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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Diagnosis and Treatment of Skin Cancer submission deadline 25 Oct 2026 | 5 articles | Viewed by 7217 | Submission Open
Keywords: skin cancer; melanoma; keratinocyte carcinoma; basal cell carcinoma; squamous cell carcinoma; biomarkers; immuno-therapy; prognosis
(This special issue belongs to the Section Oncology)
Endoscopic Diagnosis and Treatments of Gastrointestinal Diseases
edited by Madalina Ilie and Mihai Ciocîrlan
submission deadline 25 Oct 2026 | 5 articles | Viewed by 5369 | Submission Open
Keywords: esogastric lesions; pancreatic diseases; colorectal lesions; hepatobiliary diseases; optical endoscopy; endoscopic ultrasound; upper and lower endoscopy; endoscopic retrograde cholangiopancreatography
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Endometriosis and Endometrial Cancer: Challenge and Clinical Management
edited by , Tomasz Kluz and Bernhard Krämer
submission deadline 25 Oct 2026 | 2 articles | Viewed by 4556 | Submission Open
Keywords: endometriosis; endometrial cancer; non-invasive diagnosis; molecular profiling; surgical techniques; medical treatment; alternative therapies
(This special issue belongs to the Section Obstetrics & Gynecology)
Emerging Surgical Techniques in the Management of Urological Diseases
edited by
submission deadline 25 Oct 2026 | 3 articles | Viewed by 4441 | Submission Open
Keywords: minimally invasive; robotics; partial nephrectomy; radical prostatectomy; focal therapy; benign prostatic hyperplasia; prostate cancer; bladder cancer
(This special issue belongs to the Section Nephrology & Urology)
New Advances in Cleft Lip and Palate and Facial Plastic Surgery
edited by , Wolfgang Zemann and Rainer Lutz
submission deadline 25 Oct 2026 | 3 articles | Viewed by 4360 | Submission Open
Keywords: cleft lip repair; rhinoplasty; secondary rhinoplasty; cleft rhinoplasty; facial plastic surgery; nasolabial area; upper lid surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Clinical Management of Knee Arthroplasty
edited by
submission deadline 25 Oct 2026 | 4 articles | Viewed by 3533 | Submission Open
Keywords: knee surgery; knee arthroplasty; knee joint replacement; osteoarthritis; knee arthritis
(This special issue belongs to the Section Orthopedics)
New Advances in the Management of Voice Disorders: 2nd Edition submission deadline 25 Oct 2026 | 3 articles | Viewed by 3385 | Submission Open
Keywords: voice disorders; laryngology; laryngoscope; acoustic analysis; dysphonia; voice surgery; diagnosis; treatment; rehabilitation; vocal folds; voice assessment/measures
(This special issue belongs to the Section Otolaryngology)
New Clinical Advances in Psoriasis and Psoriatic Arthritis: 2nd Edition
edited by and Alessandra Narcisi
submission deadline 25 Oct 2026 | 3 articles | Viewed by 3022 | Submission Open
Keywords: psoriasis; psoriatic arthritis; inflammatory skin disease; inflammatory autoimmune disease; immunotherapy; autoimmunity; comorbidities; therapeutic; diagnosis; treatment; management; biologics
(This special issue belongs to the Section Dermatology)
New Concepts in Minimally Invasive Spine Surgery
edited by and Michael Y. Wang
submission deadline 25 Oct 2026 | 3 articles | Viewed by 2509 | Submission Open
Keywords: minimally invasive spine surgery; image navigation; tubular retractor; endoscopic spine surgery; virtual and aug-mented reality; lateral spine surgery
(This special issue belongs to the Section Clinical Neurology)
Sarcoma—Clinical Updates: 2nd Edition
edited by
submission deadline 25 Oct 2026 | 2 articles | Viewed by 2354 | Submission Open
Keywords: sarcoma; osteosarcoma; ewing’ s sarcoma; chondrosarcoma; soft-tissue sarcoma; undifferentiated pleo-morphic sarcoma; liposarcoma; leiomyosarcoma; rhabdomyosarcoma; metastatic sarcoma; targeted molecular therapy; immunotherapy; orthopedic oncology
(This special issue belongs to the Section Oncology)
Diabetic Retinopathy Screening: Current Advances and Future Options submission deadline 25 Oct 2026 | 2 articles | Viewed by 2335 | Submission Open
Keywords: diabetic retinopathy; diabetic retinopathy screening; retinal imaging; age-related macular degeneration; artificial intelli-gence; image analysis; color fundus photography; optical coherence tomography imaging; telemedicine
