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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Advances in Lower Limb Trauma and Orthopedic Surgery: From Bench to Bedside

edited by

Se Won Lee

and

Jihyo Hwang

submission deadline 20 Jul 2026 | Viewed by 18 | Submission Open

Keywords: lower limb trauma; fracture fixation; arthroplasty; biomechanics; orthopaedic surgery; translational research; clin-ical outcomes; minimally invasive techniques; rehabilitation

(This special issue belongs to the Section Orthopedics)

Outcomes in Pediatric Neurosurgery

edited by

Petra Klinge

and Konstantina Svokos

submission deadline 20 Jul 2026 | Viewed by 18 | Submission Open

Keywords: functional outcomes; pediatric neurosurgery; quality of life; innovative technologies; global neurosurgery

(This special issue belongs to the Section Clinical Pediatrics)

Updates on Reconstructive Urology

edited by

Fabio Campodonico

submission deadline 20 Jul 2026 | Viewed by 14 | Submission Open

Keywords: reconstructive urology; urethral stenosis; urethroplasty; urethral diverticulum; ureteral stenosis; male incontinence; urinary diversion; hypospadias; microsurgery; experimental microsurgery; bladder diverticulum; neobladder

(This special issue belongs to the Section Nephrology & Urology)

Diagnosis, Treatment and Prognosis of Head and Neck Cancer

edited by

Armando De Virgilio

and Elena Russo

submission deadline 20 Jul 2026 | Viewed by 13 | Submission Open

Keywords: head and neck neoplasms; surgical procedures; minimally invasive surgical procedures; radiotherapy; immunotherapy; biomarkers; treatment outcome; early diagnosis; prognosis; quality of life

(This special issue belongs to the Section Oncology)

Applications of Artificial Intelligence and Digital Therapeutics in Clinical Medicine: 2nd Edition

edited by

Carlos Escobar

submission deadline 20 Jul 2026 | Viewed by 13 | Submission Open

Keywords: artificial intelligence; biometric sensors; deep learning; digital therapies; Internet of Things; machine learning; virtual reality; augmented reality

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)

Gynecologic Cancers: Current Clinical Management and Multidisciplinary Treatment Strategies

edited by

Iason Psilopatis

and

Christos Damaskos

submission deadline 20 Jul 2026 | Viewed by 12 | Submission Open

Keywords: gynecologic; cancer; uterus; ovarian; endometrial; cervical

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Updates on Anesthesia and Perioperative Medicine

edited by Béla Fülesdi and

Sorin J. Brull

submission deadline 20 Jul 2026 | Viewed by 11 | Submission Open

Keywords: anesthesia; perioperative complications; residual neuromuscular block; postoperative pulmonary complications; intensive care unit acquired weakness; intensive care medicine; airway management; patient safety

(This special issue belongs to the Section Anesthesiology)

Clinical Challenges in Heart Failure Management: 2nd Edition

edited by Paolo Severino, Gaetano M. Ruocco and

Andrea D'Amato

submission deadline 20 Jul 2026 | Viewed by 10 | Submission Open

Keywords: acute heart failure; chronic heart failure; inotropic support; left ventricular assist device; cardiac contractility modulation; guanylate cyclase stimulators; quality of life; telemedicine; palliative care

(This special issue belongs to the Section Cardiology)

Current Measures for Diagnosis, Monitoring, and Outcome Assessment in Orthopedics, Traumatology, and Hand Surgery, 2nd Edition

edited by

Paweł Reichert

and

Piotr Morasiewicz

submission deadline 20 Jul 2026 | Viewed by 10 | Submission Open

Keywords: clinical evaluation; hand surgery; orthopaedics; performance-based measures; physical examination; reliability; traumatology

(This special issue belongs to the Section Orthopedics)

Pediatric Surgery—Current Hurdles and Future Perspectives—2nd Edition

edited by

Osnat Zmora

submission deadline 20 Jul 2026 | Viewed by 10 | Submission Open

Keywords: ongenital anomalies; esophageal atresia; anorectal malformations; pediatric trauma; necrotizing enterocolitis; pediatric oncology; biliary atresia

