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  • Article
  • Open Access
2 Citations
1,218 Views
32 Pages

Development of Functional Msalais Wines Rich in Amadori Compounds by Yeast Fermentation

  • Jiachuan Yang,
  • Liling Wang,
  • Yuelin Li,
  • Qiuye Xie and ,
  • Bin Wang,
  • Xuewei Shi,
  • Yi He and
  • Huilin Tan
  • + 3 authors+ 0 author

11 October 2025

Msalais is a type of wine made by a series of processes such as boiling and fermentation from Hotan red grape juice. The Maillard reaction occurs during the boiling of the grape juice. The Amadori compound is a product of the early stage of the Maill...

(This article belongs to the Section Drinks and Liquid Nutrition)
  • Article
  • Open Access
183 Views
16 Pages

Enhanced Antioxidant and ACE-Inhibitory Activities of L-Theanine Following Formation of the Amadori Compound N-(1-Deoxy-D-Fructose-1-yl)-L-Theanine (Fru-The)

  • Fan Li,
  • Jiao Zhou,
  • Minmin Zhang,
  • Guoqiang Zhang and ,
  • Wenting Sun,
  • Huifang Ge and
  • Renjie Zhou
  • + 2 authors+ 0 author

10 October 2026

Many amino acids, after undergoing the Maillard reaction with reducing sugars to form Amadori compounds, exhibit significantly enhanced functional activity. In this study, the Amadori compounds derived from theanine, N-(1-deoxy-D-fructose-1-yl)-L-the...

(This article belongs to the Special Issue Food Innovations: Process Enhancements, Health-Promoting Product Developments, and Value-Adding Strategies: Second Edition)
  • Article
  • Open Access
19 Citations
4,356 Views
20 Pages

1 February 2021

The thermodynamic stability of 11 complexes of Cu(II) and 26 complexes of Fe(III) is studied, comprising the ligands pyridoxamine (PM), ascorbic acid (ASC), and a model Amadori compound (AMD). In addition, the secondary antioxidant activity of PM is...

(This article belongs to the Section Natural and Synthetic Antioxidants)
  • Article
  • Open Access
15 Citations
3,786 Views
10 Pages

Maillard reactions generate a wide array of amino acid- and sugar-derived intermediates; the isomeric mixtures of glycated amino acids are of particular interest. Excluding stereoisomers, regioisomers, and various anomers, most amino acids can form t...

(This article belongs to the Special Issue Protein Glycation in Food, Nutrition, Health and Disease)
  • Article
  • Open Access
19 Citations
7,194 Views
14 Pages

Evaluation of the Availability and Antioxidant Capacity of Maillard Compounds Present in Bread Crust: Studies in Caco-2 Cells

  • Silvia Pastoriza De la Cueva,
  • Isabel Seiquer,
  • Marta Mesías,
  • José Ángel Rufián-Henares and
  • Cristina Delgado-Andrade

11 January 2017

Bread crust is one of the major contributors to the intake of Maillard reaction products (MRP). MRP improve the organoleptic properties of foods and can provide biological actions such as antioxidant properties. The transport and availability of Amad...

(This article belongs to the Special Issue New Knowledge in Analytical, Technological and Biological Aspects of the Maillard Reaction)
  • Article
  • Open Access
33 Citations
7,971 Views
13 Pages

Occurrence of Furosine and Hydroxymethylfurfural in Breakfast Cereals. Evolution of the Spanish Market from 2006 to 2018

  • Marta Mesías,
  • Laura Sáez-Escudero,
  • Francisco J. Morales and
  • Cristina Delgado-Andrade

10 May 2019

The demand for healthier products has led the breakfast cereal sector to develop new formulations to improve the nutritional profile of breakfast cereals; however, the increase in chemical risks should also be evaluated. Amadori compounds and 5-hydro...

(This article belongs to the Section Food Physics and (Bio)Chemistry)
  • Feature Paper
  • Article
  • Open Access
12 Citations
3,089 Views
23 Pages

Buckwheat honey is known for its high antioxidant activity, yet the compounds responsible for this effect have not been fully identified. This study used LC-MS-based untargeted metabolomics to investigate the metabolite profile of buckwheat honey and...

