Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 15 September 2026 | Viewed by 52
Special Issue Editors
Interests: LC-MS metabolomics; nutrition; metabolic diseases; gut microbiota-derived metabolites
Special Issue Information
Dear Colleagues,
Metabolic dysfunction-associated steatotic liver disease (MASLD) is now recognized as one of the leading causes of chronic liver diseases worldwide. It is strongly associated with obesity, insulin resistance, cardiovascular disorders, and other metabolic abnormalities. The updated terminology from “non-alcoholic fatty liver disease” (NAFLD) to MASLD emphasizes the central role of systemic metabolic dysfunction in disease development and progression. MASLD remains a highly heterogeneous condition influenced by complex metabolic, genetic, dietary, and gut microbiome factors. This variability continues to challenge early diagnosis, risk assessment, and the discovery of effective therapies. Currently, pharmacological treatments are limited, and reliable screening methods are lacking due to the disease’s gradual progression and overlap with other metabolic conditions. Recent advances in metabolomics, lipidomics, and other -omics technologies now enable researchers to profile thousands of small molecules, providing insights into the molecular mechanisms underlying MASLD.
This Special Issue welcomes original research and reviews that explore how metabolic pathways drive MASLD onset and progression. Topics of interest include biomarker discovery, novel mechanisms linking metabolism and liver injury, dietary and lifestyle influences, and new therapeutic strategies targeting metabolic dysfunction. Studies summarizing progress in small-molecule drug development, prevention strategies, and molecular-level mechanisms for MASLD diagnosis and treatment are particularly encouraged.
Dr. Ambrin Farizah Babu
Dr. Ze Xiang
Guest Editors
Manuscript Submission Information
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Keywords
- MASLD
- biomarkers
- diet and lifestyle
- molecular mechanisms
- drug development
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