(This special issue belongs to the Section Ophthalmology)
Recent Advances in Pulmonary Embolism and Thrombosis: 2nd Edition
edited by and Elena Campello
submission deadline 25 Oct 2026 | 2 articles | Viewed by 2120 | Submission Open
Keywords: pulmonary embolism; embolism and thrombosis; thrombus aspiration for pulmonary embolism; deep vein thrombosis; venous thromboembolism
(This special issue belongs to the Section Respiratory Medicine)
Insight into Infectious Disease Epidemiology and Public Health
edited by and Filomena Pietrantonio
submission deadline 25 Oct 2026 | 1 articles | Viewed by 1442 | Submission Open
Keywords: gender medicine; health management; public health; infectious disease; sindemics
(This special issue belongs to the Section Infectious Diseases)
Antithrombotic Therapy in Special and Overlooked Populations with Cardiovascular Diseases
edited by
submission deadline 25 Oct 2026 | 1 articles | Viewed by 989 | Submission Open
Keywords: antithrombotic therapy; high-risk patients; PCI; bleeding risk; atrial fibrillation; individualized treatment; real-world evidence; complex cardiovascular disease
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Oculoplastic Surgery: From Eyelid Reconstruction to Innovative Techniques
edited by Argyrios Tzamalis
submission deadline 25 Oct 2026 | 1 articles | Viewed by 947 | Submission Open
Keywords: oculoplastic surgery; eyelid reconstruction; orbital surgery; novel minimally invasive; image guided
Skin Cancers: Update on Clinical Treatment and Management
edited by Nazzaro Gianluca
submission deadline 25 Oct 2026 | 1 articles | Viewed by 936 | Submission Open
Keywords: basal cell carcinoma; squamous cell carcinoma; melanoma; skin cancers; dermoscopy; ultrasonography; immunotherapy; biomarker; prevention; diagnosis; treatment; innovative treatments; prognosis
(This special issue belongs to the Section Dermatology)
Hematologic Malignancies: Treatment Strategies and Future Challenges: 2nd Edition
edited by Masaaki Noguchi
submission deadline 25 Oct 2026 | 1 articles | Viewed by 894 | Submission Open
Keywords: hematologic malignancies; relapse; refractory; drug resistance; therapeutic strategies; new target; biomarkers; new insights
(This special issue belongs to the Section Hematology)
Controversies in Hidradenitis Suppurativa: Bridging Gaps in Science and Practice
edited by Hadar Lev-Tov and Tammy González
submission deadline 25 Oct 2026 | 1 articles | Viewed by 683 | Submission Open
Keywords: hidradenitis suppurativa (HS); inflammatory skin disorder; controversies; treatment strategies; science and practice
(This special issue belongs to the Section Dermatology)
Clinical Epidemiology in Chronic Kidney Disease: 2nd Edition
edited by and Claudia Torino
submission deadline 25 Oct 2026 | 1 articles | Viewed by 656 | Submission Open
Keywords: chronic kidney disease; end-stage kidney disease; dialysis; hypertension; renal disease; clinical nephrology; chronic renal failure
(This special issue belongs to the Section Nephrology & Urology)
Advances in the Clinical Management of Urological Cancers
edited by Athanasios Kostakopoulos and
submission deadline 25 Oct 2026 | 1 articles | Viewed by 503 | Submission Open
Keywords: urological cancers; prostate cancer; urothelial cancer; kidney cancer; advances in diagnosis; advances in treatment
(This special issue belongs to the Section Nephrology & Urology)
Orthopedic Approaches to Acute Trauma: Insights and Strategies in Trauma Care submission deadline 25 Oct 2026 | Viewed by 381 | Submission Open
Keywords: acute trauma; orthopedic surgery; fractures and dislocations; ligament injuries; cartilage lesions; post-traumatic degeneration; emergency trauma care; surgical and non-surgical management; rehabilitation strategies; musculo-skeletal injury outcomes
(This special issue belongs to the Section Orthopedics)
New Developments in the Management of Adenocarcinomas of the Esophago-Gastric Junction (AEG)
edited by
submission deadline 25 Oct 2026 | Viewed by 306 | Submission Open
Keywords: AEG; diagnostic; surgery; chemotherapy; immunotherapy; robotic; esophageal
