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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Advances in Scleral Lenses: New Insights in Lens Fitting and Customization
edited by and
submission deadline 27 Jan 2026 | Viewed by 94 | Submission Open
Keywords: scleral lenses; scleral lens customization; higher-order aberrations; scleral lens optics; corneoscleral profilometry; keratoconus; ocular surface diseases; dry eye; wavefront-guided correction
(This special issue belongs to the Section Ophthalmology)
Heart Valve Surgery: Recent Trends and Future Perspective
edited by Per Nils J.F. Wierup, Johan Sjögren and Nina Hakacova
submission deadline 27 Jan 2026 | Viewed by 60 | Submission Open
Keywords: heart valve; diagnostics; surgery; echocardiography; computer simulation; prediction models
(This special issue belongs to the Section Cardiology)
Inflammatory Bowel Disease: Pathogenesis and Management Strategies
edited by
submission deadline 28 Jan 2026 | 1 articles | Viewed by 477 | Submission Open
Keywords: inflammatory bowel diseases; ulcerative colitis; Crohn’ s disease; biomarkers; risk factors; pharmacology; advanced therapy; endoscopic evaluation and procedures; extraintestinal manifestations; IBD-associated neoplasm
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Hepatitis: Prevention, Treatment, and Global Health Impact submission deadline 28 Jan 2026 | Viewed by 132 | Submission Open
Keywords: hepatitis B; hepatitis C; liver disease; direct-acting antivirals (DAAs); global health; public health policy; viral hepa-titis elimination; health disparities; cirrhosis; vaccination programs
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Evidence and Future Directions in Clostridioides difficile Infection Epidemiology, Diagnosis and Treatment submission deadline 28 Jan 2026 | Viewed by 81 | Submission Open
Keywords: Clostridioides difficile infection; infection control; contact isolation; community-acquired CDI; CDI recurrence; recurrence prevention; rCDI; host and microbiota interaction; antimicrobial treat-ment; microbiota transplant; underdiagnosis
(This special issue belongs to the Section Infectious Diseases)
Acute Myeloid Leukemia: Latest Advances in Diagnostics, Therapeutic Strategies and Clinical Management: 2nd Edition
edited by Michael D. Diamantidis
submission deadline 28 Jan 2026 | Viewed by 38 | Submission Open
Keywords: ELN; ICC and WHO 2022 AML classifications; molecular AML diagnostics; AML biology; measurable residual disease (MRD); novel targeted AML therapies; AML immunotherapies; hematopoietic stem cell transplantation (HSCT)
(This special issue belongs to the Section Hematology)
Acute Myocardial Infarction: Clinical Advances in Prognostic Stratification, Diagnosis, and Treatment submission deadline 29 Jan 2026 | 5 articles | Viewed by 4441 | Submission Open
Keywords: acute myocardial infarction (AMI); atherosclerosis; ST segment elevation myocardial infarction (STEMI); non-ST elevation myocardial infarction (NSTEMI); acute coronary syndrome (ACS); prognosis; coronary CT angiography (CCTA); cardiac magnetic resonance (CMR); reperfusion therapy; antiplatelet therapy
(This special issue belongs to the Section Cardiology)
New Advances in Cardiorenal Syndrome: 2nd Edition submission deadline 30 Jan 2026 | 4 articles | Viewed by 8749 | Submission Open
Keywords: cardiorenal syndrome; outcome; hyperkalemia; acute kidney injury; chronic kidney disease; chronic heart failure
(This special issue belongs to the Section Cardiology)
Cerebral Palsy: Clinical Rehabilitation and Treatment
edited by Joav Merrick and
submission deadline 30 Jan 2026 | 3 articles | Viewed by 5085 | Submission Open
Keywords: cerebral palsy; physiotherapy; occupational therapy; orthopedic management; medical management; rehabilitation approaches
(This special issue belongs to the Section Clinical Neurology)
Advances and Perspectives in Cancer Diagnostics and Treatment
edited by Alexandru E. Eniu, and
submission deadline 30 Jan 2026 | 3 articles | Viewed by 1388 | Submission Open
