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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring Pathological Mechanisms in Obesity, Diabetes, and Metabolic Syndrome

edited by

Tiemin Liu

Hongmei Yan

and

Qiongyue Zhang

submission deadline 30 Sep 2025 | 9 articles | Viewed by 20469 | Submission Open

Keywords: metabolic diseases: obesity; diabetes; NAFLD; MAFLD; NASH; metabolic syndrome; etc.; multi-omics: metabolomics; lipidomics; proteomics; etc.; pathogenesis: genetic predispositions; lifestyle factors; microbiome and environmental exposures; etc.

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Food Sciences: Metabolomics to Unravel the Complexity of Food Metabolites

edited by

José Iván Serrano-Contreras

submission deadline 30 Sep 2025 | 3 articles | Viewed by 13451 | Submission Open

Keywords: foodomics; nutrimetabolomics; phytochemicals; food chemistry; food analysis; dark matter in diet; nutritional dark matter; nutritional hormesis; untargeted/targeted analysis

(This special issue belongs to the Section Food Metabolomics)

Unlocking Nature's Toolbox: Advances in Plant Metabolites Identification

edited by

Ramona Paltinean

and

Irina Ielciu

submission deadline 30 Sep 2025 | 7 articles | Viewed by 9133 | Submission Open

Keywords: natural compounds; plant metabolites; extraction methods; separation techniques; biological activities

(This special issue belongs to the Section Plant Metabolism)

Analysis of Specialized Metabolites in Natural Products

edited by

Aikaterini Koutsaviti

and

Christos Petrou

submission deadline 30 Sep 2025 | 7 articles | Viewed by 8656 | Submission Open

Keywords: structure elucidation; isolation; evaluation of activity; plant bioactive secondary metabolites; methodology development

(This special issue belongs to the Section Plant Metabolism)

Advances in Metabolomics and Multi-Omics Integration

edited by

Kurt K. Zhang

submission deadline 30 Sep 2025 | 4 articles | Viewed by 7686 | Submission Open

Keywords: metabolomics; cellular metabolism; multi-omics; metabolites; molecular interaction; cell– cell cross-talk

(This special issue belongs to the Section Integrative Metabolomics)

Insights into Metabolism, Diagnostics and Therapeutics of Cancer and Tumor Microenvironment by NMR Spectroscopy

edited by

Shivanand M. Pudakalakatti

and

Pratip K. Bhattacharya

submission deadline 30 Sep 2025 | 2 articles | Viewed by 5436 | Submission Open

Keywords: cancer metabolism; early diagnosis; therapeutic intervention; NMR spectroscopy; instrument development; pulse sequence design; metabolites; software for metabolomics

(This special issue belongs to the Section Integrative Metabolomics)

Nuclear Magnetic Resonance-Powered Metabolomics: Progress and Future Prospects

edited by Abhinav Dubey

submission deadline 30 Sep 2025 | 4 articles | Viewed by 4730 | Submission Open

Keywords: solution-state NMR; metabolism; clinical studies; biomarker discovery; high-throughput data analysis

(This special issue belongs to the Section Advances in Metabolomics)

Adrenal Neuroendocrine System and Cardiometabolic Health

edited by

Moe Thuzar

submission deadline 30 Sep 2025 | 2 articles | Viewed by 4442 | Submission Open

Keywords: adrenal; metabolic syndrome; cardiovascular health; glucocorticoid; mineralocorticoid

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mass Spectrometry-Based Technology for Metabolic Profiling

edited by Gregory Hamm,

Laura Cole

and Lin Wang

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2138 | Submission Open

Keywords: metabolomics; lipidomic; high-resolution mass spectrometry; untargeted and targeted; data processing; pathway mapping; fluxomic

(This special issue belongs to the Section Metabolomic Profiling Technology)

Amino Acid Metabolism and Function in Human Diseases

edited by Jolanta Bugajska and Krystyna Sztefko

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1802 | Submission Open

Keywords: free amino acids; civilization diseases; obesity; diabetes; liver disease; heart diseases; reference intervals

(This special issue belongs to the Section Cell Metabolism)

Application of NMR in Food Metabolomics

edited by Charalambos Fotakis and

Maria Zervou

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1702 | Submission Open

Keywords: food items; NMR; food metabolomics; quality assurance; geographical origin; authenticity

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolomics in Clinical Research: Advancing Precision Medicine Through the Analysis of Biological Samples

edited by

Joana Pinto

submission deadline 30 Sep 2025 | 1 articles | Viewed by 970 | Submission Open

Keywords: metabolomics; precision medicine; biomarker discovery; clinical research; disease mechanisms; metabolic profiling; multi-omics integration; biological samples; diagnostic biomarkers; therapeutic monitoring