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Complex Scenarios in Reverse Shoulder Arthroplasty: Bone Loss, Revisions, and Surgical Solutions
edited by Francesco Franceschi, Angelo Baldari and Antonio Caldaria
submission deadline 25 Oct 2026 | Viewed by 254 | Submission Open
Keywords: shoulder arthroplasty; revision shoulder arthroplasty; humeral fracture; failed shoulder prosthesis; bone loss management; implant failure
(This special issue belongs to the Section Orthopedics)
New Perspectives on Diagnosis, Prognosis and Treatment of Tricuspid Regurgitation According to Etiology
edited by Sergio Moral
submission deadline 25 Oct 2026 | Viewed by 220 | Submission Open
Keywords: tricuspid regurgitation; transcatheter tricuspid intervention; 3D echocardiography; cardiac magnetic resonance; valve repair techniques
(This special issue belongs to the Section Cardiology)
Thyroidectomy: Navigating New Technologies and Clinical Challenges
edited by
submission deadline 25 Oct 2026 | Viewed by 215 | Submission Open
Keywords: energy-based devices (EBDs); intraoperative neuromonitoring (IONM); enhanced recovery after surgery (ERAS); postoperative hypocalcemia & complications; minimally invasive & robotic thyroidectomy; thyroid thermal ablation; treatment de-escalation & active surveillance; precision thyroid surgery
(This special issue belongs to the Section General Surgery)
New Advances in Optic Nerve Diseases: 2nd Edition
edited by
submission deadline 25 Oct 2026 | Viewed by 186 | Submission Open
Keywords: optic nerve diseases; glaucoma; optic neuritis; ischemic optic; neuropathy; hereditary optic neuropathy; optical coherence tomography (OCT); neuroprotection; clinical management; multimodal imaging; targeted therapy; AI-assisted diagnosis; immunomodulation; genetic diagnosis; nerve regeneration
(This special issue belongs to the Section Ophthalmology)
Clinical Update in Bone and Soft Tissue Sarcomas
edited by and Niket Todi
submission deadline 25 Oct 2026 | Viewed by 175 | Submission Open
Keywords: sarcoma; musculoskeletal tumors; bone sarcoma; soft-tissue sarcoma; musculoskeletal oncology; orthopaedic on-cology; targeted molecular therapy; immunotherapy; metastatic sarcoma; chondrosarcoma; osteosarcoma
(This special issue belongs to the Section Oncology)
Thyroid Cancer: Diagnosis, Treatment, and Management submission deadline 25 Oct 2026 | Viewed by 162 | Submission Open
Keywords: thyroid cancer; advanced thyroid cancer; molecular diagnostics; risk stratification; radioiodine treatment; targeted therapy; tyrosine kinase inhibitors; short- and long-term follow-up
(This special issue belongs to the Section Endocrinology & Metabolism)
Advances in Coronary Disease and Heart Valve Disease
edited by Jagadeesh K. Kalavakunta, Tim Alexander Fischell and Vishal Gupta
submission deadline 25 Oct 2026 | Viewed by 161 | Submission Open
Keywords: coronary artery disease; ischemic heart disease; acute coronary syndromes; percutaneous coronary intervention; complex coronary intervention; coronary physiology; fractional flow reserve; intravascular imaging; IVUS; OCT; coronary ct angiography; plaque characterization; mechanical circulatory support; cardiogenic shock; antithrombotic therapy; dual antiplatelet therapy; lipid management; atherosclerosis; preventive cardiology; microvascular disease; chronic total occlusion; bifurcation lesions; left main disease; structural heart disease; valvular heart disease; aortic stenosis; mitral regurgitation; tricuspid regurgitation; pulmonic valve disease; transcatheter aortic valve replacement; TAVR; transcatheter edge-to-edge repair; TEER; transcatheter mitral valve repair; transcatheter mitral valve replacement; TMVR; valve-in-valve; valve durability; multimodality imaging; echocardiography; cardiac CT; cardiac MRI; heart team; outcomes research; quality improvement; cardiovascular devices; interventional cardiology; structural interventions; patient selection; risk stratification
(This special issue belongs to the Section Cardiology)
Artificial Intelligence in Immuno-Allergic Diseases: New Perspectives for Diagnosis, Therapy, and Clinical Practice
edited by , Pierpaolo Palumbo and
submission deadline 25 Oct 2026 | Viewed by 147 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; allergy; environmental monitoring; immunology; biomarkers; precision medicine; computational immunology; digital twins
