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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Diagnosis and Treatment of Amyloidosis

edited by Michael Rosenzweig

submission deadline 31 Dec 2025 | 9 articles | Viewed by 14093 | Submission Open

Keywords: amyloidosis; transthyretin (TTR); autologous stem cell transplantation (ASCT); chemotherapy; immunotherapy; cardiomyopathy; nephropathy; neuropathy

(This special issue belongs to the Section Cardiology)

Interdisciplinary Approach on the Oral Cavity Management Due to Musculoskeletal Conditions

edited by Cosmin Sinescu,

Elena Amaricai

and

Virgil-Florin Duma

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11368 | Submission Open

Keywords: rehabilitation medicine; biomechanics; bruxism assessment; general medicine; dental medicine; biomedical imaging; musculoskeletal disorders; shoulder girdle; cervical region; physical therapy; therapeutic exercise; postural correction; dynamic balance; pediatric rehabilitation; sports medicine; quality of life research; general conditions with resonance in the oro-maxillo-facial sphere

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Acute Kidney Injury: Latest Advances and Prospects

edited by

Emanuele de Simone

and Kianoush Kashani

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1704 | Submission Open

Keywords: acute kidney injury (AKI); sepsis; septic shock; renal replacement therapy; intensive care; specialized interventions; biomarkers; risk factors; “ Green Practice” ; nephrology; epidemiology; multidisciplinary approach

(This special issue belongs to the Section Nephrology & Urology)

Children and Adolescent Mood Disorders: Risks and Treatment

edited by

Angelo Fraschetti

and

Emanuela Mari

submission deadline 31 Dec 2025 | Viewed by 1345 | Submission Open

Keywords: emotional dysregulation; mood disorders; adolescence; anxiety; depression; addiction; psychotherapy; pharmacological treatments; prevention programs

(This special issue belongs to the Section Mental Health)

Advances in Gastroenterology and Hepatology: Bridging Basic Science, Clinical Insights, and Translational Medicine

edited by

Abdulrahman Ismaiel

and

Ștefan Lucian Popa

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1095 | Submission Open

Keywords: hepatology; gastroenterology; IBD; IBS; MASLD; liver cirrhosis; artificial intelligence; disorders of gut– brain interaction; cancer; gut microbiota; diagnosis; management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Novel Advanced Imaging in Cardiology: Current Status and Future Directions

edited by

Moshe Rav-Acha

and

Arik Wolak

submission deadline 31 Dec 2025 | 1 articles | Viewed by 915 | Submission Open

Keywords: cardiac imaging; cardiac magnetic resonance; echocardiography; computed tomography; trans-thoracic echocardiography global longitudinal strain (GLS) analyses; radiomics

(This special issue belongs to the Section Cardiovascular Medicine)

New Trends and Challenges in Critical Care Management

edited by

Anna Wrzosek

submission deadline 31 Dec 2025 | 1 articles | Viewed by 649 | Submission Open

Keywords: critical care; intensive care; extracorporeal organ support; mechanical ventilation; personalized medicine; artificial intelligence; infections; antimicrobial resistance; COVID-19

(This special issue belongs to the Section Intensive Care)

Perioperative Management in Thoracic Surgery: Current Advances and Future Perspectives

edited by

Roberto Cascone

and

Alfonso Fiorelli

submission deadline 31 Dec 2025 | 1 articles | Viewed by 344 | Submission Open

Keywords: thoracic surgery; perioperative care; ERAS; minimally invasive surgery; interventional pulmonology; preoperative assessment; postoperative management; surgical outcomes; multidisciplinary approach; technology in surgery

(This special issue belongs to the Section Respiratory Medicine)

Evidence-Based Diagnosis and Clinical Management of Low Back Pain

edited by

William J. Hanney

and

Michael Masaracchio

submission deadline 31 Dec 2025 | Viewed by 209 | Submission Open

Keywords: low back pain; classification systems; risk stratification; health services research; management strategies; timing and sequencing; prognosis; predictor; clinical decision making; primary care

