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45 Results Found

  • Article
  • Open Access
2,321 Views
11 Pages

The Mitigating Effects of Perilla Leaf Essential Oil on the Phytotoxicity of Fenoxaprop-P-Ethyl in Rice Seedlings

  • Jiuying Li,
  • Yinghui Zhu,
  • Lanlan Sun,
  • Hongle Xu,
  • Wangcang Su,
  • Fei Xue,
  • Chuantao Lu,
  • Wenwei Tang and
  • Renhai Wu

21 October 2024

Fenoxaprop-P-ethyl (FE) can effectively control weeds in rice fields, but it has been found to cause phytotoxicity in rice. In this study, the phytotoxicity of FE was mitigated by perilla leaf essential oil (PEO) in rice seedlings. The injury recover...

  • Article
  • Open Access
23 Citations
11,666 Views
11 Pages

14 October 2010

This study was undertaken to optimize the conditions for the extraction of antibacterial activity of Perilla frutescens var. acuta leaf against Pseudomonas aeruginosa KCTC 2004 using the evolutionary operation-factorial (EVOP) design technique. Incre...

  • Article
  • Open Access
37 Citations
9,994 Views
13 Pages

6 April 2011

This study was undertaken to optimize extraction using evolutionary operation-factorial (EVOP) design technique to elicit the antibacterial activity of Perilla frutescens var. acuta leaf against Staphylococcus aureus ATCC6538. Higher antibacterial ac...

  • Communication
  • Open Access
8 Citations
4,279 Views
10 Pages

14 May 2022

Perilla (Perilla frutescens) belongs to the Lamiaceae family, is used as a spicy culinary herb leafy vegetable as well as medicinal and ornamental plant. However, little is known about protocols for baby leaf perilla production. Native chitosan is a...

  • Article
  • Open Access
13 Citations
3,496 Views
13 Pages

26 October 2023

Breast cancer is a common type of cancer characterized by high mortality rates. However, chemotherapy is not selective and often leads to side-effects. Therefore, there is a need for the development of highly efficient drugs. Recent studies have show...

  • Article
  • Open Access
24 Citations
5,185 Views
18 Pages

Anti-Osteoporosis Effect of Perilla frutescens Leaf Hexane Fraction through Regulating Osteoclast and Osteoblast Differentiation

  • Kanokkarn Phromnoi,
  • Supachai Yodkeeree,
  • Komsak Pintha,
  • Sariya Mapoung,
  • Maitree Suttajit,
  • Chalermpong Saenjum and
  • Pornngarm Dejkriengkraikul

26 January 2022

Osteoporosis is the result of an imbalance in the bone-remodeling process via an increase in osteoclastic activity and a decrease in osteoblastic activity. Our previous studies have shown that Perilla frutescens seed meal has anti-osteoclastogenic ac...

  • Article
  • Open Access
50 Citations
5,185 Views
14 Pages

Perilla frutescens (L.) Britt., an annual herbaceous plant, has antibacterial, anti-inflammation, and antioxidant properties. To understand the effects of P. frutescens leaf on the ruminal microbial ecology of cattle, Illumina MiSeq 16S rRNA sequenci...

  • Article
  • Open Access
10 Citations
2,773 Views
10 Pages

Comprehensive Comparison of Two Color Varieties of Perillae Folium by GC-MS-Based Metabolomic Approach

  • Jiabao Chen,
  • Dan Zhang,
  • Qian Wang,
  • Aitong Yang,
  • Yuguang Zheng and
  • Lei Wang

11 October 2022

Perillae Folium (PF), the leaf of Perilla frutescens (L.) Britt, is extensively used as culinary vegetable in many countries. It can be divided into two major varietal forms based on leaf color variation, including purple PF (Perilla frutescens var....

  • Article
  • Open Access
11 Citations
3,174 Views
16 Pages

Bioefficacy of Nga-Mon (Perilla frutescens) Fresh and Dry Leaf: Assessment of Antioxidant, Antimutagenicity, and Anti-Inflammatory Potential

  • Payungsak Tantipaiboonwong,
  • Komsak Pintha,
  • Wittaya Chaiwangyen,
  • Maitree Suttajit,
  • Chakkrit Khanaree and
  • Orawan Khantamat

3 June 2023

Perilla leaves are known to be a rich source of polyphenols, which have been shown to exhibit various biological effects. This study aimed to compare the bioefficacies and bioactivities of fresh (PLEf) and dry (PLEd) Thai perilla (Nga-mon) leaf extra...