(This special issue belongs to the Section Immunology & Rheumatology)
Contemporary Advances in Diagnosis and Therapeutic Management of Head and Neck Cancer
edited by Federico Bolognesi, and
submission deadline 25 Oct 2026 | Viewed by 145 | Submission Open
Keywords: head and neck cancer; oral cavity squamous cell carcinoma; diagnosis; surgery; complications; neck dissection; microsurgical reconstruction; facial paralysis; radiotherapy; immunotherapy; prognostic factors; oncologic outcomes
(This special issue belongs to the Section Oncology)
Clinical Practice of Death by Neurologic Criteria and Brain Death
edited by
submission deadline 25 Oct 2026 | Viewed by 139 | Submission Open
Keywords: brain death; DNC; traumatic brain injury; death by neurologic criteria; critical care
(This special issue belongs to the Section Clinical Neurology)
Next-Generation Abdominal Surgery: Personalized, Minimally Invasive, and Data-Driven Care submission deadline 25 Oct 2026 | Viewed by 134 | Submission Open
Keywords: abdominal surgery; minimally invasive surgery; laparoscopy; robotic surgery; precision surgery; artificial intelli-gence; machine learning; surgical imaging; fluorescence-guided surgery (ICG); image-guided navigation; enhanced recovery after surgery (ERAS); prehabilitation; postoperative complications; risk stratification; outcomes research
(This special issue belongs to the Section General Surgery)
Obstructive Sleep Apnea: Latest Advances and Prospects—2nd Edition submission deadline 25 Oct 2026 | Viewed by 134 | Submission Open
Keywords: obstructive sleep apnea; sleep medicine; myofunctional therapy; sleep surgery; neurostimulation; personalized treatment; biomarkers; adherence; home sleep testing
(This special issue belongs to the Section Otolaryngology)
Clinical New Insights into Cardiac Electrophysiology submission deadline 25 Oct 2026 | Viewed by 131 | Submission Open
Keywords: cardiac electrophysiology; arrhythmias; atrial fibrillation; cardiac mapping; novel electrophysiological diagnostics; remote monitoring
(This special issue belongs to the Section Cardiology)
Acute Coronary Syndromes: From Diagnosis to Treatment (2nd Edition)
edited by and Christos Eftychiou
submission deadline 25 Oct 2026 | Viewed by 129 | Submission Open
Keywords: acute coronary syndrome; diagnosis; biomarkers; interventional cardiology; imaging; pharmacotherapy; patient management; health systems; special populations; clinical trials
(This special issue belongs to the Section Cardiology)
Plasma Cell Dyscrasias in the Clinic: Refining Screening, Diagnosis, and Laboratory Monitoring
edited by Gurmukh Singh
submission deadline 25 Oct 2026 | Viewed by 113 | Submission Open
Keywords: multiple myeloma; monoclonal gammopathies; plasma cell neoplastic disorders; hematology; hematological malignant tumors
(This special issue belongs to the Section Clinical Laboratory Medicine)
Emerging Trends and Innovative Strategies in Lumbar Spine Surgery
edited by
submission deadline 26 Oct 2026 | Viewed by 183 | Submission Open
Keywords: lumbar spine surgery; minimally invasive spine surgery (MISS); spinal instrumentation and fusion; robotic-assisted surgery; navigation in spine surgery; interbody fusion techniques; perioperative management; surgical outcomes and complications; degenerative disc disease; spinal stenosis
(This special issue belongs to the Section Orthopedics)
Sports Cardiology: Current Status and Future Challenges
edited by Giuseppe Di Gioia
submission deadline 27 Oct 2026 | 1 articles | Viewed by 920 | Submission Open
Keywords: sports cardiology; athlete’s heart; cardiac remodeling; sudden cardiac death prevention; advanced cardiac imaging; cardiopulmonary exercise testing (CPET); myocardial and atrial strain; arrhythmia risk stratification; wearable technologies and digital health; precision medicine in sports
(This special issue belongs to the Section Cardiology)
New Insights into Head and Neck Surgery—2nd Edition submission deadline 28 Oct 2026 | 3 articles | Viewed by 4532 | Submission Open
Keywords: otorhinolaryngology; head and neck surgery; ear surgery; sinonasal surgery; skull base surgery; salivary gland surgery; thyroid gland surgery; head and neck cancer surgery
