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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Obesity and Metabolic Health

edited by

Natalia Ferreira Mendes

and

Eliana Pereira De Araújo

submission deadline 30 Jul 2025 | 4 articles | Viewed by 6201 | Submission Open

Keywords: glial cells; blood– brain barrier; gut microbiota; immune surveillance; glucose metabolism; energy me-tabolism; food intake; brown adipose tissue; leptin; insulin resistance; bioactive compounds; epige-netics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Energy Metabolism in Neurodegenerative Diseases

edited by

Marta Tomczyk

and

Magdalena Podlacha

submission deadline 30 Jul 2025 | 2 articles | Viewed by 4657 | Submission Open

Keywords: energy metabolism; neurodegeneration; neurodegenerative disease; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; amyotrophic lateral sclerosis; spinal muscular atrophy; Lewy body disease; multiple sclerosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Bioactive Food Ingredients in Prevention and Alleviation of Metabolic Diseases

edited by

Marcelo Macedo Rogero

and

Marco Antonio Hernández-Lepe

submission deadline 30 Jul 2025 | 2 articles | Viewed by 3359 | Submission Open

Keywords: metabolism; diseases; bioactive compounds; food; metabolites

(This special issue belongs to the Section Nutrition and Metabolism)

Advancements in Reproductive Medicine: Unlocking the Secrets of the Ovary and Sperm for Fertility and Beyond

edited by

Konstantinos Dafopoulos

and

Efthalia Moustakli

submission deadline 30 Jul 2025 | 1 articles | Viewed by 2206 | Submission Open

Keywords: oocytes; sperm; fertility; biomarkers; omics; metabolism; PCOS; oxidative stress; reproductive aging; metabolic interventions; assisted reproductive technologies (ART)

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Bioactive Metabolites from Natural Sources (2nd Edition)

edited by

Miroslava Zhiponova

and Zhenya P. Yordanova

submission deadline 31 Jul 2025 | 4 articles | Viewed by 10744 | Submission Open

Keywords: primary metabolites; secondary metabolites; nature-based synthetic molecules; molecular mechanisms; models; evolution; food; agriculture; health; in vitro biological activities; in vivo biological activities

(This special issue belongs to the Section Plant Metabolism)

Lipid Metabolism in Age-Related Diseases

edited by

Simona Fenizia

Elettra Barberis

and

Marcello Manfredi

submission deadline 31 Jul 2025 | 4 articles | Viewed by 3769 | Submission Open

Keywords: lipid metabolism; metabolic diseases; high-throughput mass spectrometry-based lipidomics; aging; lipid biomarkers; precision medicine

(This special issue belongs to the Section Lipid Metabolism)

Integration of Emerging Technologies in Metabolite Analysis

edited by Kumari Ubhayasekera

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3111 | Submission Open

Keywords: liquid chromatography; mass spectrometry; NMR; metabolomics; smaller molecules; supercritical chromatography; gas chromatography

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolomics and Computational Research on Drugs and Diseases

edited by

Md. Altaf-Ul-Amin

Shigehiko Kanaya

, Naoaki Ono and

Ahmad Kamal Nasution

submission deadline 31 Jul 2025 | 2 articles | Viewed by 2719 | Submission Open

Keywords: metabolomics; natural products; computational research; drug discovery; disease diagnosis; disease mechanisms; machine learning algorithms

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Metabolomics Techniques in Nutrition and Pharmacy Research

edited by

Blake Rushing

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1803 | Submission Open

Keywords: metabolomics; precision nutrition; precision medicine; nutritional biomarkers; pharmacometabolomics; mass spectrometry; metabolic pathways; omics integration; diet– drug interactions; personalized therapeutics

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Responses to Abiotic Stress in Plants: Latest Advances and Prospects

edited by

Ghulam Hasnain

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1488 | Submission Open

Keywords: abiotic stress; plant metabolism; compatible solutes; antioxidant systems; energy metabolism; lipid metabolism; osmotic stress; drought stress; heat stress; salinity stress; heavy metal stress; crop productivity; stress tolerance; gene expression; proteomics; metabolomics; signaling pathways; transcription factors; reactive oxygen species

(This special issue belongs to the Section Plant Metabolism)

Cell Death and Cancer Metabolism

edited by

Zhengrong Yuan

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1371 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; tumor growth; metabolic biomarkers; therapeutic strategies; metabolic regulation; cancer treatment

(This special issue belongs to the Section Cell Metabolism)

Metabolism in Kidney Disease

edited by

Vincenzo Calabrese

Elisa Longhitano

and

Domenico Santoro

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1189 | Submission Open

Keywords: biomarkers; CKD; dialysis; electrolytes; metabolism; inflammation; survey