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Changes in Diet-Mediated Inflammatory Diseases

edited by

Beatrice Dufrusine

submission deadline 30 Sep 2025 | 1 articles | Viewed by 771 | Submission Open

Keywords: nutrition; Westernized diet; inflammation; immune system; cancer; metabolic reprogramming; au-toimmune disease; obesity; allergies; inflammatory bowel diseases; celiac disease

(This special issue belongs to the Section Nutrition and Metabolism)

Role of Metabolic Factors and Their Interactions on Diabetes and Its Complications

edited by Yun Shen

submission deadline 30 Sep 2025 | Viewed by 625 | Submission Open

Keywords: metabolic risk factors; diabetes comorbidities; bioinformatics; machine learning; multi-omics integration; cardiovascular disease; dyslipidemia; insulin resistance; biomarkers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipidomic Signatures in Pediatric Metabolic Disorders

edited by

Mónica Narváez-Rivas

submission deadline 30 Sep 2025 | Viewed by 557 | Submission Open

Keywords: lipidomics; lipids; mass spectrometry; pediatric population; therapeutic targets; biomarkers; metabolic disorder

(This special issue belongs to the Section Lipid Metabolism)

Biomarkers and Human Blood Metabolites 2025

edited by

Mina Hur

submission deadline 30 Sep 2025 | Viewed by 264 | Submission Open

Keywords: blood metabolites as human biomarkers; identification of disease and non-disease biomarkers; understanding the pathogenesis of the diseases through metabolites; physiological response against environmental stress or stimuli; exposure to toxin or chemical drugs; lifestyle; nutrition; and genetic or epigenetic factors

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Circadian System Associated with Lipid Metabolism and Metabolic Diseases

edited by

Xiaoyue Pan

submission deadline 30 Sep 2025 | Viewed by 259 | Submission Open

Keywords: circadian rhythm; circadian clock; lipid transport; lipid oxidation; lipid synthesis; lipid metabolism; lipoprotein

(This special issue belongs to the Section Cell Metabolism)

Metabolomics and Bioinformatics Approaches to Studying Human Gut Microbiota-Derived Metabolites

edited by Zhiwei Zhou, Shipei Xing and Xiaotao Shen

submission deadline 10 Oct 2025 | 2 articles | Viewed by 3746 | Submission Open

Keywords: metabolomics; bioinformatics; databases; gut microbiota; microbiome; host– microbe interaction; microbial metabolism; multiomics

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Reactive Oxygen Species and Energy Metabolic Alterations in Health and Disease

edited by

Paola Maycotte

and

Álvaro Marín-Hernández

submission deadline 15 Oct 2025 | 2 articles | Viewed by 4193 | Submission Open

Keywords: cancer; ROS; glycolysis; mitochondria; autophagy; antioxidant system; glutathione; oxidative phosphorylation

(This special issue belongs to the Section Cell Metabolism)

Effects of Secondary Plant Metabolites on Human Health

edited by

Beáta Čižmárová

and

Anna Birková

submission deadline 15 Oct 2025 | 1 articles | Viewed by 912 | Submission Open

Keywords: human health; inflammation; cancer; obesity; antioxidants; phytochemicals; phytoestrogens; secondary metabolites; natural products

(This special issue belongs to the Section Plant Metabolism)

Mass Spectrometry Imaging and Spatial Metabolomics

edited by

Zhonghua Wang

and Chenglong Sun

submission deadline 30 Oct 2025 | 5 articles | Viewed by 5648 | Submission Open

Keywords: mass spectrometry imaging (MSI); spatial metabolomics; biomarker discovery; disease diagnostics; drug development; technical advancements; interdisciplinary approaches; imaging techniques

(This special issue belongs to the Section Metabolomic Profiling Technology)

Nutritional and Metabolic Influences on Animal Growth and Reproduction

edited by

Zhipeng Li

and

Baichuan Deng

submission deadline 30 Oct 2025 | 5 articles | Viewed by 5138 | Submission Open

Keywords: metabolites; nutritional and metabolic influences; animal development; meat quality; dairy science; animal reproduction

(This special issue belongs to the Section Animal Metabolism)

Nutrition and Metabolism in Human Diseases 2nd Edition

edited by

Xinhui Wang

submission deadline 31 Oct 2025 | 4 articles | Viewed by 8107 | Submission Open

Keywords: nutrition; metabolism; nutrient; metabolite; disease

(This special issue belongs to the Section Nutrition and Metabolism)

Plant Biotic and Abiotic Stress Responses and Tolerance: Phytohormonal and Metabolic Insights

edited by

Tabibul Islam

and Md. Al Mamun

submission deadline 31 Oct 2025 | 5 articles | Viewed by 6806 | Submission Open

Keywords: biotic and abiotic stress; phytohormones: primary metabolism; secondary metabolites; plant– pathogen interactions; biostimulants; beneficial microbes; plant innate immunity; omics (genomics; transcriptomics; proteomics; metabolomics; etc.)