(This special issue belongs to the Section General Surgery)
Clinical Novel Research in the Management of Cardiac Arrest
edited by Giovanni Babini and
submission deadline 28 Oct 2026 | Viewed by 977 | Submission Open
Keywords: cardiac arrest; post-cardiac arrest syndrome; resuscitation; temperature control; target temperature management; neuroprotection; neuroprognostication; defibrillation; extracorporeal life support
(This special issue belongs to the Section Cardiology)
Clinical Advances in Cardiovascular Interventions: Second Edition
edited by
submission deadline 28 Oct 2026 | Viewed by 177 | Submission Open
Keywords: coronary artery disease; myocardial infarction; cardiovascular imaging; microvascular disease; heart failure; atrial fibrillation; ventricular arrhythmias; cardiac implantable electronic device; valvular heart disease and treatment; peripheral arterial disease
(This special issue belongs to the Section Cardiology)
Preoperative Optimization in Cardiac Surgery
edited by
submission deadline 30 Oct 2026 | 3 articles | Viewed by 5237 | Submission Open
Keywords: preoperative optimization; cardiac surgery; risk assessment; comorbid conditions; multidisciplinary collaboration; perioperative risks; cardiovascular evaluation
(This special issue belongs to the Section Cardiology)
Advances in Cardiovascular Computed Tomography (CT)
edited by
submission deadline 30 Oct 2026 | 4 articles | Viewed by 3062 | Submission Open
Keywords: computed tomography angiography; cardiovascular imaging; contrast media; spectral computed tomography; quantitative imaging; coronary artery disease; aortic disease; pulmonary embolism; structural heart disease
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Management for Anesthesia Critical Care
edited by Gianluca Zani
submission deadline 30 Oct 2026 | 2 articles | Viewed by 1214 | Submission Open
Keywords: anesthesia; critical care medicine; clinical management; critically ill patients; organ failure; organ dysfunction; per-sonalized therapy; outcome; technical skills; non-technical skills
(This special issue belongs to the Section Anesthesiology)
Therapeutic Strategies for Obesity-Metabolic Syndrome-Diabetes Continuum
edited by Jana Makuc and
submission deadline 30 Oct 2026 | Viewed by 199 | Submission Open
Keywords: obesity; metabolic syndrome; type 2 diabetes mellitus; multi-receptor agonists; adipose tissue dysfunction; metabolic surgery; chrononutrition; gut-metabolism axis; metabolic phenotyping; MASLD
(This special issue belongs to the Section Endocrinology & Metabolism)
Innovations in Geriatric Care: Managing Chronic Diseases and Emerging Challenges in an Aging World
edited by and Gianluigi Cuomo
submission deadline 31 Oct 2026 | 1 articles | Viewed by 837 | Submission Open
Keywords: geriatric; frailty; integrated care; digital health; rehabilitation; comprehensive geriatric assessment; functional capacity
(This special issue belongs to the Section Geriatric Medicine)
New Insights in Diagnosis, Symptomatology, and Therapy in Schizophrenia and Schizoaffective Disorders
edited by Felix-Martin Werner and Arturo Mangas
submission deadline 31 Oct 2026 | Viewed by 179 | Submission Open
Keywords: schizophrenia; schizoaffective disorder; paranoia; acoustic hallucinations; positive schizophrenia symptoms; negative schizophrenia symptoms; second-generation antipsychotic drugs; risperidone; clozapine; cariprazine; xanomeline combined with trospium
(This special issue belongs to the Section Mental Health)
Personalized Medicine in Dermatology: Current Status and Challenges submission deadline 31 Oct 2026 | Viewed by 138 | Submission Open
Keywords: psoriasis; quality of life; acne; hidradenitis suppurativa; biotechnological therapies; personalized medicine; autoimmune skin diseases
(This special issue belongs to the Section Dermatology)
The Hidden Threat: Nonobstructive Coronary Artery Disease in Cardiovascular Health
edited by
submission deadline 31 Oct 2026 | Viewed by 122 | Submission Open
Keywords: non-obstructive coronary artery disease; coronary microvascular dysfunction; endothelial dysfunction; vasospastic angina; ischemic heart disease
(This special issue belongs to the Section Cardiovascular Medicine)
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