(This article belongs to the Section Natural Products Chemistry)
  • Article
  • Open Access
14 Citations
3,700 Views
12 Pages

Immune Modulatory Activities of Arginyl-Fructose (AF) and AF-Enriched Natural Products in In-Vitro and In-Vivo Animal Models

  • Jin-A Yu,
  • Jung-Yun Lee,
  • Tae Yang Kim,
  • Hanna Kang and ,
  • Su-Young Lee,
  • Haimanot Mitiku,
  • Joonheum Park,
  • Young Hwan Lee,
  • Hung-Bae Chang and
  • Young-In Kwon
  • + 8 authors+ 3 authors

13 April 2021

The immune system plays an important role in maintaining body homeostasis. Recent studies on the immune-enhancing effects of ginseng saponins have revealed more diverse mechanisms of action. Maillard reaction that occurs during the manufacturing proc...

(This article belongs to the Special Issue Natural Products from Terrestrial and Marine Sources: Chemical Characterization and Biological Activity)
  • Article
  • Open Access
10 Citations
5,171 Views
14 Pages

Quantification of Furosine (Nε-(2-Furoylmethyl)-l-lysine) in Different Parts of Velvet Antler with Various Processing Methods and Factors Affecting Its Formation

  • Rui-ze Gong,
  • Yan-hua Wang,
  • Kun Gao,
  • Lei Zhang and ,
  • Chang Liu,
  • Ze-shuai Wang,
  • Yu-fang Wang and
  • Yin-shi Sun
  • + 3 authors+ 0 author

31 March 2019

Furosine (Nε-(2-furoylmethyl)-l-lysine) is formed during the early stages of the Maillard reaction from a lysine Amadori compound and is frequently used as a marker of reaction progress. Furosine is toxic, with significant effects on animal l...

(This article belongs to the Special Issue Method Development and Validation in Food and Pharmaceutical Analysis)
  • Article
  • Open Access
13 Citations
5,706 Views
10 Pages

Calorie Restriction Effect of Heat-Processed Onion Extract (ONI) Using In Vitro and In Vivo Animal Models

  • Yu-Ri Kang,
  • Hwang-Yong Choi,
  • Jung-Yun Lee,
  • Soo In Jang and ,
  • Hanna Kang,
  • Jung-Bae Oh,
  • Hae-Dong Jang and
  • Young-In Kwon
  • + 3 authors+ 0 author

Onion (Allium cepa L.) is widely consumed as food or medicinal plant due to its well-defined health benefits. The antioxidant and antihyperlipidemic effects of onion and its extracts have been reported well. However, very limited information on anti-...

(This article belongs to the Special Issue Plant Natural Products for Human Health)
  • Article
  • Open Access
10 Citations
3,927 Views
13 Pages

Anti-Obesity and Anti-Adipogenic Effects of Administration of Arginyl-Fructose-Enriched Jeju Barley (Hordeum vulgare L.) Extract in C57BL/6 Mice and in 3T3-L1 Preadipocytes Models

  • Soo-Young Lee,
  • Tae-Yang Kim,
  • Ji-Yoon Hong,
  • Gi-Jung Kim and ,
  • Jung-Bae Oh,
  • Min-Joo Kim,
  • Emmanouil Apostolidis,
  • Jung-Yun Lee and
  • Young-In Kwon
  • + 4 authors+ 0 author

In our previous study, we reported that arginyl-fructose (AF), one of the Amadori rearrangement compounds (ARCs) produced by the heat processing of Korean ginseng can reduce carbohydrate absorption by inhibiting intestinal carbohydrate hydrolyzing en...

(This article belongs to the Special Issue A Feasible Approach for Natural Products to Treatment of Diseases)
  • Article
  • Open Access
41 Citations
5,949 Views
25 Pages

Multiple Glycation Sites in Blood Plasma Proteins as an Integrated Biomarker of Type 2 Diabetes Mellitus

  • Alena Soboleva,
  • Gregory Mavropulo-Stolyarenko,
  • Tatiana Karonova,
  • Domenika Thieme and ,
  • Wolfgang Hoehenwarter,
  • Christian Ihling,
  • Vasily Stefanov,
  • Tatiana Grishina and
  • Andrej Frolov
  • + 4 authors+ 0 author

Type 2 diabetes mellitus (T2DM) is one of the most widely spread metabolic diseases. Because of its asymptomatic onset and slow development, early diagnosis and adequate glycaemic control are the prerequisites for successful T2DM therapy. In this con...

(This article belongs to the Special Issue Molecular Research on Metabolic Disorders)
  • Short Note
  • Open Access
1 Citations
3,428 Views
9 Pages

N-(1-Deoxy-α-d-tagatopyranos-1-yl)-N-methylaniline (“d-Tagatose-N-methylaniline”)

  • Valeri V. Mossine,
  • Charles L. Barnes and
  • Thomas P. Mawhinney

9 May 2018

Tagatosamines form in thermally-processed dairy products and contribute to the foods’ organoleptic and nutritional value. d-Tagatose-N-methylaniline (N-(1-deoxy-d-tagatos-1-yl)-N-methylaniline, 1-deoxy-1-(N-methylphenylamino)-d-tagatose) was synthesi...

