of...

  • Article
  • Open Access
8 Citations
6,586 Views
15 Pages

An Ex-Vivo Culture System of Ovarian Cancer Faithfully Recapitulating the Pathological Features of Primary Tumors

  • Farhana Ishrat Ghani,
  • Kasumi Dendo,
  • Reiko Watanabe,
  • Kenji Yamada,
  • Yuki Yoshimatsu,
  • Takashi Yugawa,
  • Tomomi Nakahara,
  • Katsuyuki Tanaka,
  • Hiroshi Yoshida and
  • Tohru Kiyono
  • + 4 authors

26 June 2019

The success rate of establishing human cancer cell lines is not satisfactory and the established cell lines often do not preserve the molecular and histological features of the original tissues. In this study, we developed a novel culture method whic...

  • Review
  • Open Access
26 Citations
9,174 Views
18 Pages

2 December 2020

Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection that mostly affects children with suppressed cellular immunity. PJP was the most common cause of infectious death in children with acute lymphoblastic leukemia prior to the inclusio...

  • Article
  • Open Access
13 Citations
3,957 Views
23 Pages

Contribution of miRNAs, tRNAs and tRFs to Aberrant Signaling and Translation Deregulation in Lung Cancer

  • Ilias Skeparnias,
  • Dimitrios Anastasakis,
  • Katerina Grafanaki,
  • George Kyriakopoulos,
  • Panagiotis Alexopoulos,
  • Dimitrios Dougenis,
  • Andreas Scorilas,
  • Christos K. Kontos and
  • Constantinos Stathopoulos

20 October 2020

Transcriptomics profiles of miRNAs, tRNAs or tRFs are used as biomarkers, after separate examination of several cancer cell lines, blood samples or biopsies. However, the possible contribution of all three profiles on oncogenic signaling and translat...

  • Article
  • Open Access
2 Citations
2,878 Views
15 Pages

11 October 2023

Kaolin clay, with its consistent properties, fine particle size, high surface area, and extensive historical use, stands out as a reliable choice for laboratory research. This study aims to assess the interface shear adhesion behaviour between compac...

  • Article
  • Open Access
2 Citations
1,475 Views
19 Pages

24 February 2025

In order to investigate the influence of the coexistence of clay and silt on the compression characteristics of sand, one-dimensional compression consolidation tests were carried out on reconstituted saturated sand–silt–clay mixtures with...

  • Article
  • Open Access
4 Citations
2,221 Views
21 Pages

Constitutive Behaviour of a Clay Stabilised with Alkali-Activated Cement Based on Blast Furnace Slag

  • Manuela Corrêa-Silva,
  • Nuno Cristelo,
  • Mohamed Rouainia,
  • Nuno Araújo and
  • Tiago Miranda

23 October 2022

Alkaline cements have been extensively tested for soil stabilisation in the last decade. However, only a few studies have focused on the assessment of such performance by establishing the constitutive behaviour of the cement. In this paper, we focus...

  • Article
  • Open Access
5 Citations
2,399 Views
18 Pages

Flow Behavior and Microstructure of Hot-Worked Fe-30.9Mn-4.9Al-4.5Cr-0.4C and Fe-21.3Mn-7.6Al-4.3Cr-1C Low-Density Stainless Steels

  • Takatso Komane,
  • Nthabiseng Maledi,
  • Desmond Klenam,
  • Josias van der Merwe and
  • Michael Bodunrin

10 February 2023

Two as-cast low-density steels grades (austenite-based duplex Fe-30.9Mn-4.9Al-4.5Cr-0.4C and austenitic Fe-21.3Mn-7.6Al-4.3Cr-1C) with an initial dendritic microstructure were subjected to hot working conditions to understand the influence of deforma...

  • Article
  • Open Access
1,233 Views
12 Pages

Feasibility Assessment of Autologous Human Immune System (HIS) ImmunoGraft Platform Development Using Autologous Mobilized Peripheral Blood (MPB) CD34 Cells Derived from Adult HNSCC Patient

  • Bhavna Verma,
  • Georgia Zhuo Chen,
  • Edmund K. Waller,
  • Mihir Patel,
  • Allyson Anderson,
  • Neal Goodwin,
  • Amy Wesa,
  • Yong Teng and
  • Nabil F. Saba

Humanized mice generated by hematopoietic stem cell (HSC) transplantation are limited by the immune system developed being allogeneic to the tumor. We have innovated a platform to reconstitute an autologous human immune system (HIS) in immunodeficien...