The Solid-Phase Transition of Carbapenem CS-023 Polymorphs and the Change in Helicity Observed in the Transition
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Crystallization
2.3. Phase Transition on Instrumental Analysis
2.4. Phase Transition by Absorption and Desorption of Water and Ethanol
2.5. Determination of Crystal Structure with Single-Crystal X-ray Diffraction
3. Results and Discussion
3.1. The Solid-Phase Transition of Form C to Form H
3.2. The Relationship of CS-023 Polymorphs, Form A, Form C, and Form H
3.3. A Comparison of the Crystal Structure between Form A, Form C, and Form H
3.4. The Mechanism of the Solid-Phase Transition of Form A into Form H
4. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Polymorph | Form A | Form C | Form H |
---|---|---|---|
Solvate | 5/2 Ethanol 1/2 H2O | 1 Ethanol 3 H2O | 4 H2O |
Crystal system | triclinic | orthorhombic | orthorhombic |
Space group | P1 | P212121 | P212121 |
Unit cell dimensions | |||
a (Å) | 10.23 | 9.857 | 9.879 |
b (Å) | 13.21 | 13.1136 | 13.322 |
c (Å) | 14.04 | 24.1859 | 23.45 |
α (°) | 78.07 | 90 | 90 |
β (°) | 89.02 | 90 | 90 |
γ (°) | 76.63 | 90 | 90 |
Volume (Å3) | 1805.1 | 3113.2 | 3086 |
Z | 2 | 4 | 4 |
Density (calculated) | 1.125 g/cm3 | 1.361 g/cm3 | 1.351 g/cm3 |
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Matsuura, S.; Igarashi, K.; Azuma, M.; Ooshima, H. The Solid-Phase Transition of Carbapenem CS-023 Polymorphs and the Change in Helicity Observed in the Transition. Crystals 2024, 14, 71. https://doi.org/10.3390/cryst14010071
Matsuura S, Igarashi K, Azuma M, Ooshima H. The Solid-Phase Transition of Carbapenem CS-023 Polymorphs and the Change in Helicity Observed in the Transition. Crystals. 2024; 14(1):71. https://doi.org/10.3390/cryst14010071
Chicago/Turabian StyleMatsuura, Shinji, Koichi Igarashi, Masayuki Azuma, and Hiroshi Ooshima. 2024. "The Solid-Phase Transition of Carbapenem CS-023 Polymorphs and the Change in Helicity Observed in the Transition" Crystals 14, no. 1: 71. https://doi.org/10.3390/cryst14010071
APA StyleMatsuura, S., Igarashi, K., Azuma, M., & Ooshima, H. (2024). The Solid-Phase Transition of Carbapenem CS-023 Polymorphs and the Change in Helicity Observed in the Transition. Crystals, 14(1), 71. https://doi.org/10.3390/cryst14010071