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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Challenges and Perspectives in Liver Transplantation

edited by Bogdan Dorobanţu,

Umberto Cillo

and Waldo Concepcion

submission deadline 20 Dec 2025 | 1 articles | Viewed by 491 | Submission Open

Keywords: liver transplantation; liver surgery; liver cirrhosis; liver disease; alcoholic and non-alcoholic steatohepatitis; cholangiocarcinoma; hepatocellular carcinoma; auxiliary liver transplantation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Maternal–Fetal Medicine: Current Status, Challenges, and Future Directions

edited by Jessian Munoz

submission deadline 20 Dec 2025 | Viewed by 375 | Submission Open

Keywords: maternal– fetal medicine; preterm delivery; preterm birth management; newborn; obstetrics; high-risk pregnancy; perinatal outcome; placenta accreta; fetal surgery

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Management of Bladder Cancer

edited by

Antonio Franco

, Antonio Cicione and

Francesco Ditonno

submission deadline 20 Dec 2025 | 1 articles | Viewed by 351 | Submission Open

Keywords: bladder cancer; minimally invasive surgery; immunotherapy; targeted therapy; biomarkers; imaging techniques; muscle invasive bladder cancer; non-muscle-invasive bladder cancer

(This special issue belongs to the Section Nephrology & Urology)

Novel Diagnostic and Therapeutic Strategies in Vitreoretinal Disease

edited by Jerzy Mackiewicz and

Mateusz Winiarczyk

submission deadline 20 Dec 2025 | Viewed by 278 | Submission Open

Keywords: retinal detachment; vitreoretinal diseases; PPV; vitrectomy; macular edema; uveitis; AMD; retinal imaging; retinal pathology; diabetic retinopathy; optical coherent tomography; OCT

(This special issue belongs to the Section Ophthalmology)

Innovative Treatment and Management Strategies for Inflammatory Bowel Disease

edited by Syed Adeel Hassan and

Neeraj Kapur

submission deadline 20 Dec 2025 | Viewed by 238 | Submission Open

Keywords: Crohn’ s disease; ulcerative colitis; efficacy; safety; nutrition; surgery; biomarkers

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Diagnosis and Treatment of Urological Cancers

edited by Davide Campobasso,

Stefano Puliatti

and

Daniele Amparore

submission deadline 20 Dec 2025 | Viewed by 216 | Submission Open

Keywords: prostate cancer; kidney cancer; urothelial carcinoma; testis cancer; mini-invasive surgery; precision surgery; target therapy; immunotherapy; nuclear medicine; artificial intelligence; augmented reality; biomarkers; prognostic factors and models; focal therapy; radiotherapy; imaging; genetics

(This special issue belongs to the Section Nephrology & Urology)

Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights

edited by

Shinichi Watanabe

Nobuto Nakanishi

and

Yuki Iida

submission deadline 20 Dec 2025 | Viewed by 210 | Submission Open

Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors

(This special issue belongs to the Section Clinical Rehabilitation)

Transformative Research in Hydrocephalus: Clinical Advances

edited by Afroditi D. Lalou, Zofia Helena Czosnyka and Marek Czosnyka

submission deadline 20 Dec 2025 | Viewed by 207 | Submission Open

Keywords: cerebrospinal fluid dynamics; CSF shunt; intracranial pressure monitoring; telemetric ICP; hydrocephalus pathophysiology; neuroimaging; paediatric hydrocephalus; adult hydrocephalus; translational neuroscience

(This special issue belongs to the Section Clinical Neurology)

Antithrombotic Therapies for Acute Coronary Syndrome and Atrial Fibrillation

edited by

Mojca Božič Mijovski

submission deadline 20 Dec 2025 | Viewed by 168 | Submission Open

Keywords: atrial fibrillation; acute coronary syndrome; antiplatelet agents; anticoagulants; thrombolysis; direct coagulation factor inhibitors; medical laboratory technology

(This special issue belongs to the Section Cardiology)

Anesthesia and Intensive Care in Orthopedic and Trauma Surgery

edited by Liliana Mirea, Răzvan Ene and Cristian Cobilinschi

submission deadline 20 Dec 2025 | Viewed by 148 | Submission Open

Keywords: opioid sparing analgetic technique; pain management; perioperative medicine; perioperative cognitive disfunction; delirium

