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Metabolites
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Lipid Metabolism in Age-Related Diseases: 2nd Edition
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Lipid Metabolism in Age-Related Diseases: 2nd Edition

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 1152

Special Issue Editors

Dr. Simona Fenizia

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Guest Editor
Department of Sciences and Technological Innovation, University of Piemonte Orientale, Corso Trieste 15/A, I-28100 Novara, Italy
Interests: analytical chemistry; metabolomics; lipidomics; biomarker discovery; chromatography; mass spectrometry
Special Issues, Collections and Topics in MDPI journals
Dr. Elettra Barberis

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Guest Editor
Department of Sciences and Technological Innovation, University of Piemonte Orientale, Corso Trieste 15/A, I-28100 Novara, Italy
Interests: analytical chemistry; metabolomics; lipidomics; biomarker discovery; chromatography; mass spectrometry
Special Issues, Collections and Topics in MDPI journals
Dr. Marcello Manfredi

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Guest Editor
Department of Translational Medicine (DiMeT), Center for Translational Research on Autoimmune & Allergic Diseases—CAAD, University of Piemonte Orientale, Corso Trieste 15/A, 28100 Novara, Italy
Interests: cancer and microenvironment; biochemistry; mass spectrometry based-omics analysis; tumour microenvironment; biomarkers; aging related diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Lipids play an important role in the development of aging-related diseases. The alteration of lipid metabolism has already been identified in both chronic and acute diseases, including cardiovascular, metabolic, cancer, autoimmune, and neurodegenerative diseases. In addition, impaired lipid metabolism is implicated in all the known hallmarks of aging. The growing body of literature shows that specific lipid subclasses and species can serve as biomarkers and targets for therapies, paving the way for the development of precision medicine approaches. Although lipids are involved in many cellular and physiological regulations, their heterogeneity and wide dynamic range make the study of these molecules very challenging. Mass spectrometry and chromatography have been largely developed in recent years, leading to significant advances in the exploration and analysis of human lipid profiles. This Special Issue aims to explore the contribution of lipid biosynthesis, accumulation, and metabolism in the context of aging-related diseases. Submissions from basic research and clinical studies, including the development and application of analytical methods to investigate the role of lipids in both chronic and acute diseases, are welcome. Furthermore, we aim to present cutting-edge reviews and original research articles that investigate the role of lipid metabolism both in vivo and in vitro, as well as biomarker discovery, analytical challenges in lipidomic research, and future perspectives on targeting lipid pathways to improve therapeutic strategies.

Our Special Issue welcomes researchers, scientists, and experts from different fields, including metabolomics, biochemistry, and clinical medicine, to contribute original research articles, reviews, and insights investigating the intricate mechanisms linking lipid alterations in age-related diseases.

We also encourage submissions that explore novel diagnostic biomarkers, therapeutic interventions, and preventive strategies.

Key topics of interest include the following:

  • Investigation of lipid metabolism in vitro and in vivo;
  • Discovery of new lipid biomarkers;
  • Role of lipids in aging diseases;
  • Current and future perspectives on lipids in diseases and the elderly;
  • Advanced methods for the analysis of lipids and fatty acids in biological fluids and in vitro models.

Dr. Simona Fenizia
Dr. Elettra Barberis
Dr. Marcello Manfredi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipid metabolism
  • metabolic diseases
  • high-throughput mass spectrometry-based lipidomics
  • aging
  • lipid biomarkers
  • precision medicine

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Related Special Issue

Published Papers (2 papers)