(This special issue belongs to the Section Clinical Pediatrics)

Spine Surgery: Clinical Advances and Practice Updates

edited by

Junho Song

submission deadline 20 Jul 2026 | Viewed by 9 | Submission Open

Keywords: spine surgery; minimally invasive spine surgery; endoscopic spine surgery; robotics; artificial intelligence; spinal deformity; scoliosis; spinal trauma

(This special issue belongs to the Section Orthopedics)

Clinical Updates on Application of Echocardiography

edited by Aydan Ewers

submission deadline 20 Jul 2026 | Viewed by 9 | Submission Open

Keywords: echocardiography; heart failure; cardiomyopathies; cardiac echocardiography; interventional cardiology; cardiac imaging; pulmonary hypertension

(This special issue belongs to the Section Cardiology)

Exploring Diagnostic and Therapeutic Advances in Neurodegenerative Disorders

edited by

Stefania Kalampokini

and Effrosyni Koutsouraki

submission deadline 20 Jul 2026 | Viewed by 8 | Submission Open

Keywords: neurodegenerative disease; Parkinson’ s disease; Alzheimer’ s disease; Friedreich’ s ataxia; Huntington’ s disease; Lewy body dementia; dementia; immunosenescence; inflammaging

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Application of Echocardiography

edited by

Ramdas G. Pai

submission deadline 20 Jul 2026 | Viewed by 8 | Submission Open

Keywords: echocardiography; Doppler; transesophageal echocardiography; stain imaging; valvular hemodynamics; non valvular hemodynamics; interventional echocardiography; 3-dimensional echocardiography; tissue Doppler imaging

(This special issue belongs to the Section Cardiology)

Hypertrophic Cardiomyopathy: New Insights into Complications and Treatment

edited by Ilaria Dentamaro and Ciro Santoro

submission deadline 20 Jul 2026 | Viewed by 8 | Submission Open

Keywords: hypertrophic cardiomyopathy; complications; risk stratification; multimodality imaging; myosin inhibitors; precision medicine

(This special issue belongs to the Section Cardiology)

Gastroparesis: Emerging Insights and Endoscopic Therapeutic Strategies

edited by Sabrina Testoni

submission deadline 20 Jul 2026 | Viewed by 8 | Submission Open

Keywords: gastroparesis; gastric dismotility; gastric emptying; gastric per-oral miotomy; pyloromyotomy; gastric electric stim-ulation; botulinum toxin

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Targeting the Complement for the Treatment of Autoimmune and Neurodegenerative Diseases of the Central Nervous System

edited by Charalampos Skarlis,

Maria Anagnostouli

and

Evangelia Liouta

submission deadline 20 Jul 2026 | Viewed by 6 | Submission Open

Keywords: complement; biologics; monoclonal antibodies; neurodegenerative diseases; CNS autoimmune diseases

(This special issue belongs to the Section Clinical Neurology)

The Wide World of Antinuclear Antibodies (ANA)-Associated Disorders: Patterns, Clinical Phenotypes, Comorbidities, and Impact

edited by

Daniela Opris-Belinski

submission deadline 20 Jul 2026 | Viewed by 4 | Submission Open

Keywords: antinuclear antibodies (ANA); ANA-associated disorders; clinical phenotypes; ANA patterns; lupus; Sjö gren’ s disease; systemic sclerosis; idiopathic inflammatory myopathies; comorbidities; connective tissue diseases; overlap syndromes; undifferentiated connective tissue disease; risk stratification; patient-centered management

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Research on Robot-Assisted Thoracic Surgery and Lung Surgery

edited by Marco Scarci

submission deadline 20 Jul 2026 | Viewed by 4 | Submission Open

Keywords: robot-assisted thoracic surgery; robotic lung surgery; minimally invasive surgery; lobectomy; segmentectomy; thoracic oncology; surgical outcomes; learning curve; clinical research; robotic technology

(This special issue belongs to the Section General Surgery)

