713 Results Found

The crystal structure of the Ag-exchanged form of the zirconosilicate with the simplified formula (Na6-2xCax▯x)Zr3[Si9O27] with x < 1 (the idealized formula Na6Zr3[Si9O27]), a product of thermal transformation of catapleiite, ideally Na2Zr[Si3O9]&...

Isotactic polybutene (iPB) has a wide application in the water pipe field. However, the most valuable form I, needs 7 days to complete the transformation. In this study, the attapulgite (ATP), which produces lattice matching of the iPB form I, was se...

In this study, a dabigatran etexilate edisylate (DBE) was prepared by the reaction crystallization of dabigatran etexilate (DBG) and edisilic acid. According to single crystal X-ray diffraction (SXRD), it was revealed that two DGB were combined with...

Cordycepin (3′-deoxyadenosine, 3′-dA), the flagship nucleoside antibiotic from Cordyceps militaris, exerts potent anti-inflammatory, antimicrobial, and antitumor activity but is rapidly inactivated by human adenosine deaminase (ADA). Whil...

Carbon dioxide (CO2) has a wide range of uses such as food additives and raw materials for synthetic chemicals, while its application in the solid-state transformation of pharmaceutical crystals is rare. In this work, we report a case of using 1 atm...

The cooling crystallization of carbapenem CS-023 was performed at 25 °C in an aqueous solution. Tetrahydrate crystals (form H) were obtained. Hydrate crystals are promising drugs, but there has been problems in manufacturing such crystals. During coo...

The properties of semicrystalline polymeric materials depend remarkably on their structures, especially for those exhibiting a polymorphic behavior. This offers an efficient way to tailor their properties through crystal engineering. For control of t...

Poly(1-butene) (PB-1) resin has excellent mechanical properties, outstanding creep resistance, environmental stress crack resistance and other excellent properties. However, PB-1 resin experiences a crystal transformation for a period, which seriousl...

We have investigated the polymorphism of triacylglycerol (TAG) crystals as they affect the qualities such as shelf life, mouth feel, and texture of chocolate and other products. Saturated monoacid TAGs, like trilaurin, are considered as models for TA...

The formation of nanocrystalline structures in bulk metal materials is of great significance for both investigating the structural features of nanocrystalline materials and enhancing the value of bulk metal materials in engineering applications. Here...

The objective of this work was to study the polymorphic transformation of carbamazepine from Form II to Form III in 1-propanol during seeded isothermal batch crystallization. First, the pure Form II and Form III were obtained and characterized. Then...

The crystallization behavior of the metastable α form of triacylglycerols (TAGs) plays a critical role as a precursor for the crystallization of more stable β′ and β forms for various applications in food and pharmaceutical prod...

The solution-mediated phase transformation of α-form to γ-form glycine, including dissolution of metastable α-form, nucleation, and growth of stable γ-form during polymorphic transformation, was investigated using in situ atte...

Axitinib (AXTN) is an oral tyrosine kinase inhibitor for the treatment of early to advanced renal cell carcinoma. In this work, solvates of AXTN were prepared in five solvents and subjected to desolvation treatment. The crystal form A of AXTN can for...

In transformation-induced plasticity (TRIP) steel, the strain-induced martensitic transformation (SIMT) has a close relationship with the shear band formation. At a small length scale such as that of a crystal, the explicit analysis of the shear band...

The effect of various controlling factors on the polymorphic outcome of sodium dehydroacetate crystallization was investigated in this study. Cooling crystallization experiments of sodium dehydroacetate in water were conducted at different concentrat...

Polymorphic control is vital for the quality control of pharmaceutical crystals. Here, we investigated the relationship between the hydrate and anhydrate polymorphs of a monoacylglycerol acyltransferase 2 inhibitor (S-309309). Solvent evaporation and...

In this work, the microstructural evolution and magnetic performance of the melt-spun amorphous and amorphous-crystalline Fe26.7Co26.7Ni26.7Si8.9B11.0 high-entropy alloys (HEAs) during crystallization were investigated, respectively. Upon heating ful...

In this work, poly(1-butene) (PB-1) composite films with multi-walled carbon nanotubes (MWCNT) were prepared by a solution casting method. The relationship between the dielectric properties and the crystal transformation process of the films was inve...

Polyamides’ properties are greatly influenced by the polymerization process and the type of feedstock used. The solid forms of nylon salts play a significant role in determining the final characteristics of the material. This study focuses on t...

In the present work, we report the synthesis and characterization of 2-(4-(diphenylamino)benzylidene) malononitrile (DPAM) via a piperidine-catalyzed Knoevenagel condensation reaction. Two distinct crystal forms (A-1 and A-2) of this product were obt...

To better understand and control the crystallization of different polymorphs, a comprehensive crystal structure analysis was conducted by using fluralaner as a model compound, and the thermodynamic stability, phase transformation, and selective nucle...

A transparent polyamide, poly(4,4′-aminocyclohexyl methylene dodecanedicarboxylamide) (PAPACM12), was studied and characterized by in situ wide-angle X-ray diffraction (WAXD) to establish the relationship between its crystallization behavior, crystal...

Anti-solvent crystallization of carbapenem CS-023 was performed at 25 °C. The following results were obtained: (1) A solvate crystal, Form A (5/2 Ethanol·1/2 H2O), was recovered from 80 v/v% ethanol solution; (2) Form A transformed to Form...

Changes in the morphology of betulin crystals during heating at selected temperatures corresponding to polymorphic transformations were investigated. It was shown that the prismatic crystals of starting betulin form III were converted into needles at...