(This special issue belongs to the Section Plant Metabolism)

Lipid Metabolism Dysregulation in Metabolic Disorders: Unraveling the Molecular Complexity

edited by

Joshua De Leon

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3694 | Submission Open

Keywords: lipid metabolism; dyslipidemia; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Research on Lipid Metabolism in Animals

edited by

Bing Han

Lihong Zhao

and Zhenlong Wang

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2867 | Submission Open

Keywords: lipid metabolism; bile acid; gut microbiota; obesity; meat quality

(This special issue belongs to the Section Animal Metabolism)

Research of Inborn Errors of Metabolism

edited by

Vincenza Gragnaniello

and

Maria Fuller

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2749 | Submission Open

Keywords: inborn errors of metabolism; pathogenic mechanisms; bio-chemical pathway; inherited diseases; diagnosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in LC-MS-Based Metabolomics: From (Un)targeted Screening to Structural Elucidation

edited by Andrea Castellaneta and

Ilario Losito

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2713 | Submission Open

Keywords: liquid chromatography; high-resolution and multi-stage mass spectrometry; lipidomics; structure elucidation; LC-MS methods for metabolite screening; quantitative method development

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolomics Approaches to Nutrition, Intestine and Farm Animal

edited by

Shu-cheng Huang

Lihong Zhang

and Aoyun Li

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2667 | Submission Open

Keywords: farm animal; nutrition; metabolomics; metabolism; gut microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Identification of Plant Metabolites: Characterization and Biological Activities, 2nd Edition

edited by

Irina Ielciu

and

Ramona Paltinean

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2565 | Submission Open

Keywords: natural compounds; plant metabolites; separation techniques; biological activities

(This special issue belongs to the Section Plant Metabolism)

Biosynthesis, Metabolism, and Physiological Functions of Gamma-Aminobutyric Acid (2nd Edition)

edited by

Haixing Li

and

Dandan Gao

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2334 | Submission Open

Keywords: gamma-aminobutyric acid; metabolism and metabolomics; biotechnology and bioengineering; biosynthesis; physiological function; gamma-aminobutyric-acid-producing microbes; methodology

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Advances in Mass Spectrometry for Plant Metabolite Analysis: Techniques and Applications

edited by

Mila Radan

and

Prakash Babu Adhikari

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1656 | Submission Open

Keywords: mass spectrometry; plant metabolomics; biomarker discovery; metabolic networks: metabolic flux; MS data analysis; metabolic diseases

(This special issue belongs to the Section Plant Metabolism)

Flavonoids: Novel Therapeutic Potential for Chronic Diseases

edited by Aleksandra Kozłowska and Shawn R. Campagna

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1262 | Submission Open

Keywords: flavonoids; chronic diseases; inflammation; diabetes; anthocyanins; cardiovascular diseases; neurodegenerative disorders; quercetin

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mass Spectrometry-Based Metabolomics for Advancing Personalized Medicine

edited by

Cristina Adela Iuga

and

Radu-Cristian Moldovan

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1248 | Submission Open

Keywords: mass spectrometry-based metabolomics; integrated-omics; personalized medicine; biomarker discovery

(This special issue belongs to the Section Advances in Metabolomics)

Role of Nutraceuticals in Metabolic Disorders: Mechanisms and Benefits

edited by

Susmita Barman

submission deadline 31 Oct 2025 | 1 articles | Viewed by 425 | Submission Open

Keywords: nutraceuticals; functional foods; metabolic syndrome

(This special issue belongs to the Section Nutrition and Metabolism)

Evaluation of Metabolic Changes in Mice Under Chronic Toxic Substances Exposure

edited by

Yun-Chung Hsiao

and

Kun Lu

submission deadline 31 Oct 2025 | Viewed by 261 | Submission Open

Keywords: metabolomics; environmental contaminant; persistent organic pollutant; mass spectrometry; proteomics; toxicant; toxicological assessment; chronic toxicity; xenobiotic metabolism; lipidomic; dose– response relationship; molecular toxicology

(This special issue belongs to the Section Environmental Metabolomics)

Metabolism and Reproduction in Animals

edited by

Simona Tafuri

and

Francesca Ciani

submission deadline 31 Oct 2025 | Viewed by 230 | Submission Open

Keywords: metabolism; reproduction; welfare; nutraceuticals; oxidative stress; antioxidants; inflammation; cancer

(This special issue belongs to the Section Animal Metabolism)

Advances in Translational Oncology and Oncometabolism

edited by Graham Pidgeon and

Zivile Useckaite

submission deadline 31 Oct 2025 | Viewed by 186 | Submission Open

Keywords: oncometabolism; obesity; clinical research; clinical trials; oncogenes; translational oncology