(This special issue belongs to the Section Intensive Care)

New Clinical Advances in Breast Reconstruction

edited by

Nobuyuki Mitsukawa

submission deadline 20 Dec 2025 | Viewed by 107 | Submission Open

Keywords: breast reconstruction; autologous (flap) reconstruction; implant-based reconstruction; microsurgery and perforator flaps; robotic surgery/endoscopic surgery; fat grafting (lipofilling); patient-reported outcomes; reconstructive surgical innovation

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Risk Factors in Neonatal Intensive Care

edited by

Gabriela C. Zaharie

and

Melinda Matyas

submission deadline 20 Dec 2025 | Viewed by 89 | Submission Open

Keywords: neonatal intensive care; infant birth; preterm; neonatal resuscitation; neonatal outcome; growth restriction; prenatal diagnosis; severe maternal pathology and its effects on a newborn; therapeutical hypothermia; parenteral nutrition; neonatal infection; retinopathy of prematurity

(This special issue belongs to the Section Clinical Pediatrics)

Key Challenges in Heart Transplantation and Their Solutions

edited by Elizabeth J. Maynes

submission deadline 20 Dec 2025 | Viewed by 88 | Submission Open

Keywords: heart transplantation; heart failure; cardiac surgery; minimally invasive techniques; general surgery; heart diseases

(This special issue belongs to the Section Cardiology)

Current and Emerging Treatment Options in Intestinal and Stomach Neoplasms

edited by

Ioannis Konstantinidis

submission deadline 20 Dec 2025 | Viewed by 79 | Submission Open

Keywords: colorectal cancer; colon cancer; gastric carcinoma; malignancy; gastroenterology; endoscopic techniques; therapeutic advancements; intestinal neoplasms

(This special issue belongs to the Section Oncology)

New Perspectives in Maternal–Fetal Medicine

edited by Catalina de Paco-Matallana

submission deadline 20 Dec 2025 | Viewed by 78 | Submission Open

Keywords: maternal– fetal medicine; prenatal diagnostics; fetal therapy; precision medicine; neonatal outcomes; maternal health

(This special issue belongs to the Section Obstetrics & Gynecology)

Neurological Rehabilitation: Repair Mechanisms, Plasticity, and Connectomes

edited by Thomas Mokrusch and Frank Kirchhoff

submission deadline 20 Dec 2025 | Viewed by 75 | Submission Open

Keywords: neurorehabilitation; therapeutic approaches; repair mechanism; plasticity; neurology

(This special issue belongs to the Section Clinical Neurology)

Surgical Oncology: Clinical Application of Translational Medicine

edited by Domenico Parmeggiani

submission deadline 20 Dec 2025 | Viewed by 67 | Submission Open

Keywords: surgical oncology; drug safety; adverse events; nanovesicles; targeted drug delivery; cancer biomarkers; precision oncology; tumor microenvironment; nanomedicine; personalized medicine; diagnostics; prognosis; innovative therapies; translational research

(This special issue belongs to the Section Oncology)

Elevating Standards in Anesthesia Monitoring

edited by

Marco Cascella

submission deadline 20 Dec 2025 | Viewed by 67 | Submission Open

Keywords: monitoring; analgesia; pain; nociception; awareness anesthesia; postoperative delirium; closed-loop anes-thesia; artificial intelligence

(This special issue belongs to the Section Anesthesiology)

Status, Application and Future Directions of Artificial Urinary Sphincters

edited by JiSung Shim

submission deadline 20 Dec 2025 | Viewed by 64 | Submission Open

Keywords: ISD; robot surgery; neurogenic SUI; female AUS; complication; erosion; urethroplasty; malfunction; PPI; BOO

(This special issue belongs to the Section Nephrology & Urology)

The Treatment of BPO with Minimal Invasive Approach

edited by

Lukas Lusuardi

submission deadline 20 Dec 2025 | Viewed by 63 | Submission Open

Keywords: benign prostatic obstruction (BPO); prostatectomy; non-muscle invasive bladder cancer; muscle invasive bladder cancer; robotic surgery