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Challenges and Advances in Dry Eye Disease and Meibomian Gland Dysfunction

edited by

Salvatore Troisi

and

Livio Vitiello

submission deadline 31 Dec 2025 | Viewed by 162 | Submission Open

Keywords: dry eye disease; ocular surface; corneal disease; conjunctival disease; ocular biomarkers; patient-centered care; advanced diagnostics; regenerative medicine; artificial intelligence; therapeutic innovations

(This special issue belongs to the Section Ophthalmology)

Oral Health and Dental Care: Current Advances and Future Options

edited by

Massimo Amato

Federica Di Spirito

and Alessia Bramanti

submission deadline 31 Dec 2025 | Viewed by 125 | Submission Open

Keywords: oral health; dental care; technologies; innovation; dental materials

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions

edited by Pietro C. Dattolo and

Aris Tsalouchos

submission deadline 31 Dec 2025 | Viewed by 118 | Submission Open

Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology

(This special issue belongs to the Section Nephrology & Urology)

Advances in Gene Therapy for Retinal Diseases

edited by Tahreem Aman Mir

submission deadline 31 Dec 2025 | Viewed by 113 | Submission Open

Keywords: gene therapy; inherited retinal degenerations; age-related macular degeneration; diabetic retinopathy

(This special issue belongs to the Section Ophthalmology)

Orthopedic Oncology Updates and Controversial Issues

edited by Yehuda Kollender and Ron Batash

submission deadline 31 Dec 2025 | Viewed by 102 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; oligometastatic; atypical behavior tumor; cryosurgery; rare diseases; surgery; radiation therapy; immunotherapy; chemotherapy

(This special issue belongs to the Section Orthopedics)

Clinical Trends in Diagnostic Radiology

edited by Wolfram Schwindt, Benjamin Noto and Anne Helfen

submission deadline 31 Dec 2025 | Viewed by 98 | Submission Open

Keywords: diagnostic imaging; radiology; nuclear medicine; hybrid imaging; artificial intelligence; radiomics; quantitative imaging; theranostics; imaging biomarkers; clinical applications

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Recent Progress and Future Directions in Orthopedic Oncology

edited by

Giuseppe Papalia

and Carmine Zoccali

submission deadline 31 Dec 2025 | Viewed by 97 | Submission Open

Keywords: orthopedic oncology; bone tumors; limb-sparing surgery; reconstruction techniques; 3D-printed implants; navigation and robotics; precision medicine in musculoskeletal oncology

(This special issue belongs to the Section Orthopedics)

Innovations in Psychosis and Schizophrenia: New Findings and Implications

edited by

Gabriele Nibbio

submission deadline 31 Dec 2025 | Viewed by 84 | Submission Open

Keywords: schizophrenia; psychosis; psychopathology; neurobiology; assessment; pharmacological treatment; psychosocial interventions

(This special issue belongs to the Section Mental Health)

Pregnancy Complications and Maternal-Perinatal Outcomes

edited by

Angelo Sirico

submission deadline 31 Dec 2025 | Viewed by 80 | Submission Open

Keywords: pregnancy; high-risk; GDM; preeclampsia; fetal growth restriction; diabetes; placenta; ultrasound

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Clinical Approaches to Breast Cancer Diagnosis and Treatment

edited by

Lorenzo Scardina

submission deadline 31 Dec 2025 | Viewed by 65 | Submission Open

Keywords: breast cancer; diagnosis; precision medicine; molecular profiling; targeted therapy; breast-conserving surgery; minimally invasive techniques; artificial intelligence; personalized medicine; radiation therapy

(This special issue belongs to the Section Oncology)

The Atrial Fibrillation–Heart Failure Interconnection: Challenges and Innovations in Diagnosis and Treatment

edited by

Roberto De Ponti

and

Michele Golino

submission deadline 31 Dec 2025 | Viewed by 65 | Submission Open

Keywords: atrial fibrillation; catheter ablation; ventricular dysfunction; myocardial remodeling; diastolic dysfunction; biomarkers; anti-arrhythmia agents; risk assessment; artificial intelligence; telemedicine

(This special issue belongs to the Section Cardiovascular Medicine)

