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Special Issue "Signaling: From Past to Future"
Deadline for manuscript submissions: closed (31 March 2019).
Dept. of Medical Microbiology and Hygiene, Heidelberg University Hospital, Germany
Tel. +49-6221-5638361; Fax: +49-6221-5633749
Interests: mechanisms of bacterial immune evasion; the function of Rho GTPases; cytokine receptors in the innate immune system
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The Signal Transduction Society (STS) was established in 1998 and is a non-profit organization that provides an interdisciplinary forum for scientists with an interest in signal transduction processes in cells and organisms. The STS annually organizes the “Joint Meeting Signal Transduction - Receptor, Mediators and Genes”, which will take place this year in Weimar from 5 to 7 November.
Much progress has been made in the signalling field over the last twenty years; new molecules and mechanisms have been discovered and novel methods and technologies were invented. While only a few specialists worked in the field in the 1990s, today, aspects of signal transduction are an obvious part in life science research. Often, technological advances made it possible to come to new conclusions about signalling processes. In the last two decades, protein structures helped to describe structure-function relationships, protein domains were identified and post-translational modifications characterised. Systems biology and the various -omics technologies from proteomics to genomics allowed us to investigate signalling in an integrative manner from the molecular to the cellular level. New model systems were created with the use of knockout mice and transgenic animals and the use of GFP-tagged proteins offered life scientists a new way of visualising proteins inside life cells and organisms. The development of various knockdown technologies, including the recent use of the CRISPR-CAS systems, as well as the renewed interest in metabolic events and its impact on cellular signalling prove that signal transduction remains a very dynamic field that covers many aspects from basic to translational research.
On the occasion of the Signal Transduction Society’s 20th anniversary, we want to look back on what has been achieved in the last decades and to speculate with you on future achievements that might impact the field. This Special Issue will invite both latest original research articles as well as reviews, commentaries and perspectives that cover all aspects of signal transduction, from past to future.
Dr. Katharina Kubatzky
Manuscript Submission Information
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- Signal transduction
- receptor signalling
- infection and inflammation
- cellular motility and cytoskeleton
- tumour biology
- growth factors
- cell death and differentiation
- G protein coupled receptors