(This special issue belongs to the Section Nephrology & Urology)

Clinical Research and Insights in Endometriosis

edited by

Nikolaos Machairiotis

submission deadline 20 Dec 2025 | Viewed by 61 | Submission Open

Keywords: endometriosis; pelvic pain; infertility; inflammation; minimal access surgery; laparoscopy; hysteroscopy; robotics

(This special issue belongs to the Section Obstetrics & Gynecology)

Cardiovascular Imaging: Diagnosis and Therapeutic Guidance in Clinical Practice

edited by

Stefano Figliozzi

submission deadline 20 Dec 2025 | Viewed by 60 | Submission Open

Keywords: cardiovascular magnetic resonance; cardiac imaging; T1 and T2 mapping; myocardial tissue characterization; late gadolinium enhancement; ischemic heart disease; cardiomyopathies; valvular heart disease; therapeutic guidance; precision medicine; mitral valve prolapse

(This special issue belongs to the Section Cardiology)

New Insights in Maxillofacial Surgery

edited by

Izumi Asahina

submission deadline 20 Dec 2025 | Viewed by 60 | Submission Open

Keywords: maxillofacial surgery; surgical techniques; imaging technologies; biomaterials; regenerative medicine

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Lung Transplantation and Interventional Pulmonology

edited by Anupam Kumar and Frye Laura

submission deadline 20 Dec 2025 | Viewed by 58 | Submission Open

Keywords: lung transplantation; interventional pulmonology; immunosuppressive therapies; organ rejection; pulmonary rehabilitation; surgical innovations; post-transplant complications; diagnostic advancements; donor lung shortage; thoracic surgery

(This special issue belongs to the Section Respiratory Medicine)

Clinical Perspectives of Vascular and Endovascular Surgeries

edited by

Adrian Vasile Muresan

Emil Marian Arbănași

and

Eliza Russu

submission deadline 20 Dec 2025 | Viewed by 58 | Submission Open

Keywords: vascular surgery; varicose veins; abdominal aortic aneurysms; carotid disease; peripheral arterial disease

(This special issue belongs to the Section Vascular Medicine)

Recent Developments in Urinary Incontinence

edited by

Michael Samarinas

submission deadline 20 Dec 2025 | Viewed by 58 | Submission Open

Keywords: urinary incontinence; overactive bladder; stress urinary incontinence; pelvic floor dysfunction; urodynamics; minimally invasive treatment; neuromodulation; regenerative medicine; conservative management; digital health in urology

(This special issue belongs to the Section Nephrology & Urology)

Parkinson's Disease: Recent Advances in Diagnosis and Treatment

edited by

Mariachiara Sensi

and

Fabiana Colucci

submission deadline 20 Dec 2025 | Viewed by 53 | Submission Open

Keywords: Parkinson’ s disease; disease-modifying therapies; artificial intelligence; microbiome; alpha-synuclein; neuroimaging

(This special issue belongs to the Section Clinical Neurology)

Advanced Technologies, Concepts, and Topics in Modern Neurosurgery

edited by

Samer Zawy Alsofy

and Ralf Stroop

submission deadline 20 Dec 2025 | Viewed by 51 | Submission Open

Keywords: modern neurosurgery; virtual reality; augmented reality; intraoperative imaging; neuronavigation; artificial intelligence; machine learning; robotic surgery; 3D printing; neurovascular interventions; neuro-oncology; skull base surgery; functional neurosurgery; spinal neurosurgery; surgical innovation; image-guided surgery; personalized neurosurgical planning

(This special issue belongs to the Section General Surgery)

Applications of Artificial Intelligence in Cardiology: New Tools to Transform Care

edited by

Constantinos Bakogiannis

submission deadline 20 Dec 2025 | Viewed by 49 | Submission Open

Keywords: artificial intelligence in cardiology; machine learning; deep learning; AI-driven ECG analysis; cardiovas-cular imaging and AI; predictive analytics in cardiology; mHealth and wearables; clinical decision support systems; ethics and AI in healthcare; digital health and remote monitoring

