Metabolic Pathways in Cardiovascular and Cerebrovascular Conditions
A Special Issue of Metabolites (ISSN 2218-1989) belonging to the section "Cell Metabolism".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 237
Editor
Interests: vascular zebrafish; cardiovascular disease; metabolic; disease models; molecular biology; cardiomyopathy; myocardial infarction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular and cerebrovascular diseases remain the leading causes of morbidity and mortality worldwide, driven by complex interactions between genetic, environmental, and metabolic factors. Emerging evidence indicates that metabolic dysregulation is a central contributor to disease initiation, progression, and recovery across the heart–brain axis. Alterations in glucose and lipid metabolism, mitochondrial dysfunction, redox imbalance, and amino acid and nucleotide metabolism profoundly influence vascular integrity, inflammation, energy homeostasis, and cell survival in both cardiac and cerebral tissues.
This Special Issue aims to provide a comprehensive overview of recent advances in understanding of how metabolic pathways regulate cardiovascular and cerebrovascular physiology and pathology. It will highlight cutting-edge research on metabolic reprogramming in conditions such as myocardial infarction, heart failure, atherosclerosis, stroke, vascular dementia, and related neurovascular disorders. This collection will place emphasis on cell-type-specific metabolism in cardiomyocytes, endothelial cells, vascular smooth muscle cells, neurons, glia, and immune cells, as well as metabolic crosstalk within the neurovascular and cardiometabolic systems. The Special Issue will feature original research articles, reviews, and translational studies covering topics including mitochondrial dynamics, oxidative stress, hypoxia signaling, lipid handling, metabolic inflammation, and emerging therapeutic strategies targeting metabolic pathways. By integrating insights from molecular biology, omics technologies, and preclinical and clinical studies, Metabolites seeks to advance mechanistic understanding and identify novel metabolic targets for the prevention and treatment of cardiovascular and cerebrovascular diseases.
Dr. Angom Ramcharan Singh
Guest Editor
Manuscript Submission Information
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Keywords
- cardiovascular metabolism
- cerebrovascular disease
- metabolic reprogramming
- mitochondrial dysfunction
- endothelial metabolism
- neurovascular unit
- oxidative stress and redox signaling
- lipid and glucose metabolism
- hypoxia and ischemia
- metabolic inflammation
- heart–brain axis
- therapeutic metabolic targeting
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