Keywords: solid tumors; new advances; diagnostics and treatment; clinical– pathological; genetic factors; AI; RWD; radiotherapy; biomarkers; prevention in cancer care; target therapy; immunotherapy
(This special issue belongs to the Section Oncology)
Clinical Updates in Bleeding and Thrombotic Disorders
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 481 | Submission Open
Keywords: autoimmune-acquired coagulation deficiency; acquired hemophilia A; disseminated intravascular coagulation; thrombotic microangiopathy; venous thromboembolism; acute coronary syndrome; clot waveform analysis; thrombin generation test; thromboelastogram
(This special issue belongs to the Section Hematology)
The Current Status and Future Directions of Pancreatoduodenectomy and Pancreatectomy
edited by , and Somaiah Aroori
submission deadline 30 Jan 2026 | 1 articles | Viewed by 469 | Submission Open
Keywords: pancreatic resection types; techniques and modifications; anastomotic techniques; open resection; minimally invasive surgery; laparoscopic resection; robotic resection; hybrid resection techniques; pancreatic resection post neoadjuvant treatment; lymphadenectomy; vascular resections; organ-sparing procedures; radicality; indications; complications
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The Optimal Hybrid Revascularization Approach for Multilevel Peripheral Arterial Disease
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 413 | Submission Open
Keywords: peripheral arterial disease; revascularization; endovascular procedure; endarterectomy; limb salvage; patency; hybrid procedures; lower extremity; stents; angioplasty
(This special issue belongs to the Section Vascular Medicine)
Mind–Body Connection: The Impact of Mental Health on Physical Well-Being
edited by
submission deadline 30 Jan 2026 | Viewed by 153 | Submission Open
Keywords: mind– body connection; mental health; well-being; metabolic balance; immune system; chronic medical conditions; body perception; self-image; eating disorders; psychosomatic disorders; psychosomatic medicine; innovative thera-peutic approaches; mindfulness; mind-wandering; integrated healthcare
(This special issue belongs to the Section Mental Health)
Insights on Cancer Diagnosis, Treatment and Side Effects Management submission deadline 30 Jan 2026 | Viewed by 104 | Submission Open
Keywords: cancer diagnosis; cancer treatment; side effects management; oncology; personalized medicine; supportive care
(This special issue belongs to the Section Oncology)
Colorectal Cancer: Early Detection, Treatment Advances and Patient Outcomes
edited by , and Federica Giordano
submission deadline 30 Jan 2026 | Viewed by 102 | Submission Open
Keywords: colorectal cancer; early detection; prevention; innovation; screening; precision medicine; biomarkers; genetic profile
(This special issue belongs to the Section Oncology)
Atrial Fibrillation and Heart Failure: Diagnostic and Therapeutic Challenges and Breakthroughs submission deadline 30 Jan 2026 | Viewed by 74 | Submission Open
Keywords: atrial fibrillation; heart failure; cardiac electrophysiology; ventricular remodelling; rhythm control; catheter abla-tion; neurohormonal activation; biomarkers; ischemia; integrated cardiovascular care
(This special issue belongs to the Section Cardiology)
Clinical Outcomes in Bipolar and Depressive Disorders
edited by and Francesco Monaco
submission deadline 30 Jan 2026 | Viewed by 64 | Submission Open
Keywords: mood disorders; clinical outcomes; treatment response; psychopathology; pathophysiology
(This special issue belongs to the Section Mental Health)
Current Advances in General and Regional Anesthesia
edited by Eleni Laou, Eleana Garini and Giolanda Varvarousi
submission deadline 30 Jan 2026 | Viewed by 45 | Submission Open
Keywords: anesthesiology; general anesthesia; regional anesthesia; pediatric anesthesia; perioperative medicine; surgery; postoperative outcome; monitoring; analgesia; safety
(This special issue belongs to the Section Anesthesiology)
Advances in Minimally Invasive Surgery: Transformative Technologies, Techniques and Trends
