Metabolic Research in Animal Nutrition and Production, 2nd Edition

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 922

Special Issue Editors


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Guest Editor
Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China
Interests: nutritional metabolism and digestive physiology
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Guest Editor
Public Health Research Institute, Rutgers, Rutgers University–New Brunswick, New Brunswick, NJ, USA
Interests: metabolic reprogramming in health and disease
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Special Issue Information

Dear Colleagues,

Metabolism—the network of biochemical reactions sustaining life—underpins growth, reproduction, adaptation, and health across species. While metabolic studies have become central to biomedical science, research on the metabolism of farmed animals, particularly special economic animals (e.g., fur-bearing animals, deer, rabbits) and companion animals (e.g., dogs, cats, horses), remains comparatively limited. Yet, these species are increasingly important in agriculture, veterinary practice, and the broader One Health framework linking animal and human health.

As in livestock and humans, metabolism in these animals provides the energy and molecular precursors essential for maintenance, production, and resilience under environmental challenges. Elucidating metabolic regulation therefore offers powerful tools for optimizing nutrient utilization, evaluating feed efficiency, monitoring physiological status, diagnosing diseases, and advancing animal welfare. Given the distinctive biological traits of these species and their close interactions with humans, advancing metabolic research in this domain is both challenging and highly relevant.

This Research Topic seeks to provide a comprehensive overview of recent advances and emerging frontiers in metabolism research in special economic and companion animals. We welcome original research articles, systematic reviews, perspectives, and methodological studies that expand our understanding of metabolism in these species. The article using with LC-MS, NMR, fluxomics will be recommended to the journal as a priority.Areas of particular interest include, but are not limited to:

  • Nutrient metabolism and efficiency: metabolic responses regulating nutrition, growth, reproduction, fur/antler production, and welfare.
  • Health and disease applications: metabolic biomarkers and metabolomics for phenotypic characterization, health assessment, and disease diagnosis.
  • Metabolic reprogramming: adaptive and maladaptive metabolic changes under stresses, infections, inflammatory diseases, or aging.
  • Microbiome–host interactions: roles of microbial metabolism in nutrient absorption, immunity, and systemic metabolic health.
  • Immunometabolism: metabolic regulation of immune responses during infection, inflammation, and tissue repair.
  • Omics and systems approaches: integration of metabolomics, transcriptomics, proteomics, and fluxomics to support precision nutrition and health monitoring.
  • Comparative and translational perspectives: interconnections between animal and human metabolism, with implications for food safety, zoonotic disease, and One Health in farming and pet-owning households.

By assembling diverse contributions across these themes, this Research Topic aims to highlight the central role of metabolism in animal biology, promote interdisciplinary dialogue between agricultural, veterinary, and biomedical sciences, and stimulate new research directions. Ultimately, we hope this collection will provide a foundation for advancing both production efficiency and companion animal health within a One Health perspective.

Dr. Tietao Zhang
Dr. Qingkui Jiang
Guest Editors

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Keywords

  • special economic animals
  • companion animals
  • nutrition
  • metabolomics
  • microbiome
  • metabolites
  • animal nutrition
  • animal production
  • animal health and disease
  • metabolic phenotypes

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Published Papers (1 paper)

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Research

21 pages, 6044 KB  
Article
An Initial Assessment of Rabbit Cornea as a Biomarker of Trace-Element Load in Commercial Animal Production
by Nikita Filatov, Marina Kravchik, Airat Bilyalov, Ivan Novikov, Angelina Titova, Stepan Perepechenov, Olga Pak, Anastasia Novikova, Khusam Khraistin, Alexandra Karunas and Oleg Gusev
Metabolites 2026, 16(3), 177; https://doi.org/10.3390/metabo16030177 - 7 Mar 2026
Viewed by 628
Abstract
Background/Objectives: Assessing trace-element status is fundamental for maintaining health across species. However, serum primarily reflects acute physiological variability rather than chronic exposure. Thus, we investigate the cornea as a possible stable, practical alternative for assessing chronic copper and iron accumulation in rabbit’s cornea. [...] Read more.
Background/Objectives: Assessing trace-element status is fundamental for maintaining health across species. However, serum primarily reflects acute physiological variability rather than chronic exposure. Thus, we investigate the cornea as a possible stable, practical alternative for assessing chronic copper and iron accumulation in rabbit’s cornea. Methods: A group of laboratory rabbits was housed under standardized husbandry conditions with comparable environmental and dietary backgrounds for trace-element intake. After completion of the experimental phase, corneal tissues were collected and subjected to quantitative elemental analysis using validated spectrometric procedures. In parallel, the structural integrity of the cornea was evaluated with standard histological techniques to determine whether elevated trace-element levels were associated with detectable morphological alterations. Results: Copper and iron concentrations showed approximately normal distributions, with mean values of 0.93 ± 0.46 μg/g and 0.78 ± 0.32 μg/g. All elemental concentrations were calculated relative to the original (native) wet tissue weight. Several samples exhibited elevated levels of both elements. Importantly, even in the samples with the highest copper and iron concentrations, no histological abnormalities were observed. Epithelial layers were intact, stromal collagen was well organized, and no inflammation or edema was observed. Conclusions: Overall, the cornea contained measurable copper and iron levels, and higher concentrations were not associated with morphological disruption under the trace-element conditions studied. Because ocular tissues are not used in food processing and can be collected in a standardized way during slaughter, the cornea offers a practical matrix for post-mortem monitoring of trace-element load in commercial animal production. Full article
(This article belongs to the Special Issue Metabolic Research in Animal Nutrition and Production, 2nd Edition)
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