Circulating tumor cell (CTC)- and/or tumor-derived extracellular vesicle (tdEV) loads in the blood of metastatic castration-resistant prostate cancer (CRPC) patients are associated with worse overall survival and can be used as predictive markers of...
To explore morphological features of circulating tumor cells (CTCs) and tumor-derived extracellular vesicles (tdEVs), we developed a protocol for scanning electron microscopy (SEM) of CTCs and tdEVs. CTCs and tdEVs were isolated by immunomagnetic enr...
Accurate time dissemination is essential for telecommunications, scientific instrumentation, industrial control, and distributed computer systems, motivating the development of cost-effective timing solutions. This work presents the design, implement...
Non-muscle-invasive bladder cancer (NMIBC) prognosis varies significantly due to the biological and clinical heterogeneity. High-risk stage T1-G3, comprising 15–20% of NMIBCs, involves the lamina propria and is associated with higher rates of r...
High-frequency irreversible electroporation (H-FIRE) is a nonthermal tumor ablation technique that disrupts the blood–brain barrier (BBB) in a focal and reversible manner. However, the mechanisms underlying this disruption remain poorly underst...
Elevated, tumor-derived extracellular vesicle (tdEV) and circulating tumor cell (CTC) loads in metastatic cancer are associated with poor clinical outcome. Herein, we investigate whether endothelium-derived extracellular vesicles (edEVs) can be detec...
Cancer continues to impose a substantial global health burden, particularly among the elderly, where the ongoing global demographic shift towards an ageing population underscores the growing need for early cancer detection. This is essential for enab...
Large tumor-derived Extracellular Vesicles (tdEVs) detected in blood of metastatic prostate, breast, colorectal, and non-small cell lung cancer patients after enrichment for Epithelial Cell Adhesion Molecule (EpCAM) expression and labeling with 4&pri...
Tumor-derived extracellular vesicles (TD-EVs) have active roles as cancer hallmark enablers. EVs RNA of epithelial and stromal cells carry information that facilitates the communication processes that contribute to oncological progression, so the obj...
Time synchronization between geographically separated equipment, such as, for example, that required in sensor networks for radio localization, is often based on global navigation satellite systems (GNSSs). However, in environments that are GNSS-deni...
This paper presents a high-precision transfer system of time and RF frequency via the fiber optic link based on secure encryption. On the basis of the two-way time transfer of optical fiber, a security strategy composed of an SM2 encryption algorithm...
The infiltration of primary tumors and metastasis formation at distant sites strongly impact the prognosis and the quality of life of cancer patients. Current therapies including surgery, radiotherapy, and chemotherapy are limited in targeting the co...
Cancer is the second leading contributor to global deaths caused by non-communicable diseases. The cancer cells are known to interact with the surrounding non-cancerous cells, including the immune cells and stromal cells, within the tumor microenviro...
Variations in optical fiber length and refractive index are induced by environmental perturbation, resulting in an additional dynamic propagation delay in fiber-based time synchronization systems, which deteriorate their transfer stability. This disa...
Proportion Integration Differentiation (PID) is a common clock disciplining algorithm. In satellite clock source equipment and in Internet of Things (IoT) sensor nodes it is usually required that both time and frequency signals have high accuracy. Be...
The instabilities in time and frequency transfer systems, a form of residual noise, can contribute significantly to the total uncertainty in time or frequency comparisons. Understanding the characteristics of transfer instabilities is increasingly im...
White Rabbit (WR) time synchronization has an accuracy up to a sub-nanosecond level. However, the current application scenario of WR is limited to wired transmission links. In this paper, we have proposed a time synchronization technique over a free...
Extracellular vesicles (EVs) play a crucial role in intercellular communication as vehicles for the transport of membrane and cytosolic proteins, lipids, and nucleic acids including different RNAs. Dendritic cells (DCs)-derived EVs (DEVs), albeit var...
To provide a ground-based experimental reference for free-space optical time–frequency synchronization in future space applications, this paper investigates the impact of beam drift and dynamic link-state variations on free-space laser links. A...
The accuracy of time synchronization can be significantly increased by enhancing the performance of atomic clocks. Future-generation time-frequency loads will be equipped with the latest ultrahigh-precision atomic clocks (with a day stability better...
Liquid biopsy, based on the analysis of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), provides non-invasive real-time monitoring of tumor evolution and therapeutic efficacy. We performed for the first time a direct comparison stud...