The Role of Metabolites and the Gut Microbiota in Development, Homeostasis, and Diseases
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 48
Special Issue Editors
2. Center for Advanced Studies and Technology (CAST), “G. d'Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
Interests: gut; microbiota gut–brain axis; inflammation
Interests: mucosal immunology; inflammatory bowel disease; single cell analysis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The gut microbiota and its associated metabolites play a critical role in regulating host development and maintaining physiological homeostasis. This dynamic ecosystem influences a wide array of biological processes, including immune system maturation and metabolic regulation.
Intestinal microbes produce numerous metabolites through primary and secondary metabolic pathways, which act as key signaling molecules that modulate host cellular pathways and contribute to health or disease states. Disruptions in the composition or function of the gut microbiome—known as dysbiosis—have been linked to a range of disorders, including metabolic syndrome, inflammatory diseases, and developmental conditions via the gut–organ axis, i.e., the two-way interaction between the gut microbiota and other organs.
This Special Issue aims to highlight current advances in understanding the intricate crosstalk between microbial communities, their metabolic outputs, and host physiology, with a focus on mechanisms underpinning the development and maintenance of systemic homeostasis.
This issue not only intended for results from basic research (cell or animal models) but is also open to results from epidemiological studies. In addition, new measurement methods, bioinformatical tools, and data analysis concepts are welcome.
Dr. Miriam Di Mattia
Dr. Valentina Petito
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- microbiota
- metabolites
- gut homeostasis
- intestinal barrier
- host interactions
- inflammation
- gut–organ axis
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