Human Nutrition and Metabolic Health

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 414

Special Issue Editors


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Guest Editor
Department of Human Nutrition, Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland
Interests: human nutrition; nutritional epidemiology; dietetics; dietary assessment; dietary patterns; public health nutrition; diet-related diseases; cancer; sleep disorders

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Guest Editor
Department of Food Biochemistry, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 10-726 Olsztyn, Poland
Interests: bioactive peptides; food-derived proteins; antioxidant, antihypertensive and antidiabetic peptides; metabolic health; nutrition; functional foods; public health

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Guest Editor
Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland
Interests: nutrition in cardiovascular disease; nutrition in osteoporosis; application of inulin in food; probiotics; functional fermented milk drinks; chemical analysis of toxic metals, nitrates, and nitrites in fruits and vegetables
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Special Issue Information

Dear Colleagues,

It is well established that proper nutrition plays an important role in maintaining metabolic health. Inappropriate dietary behaviors, excessive energy intake, and imbalances in dietary composition can lead to disturbances in homeostasis, intestinal dysbiosis, inflammation, and the development of diet-related metabolic diseases such as obesity, diabetes, cardiovascular disease, or cancer. Therefore, it is crucial to understand the details of the associations between diet and known diet-related diseases, as well as health disorders that are not as well known, and to explain the mechanisms underlying metabolic disorders. In this context, it is crucial to identify new potential biomarkers of the consumption of various food components with particular importance for human health. Emphasis will also be placed on food-derived bioactive compounds, including peptides, polyphenols, and other secondary metabolites, which may exert antioxidant, antihypertensive, antidiabetic, or anti-inflammatory effects and play important roles in maintaining metabolic health. The scope of this Special Issue, titled "Human Nutrition and Metabolic Health," is devoted to original papers and literature reviews relevant to the associations between nutrition and metabolic health at various stages of human life (children, adolescents, adults, and the elderly), as well as nutritional strategies for the prevention and treatment of metabolic diseases.

Dr. Beata Stasiewicz
Dr. Justyna Borawska-Dziadkiewicz
Prof. Dr. Paweł Glibowski
Guest Editors

Manuscript Submission Information

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Keywords

  • diet
  • human nutrition
  • metabolism
  • health
  • diet-related diseases
  • biomarkers
  • metabolites
  • food-derived bioactive compounds
  • peptides

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Published Papers (1 paper)

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Research

17 pages, 6697 KB  
Article
Annexin A2 Is Associated with Dietary Cholesterol-Induced Metabolic Dysregulation and the Progression of Hepatic Fibrosis
by Jiayang Liu, Ling Ou, Haiyan Tai, Yinghan Chai, Lirong Tan, Jie Lin, Bing Li, Ying Cao and Tingting Zhu
Metabolites 2026, 16(5), 331; https://doi.org/10.3390/metabo16050331 - 15 May 2026
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Abstract
Background/Objectives: Dietary cholesterol intake significantly influences liver health, yet the specific molecular mechanisms by which it accelerates fibrogenesis remain incompletely defined. This study aimed to characterize the dose-dependent effects of dietary cholesterol on hepatic injury and fibrogenesis, identify cholesterol-responsive gene networks through [...] Read more.
Background/Objectives: Dietary cholesterol intake significantly influences liver health, yet the specific molecular mechanisms by which it accelerates fibrogenesis remain incompletely defined. This study aimed to characterize the dose-dependent effects of dietary cholesterol on hepatic injury and fibrogenesis, identify cholesterol-responsive gene networks through transcriptomic analysis, and investigate Annexin A2 (ANXA2) as a candidate molecular mediator linking dietary cholesterol to hepatic fibrosis progression. Methods: A CCl4-induced liver fibrosis mouse model was established and supplemented with dietary cholesterol (1–2%). Liver injury and fibrosis were assessed by liver-to-body weight ratios, serum biochemical markers, histological analysis, and fibrogenic gene expression. RNA sequencing combined with multiple hepatic fibrosis database analyses was performed to identify potential molecular mediators. Results: Dietary cholesterol supplementation aggravated CCl4-induced hepatic fibrosis in mice, with dose-dependent increases in liver-to-body weight ratios and serum AST and ALT levels. Histological analysis showed enhanced collagen deposition and upregulation of fibrogenic genes. By integrating RNA-sequencing with multiple hepatic fibrosis database analysis and correlation analysis, we identified Annexin A2 (ANXA2) as a cholesterol-responsive gene associated with fibrosis. Conclusions: Dietary cholesterol promotes liver fibrosis progression, and ANXA2 may act as a potential mediator linking cholesterol metabolism to hepatic fibrogenesis. Full article
(This article belongs to the Special Issue Human Nutrition and Metabolic Health)
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