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Immunometabolism and Lung Fibrosis

edited by

Chao He

, Jennifer Larson-Casey and Hongli Liu

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1031 | Submission Open

Keywords: lung fibrosis; metabolism; mitochondria; fatty acid oxidation; innate immunity; adaptive immunity

(This special issue belongs to the Section Cell Metabolism)

Primary Hyperparathyroidism: Mechanisms and Treatment

edited by Elena Castellano and

Federica Saponaro

submission deadline 31 Jul 2025 | 1 articles | Viewed by 691 | Submission Open

Keywords: primary pyperparathyroidism; mechanism; metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Programming of Hepatic Organ Function—2nd Edition

edited by

Philipp Kasper

submission deadline 31 Jul 2025 | Viewed by 333 | Submission Open

Keywords: metabolism; liver; early life environment; developmental programming; epigenetics; metabolic syndrome; obesity; metabolic-dysfunction-associated fatty liver disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Microalgae Bioactive Compounds with Therapeutical Properties

edited by Miguel Martín-Pérez and

Sergio Balzano

submission deadline 31 Jul 2025 | Viewed by 300 | Submission Open

Keywords: microalgae; bioactive compounds; therapeutical properties; cancer; neurodegenerative diseases

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Toxicometabolomics for Metabotyping and Novel Mechanisms

edited by

Chi Chen

and Qingqing Mao

submission deadline 31 Jul 2025 | Viewed by 234 | Submission Open

Keywords: toxicometabolomics; metabolite markers; xenobiotic metabolism; endogenous metabolism; microbial metabolism; metabolic activation; metabolic detoxification

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Nutritional Metabolism and Metabolome in Plants

edited by

Chuanying Fang

and Kang Li

submission deadline 31 Jul 2025 | Viewed by 140 | Submission Open

Keywords: nutritional metabolism; metabolomic; plant growth; development; and stress responses; metabolism-environmental factor interactions; genetic and molecular mechanisms; applications of plant metabolites

(This special issue belongs to the Section Plant Metabolism)

Metabolic Syndrome in Polycystic Ovary Syndrome

edited by Sebastiao Freitas De Medeiros and

Alice S. Ryan

submission deadline 31 Jul 2025 | Viewed by 131 | Submission Open

Keywords: cardiovascular disease; dyslipidemia; hyperandrogenism; hyperinsulinemia; hypertension; metabolic syndrome; polycystic ovary syndrome; visceral obesity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Research on Biomarkers for Cardiometabolic Risk in Metabolic Syndrome

edited by Antoaneta Trifonova Gateva and Yavor Sashov Assyov

submission deadline 4 Aug 2025 | 3 articles | Viewed by 3416 | Submission Open

Keywords: metabolic syndrome; vascular complications; biomarkers; carbohydrate disturbances; diabetes; pre-diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

NMR-Based Metabolomics in Biomedicine and Food Science

edited by

Gaia Meoni

and

Alessia Vignoli

submission deadline 11 Aug 2025 | Viewed by 195 | Submission Open

Keywords: metabolomics; NMR; biomedicine; food; fingerprinting; profiling; AI; ML

(This special issue belongs to the Section Metabolomic Profiling Technology)

The Multifaceted Roles of Biomarkers in Metabolic Disorders: From Diagnosis and Monitoring to Prediction, Management, and Treatment

edited by

Prince Dadson

and

Miikka-Juhani Honka

submission deadline 15 Aug 2025 | 5 articles | Viewed by 4171 | Submission Open

Keywords: metabolism; dysmetabolism; tissue-specific metabolism; cardiometabolic disorders; nutritional dis-orders; functional biomarkers; metabolomics profiling; multi-omics data integration; biochemical pathways; personalized medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Investigation of the Metabolic Mechanisms Underlying Breast Cancer: Navigating from Diagnosis to Survivorship

edited by Hongjin Li

submission deadline 15 Aug 2025 | 2 articles | Viewed by 2981 | Submission Open

Keywords: breast cancer; metabolomics; biomarker; diagnosis; tumor; survivorship; treatment; data analysis

(This special issue belongs to the Section Advances in Metabolomics)

Biostatistics and Bioinformatics in Metabolomics Research: From Study Design and Analytics to Clinical Insights and Public Health Implications

edited by Marinella Temprosa

submission deadline 15 Aug 2025 | 1 articles | Viewed by 1064 | Submission Open

Keywords: biostatistics; bioinformatics; metabolomics; data preprocessing in metabolomics; feature selection in high-dimensional data; statistical pathway analysis; multi-omics integration; predictive modeling

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Effects of Stress on Animal Metabolism

edited by

Krystyna Pierzchala-Koziec

and Colin Scanes

submission deadline 18 Aug 2025 | 3 articles | Viewed by 1714 | Submission Open

Keywords: stressors; ACTH; glucocorticoids; mineralocorticoids; opioids; glycemia; growth; development; lactation; pregnancy

