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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Obesity and Metabolic Dysfunction: Disease Development and Breaking the Cycle

edited by Paulo Cezar de Freitas Mathias, Lucas Paulo Jacinto Saavedra and

Rodrigo Mello Gomes

submission deadline 15 Sep 2026 | 5 articles | Viewed by 18637 | Submission Open

Keywords: obesity; diabetes; DOHaD; metabolic programming; treatment; intervention; cardiovascular disease; metabolic syndrome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Changes in Body Composition (Bone, Muscle, Adipose Tissue) with Age and Accompanying Biomarkers for Each Tissue

edited by

Jasminka Ilich

submission deadline 15 Sep 2026 | 2 articles | Viewed by 3036 | Submission Open

Keywords: bone; muscle; adipose tissue; osteosarcopenic adiposity; nutrition, physical activity, and lifestyle habits influencing body composition; inflammatory markers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Biomarkers in Cardiometabolic Disease: Early Detection, Risk Assessment, and Guiding Treatment

edited by

Grzegorz K. Jakubiak

submission deadline 15 Sep 2026 | 2 articles | Viewed by 2843 | Submission Open

Keywords: atherosclerosis; biomarkers; endothelial dysfunction; oxidative stress; inflammation; dyslipidemia; hyperglycemia; visceral adipose tissue; myocardial ischemia

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomic Technology in Quality and Safety of Agricultural Products and Foods, 2nd Edition

edited by

Yasuhiro Date

submission deadline 15 Sep 2026 | 2 articles | Viewed by 2130 | Submission Open

Keywords: metabolomics; metabolic profiling; metabolic fingerprinting; foodomics; nuclear magnetic resonance spectroscopy; mass spectrometry; multivariate analysis; machine learning

(This special issue belongs to the Section Food Metabolomics)

New Findings on Microbial Metabolism and Its Effects on Human Health

edited by

Ulrike E. Rolle-Kampczyk

Beatrice Engelmann

and

Sven-Bastiaan Haange

submission deadline 15 Sep 2026 | 1 articles | Viewed by 1334 | Submission Open

Keywords: metabolomics; microbial metabolism; microbial crosstalk; cross-feeding; xenobiotic and microbial metabolism; multi-omics integration; system biology

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Metabolomics in Infectious Diseases

edited by

María Ángeles Jiménez Sousa

and

Rubén Martín-Escolano

submission deadline 15 Sep 2026 | 1 articles | Viewed by 1234 | Submission Open

Keywords: metabolomics; infectious diseases; pathogenesis; prognosis; biomarkers; host–pathogen interaction; therapeutic targets; diagnosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Probiotics and Dietary Supplements for Metabolic Health

edited by

Katarzyna Skrypnik

submission deadline 15 Sep 2026 | Viewed by 424 | Submission Open

Keywords: probiotics; prebiotics; synbiotics; dietary supplements; gut microbiota; metabolomics; metabolic syndrome; obesity; insulin resistance; lipid metabolism

(This special issue belongs to the Section Nutrition and Metabolism)

Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Ambrin Farizah Babu and

Ze Xiang

submission deadline 15 Sep 2026 | 1 articles | Viewed by 344 | Submission Open

Keywords: MASLD; biomarkers; diet and lifestyle; molecular mechanisms; drug development

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Immunometabolic Role of the Erythrocyte

edited by

Charalampos Papadopoulos

and

Vassilis L. Tzounakas

submission deadline 20 Sep 2026 | Viewed by 398 | Submission Open

Keywords: erythrocyte; immunometabolism; TLR9; glycerophospholipids; sphingolipids; purines; sugars; amino acids; eryptosis; CD47

(This special issue belongs to the Section Cell Metabolism)

Redox Signaling and Metabolic Changes in Liver Diseases

edited by

Kamalakannan Radhakrishnan

submission deadline 20 Sep 2026 | Viewed by 328 | Submission Open

Keywords: redox signaling; metabolic disease; oxidative stress; mitochondrial function; antioxidant defense; energy metabolism; therapeutic targets