Emerging Clinical Insights into Adolescent Behavioral Development and Mental Health

edited by

Ainzara Favini

and Anne-Marie Iselin

submission deadline 31 Dec 2025 | Viewed by 60 | Submission Open

Keywords: adolescence; behavioral development; clinical maladjustment; adolescents’ mental health; innovative clinical approach; adolescents’ emotional problems; clinical settings; innovative developmental research; adolescents’ symptoms

(This special issue belongs to the Section Mental Health)

Paradigms, Advances and Future Directions in Oral Medicine

edited by

Pia Lopez-Jornet

submission deadline 31 Dec 2025 | Viewed by 55 | Submission Open

Keywords: oral medicine; oral potentially malignant disorders; leukoplakia; oral lichen planus; orofacial pain; biopsy and liquid biopsy; biomarkers

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Optimizing Outcomes in Deep Vein Thrombosis: A Focus on Interventional Management

edited by Adam Gwozdz

submission deadline 31 Dec 2025 | Viewed by 48 | Submission Open

Keywords: deep vein thrombosis; post-thrombotic syndrome; venous patency; emerging technology; vascular surgery

(This special issue belongs to the Section Vascular Medicine)

Progress in the Multimodal Treatment of Pancreatic Disease

edited by

Gennaro Nappo

submission deadline 31 Dec 2025 | Viewed by 48 | Submission Open

Keywords: pancreatic diseases; pancreatic cancer; multimodal treatment; neoadjuvant therapy; imaging techniques; minimally invasive surgery; immunotherapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Broadening the Knowledge of Autism Spectrum Disorder in Adulthood: Advances in Diagnosis, Assessment and Treatment

edited by

Camilla Gesi

submission deadline 5 Jan 2026 | 1 articles | Viewed by 704 | Submission Open

Keywords: autism spectrum disorder; adulthood; autism; comorbidity; gender; age-adjusted

(This special issue belongs to the Section Mental Health)

Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition

edited by

Francesca Lodato

submission deadline 9 Jan 2026 | 1 articles | Viewed by 570 | Submission Open

Keywords: pancreas diseases; pancreatic tumors; biliary tract diseases and neoplams; ERCP; EUS; cholangioscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advance in Chronic Total Occlusion Percutaneous Coronary Intervention

edited by Anbukarasi Maran and Kevin Croce

submission deadline 9 Jan 2026 | Viewed by 44 | Submission Open

Keywords: chronic total occlusion (CTO); percutaneous coronary intervention (PCI); innovative techniques; guidewire technology; retrograde PCI; interventional cardiology

(This special issue belongs to the Section Cardiovascular Medicine)

New Clinical Advances in Pancreatobiliary Diseases

edited by

Kyong Joo Lee

submission deadline 9 Jan 2026 | Viewed by 30 | Submission Open

Keywords: pancreatobiliary diseases; EUS; ERCP; interventional endoscopy; targeted therapy; pancreatobiliary cancer

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Guidelines in Critical Care Medicine

edited by

Ana Vujaklija Brajković

Andrej Markota

and Daniela Bandic-Pavlovic

submission deadline 10 Jan 2026 | 3 articles | Viewed by 2848 | Submission Open

Keywords: critical illness; immunocompromised host; biomarkers; thrombocytopenia; blood coagulation disorders; multiple trauma; diagnostic imaging

(This special issue belongs to the Section Intensive Care)

From Acute Injury to Personalized Prevention—Developing Modern Strategies

edited by

Markus Gesslein

and

Eduard Kurz

submission deadline 10 Jan 2026 | Viewed by 109 | Submission Open

Keywords: orthopedics; acute injury; personalized prevention; innovative methodologies; musculoskeletal disorders; musculoskeletal injury; conservative therapy; functional testing; intervention

(This special issue belongs to the Section Orthopedics)

Advanced Physiotherapy Practice in Patients with Musculoskeletal Disorders

edited by

Filippo Maselli

and

Firas Mourad

submission deadline 10 Jan 2026 | Viewed by 42 | Submission Open

Keywords: differential diagnosis; physiotherapy; rehabilitation; multidisciplinary; effectiveness; musculoskeletal disorders; screening for referral; manual therapy; exercise; cognitive behavioral therapy; pain neuroscience

(This special issue belongs to the Section Clinical Rehabilitation)