edited by Michail Pitiakoudis
submission deadline 30 Jan 2026 | Viewed by 41 | Submission Open
Keywords: minimally invasive surgery; laparoscopic surgery; robotic surgery; surgical innovation; hernia repair; colorectal surgery; gastrointestinal surgery; hepatopancreatobiliary surgery; surgical simulation; virtual reality; augmented reality; artificial intelligence; surgical training; patient outcomes; surgical oncology
(This special issue belongs to the Section General Surgery)
Diagnosis and Treatment of Obstetrics and Gynecology Cancers
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1150 | Submission Open
Keywords: gynecological cancers; endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; vaginal cancer; breast cancer; surgery; radio-therapy; systemic treatment; immunotherapy; sentinel lymph node biopsy; minimally invasive surgery; fertility preservation; gestational trophoblastic disease
(This special issue belongs to the Section Obstetrics & Gynecology)
Thoracic Surgery: Updates and New Trends
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 656 | Submission Open
Keywords: minimally invasive surgery; new technology; diagnosis; bronchoscopy; robotic system; artificial intelligence
(This special issue belongs to the Section Respiratory Medicine)
Clinical Management, Diagnosis and Treatment of Thoracic Diseases: 2nd Edition submission deadline 31 Jan 2026 | 1 articles | Viewed by 652 | Submission Open
Keywords: lung; thorax; pneumonia; chest; imaging; ultrasound
(This special issue belongs to the Section Respiratory Medicine)
Diagnosis and Treatment of Aortic Dissection: Experts' Views
edited by Marja K Hedman and Annastiina Husso
submission deadline 31 Jan 2026 | 1 articles | Viewed by 488 | Submission Open
Keywords: aortic diseases; aortic type A dissection; aortic growth rate; aortic length; aortic imaging
(This special issue belongs to the Section Cardiology)
Acute Coronary Syndromes: Clinical Advances in Diagnosis and Treatment
edited by Pierre Sabouret, and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 481 | Submission Open
Keywords: acute coronary syndromes; myocardial infarction; cardiac biomarkers; antiplatelet therapy; revascularization; precision medicine; risk stratification
(This special issue belongs to the Section Cardiology)
Revolutionizing Neurosurgery: Cutting-Edge Techniques and Innovations
edited by
submission deadline 31 Jan 2026 | Viewed by 224 | Submission Open
Keywords: neuroendovascular surgery; neuroimaging; neurosurgery; neuroendoscopic surgery
(This special issue belongs to the Section Clinical Neurology)
Application of Artificial Intelligence in Gastric Cancer submission deadline 31 Jan 2026 | Viewed by 128 | Submission Open
Keywords: artificial intelligence (AI); gastric cancer; AI-assisted endoscopy; radiomics; robotic surgery; gastrointestinal diseases; digital pathology; translational research; innovation in healthcare
(This special issue belongs to the Section Oncology)
Artificial Intelligence and Machine Learning in Clinical Practice
edited by Theodosis Kalamatianos and
submission deadline 31 Jan 2026 | Viewed by 114 | Submission Open
Keywords: artificial intelligence in healthcare; medical image/signal analysis; clinical decision support systems; predictive analytics; personalized medicine; explainable AI; diagnosis; prognosis
(This special issue belongs to the Section General Surgery)
Clinical Challenges and Advances in Periodontology and Oral Surgery: 2nd Edition
edited by
submission deadline 31 Jan 2026 | Viewed by 88 | Submission Open
Keywords: oral surgery; third molar; periodontitis; antibiotics; infection; pain; research; advances; complications; dental implants; bone regeneration; maxillofacial surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Pushing Boundaries in Cardiac Resynchronization Therapy: Clinical Innovations Transforming Heart Failure Management
edited by István Szokodi and
submission deadline 31 Jan 2026 | Viewed by 86 | Submission Open
Keywords: cardiac resynchronization therapy; heart failure; pacing strategies; patient selection; multi-point pacing; clinical innovations; nonresponders