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Obesity and Metabolic Health, 2nd Edition

edited by

Natalia Ferreira Mendes

and

Eliana Pereira De Araújo

submission deadline 25 Sep 2026 | 2 articles | Viewed by 2359 | Submission Open

Keywords: glial cells; blood–brain barrier; gut microbiota; immune surveillance; glucose metabolism; energy metabolism; food intake

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Pharmacodynamics and Innovative Therapeutic Strategies for Metabolic Disorders

edited by

Josué V. Espinosa-Juárez

Osmar Antonio Jaramillo-Morales

and

Victor Gault

submission deadline 25 Sep 2026 | 1 articles | Viewed by 1762 | Submission Open

Keywords: pharmacology; experimental therapeutics; metabolic diseases; drug development; therapeutic innovations; metabolic pathways; pharmacodynamics; disease management

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Lipid Signaling, Therapeutics and Controlled Release

edited by Wen-Lung Ma and Hung-Yu Sun

submission deadline 30 Sep 2026 | 2 articles | Viewed by 6509 | Submission Open

Keywords: lipid signaling; therapeutics; controlled release

(This special issue belongs to the Section Lipid Metabolism)

LC-MS/MS Analysis for Plant Secondary Metabolites, 2nd Edition

edited by Tiantian Ye

submission deadline 30 Sep 2026 | 8 articles | Viewed by 6129 | Submission Open

Keywords: liquid chromatography; mass spectrometry; secondary metabolites; metabolomics; abiotic and biotic stress; plant development

(This special issue belongs to the Section Plant Metabolism)

Metabolomics Insights into Environmental Pollution: Unraveling Metabolic Responses to Contaminants

edited by

Dechun Chen

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5748 | Submission Open

Keywords: metabolomics; environmental contaminants; biomarkers; toxicity mechanisms; metabolic alterations; ecological health; human health; cellular metabolism; organismal metabolism; pollution mitigation strategies

(This special issue belongs to the Section Environmental Metabolomics)

The Impact of Environmental Contaminants on Neurodevelopment and Human Metabolism

edited by

Cláudia Sirlene Oliveira

and

Izonete Cristina Guiloski

submission deadline 30 Sep 2026 | 2 articles | Viewed by 5007 | Submission Open

Keywords: pesticides; metals; mercury; methylmercury; developing organism; oxidative stress

(This special issue belongs to the Section Environmental Metabolomics)

Metabolomics in Human Diseases and Health: 2nd Edition

edited by

Dimitris Kounatidis

and

Iordanis Mourouzis

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5002 | Submission Open

Keywords: metabolomics; NAFLD; biomarkers; obesity; mass spectrometry; NMR spectroscopy; diabetes mellitus; cancer; cardiovascular diseases; neurodegenerative diseases

(This special issue belongs to the Section Advances in Metabolomics)

The Role of Metabolites and the Gut Microbiota in Development, Homeostasis, and Diseases

edited by Miriam Di Mattia and

Valentina Petito

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2669 | Submission Open

Keywords: microbiota; metabolites; gut homeostasis; intestinal barrier; host interactions; inflammation; gut–organ axis

(This special issue belongs to the Section Cell Metabolism)

Metabolic Research in Animal Nutrition and Production, 2nd Edition

edited by Tietao Zhang and Qingkui Jiang

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1508 | Submission Open

Keywords: special economic animals; companion animals; nutrition; metabolomics; microbiome; metabolites; animal nutrition; animal production; animal health and disease; metabolic phenotypes

(This special issue belongs to the Section Animal Metabolism)

Metabolism in Lung Development and Injury/Repair Throughout Human Lifetime

edited by

Evgenia Dobrinskikh

submission deadline 30 Sep 2026 | Viewed by 375 | Submission Open

Keywords: lung development; injury and repair; metabolomics; transcriptomics; lipidomics; surfactant metabolism; redox biology; spatial metabolomics; imaging; single cell; FGR; CDH; preterm birth; fibrosis; environmental exposure; aging

(This special issue belongs to the Section Cell Metabolism)

