Special Issue "Micromachines on Biosensors"

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "E:Engineering and Technology".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 1249

Special Issue Editors

Prof. Dr. Teen-­Hang Meen
E-Mail Website
Guest Editor
Department of Electronic Engineering, National Formosa University, Yunlin 632, Taiwan
Interests: IoT devices; photovoltaic devices; STEM education
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Charles Tijus
E-Mail Website
Guest Editor
Director of the Cognitions Humaine et Artificielle Laboratory, Professeur de Psychologie Cognitive – Université, Paris 8, France
Interests: internet of objects; data mining; brain–computer interaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A biosensor is an analytical device, used for the detection of a chemical substance, which combines a biological component with a physicochemical detector. The sensitive biological element, e.g., tissue, microorganisms, organelles, cell receptors, enzymes, antibodies, nucleic acids, is a biologically derived material or biomimetic component that interacts with, binds with, or recognizes the analyte under study. Biologically sensitive elements can also be created by biological engineering. The transducer or the detector element, which transforms one signal into another one, works in a physicochemical way: optical, piezoelectric, electrochemical, electrochemiluminescence, etc., resulting from the interaction of the analyte with the biological element, to easily measure and quantify. In recent years, micro/nano-scaled structures, materials, devices, systems, and nanotechnology on biosensors have been widely studied. These biosensors can be applied in biomedical engineering and healthcare. Healthcare is undergoing a sector-wide transformation thanks to advances in computing, networking technologies, big data, and artificial intelligence. Healthcare is not only changing from reactive and hospital-centered to preventive and personalized but is also changing from disease-focused to wellbeing-centered. Healthcare systems, as well as fundamental medicine research, are becoming smarter and enabled in biomedical engineering. Furthermore, with cutting-edge sensors and computer technologies, healthcare delivery could also yield better efficiency, higher quality, and lower cost. Science and technology are to be complemented by the arts, humanities, social sciences, and indigenous know-how and wisdom, in order to increase the accessibility of the benefits for the needy across all regions and classes of people.

In addition, the International Institute of Knowledge Innovation and Invention (IIKII, http://www.iikii.org) promotes the exchange of innovations and inventions and establishes a communication platform for international innovations and research. This year, IIKII is cooperating with the IEEE Tainan Section Sensors Council to hold IEEE conferences such as IEEE ECBIOS 2021 (http://www.ecbios.asia), IEEE ICAIRC 2021 (http://www.icairc.asia), IEEE ICKII 2021 (http://www.ickii.org), and IEEE ECICE 2021 (http://www.ecice.asia). This Special Issue entitled “Micromachines on Biosensors” aims to select excellent papers from IIKII 2021 conferences relative to the topics of micromachines applied on biosensors. It provides a platform for advances in healthcare/clinical practices and the study of direct observation of patients and general medical research. Potential topics include but are not limited to:

  • BioMEMS;
  • Miniaturized biosensors;
  • DNA and PCR chips;
  • Electronic noses;
  • Organ-on-a-chip;
  • Microfluidic cell culture;
  • Point-of-care diagnostic chips;
  • Molecular imprinting applications in medicine (nanomedicine);
  • Tissue engineering;
  • Regenerative medicine;
  • Biomedical and healthcare research.

Prof. Dr. Teen-­Hang Meen
Prof. Dr. Charles Tijus
Prof. Dr. Kuei-Shu Hsu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bioMEMS
  • miniaturized biosensors
  • DNA and PCR chips
  • organ-on-a-chip
  • microfluidic cell culture
  • point-of-care diagnostic chips

Published Papers (1 paper)

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An ISFET Microarray Sensor System for Detecting the DNA Base Pairing
Micromachines 2021, 12(7), 731; https://doi.org/10.3390/mi12070731 - 22 Jun 2021
Cited by 2 | Viewed by 825
Deoxyribonucleic acid (DNA) sequencing technology provides important data for the disclosure of genetic information and plays an important role in gene diagnosis and gene therapy. Conventional sequencing devices are expensive and require large and bulky optical structures and additional fluorescent labeling steps. Sequencing [...] Read more.
Deoxyribonucleic acid (DNA) sequencing technology provides important data for the disclosure of genetic information and plays an important role in gene diagnosis and gene therapy. Conventional sequencing devices are expensive and require large and bulky optical structures and additional fluorescent labeling steps. Sequencing equipment based on a semiconductor chip has the advantages of fast sequencing speed, low cost and small size. The detection of DNA base pairing is the most important step in gene sequencing. In this study, a large-scale ion-sensitive field-effect transistor (ISFET) array chip with more than 13 million sensitive units is successfully designed for detecting the DNA base pairing. DNA base pairing is successfully detected by the sensor system, which includes the ISFET microarray chip, microfluidic system, and test platform. The chip achieves a high resolution of at least 0.5 mV, thus enabling the recognition of the change of 0.01 pH value. This complementary metal-oxide semiconductor (CMOS) compatible and cost-efficient sensor array chip, together with other specially designed components, can form a complete DNA sequencing system with potential application in the molecular biology fields. Full article
(This article belongs to the Special Issue Micromachines on Biosensors)
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