(This special issue belongs to the Section Cardiology)
Innovations in Spine Care: Advancing Clinical Solutions and Emerging Technologies
edited by , , Gianluca Vadalà and Vincenzo Denaro
submission deadline 31 Jan 2026 | Viewed by 84 | Submission Open
Keywords: artificial intelligence; AI; minimally invasive spine surgery; MIS; endoscopic spine surgery; intervertebral disc regeneration; precision medicine; spine care; spine fusion; osteobiologics
(This special issue belongs to the Section Orthopedics)
Clinical Management and Update of Aortic Dissection and Aortic Aneurysm Diseases
edited by
submission deadline 31 Jan 2026 | Viewed by 84 | Submission Open
Keywords: aortic aneurysm; aortic dissection; aortic surgery; endovascular procedures
(This special issue belongs to the Section Cardiovascular Medicine)
Innovations in Interventional Cardiology: Advancing Minimally Invasive Cardiac Care submission deadline 31 Jan 2026 | Viewed by 82 | Submission Open
Keywords: TAVI; TAVR; MTEER; TTEER; TTVR; ASD; PFO; IVUS; OCT
(This special issue belongs to the Section Cardiology)
Management of Ligaments and Tendons Injuries
edited by Vivek Kumar Morya
submission deadline 31 Jan 2026 | Viewed by 69 | Submission Open
Keywords: tendinopathy; ligaments; tendons; anterior cruciate ligament (ACL); rotator cuff
(This special issue belongs to the Section Orthopedics)
Molecular Injection Therapy in Orthopedic and Musculoskeletal Disorders: Conservative Approaches and Innovative Treatments
edited by , Paolo Domenico Parchi and Andrea del Chiaro
submission deadline 31 Jan 2026 | Viewed by 67 | Submission Open
Keywords: injection therapy; conservative approaches; medical devices; collagen; polyribonucleotide; plasma-rich platelets; hyaluronic acids; anti-inflammatory therapy; tendinitis; osteoarthritis; musculoskeletal disorder; pain reduction; regenerative medicine; new clinical approaches; physiotherapy; comparative studies: surgery vs. conservative approaches
(This special issue belongs to the Section Orthopedics)
Cardiothoracic and Vascular Anesthesia—Clinical Management and Challenges
edited by Marko Zdravković and
submission deadline 31 Jan 2026 | Viewed by 57 | Submission Open
Keywords: cardiac anesthesia; thoracic anesthesia; vascular anesthesia; innovation; perioperative medicine; healthcare; outcomes; challenges
(This special issue belongs to the Section Anesthesiology)
Strategies to Optimize Efficiency of Clear Aligners and Fixed Appliances in the Digital Orthodontics Era
edited by
submission deadline 31 Jan 2026 | Viewed by 55 | Submission Open
Keywords: clear aligners; fixed orthodontic appliances; digital orthodontics; orthodontic treatment planning; tooth movement efficiency; patient-centered care; treatment modality selection
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Anesthesia and Pain Management for Women: 2nd Edition
edited by Gaetano Draisci and Stefano Catarci
submission deadline 31 Jan 2026 | Viewed by 53 | Submission Open
Keywords: anesthesia; women; gender differences; acute pain; chronic pain; hormonitoring; pain perception; fibromyalgia; migraine; monitoring; obstetrics; cesarean section; gynecologic surgery
(This special issue belongs to the Section Anesthesiology)
Skin Cancer: From Diagnosis to Personalized Treatment
edited by
submission deadline 31 Jan 2026 | Viewed by 48 | Submission Open
Keywords: immunotherapy; neoadjuvant; melanoma; cutaneous sarcoma; merkel cel tumor; risk assessment; combination therapy; surgery
(This special issue belongs to the Section Dermatology)
New Advances in Hip and Knee Reconstructive Surgery: 2nd Edition
edited by Senthil Sambandam
submission deadline 31 Jan 2026 | Viewed by 45 | Submission Open
Keywords: knee; hip; joint arthroplasty; minimally invasive surgery; revision arthroplasty; periprosthetic joint infection; muscle injury; joint alignment; surgical advances; osteotomy; fracture; robotic-assisted surgery; perioperative optimization; telerehabilitation; aseptic loosening
(This special issue belongs to the Section Orthopedics)
