- Article
AUP1 Regulates the Endoplasmic Reticulum-Associated Degradation and Polyubiquitination of NKCC2
- Nadia Frachon,
- Sylvie Demaretz,
- Elie Seaayfan,
- Lydia Chelbi,
- Dalal Bakhos-Douaihy and
- Kamel Laghmani
Inactivating mutations of kidney Na-K-2Cl cotransporter NKCC2 lead to antenatal Bartter syndrome (BS) type 1, a life-threatening salt-losing tubulopathy. We previously reported that this serious inherited renal disease is linked to the endoplasmic re...