Metabolomics Insights into Environmental Pollution: Unraveling Metabolic Responses to Contaminants

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Environmental Metabolomics".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 923

Special Issue Editor


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Guest Editor
College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China
Interests: metabolomics; environmental contaminants; biomarkers; toxicity mecha-nisms; metabolic alterations; ecological health; human health; cellular metabolism; organismal metabolism; pollution mitigation strategies
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Special Issue Information

Dear Colleagues,

The Special Issue "Metabolomics Insights into Environmental Pollution Unraveling Metabolic Responses to Contaminants" is a cutting-edge collection of research focused on the intersection of environmental pollution and metabolomics. The rationale behind this Issue is to delve into the metabolic responses triggered by environmental contaminants, offering a comprehensive view of their impact on human and ecological health.

Focus: The Issue zeros in on the identification of biomarkers for contaminant exposure and the elucidation of toxicity mechanisms. It aims to uncover the metabolic fingerprints left by pollutants, which can serve as indicators of environmental stress and potential health risks.

Scope: Spanning from cellular to organismal levels, the scope of this Issue is broad, encompassing various biological matrices and pollution. It encourages interdisciplinary research that can provide a holistic understanding of how different organisms respond metabolically to pollution.

Purpose: The ultimate goal is to foster innovative strategies in pollution detection, remediation, and therapeutic interventions. By bringing together contributions from diverse fields such as toxicology, environmental science, molecular biology, and public health, the Issue aspires to be a catalyst for developing effective mitigation strategies and enhancing our environment's health.

This Special Issue serves as a beacon for researchers, providing a dedicated platform to showcase their work and collaborate on significant issues related to environmental pollution and its metabolic ramifications. It offers an opportunity to publish in a targeted, timely, and insightful collection that will be well received by the scientific community.

Dr. Dechun Chen
Guest Editor

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Keywords

  • metabolomics
  • environmental contaminants
  • biomarkers
  • toxicity mechanisms
  • metabolic alterations
  • ecological health
  • human health
  • cellular metabolism
  • organismal metabolism
  • pollution mitigation strategies

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Published Papers (1 paper)

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Research

22 pages, 3314 KiB  
Article
Metabolomics’ Change Under β-Cypermethrin Stress and Detoxification Role of CYP5011A1 in Tetrahymena thermophila
by Wenyong Zhang, Wenliang Lei, Tao Bo, Jing Xu and Wei Wang
Metabolites 2025, 15(3), 143; https://doi.org/10.3390/metabo15030143 - 20 Feb 2025
Viewed by 571
Abstract
Background: β-cypermethrin (β-CYP) exhibits high toxicity to aquatic organisms and poses significant risks to aquatic ecosystems. Tetrahymena thermophila, a protozoa widely distributed in aquatic environments, can tolerate high concentrations of β-cypermethrin. However, the comprehensive detoxification mechanisms remain poorly understood in Tetrahymena. [...] Read more.
Background: β-cypermethrin (β-CYP) exhibits high toxicity to aquatic organisms and poses significant risks to aquatic ecosystems. Tetrahymena thermophila, a protozoa widely distributed in aquatic environments, can tolerate high concentrations of β-cypermethrin. However, the comprehensive detoxification mechanisms remain poorly understood in Tetrahymena. Methods: Untargeted metabolomics was used to explore the detoxification mechanisms of T. thermophila under β-CYP stress. Results: Trehalose, maltose, glycerol, and D-myo-inositol were upregulated under β-CYP exposure in Tetrahymena. Furthermore, the expression level of CYP5011A1 was upregulated under β-CYP treatment. CYP5011A1 knockout mutants resulted in a decreasing proliferation rate of T. thermophila under β-CYP stress. The valine–leucine and isoleucine biosynthesis and glycine–serine and threonine metabolism were significantly affected, with significantly changed amino acids including serine, isoleucine, and valine. Conclusions: These findings confirmed that T. thermophila develops β-CYP tolerance by carbohydrate metabolism reprogramming and Cyp5011A1 improves cellular adaptations by influencing amino acid metabolisms. Understanding these mechanisms can inform practices aimed at reducing the adverse effects of agricultural chemicals on microbial and environmental health. Full article
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