  • Communication
  • Open Access
1,278 Views
11 Pages

1 August 2025

Inflammatory arthritis (IA) is a chronic condition marked by joint dysfunction and pain, posing significant challenges for effective drug delivery. This study separated Perilla frutescens leaf-derived exosome-like nanovesicles (PFE) to effectively pe...

  • Article
  • Open Access
4 Citations
2,738 Views
12 Pages

10 October 2023

Lowering blood cholesterol levels is crucial for reducing the risk of cardiovascular disease in patients with familial hypercholesterolemia. To develop Perilla frutescens (L.) Britt. leaves as a functional food with a cholesterol-lowering effect, in...

  • Correction
  • Open Access
305 Views
2 Pages

17 November 2025

I am writing to inform you of an error in my recently published paper titled “Determination of Luteolin-7-O-diglucuronide in Perilla frutescens (L.) Britt. Leaf Extracts from Different Regions of China and Republic of Korea and Its Cholesterol-...

  • Article
  • Open Access
13 Citations
4,194 Views
16 Pages

Perilla frutescens Leaf Extract Attenuates Vascular Dementia-Associated Memory Deficits, Neuronal Damages, and Microglial Activation

  • Hyun-Bae Kang,
  • Shin-Hye Kim,
  • Sun-Ho Uhm,
  • Do-Kyung Kim,
  • Nam-Seob Lee,
  • Young-Gil Jeong,
  • Nak-Yun Sung,
  • Dong-Sub Kim,
  • In-Jun Han and
  • Seung-Yun Han
  • + 1 author

Vascular dementia (VaD) is characterized by a time-dependent memory deficit and essentially combined with evidence of neuroinflammation. Thus, polyphenol-rich natural plants, which possess anti-inflammatory properties, have received much scientific a...

  • Article
  • Open Access
2 Citations
2,919 Views
24 Pages

20 March 2023

The leaf of Perilla frutescens (L.) Britt (PF) has been reported to negatively affect adipocyte formation, inhibit body-fat formation, and lower body weight. However, its effect on adipocyte browning remains unknown. Thus, the mechanism of PF in prom...

  • Article
  • Open Access
30 Citations
5,950 Views
15 Pages

Intake of Alpha-Linolenic Acid-Rich Perilla frutescens Leaf Powder Decreases Home Blood Pressure and Serum Oxidized Low-Density Lipoprotein in Japanese Adults

  • Michio Hashimoto,
  • Yoko Tanabe,
  • Shahdat Hossain,
  • Kentaro Matsuzaki,
  • Miho Ohno,
  • Setsushi Kato,
  • Masanori Katakura and
  • Osamu Shido

30 April 2020

Oxidized low-density lipoprotein (Ox-LDL) is known to be highly atherogenic. Thus, decreasing the blood levels of Ox-LDL through dietary means is an important approach to reduce cardiovascular events in high-risk individuals. In this randomized place...

  • Article
  • Open Access
3 Citations
1,759 Views
25 Pages

15 May 2025

This study focuses on multiple origins of green-back purple and dual-faced purple Perilla frutescens, employing field cultivation experiments combined with detection methods, such as HPLC, LC-MS, and GC-MS, to compare the differences in yield, qualit...

  • Article
  • Open Access
10 Citations
7,843 Views
10 Pages

2 August 2013

Growth kinetics for Escherichia coli O157:H7 in perilla leaves were compared to those of pathogenic E. coli strains, including enteropathogenic (EPEC), enterotoxigenic (ETEC), enteroinvasive (EIEC) and other enterohemorrhagic (EHEC) at 13, 17, 24, 30...

  • Article
  • Open Access
2 Citations
4,601 Views
22 Pages

Background/Objectives: Perilla frutescens has historically been used to protect against inflammation and redox stress. This has been partly attributed to its high polyphenolic content; however, polyphenolic components in Perilla extract remain i...

  • Article
  • Open Access
14 Citations
5,331 Views
13 Pages

12 April 2021

Physiological processes in skin are associated with exposure to UV light and are essential for skin maintenance and regeneration. Here, we investigated whether the leaf and callus extracts of Perilla frutescens (Perilla), a well-known Asian herb, aff...

  • Article
  • Open Access
58 Citations
7,362 Views
19 Pages

3 February 2021

This study aims to evaluate the bioactive components, in vitro bioactivities, and in vivo hypoglycemic effect of P. frutescens leaf, which is a traditional medicine-food homology plant. P. frutescens methanol crude extract and its fractions (petroleu...