(This special issue belongs to the Section Animal Metabolism)

Effects of Nutrition and Exercise on Cardiometabolic Health

edited by

Sam Emerson

submission deadline 18 Aug 2025 | Viewed by 250 | Submission Open

Keywords: cardiovascular health; metabolic health; diet; nutrition; exercise; physical activity; body composition; obesity; metabolites; metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Machine Learning in Metabolomics: Unlocking the Future of Data Analysis

edited by

Boryana Petrova

and Arzu Tugce Guler

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1619 | Submission Open

Keywords: metabolomics; MS imaging; machine learning; AI; multi-omics; integration; biomarker discovery; compound annotation; spectra interpretation

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Bioactive Metabolites from Plants

edited by

Luis Francisco Salomé-Abarca

and

Dejan Godjevac

submission deadline 25 Aug 2025 | 2 articles | Viewed by 1989 | Submission Open

Keywords: metabolites; bioactivity; identification; quantification; metabolomics; nutraceuticals; antibiosis; antixenosis; medicinal

(This special issue belongs to the Section Plant Metabolism)

Bioactive Plant Extracts: Phytochemical Characterization, Isolation and Biological Evaluation

edited by

Sergio Ortiz

submission deadline 25 Aug 2025 | Viewed by 211 | Submission Open

Keywords: extraction; metabolomics; phytochemical dereplication; isolation of plant metabolites; biological evaluation

(This special issue belongs to the Section Plant Metabolism)

Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment

edited by

Susumu Muroya

submission deadline 30 Aug 2025 | 6 articles | Viewed by 13306 | Submission Open

Keywords: skeletal muscle; metabolomics; mitochondria; energy metabolism; lipid metabolism; nutrition; feeding; environment; exercise; stress

(This special issue belongs to the Section Animal Metabolism)

Mechanism of Metabolic Diseases

edited by

Dipsikha Biswas

and Logan Slade

submission deadline 30 Aug 2025 | Viewed by 803 | Submission Open

Keywords: metabolic diseases; nutrient signaling; metabolite profiling; genetic regulation; metabolomics; proteomics; organ crosstalk

(This special issue belongs to the Section Cell Metabolism)

Targeting Microbiota and Metabolites for Prevention and Treatment of Human Diseases

edited by

Zhipeng Tao

and

Danhui Wang

submission deadline 31 Aug 2025 | 8 articles | Viewed by 13623 | Submission Open

Keywords: microbiota; metabolites; metabolic diseases; cancer; cardiovascular diseases; liver diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Diabetes and Metabolic Diseases: From Prevention to Clinical Management

edited by

Davide Masi

and

Renata Risi

submission deadline 31 Aug 2025 | 6 articles | Viewed by 12508 | Submission Open

Keywords: obesity; nutritional ketosis; dietary manipulations; therapeutic inertia; type 2 diabetes; gut microbiome; incretins; hormone regulation

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Brain Metabolic Alterations in Neurodegenerative Diseases

edited by Luciene Bruno Vieira and Fabíola Mara Ribeiro

submission deadline 31 Aug 2025 | 2 articles | Viewed by 8991 | Submission Open

Keywords: glucose metabolism; mitochondrial dysfunction; neuroinflammation; neurodegeneration

(This special issue belongs to the Section Nutrition and Metabolism)

Drug Metabolism and New Drug Development for Cancers

edited by

Anna Jelińska

and

Szymon Tomczak

submission deadline 31 Aug 2025 | 4 articles | Viewed by 8289 | Submission Open

Keywords: cancer; new drug development; metabolites; secondary plant metabolites; drug delivery; nanoformulation; anticancer treatment

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Emerging Applications of Metabolomics in Fermented Food

edited by

Eiichiro Fukusaki

, Akira Oikawa,

Yasuyo Sekiyama

and Kazuhiro Iwashita

submission deadline 31 Aug 2025 | 3 articles | Viewed by 7350 | Submission Open

Keywords: food metabolomics; fermented food; fermentation; fermentation microorganisms; flavor; food secondary function; sensory evaluation; health-promoting function; food ternary function; nutrition

(This special issue belongs to the Section Food Metabolomics)

Nutrition, Metabolism and Physiology in Aquatic Animals

edited by

Renlei Ji

and Xueshan Li

submission deadline 31 Aug 2025 | 4 articles | Viewed by 6368 | Submission Open

Keywords: nutrition; metabolism; physiology; metabolism; aquaculture; metabolome; nutrients; hazardous materials

(This special issue belongs to the Section Nutrition and Metabolism)

Insights into the Metabolic Absorption of Bioactive Peptides Derived from Food Sources

edited by

Boqun Liu

submission deadline 31 Aug 2025 | 2 articles | Viewed by 5270 | Submission Open

Keywords: peptide; absorption; metabolism; structure– function relationships; metabolic pathways