Metabolic Pathways in Cardiovascular and Cerebrovascular Conditions

edited by

Angom Ramcharan Singh

submission deadline 30 Sep 2026 | Viewed by 237 | Submission Open

Keywords: cardiovascular metabolism; cerebrovascular disease; metabolic reprogramming; mitochondrial dysfunction; endothelial metabolism; neurovascular unit; oxidative stress and redox signaling; lipid and glucose metabolism; hypoxia and ischemia; metabolic inflammation; heart–brain axis; therapeutic metabolic targeting

(This special issue belongs to the Section Cell Metabolism)

Management of Diabetes and Its Metabolic Complications

edited by

Aldo Ferreira-Hermosillo

submission deadline 12 Oct 2026 | 3 articles | Viewed by 3797 | Submission Open

Keywords: diabetes complications; physiopathology; therapeutics; diet therapy; cardiovascular disease; metabolic dysfunction-associated steatotic liver disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics and Lipidomics in MASLD and Related Liver Disorders

edited by Aleksandra Bołdys and Michał Nicze

submission deadline 15 Oct 2026 | 2 articles | Viewed by 3902 | Submission Open

Keywords: MASLD; metabolomics; lipidomics; liver disease; biomarkers; metabolic profiling; nonalcoholic fatty liver disease; oxidative stress; mitochondrial dysfunction; systems biology

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Expanding Boundaries in Spatial Metabolomics and Lipidomics: Advances in Mass Spectrometry Imaging

edited by

Vanna Denti

and

Simone Serrao

submission deadline 15 Oct 2026 | 1 articles | Viewed by 2411 | Submission Open

Keywords: spatial omics; mass spectrometry imaging; multimodal; imaging data analysis; spatial functional analysis; small-molecule biochemistry

(This special issue belongs to the Section Advances in Metabolomics)

Early-Stage Biomarkers: Metabolomics in Preclinical and Prodromal Disease Detection

edited by

Sonali Mishra

submission deadline 15 Oct 2026 | 2 articles | Viewed by 2050 | Submission Open

Keywords: early-stage biomarkers; metabolomics; biomarker validation; untargeted and targeted approaches; cohort studies; multi-omics integration; machine learning / AI; translational research; early disease detection; cancer, neurodegenerative, cerebrovascular, autoimmune, infectious, and psychiatric disorders

(This special issue belongs to the Section Advances in Metabolomics)

Biological Activity and Chemical Biodiversity of Plant Secondary Metabolites

edited by

Catherine Cook

submission deadline 15 Oct 2026 | 2 articles | Viewed by 1385 | Submission Open

Keywords: secondary metabolites; chemical diversity; biological activities; plant defense; environmental interactions; nutritional and medicinal applications

(This special issue belongs to the Section Plant Metabolism)

Metabolomics in Plant–Microbe Interactions: Advances and Applications

edited by

Nabil Radouane

and Salima Boutahiri

submission deadline 15 Oct 2026 | 1 articles | Viewed by 1215 | Submission Open

Keywords: metabolomics; plant–microbe interactions; sustainable agriculture; biocontrol; disease resistance; LC-MS; GC-MS; metagenomics

(This special issue belongs to the Section Plant Metabolism)

Metabolic Responses to Exercise Training

edited by

Hee-Tae Roh

submission deadline 15 Oct 2026 | 1 articles | Viewed by 737 | Submission Open

Keywords: exercise metabolism; exercise training; physical activity; acute exercise responses; environmental exercise physiology; metabolomics; metabolic pathways; myokines and adipokines; metabolic flexibility; chronic disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Control of Inflammatory Responses

edited by

Xin Li

submission deadline 15 Oct 2026 | Viewed by 326 | Submission Open

Keywords: immunometabolism; inflammation; metabolic reprogramming; macrophages; metabolites; immune signaling; metabolomics; metabolic pathways; tissue microenvironment; chronic inflammation

(This special issue belongs to the Section Cell Metabolism)