Pelvic Organ Prolapse: Clinical Advances and Challenges

edited by

Barbara Bodner-Adler

submission deadline 10 Jan 2026 | Viewed by 19 | Submission Open

Keywords: pelvic organ prolapse; pessary treatment; uterus-preserving prolapse surgery; clinical management; clinical treatment

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Vascular and Endovascular Surgery: Second Edition

edited by

Fadi Taher

and Afshin Assadian

submission deadline 11 Jan 2026 | Viewed by 69 | Submission Open

Keywords: vascular surgery; endovascular surgery; aortic surgery; peripheral arterial disease; vascular imaging; EVAR; FEVAR; vascular access; vascular education; aneurysms

(This special issue belongs to the Section Vascular Medicine)

Physical Therapy in Neurorehabilitation

edited by

Marianna Papadopoulou

and

George K. Papadimas

submission deadline 15 Jan 2026 | 7 articles | Viewed by 11209 | Submission Open

Keywords: physical therapy; transcutaneous electrical nerve stimulation (TENS); muscle strengthening; balance exercising; pain; quality of life; neurodegenerative disorders; neuromuscular disorders; stroke; demyelinating disorders

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in the Diagnosis and Treatment of Cardiac Arrhythmias

edited by Fabrizio Guarracini and

Marisa Varrenti

submission deadline 15 Jan 2026 | 1 articles | Viewed by 579 | Submission Open

Keywords: cardiac arrhythmias; antiarrhythmic agents; pacemakers; cardiac resynchronization; catheter ablation; electrophysiology

(This special issue belongs to the Section Cardiology)

Pediatric Nephrology: Advances in the Diagnosis and Management of Pediatric Kidney Disorders

edited by

Agnieszka Rybi-Szumińska

and

Anna Maria Wasilewska

submission deadline 15 Jan 2026 | 1 articles | Viewed by 334 | Submission Open

Keywords: diagnosis; management; treatment; kidney disorders; chronic kidney disease; biomarkers; genetic testing; kidney; children; newborn

(This special issue belongs to the Section Nephrology & Urology)

Advances in Pulmonary Disease Management and Innovation in Treatment

edited by

Monica Steluța Marc

and

Florin Mihaltan

submission deadline 15 Jan 2026 | Viewed by 75 | Submission Open

Keywords: severe asthma; COPD; sleep-related breathing disorders; respiratory tract infections; innovative respiratory therapies; translational pulmonary research; pulmonary vascular disease; interstitial lung disease; eHealth in respiratory care

(This special issue belongs to the Section Respiratory Medicine)

Up-to-Date Research in Liver Transplantation

edited by

Pierluigi Toniutto

submission deadline 15 Jan 2026 | 1 articles | Viewed by 64 | Submission Open

Keywords: liver transplantation; acute or chronic liver diseases; hepatitis C virus infection; hepatocellular carcinoma (HCC); cirrhosis; intrahepatic (ICCA); perihilar (PCCA) cholangiocarcinoma; unresectable liver metastases; acute or chronic liver failure (ACLF); acute alcoholic hepatitis (AAH)

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Minimally Invasive Cardiothoracic Surgery: Current Techniques and Future Innovations

edited by

Akshay Kumar

and

Mohamed Rahouma

submission deadline 15 Jan 2026 | Viewed by 56 | Submission Open

Keywords: cardiothoracic surgery; lung cancer; cardiac imaging; minimally invasive surgery; thoracic oncology

(This special issue belongs to the Section Cardiovascular Medicine)

Recent Clinical Advances in Percutaneous Coronary Intervention

edited by

Lampson Fan

and Luke Pickup

submission deadline 15 Jan 2026 | Viewed by 51 | Submission Open

Keywords: complex PCI; calcium modification; left main stem; stent; coronary artery disease; atherectomy; mechanical circula-tory support device; Impella; DCB; intra-coronary imaging; IVUS; OCT

(This special issue belongs to the Section Cardiology)

