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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Rhinosinusitis and Nasal Polyposis: From Emerging Trends and Therapeutic Opportunities to Surgery
edited by Gian Luca Fadda, Giovanni Cavallo and Giuseppe Guida
submission deadline 20 Jun 2026 | Viewed by 18 | Submission Open
Keywords: nasal polyps; chronic rhinosinusitis; asthma; endoscopic sinus surgery; anatomical variation; biologic treatment; type-2 inflammation; paranasal sinuses; CRSwNP; late response; long term; remission; dupilumab; control
(This special issue belongs to the Section Otolaryngology)
Clinical Advances and Challenges in Liver Transplantation: 3rd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 17 | Submission Open
Keywords: liver transplantation (LT); elderly donors; steatotic livers; donors after circulatory death (DCD); hepatocellular carcinoma (HCC); perioperative management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Hematoinflammatory Diseases: Bridging Autoimmunity and Autoinflammation
edited by Andrés González García and
submission deadline 20 Jun 2026 | Viewed by 16 | Submission Open
Keywords: hematoinflammatory diseases; clonal hematopoiesis; vexas syndrome; castleman disease; Igg4-related disease; cytokine storm; autoinflammatory syndromes; immunopathogenesis; targeted therapies; biomarkers
(This special issue belongs to the Section Immunology & Rheumatology)
Assisted Knee Arthroplasty: From Preoperative Planning to Postoperative Outcomes
edited by and Matteo Innocenti
submission deadline 20 Jun 2026 | Viewed by 11 | Submission Open
Keywords: assisted knee arthroplasty; robotic-assisted surgery; computer navigation; preoperative planning; patient-specific alignment; minimally invasive surgery; digital health technologies
(This special issue belongs to the Section Orthopedics)
Stroke Care: From Acute Interventions to Long-Term Recovery submission deadline 20 Jun 2026 | Viewed by 11 | Submission Open
Keywords: cerebrovascular diseases; acute ischemic stroke; intravenous thrombolysis; endovascular thrombectomy; intracerebral hemorrhage; etiology; cerebral amyloid angiopathy; stroke rehabilitation
(This special issue belongs to the Section Clinical Neurology)
Aortic Valve Replacement: Current Trends, Future Perspectives, and Emerging Technologies
edited by
submission deadline 20 Jun 2026 | Viewed by 7 | Submission Open
Keywords: aortic valve; heart valve prosthesis; transcatheter aortic valve replacement; surgical aortic valve replacement; aortic valve insufficiency; minimally invasive surgical procedures; treatment outcome; vulnerable populations
(This special issue belongs to the Section Cardiology)
The Changing Landscape of Biliary Cancers
edited by Arvind Arora
submission deadline 20 Jun 2026 | Viewed by 2 | Submission Open
Keywords: biliary tract cancer; cholangiocarcinoma; gallbladder cancer; precision oncology; molecular profiling; immunotherapy; targeted therapy; clinical trials; multidisciplinary care; early detection; global oncology
(This special issue belongs to the Section Oncology)
Clinical Research on Minimally Invasive Spine Surgery
edited by Daniel K. Fahim
submission deadline 20 Jun 2026 | Submission Open
Keywords: minimally invasive spine surgery; spine tumors; spine trauma; spine fractures; lumbar stenosis; lumbar spondylolisthesis; lumbar disc herniation; lumbar radiculopathy; thoracic disc herniations; cervical radiculopathy
(This special issue belongs to the Section Orthopedics)
Novel Insights into the Use of Artificial Intelligence in Clinical Medicine
edited by Sharon C. Kiang and Roger T. Tomihama
submission deadline 20 Jun 2026 | Submission Open
Keywords: artificial intelligence; disease predictive models; wearable technology; surgical innovation; molecular targeting; big data science; machine learning; deep learning
Endoscopic Management of Pancreaticobiliary Disease: Updates and Future Directions
edited by
submission deadline 20 Jun 2026 | Submission Open
Keywords: pancreaticobiliary disease; ERCP; interventional EUS; tissue acquisition; early detection of pancreaticobiliary malignancy; management of AEs
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances of Aesthetic Plastic Surgery and Aesthetic Medicine
edited by Valentina Pinto and Rosalba Russo
submission deadline 25 Jun 2026 | Viewed by 55 | Submission Open
Keywords: aesthetic plastic surgery; aesthetic medicine; emerging technologies and devices in aesthetics; regenerative medicine and surgery; vulvovaginal surgery; complications in aesthetic medicine
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Emerging Biomarkers and Novel Diagnostic Tools in Respiratory Diseases: From Bench to Bedside submission deadline 10 Jul 2026 | Viewed by 18 | Submission Open
Keywords: respiratory diseases; biomarkers; non-invasive approaches; novel diagnostic tests; precision medicine; personalized therapy; disease phenotyping; diagnostic tools; functional biomarkers; imaging biomarkers; molecular biomarkers
(This special issue belongs to the Section Respiratory Medicine)
Personalized Medicine: Future Perspectives on Personalized Oral and Maxillofacial Surgery
edited by , Rareș Calin Roman and Mihaela Carmen Hedeşiu
submission deadline 15 Jul 2026 | Viewed by 309 | Submission Open
Keywords: head and neck surgery; head and neck oncology; head and neck reconstructions; personalized medicine; artificial intelligence; head and neck trauma; integrative medicine
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Current Concepts in Melanoma: Innovations in Early Detection, Prognosis and Management
edited by Babar Khan Rao
submission deadline 20 Jul 2026 | Viewed by 65 | Submission Open
Keywords: melanoma; early detection; non-invasive diagnostic innovations; artificial intelligence-assisted diagnosis; melanoma management
(This special issue belongs to the Section Dermatology)
Clinical Implications of Artificial Intelligence in Patient Care
edited by and
submission deadline 20 Jul 2026 | Viewed by 1 | Submission Open
Keywords: artificial intelligence; clinical decision support; human factors; digital health; patient care; implementation science; medical informatics; trust in AI
(This special issue belongs to the Section Clinical Research Methods)
Improving Outcomes in Systemic Lupus Erythematosus: Latest Advances and Prospects in Relation to Comorbidity, Damage, and Quality of Life
edited by and Shaye Kivity
submission deadline 30 Jul 2026 | Viewed by 26 | Submission Open
Keywords: systemic lupus erythematosus; comorbidities; outcome measures; damage accrual; quality of life; cognitive im-pairment; infections and vaccination; treat-to-target; digital biomarkers
(This special issue belongs to the Section Immunology & Rheumatology)
Current Trends and Innovations in Coronary Artery Disease and Myocardial Ischemia: Second Edition
edited by
submission deadline 20 Aug 2026 | Viewed by 23 | Submission Open
Keywords: coronary artery disease; fractional flow reserve; invasive coronary angiography; cardiac CT; cardiac MRI
(This special issue belongs to the Section Cardiovascular Medicine)
Dental Care: Oral and Systemic Disease Prevention: 2nd Edition
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 913 | Submission Open
Keywords: oral health; oral diseases; oral manifestations; systemic diseases; oral care; dental prevention; dental caries; periodontal disease; oral medicine; dentistry; oral microbiome; salivary diagnostics; AI-assisted tools
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Aortic Diseases: Modern Strategies in Diagnosis, Management, and Prevention of Complications
edited by , Tilo Kölbel and José Ignacio F. Torrealba
submission deadline 20 Jul 2027 | Viewed by 39 | Submission Open
Keywords: aortic aneurysm; aortic dissection; genetic aortic disease; acute aortic syndromes; endovascular repair; complica-tions; outcomes
(This special issue belongs to the Section Vascular Medicine)
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