Update on Acute Severe Respiratory Infections: 2nd Edition submission deadline 31 Jan 2026 | Viewed by 42 | Submission Open
Keywords: acute severe respiratory infection (ASRI); acute respiratory distress syndrome (ARDS); severe pneumonia; sepsis; ICU; viral respiratory infection; COVID-19; bacterial co-infection; diagnostic technology; treatment strategy; mechanical ventilation; extracorporeal membrane oxygenation (ECMO); antibiotics; non-antibiotics; pulmonary rehabilitation
(This special issue belongs to the Section Respiratory Medicine)
Clinical Updates on Dyslipidemia
edited by
submission deadline 31 Jan 2026 | Viewed by 36 | Submission Open
Keywords: dyslipidemia; cardiovascular disease; prevention; treatment; risk factors
(This special issue belongs to the Section Cardiovascular Medicine)
Trauma Surgery: Strategies, Challenges and Vision of the Future
edited by Shai Factor and Yaniv S. Warschawski
submission deadline 31 Jan 2026 | Viewed by 32 | Submission Open
Keywords: orthopaedic surgery; fractures; injuries; upper limb; trauma
(This special issue belongs to the Section Clinical Research Methods)
Exercise, Injury and Rehabilitation: Integrated Perspectives in Sports Medicine submission deadline 3 Feb 2026 | Viewed by 134 | Submission Open
Keywords: sports medicine; biomechanics; injury prevention; exercise physiology; sports performance; load management; exercise prescription; return to play; recovery
(This special issue belongs to the Section Sports Medicine)
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) as a Global but Not Liver-Limited Health Challenge—from Disease Pathogenesis to Therapeutic Targets
edited by Beata Kasztelan-Szczerbinska and Halina Cichoż-Lach
submission deadline 5 Feb 2026 | 2 articles | Viewed by 3784 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); non-alcoholic fatty liver disease (NAFLD); hepatic steatosis; multiorgan metabolic interactions; liver-related morbidity; liver-related mortality; lipid metabolism; cardiovascular metabolic complications; metabolic dysfunction-related cancer
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Advances and Clinical Outcomes of Cardiothoracic Surgery
edited by Hee-Jung Kim and
submission deadline 5 Feb 2026 | Viewed by 54 | Submission Open
Keywords: cardiac surgery; coronary artery bypass grafting; heart valve surgery; aortic intervention; materials; precision medicine; artificial intelligence
(This special issue belongs to the Section General Surgery)
Physical Therapy in Neurorehabilitation: Innovations, Challenges and Opportunities submission deadline 6 Feb 2026 | Viewed by 38 | Submission Open
Keywords: neurorehabilitation; physical activity; neurocognitive rehabilitation; neurogenic bladder; fatigue; sexual dysfunction; accessibility
(This special issue belongs to the Section Clinical Neurology)
Current Challenges and Advancements in Lateral Skull Base Surgery
edited by Alessia Rubini
submission deadline 10 Feb 2026 | 1 articles | Viewed by 1039 | Submission Open
Keywords: lateral skull base; neurotology; jugular foramen; cerebellopontine angle; petrous apex; inner ear; acoustic neuroma; jugular paraganglioma; transtemporal approaches; infratemporal approaches
(This special issue belongs to the Section Otolaryngology)
Application of Anticoagulation and Antiplatelet Therapy submission deadline 10 Feb 2026 | Viewed by 129 | Submission Open
Keywords: antiplatelets; anticoagulants; atherothrombosis; coronary artery disease; peripheral artery disease; cerebral artery disease; vitamin K antagonists; direct oral anticoagulants; clopidogrel; aspirin; ticagrelor; prasugrel
(This special issue belongs to the Section Cardiovascular Medicine)
Plastic and Reconstructive Surgery: Cutting-Edge Expert Perspective
edited by and
submission deadline 10 Feb 2026 | Viewed by 117 | Submission Open
Keywords: plastic and reconstructive surgery; new perspectives; regeneration; microsurgery; oncoplastic; post bariatric; breast implant
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
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