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Journal of Clinical Medicine, Volume 14, Issue 15

August-1 2025 - 435 articles

Cover Story: Acute respiratory distress syndrome (ARDS) is characterized by hypoxemic respiratory failure and bilateral pulmonary infiltrates not fully explained by cardiac failure or hypervolemia but linked to alveolo-capillary barrier dysfunction, dysregulated inflammation, immune abnormalities, and responses to mechanical stimuli. Nearly 60 years after its first description, effective treatments remain largely supportive, and mortality is high—possibly due to distinct ARDS subphenotypes. This heterogeneity spans physiological and clinical features, etiology, timing, inflammatory status, biomarkers, and genetic factors. Improving the identification and characterization of discrete subphenotypes using clinical, biological, physiological, and radiographic criteria may enhance understanding of ARDS pathophysiology and enable more personalized therapeutic strategies. View this paper
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Articles (435)

  • Article
  • Open Access
1,130 Views
19 Pages

Biomarkers of Inflammation and Radiographic Progression in Axial Spondyloarthritis: A Clinical Evaluation of Leptin, Adiponectin, TNF-α, and IL-17A

  • Alexandra-Diana Diaconu,
  • Laurențiu Șorodoc,
  • Cristina Pomîrleanu,
  • Liliana Georgeta Foia,
  • Victorița Șorodoc,
  • Cătălina Lionte,
  • Mara Russu,
  • Vladia Lăpuște,
  • Larisa Ghemiș and
  • Codrina Ancuța

7 August 2025

Background/Objectives: Axial spondyloarthritis (axSpA) is a chronic immune-mediated inflammatory disorder affecting the spine and sacroiliac joints, with variable clinical expression. This study assessed serum levels of inflammatory (TNF-α, IL-...

  • Article
  • Open Access
1 Citations
861 Views
11 Pages

Impact of Transcatheter Edge-to-Edge Repair on Tricuspid Annular Remodeling in Patients with Tricuspid Regurgitation

  • Maddalena Widmann,
  • Roberto Nerla,
  • Fausto Castriota,
  • Andrea Fisicaro,
  • Valeria Maria De Luca,
  • Gabriele Pesarini,
  • Flavio Luciano Ribichini and
  • Angelo Squeri

7 August 2025

Background: In recent years, multiple transcatheter devices have been developed for tricuspid valve intervention. The aim of this study was to evaluate acute tricuspid annular remodeling following percutaneous leaflet repair using a leaflet approxima...

  • Article
  • Open Access
649 Views
16 Pages

7 August 2025

Background/Objectives: Achieving renal access is a key step in percutaneous nephrolithotomy (PNL), with transpapillary access considered the safest anatomical approach. This prospective pilot study aimed to compare the effectiveness of freehand ultra...

  • Article
  • Open Access
1,467 Views
18 Pages

Steady Quiet Asthma Without Biologics: One-Year Outcomes of Single-Inhaler Triple Therapy for Severe Asthma with Small Airway Dysfunction

  • Vitaliano Nicola Quaranta,
  • Francesca Montagnolo,
  • Andrea Portacci,
  • Silvano Dragonieri,
  • Maria Granito,
  • Gennaro Rociola,
  • Santina Ferrulli,
  • Leonardo Maselli and
  • Giovanna Elisiana Carpagnano

7 August 2025

Background: Small airway dysfunction (SAD) plays a critical role in the management of severe asthma, particularly in patients at risk of requiring biological therapies (BTs). Short-term studies have shown that switching to single-inhaler triple thera...

  • Review
  • Open Access
1 Citations
2,444 Views
17 Pages

Interdisciplinary Perspectives on Dentistry and Sleep Medicine: A Narrative Review of Sleep Apnea and Oral Health

  • Ramona Cioboata,
  • Mara Amalia Balteanu,
  • Denisa Maria Mitroi,
  • Oana Maria Catana,
  • Maria-Loredana Tieranu,
  • Silviu Gabriel Vlasceanu,
  • Eugen Nicolae Tieranu,
  • Viorel Biciusca and
  • Adina Andreea Mirea

7 August 2025

Obstructive sleep apnea syndrome (OSAS) is a prevalent disorder with significant systemic and oral health consequences. This narrative review synthesizes the current knowledge on the interplay between dental health and sleep apnea, highlighting the e...

  • Article
  • Open Access
750 Views
12 Pages

7 August 2025

Background: Chemical eye burns are a serious ophthalmic emergency that can lead to permanent vision loss in severe cases. This study aims to evaluate structural changes in the posterior segment of the eye in individuals who have experienced chemical...

  • Review
  • Open Access
3 Citations
1,192 Views
14 Pages

Atrial Fibrillation and Cancer: Pathophysiological Mechanism and Clinical Implications

  • Alfredo Mauriello,
  • Adriana Correra,
  • Vincenzo Quagliariello,
  • Martina Iovine,
  • Pierpaolo Di Micco,
  • Egidio Imbalzano,
  • Francesco Giallauria,
  • Antonio Giordano,
  • Vincenzo Russo and
  • Antonello D’Andrea
  • + 1 author

7 August 2025

Atrial fibrillation is the most frequent arrhythmia in elderly subjects. Cancer currently represents one of the most important causes of mortality and morbidity in the world. Often, the two pathologies coexist. Several pathophysiological mechanisms c...

  • Article
  • Open Access
1 Citations
1,471 Views
19 Pages

Does the Timing of Response Impact the Outcome of Relapsed/Refractory Acute Myeloid Leukemia Treated with Venetoclax in Combination with Hypomethylating Agents? A Proof of Concept from a Monocentric Observational Study

  • Ermelinda Longo,
  • Fanny Erika Palumbo,
  • Andrea Duminuco,
  • Laura Longo,
  • Daniela Cristina Vitale,
  • Serena Brancati,
  • Cinzia Maugeri,
  • Marina Silvia Parisi,
  • Giuseppe Alberto Palumbo and
  • Giovanni Luca Romano
  • + 4 authors

7 August 2025

Background: Relapsed/refractory acute myeloid leukemia (R/R AML) remains a therapeutic challenge due to disease heterogeneity, resistance mechanisms, and poor tolerability to intensive regimens. Venetoclax (VEN), a BCL-2 inhibitor, has shown promise...

  • Review
  • Open Access
1 Citations
2,771 Views
13 Pages

Integrating Peripheral Nerve Blocks in Multiple Trauma Care: Current Evidence and Clinical Challenges

  • Liliana Mirea,
  • Ana-Maria Dumitriu,
  • Cristian Cobilinschi,
  • Răzvan Ene and
  • Raluca Ungureanu

7 August 2025

Pain management in multiple trauma patients presents a complex clinical challenge due to competing priorities such as hemodynamic instability, polypharmacy, coagulopathy, and the urgency of life-saving interventions. In this context, peripheral nerve...

  • Article
  • Open Access
951 Views
9 Pages

Do All Fractures in the Ankylotic Spine Really Require Surgical Intervention?

  • Moshe Stavsky,
  • Elad Harats,
  • Ahmad Sharabati,
  • Amjad Hamad,
  • Harel Arzi,
  • Bilal Qutteineh and
  • Yair Barzilay

7 August 2025

Background: Patients with ankylotic spines suffering from vertebral column fractures are frequently operated on to maintain spinal stability and prevent secondary displacement and nerve damage. The aim of this study was to identify a subset of patien...

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J. Clin. Med. - ISSN 2077-0383