(This special issue belongs to the Section Cardiology)

Hospital-Acquired Infections: Insights, Prevention, and Control Strategies

edited by

Andrea Fabbri

submission deadline 20 Dec 2025 | Viewed by 44 | Submission Open

Keywords: healthcare-acquired infections; bloodstream infections; hospital‐acquired pneumonia; intestinal infections; clostridium difficile; surgical site infections; urinary tract infections; emergency department

(This special issue belongs to the Section Epidemiology & Public Health)

Laparoscopy and Surgery in Gynecologic Oncology: 2nd Edition

edited by Zoltan Novak

submission deadline 20 Dec 2025 | Viewed by 41 | Submission Open

Keywords: gynecologic cancers; ovarian; uterine; cervical; laparoscopy; diagnosis; staging; treatment; palliative care; fertility preservation

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Clinical Management of Temporomandibular Joint Diseases

edited by

João Luiz Monteiro

submission deadline 20 Dec 2025 | Viewed by 39 | Submission Open

Keywords: minimally invasive surgical procedure; artificial intelligence; temporomandibular joint disorders; temporomandibular disorders; temporomandibular joint

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Current Perspectives and Innovations in Urogynecology

edited by Stavros Athanasiou

submission deadline 20 Dec 2025 | Viewed by 38 | Submission Open

Keywords: urogynecology; pelvic organ prolapse; urinary incontinence; overactive bladder; pelvic floor surgery; reconstructive surgery; minimally invasive surgery; pelvic floor disorders; innovative surgical techniques; quality of life

(This special issue belongs to the Section Obstetrics & Gynecology)

Gastric Cancer: Epidemiology, Clinical Management and Emerging Biomarkers

edited by

Akira Tsuburaya

and

Takashi Oshima

submission deadline 20 Dec 2025 | Viewed by 37 | Submission Open

Keywords: gastric cancer; metabolism; biomarkers; surgical stress; adjuvant therapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advanced Image-Enhanced Endoscopy and Colonoscopy

edited by

Giuseppinella Melita

Marcello F. Maida

and Simona Di Caro

submission deadline 20 Dec 2025 | Viewed by 33 | Submission Open

Keywords: gastrointestinal endoscopy; colorectal cancer; endoscopic screening; artificial intelligence; chromoendoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Innovations in Preeclampsia

edited by Jeffrey M. Denney and

Liliya Yamaleyeva

submission deadline 22 Dec 2025 | 3 articles | Viewed by 4716 | Submission Open

Keywords: preeclampsia; pathophysiology; renin; SFlt-1; PlGF; hypertensive disorders of pregnancy; imitators of preeclampsia; vascular reactivity

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances of Adolescent Idiopathic Scoliosis: Current Status and Prospects

edited by Maria Chiara Maccarone and

Stefano Masiero

submission deadline 22 Dec 2025 | 2 articles | Viewed by 1499 | Submission Open

Keywords: adolescent idiopathic scoliosis; treatment; non-invasive therapies; surgery; neurophisiology; imaging; motion analysis; personalized medicine

(This special issue belongs to the Section Orthopedics)

Scoliosis: Advances in Diagnosis and Management

edited by Michal Latalski

submission deadline 22 Dec 2025 | Viewed by 160 | Submission Open

Keywords: scoliosis; adolescent idiopathic scoliosis; adult scoliosis; congenital scoliosis; neuromuscular scoliosis; diagnosis; imaging; treatment; surgery; bracing; rehabilitation; patient-reported outcomes; quality of life

(This special issue belongs to the Section Orthopedics)

Oral Surgery: Recent Advances and Future Perspectives

edited by

Carlo Barausse

and

Gerardo Pellegrino

submission deadline 22 Dec 2025 | Viewed by 94 | Submission Open

Keywords: oral surgery; implant dentistry; atrophic jaws; bone regeneration; digital dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Innovative Aspects in Dental Implantology and Related Clinical Research (Second Edition)

edited by

Carlo Barausse

and

Gerardo Pellegrino

submission deadline 22 Dec 2025 | Viewed by 68 | Submission Open

Keywords: dental implants; implantology; bone regeneration; implant-supported prosthesis; zygomatic implants; reconstructive surgery; pre-implant surgery; short implants