Pulmonary Critical Care: Diagnosis and Treatment of Respiratory System Diseases

edited by Yaron Bar-Lavie

submission deadline 15 Jan 2026 | Viewed by 50 | Submission Open

Keywords: acute respiratory distress syndrome (ARDS); mechanical ventilation; chronic obstructive pulmonary disease (COPD); sepsis-induced lung injury; pulmonary fibrosis; bronchoscopy in critical care

(This special issue belongs to the Section Intensive Care)

Chronic Kidney Disease: Current Challenges and Adverse Outcomes

edited by

Diana Tania Luminița Moldovan

and Flaviu Bob

submission deadline 15 Jan 2026 | Viewed by 50 | Submission Open

Keywords: chronic kidney disease; CKD progression; hemodialysis; cardiovascular complications; vascular calcification; lifestyle; nutrition; bone and mineral disorders; CKD-associated osteoporosis; mortality

(This special issue belongs to the Section Nephrology & Urology)

Advances in Oculoplastic Surgery and Ocular Surface Diseases

edited by Michael T. Yen, Francesco Quaranta Leoni and

Balestrazzi Alessandra

submission deadline 15 Jan 2026 | Viewed by 44 | Submission Open

Keywords: ocular surface disease; corneal neurotization; neurotrophic keratopathy; eyelid malposition; facial nerve palsy; thyroid eye disease; oculoplastic surgery; hemocomponents; dry anophthalmic socket; corneal pathology; ocular surface reconstruction; exposure keratopathy

(This special issue belongs to the Section Ophthalmology)

Clinical Updates on Epilepsy Researches

edited by

Guillermo Estivill-Torrús

submission deadline 15 Jan 2026 | Viewed by 44 | Submission Open

Keywords: epilepsy; autoimmune epilepsy; neural autoantibodies; seizure disorders; experimental epilepsy models; animal studies; neuronal excitability; immunotherapy; predictive scoring systems; epilepsy biomarkers

(This special issue belongs to the Section Clinical Neurology)

Intracranial Hemorrhage: Advances in Diagnosis, Management and Treatment

edited by Hitoshi Fukuda

submission deadline 15 Jan 2026 | Viewed by 44 | Submission Open

Keywords: intracerebral hemorrhage; subarachnoid hemorrhage; traumatic hemorrhage; prehospital care; less invasive surgery; vascular malformation; antihypertensive drug; intracranial pressure elevation; decompressive craniectomy; neurocritical care; nursing care; rehabilitation

(This special issue belongs to the Section Clinical Neurology)

Insights into Acute Pancreatitis: Pathogenesis, Diagnosis, and Management

edited by Gil Nissim Bachar and Ram Dickman

submission deadline 15 Jan 2026 | Viewed by 38 | Submission Open

Keywords: acute pancreatitis; pancreatic inflammation; necrotizing pancreatitis; clinical outcomes; ultrasound examination

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Diagnosis and Management of Chronic Venous Diseases

edited by

Sigitas Urbonavičius

submission deadline 15 Jan 2026 | Viewed by 20 | Submission Open

Keywords: varicose veins; chronic venous insufficiency; pathogenesis; operative treatment; conservative treatment; profilaxis

(This special issue belongs to the Section Vascular Medicine)

Artificial Intelligence in Gastrointestinal Disorders: Current Updates from Theory to Clinical Practice

edited by

Maria Pina Dore

and

Elettra Merola

submission deadline 15 Jan 2026 | Viewed by 17 | Submission Open

Keywords: artificial intelligence; gastroenterology; medical imaging; endoscopy; prognostic modeling; ethical considerations

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Novel Sepsis and Post-Sepsis Care: The Heart and Beyond

edited by Alexander Liu and Barbara J. Philips

submission deadline 16 Jan 2026 | Viewed by 63 | Submission Open

Keywords: sepsis; post sepsis; inflammation; cardiomyopathy; heart failure; cardiac imaging; biomarkers; novel therapies; prognosis; clinical outcomes

Innovations in Plastic and Reconstructive Research

edited by Damiano Tambasco and Roberta Albanese

submission deadline 18 Jan 2026 | 3 articles | Viewed by 1990 | Submission Open

Keywords: microvascular surgery; 3D printing; regenerative medicine; aesthetic surgery; minimally invasive techniques

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Displaying special issue 1101-1150 on page 23 of 28.

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