(This article belongs to the Section Structure Determination)
  • Article
  • Open Access
8 Citations
2,562 Views
18 Pages

Unravelling the Role of Biochemical Compounds within the Hydrothermal Liquefaction Process of Real Sludge Mixtures

  • Marco Balsamo,
  • Francesca Di Lauro,
  • Maria Laura Alfieri,
  • Paola Manini and ,
  • Piero Salatino,
  • Fabio Montagnaro and
  • Roberto Solimene
  • + 2 authors+ 0 author

21 February 2024

This paper aims to provide a contribution to understanding the role of sludge macro-components (lipids, proteins and carbohydrates) on the yield/quality of bio-crude obtained via hydrothermal liquefaction (HTL). This was pursued by analysing the HTL...

(This article belongs to the Section Energy Sustainability)
  • Article
  • Open Access
71 Citations
9,924 Views
15 Pages

Phenolics from Garcinia mangostana Inhibit Advanced Glycation Endproducts Formation: Effect on Amadori Products, Cross-Linked Structures and Protein Thiols

  • Hossam M. Abdallah,
  • Hany El-Bassossy,
  • Gamal A. Mohamed,
  • Ali M. El-Halawany and ,
  • Khalid Z. Alshali and
  • Zainy M. Banjar
  • + 1 author+ 0 author

22 February 2016

Accumulation of Advanced Glycation Endproducts (AGEs) in body tissues plays a major role in the development of diabetic complications. Here, the inhibitory effect of bioactive metabolites isolated from fruit hulls of Garcinia mangostana on AGE format...

(This article belongs to the Section Natural Products Chemistry)
  • Review
  • Open Access
70 Citations
9,484 Views
21 Pages

Glycation of Plant Proteins: Regulatory Roles and Interplay with Sugar Signalling?

  • Julia Shumilina,
  • Alena Kusnetsova,
  • Alexander Tsarev,
  • Henry C. Janse van Rensburg and ,
  • Sergei Medvedev,
  • Vadim Demidchik,
  • Wim Van den Ende and
  • Andrej Frolov
  • + 3 authors+ 0 author

Glycation can be defined as an array of non-enzymatic post-translational modifications of proteins formed by their interaction with reducing carbohydrates and carbonyl products of their degradation. Initial steps of this process rely on reducing suga...

(This article belongs to the Special Issue Signaling: From Past to Future)
  • Article
  • Open Access
7 Citations
3,039 Views
15 Pages

A Debittered Complex of Glucose-Phenylalanine Amadori Rearrangement Products with β-Cyclodextrin: Structure, Molecular Docking and Thermal Degradation Kinetic Study

  • Xiaotong Wu,
  • Baoshang Fu,
  • Yunjiao Ma,
  • Liang Dong and ,
  • Ming Du,
  • Xiuping Dong and
  • Xianbing Xu
  • + 2 authors+ 0 author

29 April 2022

Non-volatile flavor precursors could be used to overcome the flavor loss problems of volatile flavor enhancers during long-term storage. Glu- and Phe-derived Amadori rearrangement products (ARPs) produce pleasant aroma tones thermally but are bitter....

(This article belongs to the Section Food Physics and (Bio)Chemistry)
  • Article
  • Open Access
18 Citations
3,597 Views
11 Pages

22 January 2022

Advanced glycation end products (AGEs) are associated with diabetes and its complications. AGEs are formed by the non-enzymatic reactions of proteins and reducing sugars, such as glucose and ribose. Ribose is widely used in glycation research as it g...

(This article belongs to the Special Issue Protein Glycation in Food, Nutrition, Health and Disease)
  • Article
  • Open Access
31 Citations
6,699 Views
23 Pages

Metabolic Profiling of Water-Soluble Compounds from the Extracts of Dark Septate Endophytic Fungi (DSE) Isolated from Scots Pine (Pinus sylvestris L.) Seedlings Using UPLC–Orbitrap–MS

  • Jenni Tienaho,
  • Maarit Karonen,
  • Riina Muilu–Mäkelä,
  • Kristiina Wähälä and ,
  • Eduardo Leon Denegri,
  • Robert Franzén,
  • Matti Karp,
  • Ville Santala and
  • Tytti Sarjala
  • + 4 authors+ 0 author

25 June 2019

Endophytes are microorganisms living inside plant hosts and are known to be beneficial for the host plant vitality. In this study, we isolated three endophytic fungus species from the roots of Scots pine seedlings growing on Finnish drained peatland...