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Ablation, Embolization, and Stenting: Current Trends in Interventional Radiology

edited by Praveen Peddu

submission deadline 22 Dec 2025 | Viewed by 46 | Submission Open

Keywords: interventional radiology; ablation; embolization; stenting; minimally invasive therapy

(This special issue belongs to the Section Nuclear Medicine & Radiology)

New Advances in Stereotactic Radiosurgery

edited by Shafak S. Aluwini

submission deadline 24 Dec 2025 | Viewed by 69 | Submission Open

Keywords: stereotactic radiosurgery; clinical outcomes; brachytherapy; IMRT; brain metastases; arteriovenous malformations; functional disorders; radiosurgery

(This special issue belongs to the Section Oncology)

Sports Injury: Clinical Prevention and Treatment

edited by

Carlos Lago-Fuentes

, Susana Pulgar and

Nuno Leite

submission deadline 25 Dec 2025 | 3 articles | Viewed by 6831 | Submission Open

Keywords: injury prevention; team sports; talent identification; biobanding; injury burden; muscle injury; PHV

(This special issue belongs to the Section Sports Medicine)

Skin Diseases: From Diagnosis to Treatment

edited by

Anna Colagrande

submission deadline 25 Dec 2025 | 4 articles | Viewed by 6768 | Submission Open

Keywords: skin; melanoma; NMSC; CTCL; mesenchymal

(This special issue belongs to the Section Dermatology)

Technological Advances, Innovative Applications, and New Clinical Benefits of Computed Tomography

edited by

Massimo Venturini

and

Federico Fontana

submission deadline 25 Dec 2025 | 3 articles | Viewed by 6380 | Submission Open

Keywords: computed tomography (CT); spectral CT; dual-energy CT; dual-source spectral CT; dual-layer spectral CT; pho-ton-counting CT; photon-counting detector CT; spectral photon-counting CT; artificial intelligence; radiomics

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Pathogenesis, Diagnosis, and Management of Upper Gastrointestinal Disease

edited by

Hidekazu Suzuki

submission deadline 25 Dec 2025 | 3 articles | Viewed by 6170 | Submission Open

Keywords: esophagus; stomach; duodenum; DGBI; FGIDs; Helicobacter; eosinophilic esophagitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Epidemiology in Chronic Kidney Disease

edited by

Vincenzo Antonio Panuccio

and Claudia Torino

submission deadline 25 Dec 2025 | 6 articles | Viewed by 5582 | Submission Open

Keywords: chronic kidney disease; end-stage kidney disease; dialysis; hypertension; renal disease; clinical nephrology; chronic renal failure

(This special issue belongs to the Section Nephrology & Urology)

Anterior Cruciate Ligament (ACL): Innovations in Clinical Management

edited by Xaver Feichtinger,

Thomas Hoffelner

and Georg Brandl

submission deadline 25 Dec 2025 | 4 articles | Viewed by 4297 | Submission Open

Keywords: ACL; graft choice; ACL repair; ALL; tibial slope

(This special issue belongs to the Section Orthopedics)

Innovations in Maxillofacial Surgery

edited by

Carlos Navarro-Cuéllar

José Luis Cebríán-Carretero

and Ignacio Navarro Cuéllar

submission deadline 25 Dec 2025 | 4 articles | Viewed by 2550 | Submission Open

Keywords: orthognathic surgery; sleep apnea; 3D technologies; regenerative medicine; reconstructive surgery; facial trauma; minimally invasive surgery; oncology

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Recent Advances in Inflammatory and Infectious Skin Diseases (Second Edition)

edited by

Giulia Ciccarese

, Astrid Herzum and Paolo Romita

submission deadline 25 Dec 2025 | 3 articles | Viewed by 2409 | Submission Open

Keywords: atopic dermatitis; eczematous diseases; inflammatory skin diseases; chronic skin diseases; human herpesvirus; roseola syphilitica; psoriasis

(This special issue belongs to the Section Dermatology)

Displaying special issue 1001-1050 on page 21 of 28.

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