Metabolomics and Lipidomics in MASLD and Related Liver Disorders
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 1 April 2026 | Viewed by 31
Special Issue Editors
Interests: pharmacotherapy; gastroenterology; hepatology
Special Issues, Collections and Topics in MDPI journals
Interests: pharmacotherapy; lipids metabolism; diabetes mellitus; antidiabetic therapy; coagulation; obesity
Special Issue Information
Dear Colleagues,
Metabolomics and lipidomics offer powerful insights into the complex metabolic dysregulation underlying MASLD (metabolic dysfunction-associated steatotic liver disease) and related liver disorders. These complementary approaches enable the comprehensive profiling of small molecules—including amino acids, fatty acids, bile acids, and lipids—providing a deeper understanding of disease mechanisms, progression, and potential biomarkers.
In MASLD, disturbances in lipid and amino acid metabolism—such as elevated free fatty acids, branched-chain amino acids, and changes in bile acid profiles—are closely linked to hepatic steatosis, inflammation, and fibrosis. By applying advanced analytical platforms such as mass spectrometry, NMR spectroscopy, and chromatography, researchers can explore mitochondrial dysfunction, oxidative stress, and systemic metabolic changes in liver pathology.
This Special Issue invites original research and reviews exploring the use of metabolomics and lipidomics in MASLD and related conditions. Topics may include biomarker discovery, disease stratification, drug response monitoring, and mechanistic studies. Contributions advancing our understanding of liver metabolism in the context of metabolic diseases, cardiovascular risk, and hepatocarcinogenesis are especially welcome.
Dr. Aleksandra Bołdys
Dr. Michał Nicze
Guest Editors
Manuscript Submission Information
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Keywords
- MASLD
- metabolomics
- lipidomics
- liver disease
- biomarkers
- metabolic profiling
- nonalcoholic fatty liver disease
- oxidative stress
- mitochondrial dysfunction
- systems biology
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