(This special issue belongs to the Section Cell Metabolism)

Salivary Biomarkers and Metabolites in Pigs

edited by

Fernando Tecles

submission deadline 31 Oct 2025 | Viewed by 161 | Submission Open

Keywords: saliva; biomarkers; welfare and health; animals

(This special issue belongs to the Section Animal Metabolism)

Metabolomics of Human Nutrition: The Dot of Human Nutrition and the Circle of Soil, Plants, Animals and Microbes in Relation to It, 2nd Edition

edited by

Shoma Berkemeyer

submission deadline 31 Oct 2025 | Viewed by 136 | Submission Open

Keywords: human nutrition; metabolomics; physiology; biochemistry; dietetics; pathophysiology; soil science; crop science; animal husbandry; microbes

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Biomarkers and Nutrition in Degenerative Conditions and Gastrointestinal Cancer Surgery: 2nd Edition

edited by

Irene Lidoriki

Dimitrios Schizas

and Maximos Frountzas

submission deadline 31 Oct 2025 | Viewed by 131 | Submission Open

Keywords: biomarkers; nutrition; metabolism; metabolomics; degenerative disease; Parkinson’ s disease; Alzheimer’ s disease; cardiovascular disease; gastrointestinal cancer surgery

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Interaction Between Metabolic Dysfunction and Hypothalamic Inflammation

edited by

Joana M. Gaspar

submission deadline 31 Oct 2025 | Viewed by 111 | Submission Open

Keywords: metabolic disorders; neuroinflammation; hypothalamus; energy homeostasis; feeding behavior; high-fat diets; obesity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Dysbiosis and Metabolic Disorders of the Microbiota

edited by

Guozhu Ye

submission deadline 1 Nov 2025 | 4 articles | Viewed by 6054 | Submission Open

Keywords: metabolomics; metagenomics; metaproteomics; metatranscriptomics; Liquid Chromatograph-Mass Spectrometer; Gas Chromatography-Mass Spectrometer; gut microbiota; environmental microbiota; metabolism; metabolic disorders

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Nutrition and Metabolism in Poultry

edited by

Catarina Stefanello

submission deadline 10 Nov 2025 | 1 articles | Viewed by 1214 | Submission Open

Keywords: ingredient; feed additive; feed quality; nutrient utilization; intestinal health

(This special issue belongs to the Section Animal Metabolism)

Mechanistic Insights into Metabolic Interactions with the Tumor Microenvironment

edited by

Jyoti Kaushal

submission deadline 15 Nov 2025 | 1 articles | Viewed by 1711 | Submission Open

Keywords: metabolism; tumor microenvironment; therapy; immune cells; clinical oncology; metabolic pathways

(This special issue belongs to the Section Cell Metabolism)

The Relationship Between Adipose Tissue Insulin Resistance and Metabolic Syndrome

edited by

Atefeh Rabiee

submission deadline 15 Nov 2025 | Viewed by 120 | Submission Open

Keywords: adipose insulin resistance; metabolic syndrome; visceral adiposity; adipocytokines; insulin signaling; lipolysis dysregulation; cardiometabolic risk; lipotoxicity; adipose inflammation; insulin sensitivity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Targeted and Non-Targeted LC- and GC-HRMS Workflows for the Analysis of Emerging Contaminants and the Environmental Exposome

edited by Lapo Renai and

Massimo Del Bubba

submission deadline 16 Nov 2025 | 1 articles | Viewed by 818 | Submission Open

Keywords: chromatography; high-resolution mass spectrometry; non-targeted analysis; exposome; data analysis; environmental analysis; pharmaceuticals; poly- and perfluorinated substances; personal care products; transformation products feature detection and identification

(This special issue belongs to the Section Environmental Metabolomics)

Diet, Gut Microbiota and Metabolic Health

edited by

Hui Han

and

Jing Wang

submission deadline 17 Nov 2025 | 1 articles | Viewed by 1072 | Submission Open

Keywords: diet; nutrition; gut microbiota; metabolites; metabolism

(This special issue belongs to the Section Animal Metabolism)

Neurometabolics in a Nutshell

edited by

Justyna Paprocka

submission deadline 20 Nov 2025 | Viewed by 177 | Submission Open

Keywords: neurometabolic disorders; rare diseases; diagnosis; differential diagnosis; treatment options

(This special issue belongs to the Section Cell Metabolism)

Effects of Various Exercise Methods on Metabolic Health

edited by

Hun-Young Park

and Won-Sang Jung

submission deadline 28 Nov 2025 | 3 articles | Viewed by 3297 | Submission Open

Keywords: exercise physiology; metabolism; insulin sensitivity; energy expenditure; cardiovascular health; resistance training; high-intensity interval training; hypoxia; mitochondrial function; metabolic syndrome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

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