Muscle Wasting in Metabolic Dysfunction: Mechanisms and Therapeutic Innovations
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 109
Special Issue Editor
Interests: adipose tissue remodeling; muscle wasting; lipid metabolism; obesity; type 2 diabetes; acute respiratory distress syndrome
Special Issue Information
Dear Colleagues,
This Special Issue will highlight the molecular and physiological mechanisms underlying muscle wasting in the context of metabolic dysfunction, including obesity, type 2 diabetes, and critical illness. These conditions are commonly associated with a significant loss of skeletal muscle mass and function, which contributes to poor clinical outcomes, increased morbidity, and impaired recovery. This Special Issue will showcase mechanistic insights and translational strategies that address muscle atrophy, with a particular emphasis on metabolic stressors and systemic alterations.
We invite the submission of original research articles and comprehensive reviews that investigate how metabolic dysregulation—such as altered lipid metabolism, insulin resistance, mitochondrial dysfunction, inflammation, and hormonal imbalances—drives muscle degradation. Studies utilizing nutritional models (e.g., a high-fat diet), pharmacological interventions (e.g., GLP-1 receptor agonists), and disease models (e.g., acute respiratory distress syndrome/ARDS, pneumonia, and sepsis) affecting body composition are encouraged. Submissions may comprise in vitro studies, animal models, and human clinical research, particularly those integrating multi-omics approaches or identifying novel biomarkers and therapeutic targets. We also welcome research exploring adipose–muscle crosstalk and systemic metabolic stressors such as hyperglycemia and dyslipidemia.
The aim of this Special Issue is to deepen our understanding of the mechanisms driving muscle wasting in metabolic dysfunction and to promote the development of targeted nutritional and pharmacological therapies. By bringing together diverse methodologies and perspectives, we aim to reveal translational insights that can bridge basic science and clinical application, ultimately improving muscle health and metabolic outcomes in affected populations.
Dr. Chia Chi Chuang Key
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- muscle wasting
- obesity
- diabetes
- critical illness
- adipose–muscle crosstalk
- inflammation
- metabolic dysfunction
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