Determining the mechanisms of the formation of giant crystals is a challenging subject. Gypsum, calcium sulfate dihydrate (CaSO4·2H2O), is known to form crystals larger than one meter in several locations worldwide. These selenite crystals grow at di...

Clopidogrel bisulfate (CLP) form-I crystals are irregular, rectangular-shaped crystals. Because of their poor compressibility, flowability and their strong surface tension, manufacturers apply spherical crystallization methods to produce CLP form-I s...

In this article, we discuss the preparation of organic 2-chloro-5 nitroaniline (2C5NA) crystals and their different kinds of physical, chemical, and mechanical properties. The vertical Bridgman approach was used to effectively produce the bulk organi...

Two polymorphic forms of a conformationally flexible molecule, 5-[(Diphenylphosphoryl)methyl]-4-(prop-2-en-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione, were obtained by crystallization and characterized by X-ray diffraction analysis and differential...

We propose a new concept of fractal quasi-Coulomb crystals. We have shown that self-similar quasi-Coulomb crystals can be formed in surface electrodynamic traps with the Cantor Dust electrode configuration. Quasi-Coulomb crystal fractal dimension app...

Pd-rich pentlandite (PdPn) along with ore-forming pentlandite (Pn) occurs in the cubanite and chalcopyrite massive sulfide ores in the EM-7 well of the Southern-2 ore body of the Talnakh deposit. PdPn forms groups of small grains and comprises margin...

In this work, the influence of Batchelor flow on the polymorphic crystallization in a rotating disk (RD) crystallizer was investigated. By regulating crystallization parameters, i.e., the rotation speed, cooling rate, and ethanol fraction, we found t...

Traditional ideas about linearly polarized paraxial beam propagation along the optical axis of a uniaxial crystal suggest that at the crystal exit face, after propagation through the polarizer, the beam will form an intensity distribution in the form...

Plate-like calcite crystals with expressed unstable {001} planes are interesting research model for investigations of interfacial interactions of different additive molecules, but also the crystal growth mechanisms. The aim of this study is to reprod...

In this paper we extend the study of polymorphism and crystallization kinetics of aliphatic polyacetals to include shorter (PA-6) and longer (PA-26) methylene lengths in a series of even long-spaced systems. On a deep quenching to 0 °C, the longest e...

Combining different drugs into a single crystal form is one of the current challenges in crystal engineering, with the number of reported multi-drug solid forms remaining limited. This paper builds upon an efficient approach to combining Active Pharm...

The present study is dedicated to the microstructure characterization of the as-cast high entropy intermetallics that undergo a martensitic transformation, which is associated with the shape memory effect. It is shown that the TiZrHfCoNiCu system exh...

Designing co-crystals can be considered as a commonly used strategy to improve the bioavailability of many low molecular weight drug candidates. The present study has revealed the existence of three pseudo polymorphic forms of theophylline–citr...

Recycling of valuable metals such as nickel is instrumental to meet the need from the dramatic increase in electric vehicle battery production and to improve its sustainability. Nickel required in the battery manufacture can be recovered from the hyd...

Oxalate crystals and other types of crystals are the cause of urolithiasis, and these are related to oxidative stress. The search for new compounds with antioxidant qualities and inhibitors of these crystal formations is therefore necessary. In this...

Salt formation is a useful technique for improving the solubility of active pharmaceutical ingredients (APIs). For instance, a nonsteroidal anti-inflammatory drug, diclofenac (DIC), is used in a sodium salt form, and it has been reported to form seve...

We herein report the synthesis, single-crystal structures of coordination polymers, and structural transformations of complexes employing 1,4,5,6-tetrahydro-5,6-dioxo-2,3-pyrazinedicarbonitrile (tdpd2−) and pyrazine (pyz) as bridging ligands. {...

Space is expected to be a convection-free, quiescent environment for the production of large-size and high-quality protein crystals. However, the mechanisms by which the diffusion environment in space improves the quality of the protein crystals are...

The knowledge about the solid forms landscape of Bilastine (BL) has been extended. The crystal structures of two anhydrous forms have been determined, and the relative thermodynamic stability among the three known anhydrous polymorphs has been establ...

To modulate the physicochemical properties of fluconazole (FLZ), a multifunctional antifungal drug, the crystal engineering technique was employed. In this paper, five novel cocrystal hydrates of FLZ with a range of phenolic acids from the GRAS list,...

Triclabendazole is an effective medication to treat fascioliasis and paragonimiasis parasitic infections. We implemented a reliable quantum mechanical method which is density functional theory at the level of ωB97XD/6-31G* along with embedded f...

In situ ATR-FTIR spectroscopy and imaging and image analysis were applied to the study of the multicomponent co-crystallization process involving S-valsartan and sacubitril in which LCZ696 crystals were formed. LCZ696 is a combination drug for use in...

Indomethacin (IM) is a small molecule active pharmaceutical ingredient (API) that exhibits polymorphism with the γ-form being the most thermodynamically stable form of the drug. The α-form is metastable, but it exhibits higher solubility, making it a...

This study reports the discovery and structural characterization of a novel polymorph, designated as Form III, of Alclometasone dipropionate, a corticosteroid commonly used in the treatment of inflammatory dermatoses. Form III was obtained by modifyi...

One of the most consequential assumptions of the classical theories of crystal nucleation and growth is the Szilard postulate, which states that molecules from a supersaturated phase join a nucleus or a growing crystal individually. In the last 20 ye...