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Research

12 pages, 443 KB  
Article
Atherogenic Index of Plasma Relationship with Cardiovascular Risk Factors and Frailty and Value as Determinant of Mortality in Elderly Patients with Severe Aortic Stenosis
by Annamaria Mazzone, Melania Gaggini and Cristina Vassalle
Metabolites 2026, 16(5), 289; https://doi.org/10.3390/metabo16050289 - 22 Apr 2026
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Abstract
Background: Frailty is a common finding in elderly subjects with severe aortic stenosis (AoS) and a strong predictor of mortality and disability after aortic valve surgery. The atherogenic index of plasma (AIP) is related to different cardiovascular (CV) risk factors, which in [...] Read more.
Background: Frailty is a common finding in elderly subjects with severe aortic stenosis (AoS) and a strong predictor of mortality and disability after aortic valve surgery. The atherogenic index of plasma (AIP) is related to different cardiovascular (CV) risk factors, which in turn are correlated to the progression of frailty as well as of AoS. Aim: to analyze the association of AIP with different CV risk factors and frailty scores and its value as a determinant of mortality in older adults with severe AoS. Methods: The association of AIP with a multidimensional assessment of frailty by using Fried criteria and the following indices; timed up-and-go test (TUG) for gait function; Charlson Index (CI), basic activities of daily living (BADL) and instrumental activities of daily living (IADL) for disability; mini–mental state examination for cognitive function evaluation (MMSE); Geriatric Depression Score for mood disorder (GDS); Mini Nutritional Assessment (MNA) for nutritional status was assessed in 102 elderly AoS patients (33 males; mean age 83 ± 6 yrs). Moreover, the relationship between AIP and demographic, lifestyle, traditional CV risk factors and CV mortality was also evaluated. Results: Significant relationships between AIP and glycemia and inflammatory parameters (CRP, ESR and fibrinogen) as well as with troponin I were found. Moreover, AIP significantly correlates with CI, BADL, IADL and MNA. However, the Kaplan–Meier analysis did not show any significant difference for survival rates according to AIP intervals of risk, whereas ejection fraction remained the only significant determinant after multivariate adjustment for mortality at the Cox proportional hazard models analysis in this patient population. Conclusions: Higher AIP is significantly associated with cardiometabolic risk and increased physical dysfunction risk and frailty in AoS pts, evidencing its potential use as a simple biomarker in this clinical setting, although it did not represent a significant determinant for mortality in this population. Full article
(This article belongs to the Special Issue Lipid Metabolism in Age-Related Diseases: 2nd Edition)
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13 pages, 517 KB  
Article
Multimatrix Detection and Quantification of the Advanced Glycation End Products Precursor Fructoselysine via UHPLC-HRMS/MS
by Simona Fenizia, Marcello Manfredi, Valentina Antoniotti, Sabrina Tini, Jessica Baima, Flavia Prodam and Elettra Barberis
Metabolites 2026, 16(1), 78; https://doi.org/10.3390/metabo16010078 - 16 Jan 2026
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Abstract
Background: Advanced glycation end products (AGEs) play a pivotal role in various human pathologies, including aging and metabolic diseases, and their formation may have significant physiological consequences for human health. Fructoselysine (FL) is an intermediate in the formation of AGEs, and its accumulation [...] Read more.
Background: Advanced glycation end products (AGEs) play a pivotal role in various human pathologies, including aging and metabolic diseases, and their formation may have significant physiological consequences for human health. Fructoselysine (FL) is an intermediate in the formation of AGEs, and its accumulation has been associated with detrimental health effects. Although several chromatographic methods have been developed for AGEs detection and quantification, no mass spectrometry-based approach has previously been established to quantify FL in different human biological matrices. Methods: In this study, we present a novel UHPLC-HRMS/MS method for the identification and quantification of this compound in various biological matrices, including plasma, feces, and urine. Results: The method demonstrates excellent linearity, accuracy, and precision, with limit of detection (LOD) of 0.02 µM and limit of quantification (LOQ) of 0.06 µM. Recovery rates ranged from 95% to 109% and intra- and inter-day relative standard deviations (RSDs) were below 10%, indicating robust analytical performance. The validated method was successfully applied to quantify FL in plasma, feces, and urine samples from healthy individuals. Additionally, given the known association between AGEs and diabetes, we analyzed a small cohort of prediabetic patients and observed elevated circulating levels of FL compared to healthy controls. Conclusions: This study introduces a sensitive and reliable method for the specific detection and quantification of FL in biological samples and provides new insights into early molecular changes associated with prediabetic condition to improve early diagnosis in aging related diseases. Full article
(This article belongs to the Special Issue Lipid Metabolism in Age-Related Diseases: 2nd Edition)
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