Microbiome in Diabetes Progression and Insulin Resistance

edited by Dragan M. Nikolic and

Snežana B. Pajović

submission deadline 15 Oct 2026 | Viewed by 280 | Submission Open

Keywords: microbiome; insulin secretion; insulin resistance; obesity; diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Agriculture and Food: Advanced Detection, Risk Assessment, and Management of Plant Diseases, Pest Damage, and Toxins in the Agri-Food Chain

edited by

Yasuhiro Date

submission deadline 15 Oct 2026 | Viewed by 258 | Submission Open

Keywords: metabolomics; metabolic profiling; agri-food chain; plant diseases; pest damage; toxins; nuclear magnetic resonance spectroscopy; mass spectrometry

(This special issue belongs to the Section Food Metabolomics)

Advances in Bioactive Compounds and Functional Foods

edited by

Aurelia Scarano

and

Teodoro Semeraro

submission deadline 16 Oct 2026 | 1 articles | Viewed by 891 | Submission Open

Keywords: bioactive compounds; secondary metabolites; metabolic processes; functional foods; biodiversity; nutritional applications; biological activities

(This special issue belongs to the Section Plant Metabolism)

From Feed to Function: Metabolic Insights into Animal Nutrition

edited by

Kinga Szczepanik

and

Mengyao Guo

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1334 | Submission Open

Keywords: metabolism; nutrition; metabolic pathways; animal physiology

(This special issue belongs to the Section Animal Metabolism)

Nutritional and Metabolic Regulation of Animal Reproduction

edited by

Gabriele Brecchia

and

Olimpia Barbato

submission deadline 23 Oct 2026 | Viewed by 257 | Submission Open

Keywords: metabolic regulation; reproductive physiology; livestock reproduction; energy balance; nutrient metabolism; fertility biomarkers; hormonal regulation; metabolic disorders; reproductive efficiency

(This special issue belongs to the Section Animal Metabolism)

Gene-Regulated Metabolic Networks

edited by Babak Nami

submission deadline 25 Oct 2026 | Viewed by 239 | Submission Open

Keywords: genetics; metabolism; metabolic networks; mitochondrial biogenesis; epigenetics; nutrient sensing; metabolomics; metabolic signaling; cellular homeostasis

(This special issue belongs to the Section Cell Metabolism)

Research on Metabolic Biomarkers in Different Diseases

edited by Xiaohui Liu

submission deadline 30 Oct 2026 | 3 articles | Viewed by 3264 | Submission Open

Keywords: metabolomics; biomarkers; diseases; methodology; bioinformatics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mass Spectrometry-Based Metabolomics and Multi-Omics Approaches to Study Metabolite-Host Interactions

edited by

Paulo Wender Portal Gomes

and

Olimpio Montero

submission deadline 30 Oct 2026 | Viewed by 268 | Submission Open

Keywords: metabolite–host interactions; mass spectrometry; multi-omics integration; untargeted metabolomics; systems biology; biomarkers; environmental metabolomics; computational metabolomics

(This special issue belongs to the Section Integrative Metabolomics)

Plant-Derived Molecules in Prevention of Metabolic and Oxidative Stress-Related Diseases

edited by Hicham Harnafi

submission deadline 31 Oct 2026 | 2 articles | Viewed by 7956 | Submission Open

Keywords: lipid metabolism; oxidative stress; inflammation; metabolic diseases; cardiometabolic health; plant-derived molecules

(This special issue belongs to the Section Nutrition and Metabolism)

Machine Learning Applications in Metabolomics Analysis: 2nd Edition

edited by

Leonardo Franco

and

Martin Grootveld

submission deadline 31 Oct 2026 | 4 articles | Viewed by 4992 | Submission Open

Keywords: metabolites; biofluids; artificial intelligence; metabolomics; machine learning

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Mass Spectrometry-Based Metabolomics for Advancing Personalized Medicine

edited by

Cristina Adela Iuga

and

Radu-Cristian Moldovan

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4602 | Submission Open

Keywords: mass spectrometry-based metabolomics; integrated-omics; personalized medicine; biomarker discovery

(This special issue belongs to the Section Advances in Metabolomics)