  • Article
  • Open Access
11 Citations
3,283 Views
17 Pages

12 November 2023

The development of natural antioxidants to replace synthetic compounds is attractive. Perilla frutescens leaves were proven to be rich in antioxidants. The extraction of antioxidants from Perilla leaves via ultrasonic-assisted extraction (UAE) based...

  • Article
  • Open Access
13 Citations
5,272 Views
11 Pages

19 November 2021

Cyanobacteria rapidly form harmful algal blooms (HABs) that cause serious nutritional imbalances in crop production via hydroponics. Allelopathic extracts from plants can be applied as a solution for ecologically sustainable control of algal blooms....

  • Article
  • Open Access
13 Citations
3,634 Views
17 Pages

20 June 2021

In Japan, red perilla leaves are used in the food and coloring industries, as well as in crude medicine. Perilla leaves contain a high concentration of phytochemicals such as perillaldehyde (PA) and rosmarinic acid (RA). The effects of UV-B radiation...

  • Article
  • Open Access
13 Citations
5,564 Views
10 Pages

17 February 2017

In this study, we aimed to compare supercritical carbon dioxide extraction and ethanol extraction for isoegomaketone (IK) content in perilla leaf extracts and to identify the optimal method. We measured the IK concentration using HPLC and inflammator...

  • Article
  • Open Access
9 Citations
3,833 Views
18 Pages

25 August 2021

Using morphological characteristics and simple sequence repeat (SSR) markers, we evaluated the morphological variation and genetic diversity of 200 Perilla accessions collected from the five regions of South Korea and another region. In morphological...

  • Article
  • Open Access
37 Citations
4,055 Views
10 Pages

Zinc Oxide Nanoparticles Enhanced Biomass and Zinc Content and Induced Changes in Biological Properties of Red Perilla frutescens

  • Piotr Salachna,
  • Małgorzata Mizielińska,
  • Beata Płoszaj-Witkowska and
  • Agnieszka Jaszczak

18 October 2021

The above-ground parts of plants, including leaves, constitute an important part of a human diet. Their mineral and biological composition can be modified by proper preparation of the soil substrate, i.e., supplying it with nutrients. The objective o...

  • Article
  • Open Access
8 Citations
2,881 Views
15 Pages

Comparative Metabolomics Analysis of Different Perilla Varieties Provides Insights into Variation in Seed Metabolite Profiles and Antioxidant Activities

  • Senouwa Segla Koffi Dossou,
  • Qianchun Deng,
  • Feng Li,
  • Nanjun Jiang,
  • Rong Zhou,
  • Lei Wang,
  • Donghua Li,
  • Meilian Tan,
  • Jun You and
  • Linhai Wang

4 December 2023

Perilla seeds are essential functional foods and key ingredients in traditional medicine. Herein, we investigated the variation in phytochemical profiles and antioxidant activities of twelve different perilla seeds. The seeds showed significant varia...

  • Article
  • Open Access
3 Citations
2,840 Views
21 Pages

Effect of Organic and Synthetic Fertilizers on Nitrate, Nitrite, and Vitamin C Levels in Leafy Vegetables and Herbs

  • Nga Thi Thu Nguyen,
  • Bac Xuan Nguyen,
  • Nasratullah Habibi,
  • Maryam Dabirimirhosseinloo,
  • Leonardo de Almeida Oliveira,
  • Naoki Terada,
  • Atsushi Sanada,
  • Atsushi Kamata and
  • Kaihei Koshio

14 March 2025

This study investigated the accumulation of nitrate and nitrite, as well as the vitamin C content, in various leafy vegetables, including amaranth greens, katuk, morning glory, squash leaves, vine spinach, leaf lettuce, romaine lettuce, Vietnamese ba...

  • Article
  • Open Access
12 Citations
3,873 Views
23 Pages

A Novel Perilla frutescens (L.) Britton Cell-Derived Phytocomplex Regulates Keratinocytes Inflammatory Cascade and Barrier Function and Preserves Vaginal Mucosal Integrity In Vivo

  • Giovanna Pressi,
  • Giovanna Rigillo,
  • Paolo Governa,
  • Vittoria Borgonetti,
  • Giulia Baini,
  • Raffaella Rizzi,
  • Chiara Guarnerio,
  • Oriana Bertaiola,
  • Marco Frigo and
  • Marco Biagi
  • + 4 authors

In the last years, the medicinal plant Perilla frutescens (L.) Britton has gained scientific interest because leaf extracts, due to the presence of rosmarinic acid and other polyphenols, have shown anti-allergic and skin protective potential in pre-c...