  • Article
  • Open Access
22 Citations
7,668 Views
8 Pages

Effect of Long-Term Dietary Arginyl-Fructose (AF) on Hyperglycemia and HbA1c in Diabetic db/db Mice

  • Kwang-Hyoung Lee,
  • Kyoung-Soo Ha,
  • Sung-Hoon Jo,
  • Chong M. Lee and ,
  • Young-Cheul Kim,
  • Kwang-Hoe Chung and
  • Young-In Kwon
  • + 2 authors+ 0 author

12 May 2014

We have previously reported that Amadori compounds exert anti-diabetic effects by lowering sucrose-induced hyperglycemia in normal Sprague-Dawley rats. In the present study we extended our recent findings to evaluate whether α-glucosidase inhibitor a...

(This article belongs to the Section Biochemistry)
  • Article
  • Open Access
7 Citations
3,823 Views
17 Pages

Exploratory Metabolomic Analysis Based on Reversed-Phase Liquid Chromatography–Mass Spectrometry to Study an In Vitro Model of Hypoxia-Induced Metabolic Alterations in HK-2 Cells

  • Samuel Bernardo-Bermejo,
  • Elena Sánchez-López,
  • Lei Tan,
  • Selma Benito-Martínez and ,
  • Zhengjin Jiang,
  • María Castro-Puyana,
  • Francisco Javier Lucio-Cazaña and
  • María Luisa Marina
  • + 3 authors+ 0 author

Oxygen deficiency in cells, tissues, and organs can not only prevent the proper development of biological functions but it can also lead to several diseases and disorders. In this sense, the kidney deserves special attention since hypoxia can be cons...

(This article belongs to the Special Issue Molecular Pathology, Diagnostics, and Therapeutics of Nephropathy)
  • Article
  • Open Access
13 Citations
8,442 Views
13 Pages

5 March 2021

Glycation between proteins and sugars via the Maillard reaction has been shown to improve the heat stability of proteins. In this study, inulin, a healthy dietary fiber, was glycated with whey protein isolate (WPI), and the effects of reaction condit...

  • Article
  • Open Access
15 Citations
4,805 Views
19 Pages

24 April 2022

Arnica montana L. has been recognized for centuries as an herbal remedy to treat wounds and promote healing. It also has a long tradition of use in homeopathy. Depending on its medicinal utilization, standardization regulations allow different manufa...

(This article belongs to the Section Analytical Chemistry)
  • Article
  • Open Access
6 Citations
3,111 Views
17 Pages

Antidiabetic Potential of Abelmoschus manihot Flower Extract: In Vitro and Intracellular Studies

  • Shih-Wei Wang,
  • Thung-Lip Lee,
  • Tzu-Hsien Chang,
  • Ya-Ling Chen and ,
  • Hsin-Ya Houng,
  • Natasha Chang,
  • Sabrina Chang,
  • Chi-Chang Chang and
  • Jer-Yiing Houng
  • + 4 authors+ 0 author

26 July 2024

Abelmoschus manihot (L.) Medic flower (AMf) exhibits both nutritional value and bioactivities such as antioxidative, anti-inflammatory, neuroprotective, cardioprotective, and hepatoprotective effects. The aim of this investigation was to examine the...

(This article belongs to the Section Pharmacology)
  • Article
  • Open Access
12 Citations
3,335 Views
20 Pages

29 August 2024

Honey differentiation based on the botanical origin is crucial to guarantee product authenticity, especially considering the increasing number of fraud cases. This study assessed the metabolomic differences arising from various botanical origins in h...

(This article belongs to the Section Foodomics)
  • Article
  • Open Access
4 Citations
2,346 Views
24 Pages

Italian Biodiversity: A Source of Edible Plant Extracts with Protective Effects Against Advanced Glycation End Product-Related Diseases

  • Giulia Moretto,
  • Raffaella Colombo,
  • Stefano Negri,
  • Hellas Cena and ,
  • Lorena Vailati and
  • Adele Papetti
  • + 1 author+ 0 author

7 March 2025

Background: Italy’s plant biodiversity, characterized by many plant species, is an important source of bioactive secondary metabolites that help reduce the risk of the development of advanced glycation end product (AGE)-related diseases. AGEs a...

(This article belongs to the Special Issue Bioactive Ingredients in Plants Related to Human Health)