Colorectal Surgery: Advances in Modern Clinical Management

edited by Algimantas A. Tamelis

submission deadline 20 Jul 2026 | Viewed by 1 | Submission Open

Keywords: colorectal cancer management; surgery; complications; organ preservation; screening; colonic diverticular disease; colonic diverticulitis; hemorrhoids

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Novel Research in Cardiovascular Imaging

edited by Stanciu Silviu and

Lucia Agoston-Coldea

submission deadline 20 Jul 2026 | Submission Open

Keywords: echocardiography; cardiac CT; CMR; nuclear medicine; artificial intelligence

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Perioperative Anesthesia: Emerging Techniques and Clinical Practices

edited by Mitchell H. Tsai, Matthew Bergeron Allen and Roya Saffary

submission deadline 20 Jul 2026 | Submission Open

Keywords: perioperative medicine; goal-concordant care; anesthesia co-management; postoperative outcomes; perioperative anesthesia

(This special issue belongs to the Section Anesthesiology)

Early Diagnosis and Treatment of Hepatitis B and C: Bridging Innovation and Implementation

edited by

Rawi Hazzan

and

Fadi Abu Baker

submission deadline 20 Jul 2026 | Submission Open

Keywords: hepatitis B virus (HBV); hepatitis C virus (HCV); hepatitis delta virus (HDV); early diagnosis; viral hepatitis elimination; functional cure; direct-acting antivirals (DAAs); antiviral therapy; treatment adherence; care cascade; screening programs; health policy

(This special issue belongs to the Section Infectious Diseases)

Sarcopenia: Prevention and Treatment Options

edited by Steven Phu

submission deadline 20 Jul 2026 | Submission Open

Keywords: sarcopenia; skeletal muscle; ageing; falls; frailty; exercise; rehabilitation; nutrition

(This special issue belongs to the Section Geriatric Medicine)

Current Challenges in Adult Congenital Heart Diseases

edited by

Agata Bielecka-Dabrowa

submission deadline 20 Jul 2026 | Submission Open

Keywords: adult congenital heart disease; quality of life; pregnancy in congenital heart disease; heart failure; arrhythmia; septal defect; congenital valve stenosis; coarctation of the Aorta; Fontan circulation; Tetralogy of Fallot

(This special issue belongs to the Section Cardiology)

Therapeutic Advances in Hematological Malignancies: New Breakthroughs and Future Directions

edited by Seema Naik

submission deadline 20 Jul 2026 | Submission Open

Keywords: leukemia; lymphoma; myeloma; cell therapy; targeted therapy

(This special issue belongs to the Section Hematology)

Advances in Interventional Cardiology: From Access to Outcomes

edited by James Cotton and Benjamin Wrigley

submission deadline 20 Jul 2026 | Submission Open

Keywords: interventional cardiology; acute coronary syndrome; chronic coronary syndrome; TAVI; TAVR; TEER; TMVR; T-TEER; TTVR; service redesign

(This special issue belongs to the Section Cardiology)

Clinical Advances in Pediatric Hepatobiliary Surgery

edited by Ioannis A. Ziogas

submission deadline 20 Jul 2026 | Submission Open

Keywords: pediatric hepatobiliary surgery; pediatric transplantation; pediatric surgery; liver transplantation; biliary atresia; choledochal cyst; liver cancer

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Application of Digital Transformation in Ophthalmology

edited by

Eisuke Shimizu

submission deadline 20 Jul 2026 | Submission Open

Keywords: clinical application; ocular diseases; artificial intelligence (AI); machine learning/ deep learning; smart ophthalmology

(This special issue belongs to the Section Ophthalmology)

New Clinical Insight: From Open Surgery to Minimally Invasive Foot and Ankle Surgery

edited by Enrique A. Testa and Daniel Poggio

submission deadline 20 Jul 2026 | Submission Open

Keywords: minimally invasive surgery; foot surgery; ankle surgery; trauma surgery; orthopedic surgery; ankle arthroscopy

(This special issue belongs to the Section Orthopedics)

Novel Perspectives in Transcatheter Aortic Valve Implantation

edited by Nay Min Htun

submission deadline 20 Jul 2026 | Submission Open

Keywords: TAVI; life-time management; TAVI-in-TAVI; bicuspid valve; pure aortic regurgitation; small annuli