  • Article
  • Open Access
17 Citations
3,470 Views
16 Pages

Study on Purification, Identification and Antioxidant of Flavonoids Extracted from Perilla leaves

  • Hui Li,
  • Jiayu Lin,
  • Baoqing Bai,
  • Tao Bo,
  • Yufei He,
  • Shanhong Fan and
  • Jinhua Zhang

26 October 2023

The flavonoids from Perilla leaves were extracted using flash extraction assisted by ultrasonic extraction with ethanol. Subsequently, macroporous resin was employed for the isolation and purification of these flavonoids, followed by an investigation...

  • Article
  • Open Access
6 Citations
5,987 Views
15 Pages

Exploring the Efficacy of Four Essential Oils as Potential Insecticides against Thrips flavus

  • Yulong Niu,
  • Tianhao Pei,
  • Yijin Zhao,
  • Changjun Zhou,
  • Bing Liu,
  • Shusen Shi,
  • Meng-Lei Xu and
  • Yu Gao

4 June 2024

Plant essential oils are important alternatives in green integrated pest management. This study examined the chemical composition, bioactivity, and control efficacy of four Lamiaceae essential oils (EOs) against Thrips flavus Schrank in laboratory co...

  • Article
  • Open Access
18 Citations
12,880 Views
14 Pages

Fluctuating Asymmetry of Plant Leaves: Batch Processing with LAMINA and Continuous Symmetry Measures

  • John H. Graham,
  • Mattie J. Whitesell,
  • Mark Fleming II,
  • Hagit Hel-Or,
  • Eviatar Nevo and
  • Shmuel Raz

13 March 2015

Unlike landmark methods for estimating object asymmetry, continuous symmetry measures (CSM) can be used to measure the symmetry distance (ds) of inconsistent objects, such as plant leaves. Inconsistent objects have no homologous landmarks, no consist...

  • Article
  • Open Access
11 Citations
3,115 Views
12 Pages

In this study, we investigated the effect of UV-B irradiation 3 days prior to harvest, on the accumulation of rosmarinic acid (RA) and anthocyanin, and the expression of genes related to phenylpropanoid and flavonoid biosynthetic pathways, in red per...

  • Article
  • Open Access
828 Views
17 Pages

6 September 2025

To identify SSR markers associated with both quantitative and qualitative traits in Perilla, we analyzed a total of 68 individuals from an F2 population derived from a cross between WPC06-339 (weedy var. crispa) and WPF17-049 (weedy var. frutescens)...

  • Article
  • Open Access
2 Citations
2,411 Views
14 Pages

28 February 2023

Vegetable oils are indispensable in human and animal diets and have been widely used for the production of detergents, lubricants, cosmetics, and biofuels. The seeds of an allotetraploid Perilla frutescens contain approximately 35 to 40% oils with hi...

  • Article
  • Open Access
5 Citations
2,416 Views
14 Pages

Therapeutic Effects of Perilla Phenols in Oral Squamous Cell Carcinoma

  • Chia-Huei Lee,
  • Yu-Hsin Tsao,
  • Yui-Ping Weng,
  • I-Ching Wang,
  • Yao-Ping Chen and
  • Pin-Feng Hung

5 October 2023

The herbal medicine perilla leaf extract (PLE) exhibits various pharmacological properties. We showed that PLE inhibits the viability of oral squamous cell carcinoma (OSCC) cells. HPLC analysis revealed that caffeic acid (CA) and rosmarinic acid (RA)...

  • Article
  • Open Access
8 Citations
4,476 Views
18 Pages

An In Vitro Evaluation and Network Pharmacology Analysis of Prospective Anti-Prostate Cancer Activity from Perilla frutescens

  • Patrick Jay B. Garcia,
  • Steven Kuan-Hua Huang,
  • Kathlia A. De Castro-Cruz,
  • Rhoda B. Leron and
  • Po-Wei Tsai

21 August 2023

Perilla frutescens (L.) Britt. is extensively cultivated in East Asia as a dietary vegetable, and nutraceuticals are reportedly rich in bioactive compounds, especially with anticancer activities. This study explored the in vitro cytotoxic effects of...