(This special issue belongs to the Section Nutrition and Metabolism)

Secondary Metabolites and Their Activities: From the Identification to the Biological Investigation

edited by Valeria Cavalloro and

Emanuela Martino

submission deadline 31 Aug 2025 | 5 articles | Viewed by 4952 | Submission Open

Keywords: active metabolites; green extraction; bioactivity; natural products; structural elucidation

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Neuronutrition: Metabolomic Insights and Perspectives

edited by

Abraham Wall Medrano

and Rocío Campos Vega

submission deadline 31 Aug 2025 | 1 articles | Viewed by 4286 | Submission Open

Keywords: neuronutrition; neurological disorders; nutrition; functional foods; nutraceutical; nutrition physiology; nutriomics

(This special issue belongs to the Section Nutrition and Metabolism)

Recent Developments and Emerging Trends in Metabolic Modelling and Metabolomics

edited by Johnjoe McFadden and

Khushboo Borah Slater

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4084 | Submission Open

Keywords: constraint-based modelling; genome scale models; metabolic flux analysis; metabolomics; infectious disease

(This special issue belongs to the Section Advances in Metabolomics)

Advances in Food Metabolomics for Functional Food Development and Analysis

edited by

Amanda J. Lloyd

and

MJ Pilar Martinez-Martin

submission deadline 31 Aug 2025 | 3 articles | Viewed by 1923 | Submission Open

Keywords: natural food fortification; functional foods; bioactive compounds; nutraceuticals; food biofortification; food analysis; nutritional enhancement; food testing; metabolomics

(This special issue belongs to the Section Food Metabolomics)

Plant-Derived Molecules in Prevention of Metabolic and Oxidative Stress-Related Diseases

edited by Hicham Harnafi

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1863 | Submission Open

Keywords: lipid metabolism; oxidative stress; inflammation; metabolic diseases; cardiometabolic health; plant-derived molecules

(This special issue belongs to the Section Nutrition and Metabolism)

The Molecular Cargo of Extracellular Vesicles: A Key to Understanding Their Biological Role

edited by

Elisabetta Chiaradia

and

Sandra Buratta

submission deadline 31 Aug 2025 | 1 articles | Viewed by 960 | Submission Open

Keywords: extracellular vesicles (EVs); intercellular communication; molecular cargo; proteins in EVs; lipids in EVs; metabolites in EVs; nucleic acids in EVs; horizontal gene transfer; bioactive molecules in EVs

(This special issue belongs to the Section Cell Metabolism)

New Insights into Microalgae Metabolism

edited by Wei Ding and

Yongteng Zhao

submission deadline 31 Aug 2025 | 1 articles | Viewed by 934 | Submission Open

Keywords: microalgae metabolism; carbon fixation; lipids; high-value compounds; synthetic biology; stress responses

(This special issue belongs to the Section Food Metabolomics)

Metabolomic Insights: Interplay Between Metabolism and Immune Response in Cancer

edited by

Dimitra Rafailia Bakaloudi

submission deadline 31 Aug 2025 | Viewed by 479 | Submission Open

Keywords: metabolites; metabolism; cancer; immune response; immunotherapy; immunometabolism

(This special issue belongs to the Section Cell Metabolism)

New Trends in Drug Pharmacokinetics and Metabolism Research

edited by

Rongjin Sun

and Steven C. Laizure

submission deadline 31 Aug 2025 | Viewed by 370 | Submission Open

Keywords: local bioavailable drug; drug– herb interactions; machine learning; advanced modeling techniques; gut microbiome; in vitro to in vivo extrapolation; monoclonal antibodies; peptides; oligonucleotides

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Insulin Clearance and Metabolic Dysregulation in Health and Disease

edited by

Morvarid Kabir

and Richard N. Bergman

submission deadline 31 Aug 2025 | Viewed by 261 | Submission Open

Keywords: insulin clearance; insulin resistance; type 2 diabetes; obesity; hyperinsulinemia; metabolic dysfunction

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Modulators in Cardiovascular Disease Management

edited by

Syed Siraj A. Quadri

submission deadline 31 Aug 2025 | Viewed by 242 | Submission Open

Keywords: metabolic modulators; cardiovascular therapeutics; mitochondrial function; cardiometabolic disorders; energy metabolism; metabolic syndrome; therapeutic targets; heart failure; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Food Science and Nutrition Using GC-MS

edited by

Ryota Mabuchi

Genya Okada

and

Yonghuan Yun

submission deadline 31 Aug 2025 | Viewed by 234 | Submission Open

Keywords: GC-MS; metabolome analysis; metabolic profiling; foodomics; nutritional metabolomics; dietary bi-omarkers; food quality; primary metabolites; lipidomics; odor and/or aroma components

(This special issue belongs to the Section Food Metabolomics)

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