New Technology and Workflows for Advancing Metabolomics

edited by Lee Andrew Gethings

submission deadline 31 Oct 2026 | 3 articles | Viewed by 3169 | Submission Open

Keywords: mass spectrometry; NMR; discovery metabolomics; targeted metabolomics; lipidomics; mass spectrometry imaging; new technology

(This special issue belongs to the Section Metabolomic Profiling Technology)

Advances in Secondary Metabolites: Phytochemical Profiling and Bioactivity Evaluation

edited by

Raquel Cariño-Cortés

and

Mario Ortiz

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3074 | Submission Open

Keywords: secondary metabolites; pain; inflammation; chronic-degenerative diseases; chemoprevention; metabolic syndrome; plants

(This special issue belongs to the Section Plant Metabolism)

Metabolomics in Clinical Research: Advancing Precision Medicine Through the Analysis of Biological Samples

edited by

Joana Pinto

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2978 | Submission Open

Keywords: metabolomics; precision medicine; biomarker discovery; clinical research; disease mechanisms; metabolic profiling; multi-omics integration; biological samples; diagnostic biomarkers; therapeutic monitoring

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Human Nutrition and Metabolic Health

edited by

Beata Stasiewicz

Justyna Borawska-Dziadkiewicz

and

Paweł Glibowski

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1778 | Submission Open

Keywords: diet; human nutrition; metabolism; health; diet-related diseases; biomarkers; metabolites; food-derived bioactive compounds; peptides

(This special issue belongs to the Section Nutrition and Metabolism)

Lipid Metabolism in Age-Related Diseases: 2nd Edition

edited by

Simona Fenizia

Elettra Barberis

and

Marcello Manfredi

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1735 | Submission Open

Keywords: lipid metabolism; metabolic diseases; high-throughput mass spectrometry-based lipidomics; aging; lipid biomarkers; precision medicine

(This special issue belongs to the Section Lipid Metabolism)

Muscle Wasting in Metabolic Dysfunction: Mechanisms and Therapeutic Innovations

edited by

Chia Chi Chuang Key

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1363 | Submission Open

Keywords: muscle wasting; obesity; diabetes; critical illness; adipose–muscle crosstalk; inflammation; metabolic dysfunction

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Pharmacometabolomics in Drug Mechanism, Efficacy and Toxicity

edited by Christian Giommi and Camilla Morresi

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1067 | Submission Open

Keywords: pharmacometabolomics; drug mechanisms; metabolic biomarkers; drug efficacy; drug toxicity; metabolic flux analysis; lipidomics and metabolomics profiling; computational metabolomics; systems pharmacology; precision medicine

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Women’s Special Issue Series: Metabolomic Profiling Technology

edited by

Thusitha W. Rupasinghe

and

RuAngelie Edrada-Ebel

submission deadline 31 Oct 2026 | Viewed by 682 | Submission Open

Keywords: metabolomics; metabolomic profiling technology; metabolism; analytical chemistry; NMR; mass spectrometry

(This special issue belongs to the Section Metabolomic Profiling Technology)

Analytical Techniques Applied in Metabolomics

edited by

María García Nicolás

and Anil Meher

submission deadline 31 Oct 2026 | 1 articles | Viewed by 532 | Submission Open

Keywords: metabolomics; analytical techniques; mass spectrometry; chromatography; ion mobility spectrometry; nuclear magnetic resonance (NMR); targeted and untargeted metabolomics; sample preparation; metabolite identification; data processing and analysis

(This special issue belongs to the Section Advances in Metabolomics)

Advanced Metabolic Profiling via Gas Chromatography–Mass Spectrometry and Liquid Chromatography–Mass Spectrometry: 2nd Edition

edited by

Ana Margarida Araújo

submission deadline 31 Oct 2026 | Viewed by 451 | Submission Open

Keywords: chromatographic methods; mass spectrometry techniques; metabolic profiling; methodological ad-vancements; biomarker discovery; environmental monitoring; food safety and quality; clinical diagnosis; drug development

(This special issue belongs to the Section Advances in Metabolomics)

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