  • Article
  • Open Access
8 Citations
3,409 Views
11 Pages

4 December 2019

We investigated the anti-arthritic effects of the radiation mutant Perilla frutescens var. crispa leaf extract (SFE-M) and wild type leaf extract (SFE-W), both prepared by supercritical carbon dioxide (SC-CO2) extraction, on collagen antibody-induced...

  • Article
  • Open Access
2 Citations
2,705 Views
13 Pages

Light Intensity Effects on Productivity and Post-Harvest Quality in Perilla frutescens Cultivated in CEA

  • Akvilė Viršilė,
  • Ieva Gudžinskaitė,
  • Kristina Laužikė,
  • Gediminas Kudirka,
  • Audrius Pukalskas and
  • Giedrė Samuolienė

19 November 2024

Leafy vegetables, mainly lettuces, are currently the main crop cultivated in controlled environment agriculture (CEA), including vertical farming and plant factories. There is a rising demand to expand this portfolio with a wider variety of underutil...

  • Article
  • Open Access
40 Citations
17,019 Views
21 Pages

Effectiveness of Different Washing Strategies on Pesticide Residue Removal: The First Comparative Study on Leafy Vegetables

  • So-Jin Yang,
  • Sujin Mun,
  • Hye Jin Kim,
  • Sue Ji Han,
  • Do Woo Kim,
  • Bae-Sik Cho,
  • Ae Gyeong Kim and
  • Duck Woong Park

19 September 2022

Leafy vegetables are used in various cuisines worldwide; however, as they cannot be peeled and their leaf surface area is large, the risk of retaining pesticide residues on these vegetables is relatively higher than on others. To our knowledge, this...

  • Article
  • Open Access
78 Citations
17,183 Views
16 Pages

Antioxidant Activity in Extracts of 27 Indigenous Taiwanese Vegetables

  • Pi-Yu Chao,
  • Su-Yi Lin,
  • Kuan-Hung Lin,
  • Yu-Fen Liu,
  • Ju-Ing Hsu,
  • Chi-Ming Yang and
  • Jun-You Lai

23 May 2014

The objectives of this study were to identify the antioxidants and antioxidant axtivity in 27 of Taiwan’s indigenous vegetables. Lycium chinense (Lc), Lactuca indica (Li), and Perilla ocymoides (Po) contained abundant quercetin (Que), while Artemisi...

  • Article
  • Open Access
127 Citations
25,338 Views
8 Pages

Antioxidant Activities of Polyphenols Extracted from Perilla frutescens Varieties

  • Linghua Meng,
  • Yves F. Lozano,
  • Emile M. Gaydou and
  • Bin Li

31 December 2008

Various cultivars of Perilla frutescens (L.) (var. crispa and var. frutescens) Britt. were harvested in China and Japan. They were easily differentiated on the basis of their foliage color, that varied from red to green. Water extracts of dried plant...

  • Article
  • Open Access
3 Citations
2,040 Views
11 Pages

30 July 2024

Volatile oil, mainly extracted from aromatic plants, is widely used in medical, cosmetics, and other industries for its disinfection, sterilization, antioxidant, and other effects. The yield of volatile oil was influenced by plant density and harvest...

  • Article
  • Open Access
5 Citations
3,395 Views
17 Pages

Cultivation Factors That Affect Amyloid-β Aggregation Inhibitory Activity in Perilla frutescens var. crispa

  • Keiya Shimamori,
  • Tomohiko Nambu,
  • Daiki Kawamata,
  • Masahiro Kuragano,
  • Naoki Nishishita,
  • Toshifumi Iimori,
  • Shinya Yamanaka,
  • Koji Uwai and
  • Kiyotaka Tokuraku

20 January 2023

Alzheimer’s disease (AD) is thought to be caused by the deposition of amyloid-β (Aβ) in the brain. Aβ begins to aggregate approximately 20 years before the expression of its symptoms. Previously, we developed a microliter-scale h...

  • Article
  • Open Access
11 Citations
5,313 Views
17 Pages

Optimizing Light Use Efficiency and Quality of Indoor Organically Grown Leafy Greens by Using Different Lighting Strategies

  • Laurent Boucher,
  • Thi-Thuy-An Nguyen,
  • Annie Brégard,
  • Steeve Pepin and
  • Martine Dorais

9 October 2023

Vertical farming is experiencing significant growth, and the optimization of artificial lighting is essential for enhancing the sustainability of this growing system. Therefore, the aim of this study was to examine how light segmentation, the incorpo...