(This special issue belongs to the Section Cardiology)

Current Challenges and Innovation in Trauma and Acute Care Surgery

edited by Michel Teuben

submission deadline 20 Jul 2026 | Submission Open

Keywords: traumatology; trauma surgery; acute care surgery; femur; injury

(This special issue belongs to the Section Emergency Medicine)

Colorectal Surgery: Current Concept and Emerging Trends

edited by

Valentin Calu

submission deadline 20 Jul 2026 | Submission Open

Keywords: colorectal surgery; robotic surgery; neoadjuvant treatment; minimally invasive techniques; enhanced recovery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Strategies for Preventing Healthcare-Associated Infections

edited by

Monica Marilena Țânțu

Rogozea Liliana Marcela

and

Corneliu Ovidiu Vrancianu

submission deadline 24 Jul 2026 | Viewed by 23 | Submission Open

Keywords: healthcare-associated infections; multidrug resistance; prevention; screening scales; polymicrobial infections; oppor-tunistic infections; sepsis

(This special issue belongs to the Section Infectious Diseases)

Recent Clinical Advances in Pelvic Organ Prolapse

edited by José Antonio García-Mejido and José Antonio Sainz-Bueno

submission deadline 24 Jul 2026 | Viewed by 11 | Submission Open

Keywords: pelvic organ prolapse; pelvic floor dysfunction; urogynecology; pelvic reconstructive surgery; pathophysiology of POP; surgical techniques; conservative management; patient-reported outcomes; biomaterials in pelvic surgery; levator ani muscle

(This special issue belongs to the Section Obstetrics & Gynecology)

Psychological Affliction in Pregnancy, Delivery and Postpartum Period: A Multidisciplinary Approach

edited by

Beata Pięta

and

Edyta Barnas̈

submission deadline 24 Jul 2026 | Submission Open

Keywords: maternal mental health; pregnancy; postpartum depression; perinatal anxiety; midwifery; multidisciplinary care

(This special issue belongs to the Section Mental Health)

Rewriting Metastatic Colorectal Cancer Management: Innovative Frontiers in Clinical Diagnosis and Personalized Oncology

edited by

Maria Maddalena Laterza

submission deadline 24 Jul 2026 | Submission Open

Keywords: molecular profiling; liquid biopsy; targeted therapy; immunotherapy; biomarkers treatment; sequencing; tumor heterogeneity; personalized medicine

(This special issue belongs to the Section Oncology)

Clinical Advances in Spinal Neurosurgery

edited by Jang-Won Yoon

submission deadline 25 Jul 2026 | 2 articles | Viewed by 1955 | Submission Open

Keywords: minimally invasive spine surgery; lateral lumbar interbody fusion; endoscopic spine surgery; patient-reported out-comes; functional assessment; perioperative care; surgical decision-making

(This special issue belongs to the Section Clinical Neurology)

High-Risk Pregnancy Management: From Prenatal Care to Postpartum Outcomes

edited by

Angela Vinturache

submission deadline 25 Jul 2026 | Viewed by 44 | Submission Open

Keywords: high-risk pregnancy; prenatal care; postpartum outcomes; postpartum mental health; birth trauma; AI in obstetrics; medico-legal liability; equity & culturally safe care; indigenous and rural/remote care; EMR-enabled decision support; quality trend monitoring; maternal morbidity and mortality; perinatal morbidity; standardized care bundles & pathways

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Updates on Transcatheter Structural Heart Disease Interventions

edited by Nazan Puluca and Hendrik Ruge

submission deadline 25 Jul 2026 | Viewed by 28 | Submission Open

Keywords: interventional valve therapy; TAVR; TEER; TMVR; mitral valve; tricuspid valve; coronary access

(This special issue belongs to the Section Cardiology)

Current Advances and Future Perspectives in Cardiac Arrest and Cardiogenic Shock

edited by Giulia Maj

submission deadline 25 Jul 2026 | Viewed by 27 | Submission Open

Keywords: cardiogenic shock; left ventricular unloading; biomarkers; recovery; cardiac arrest

(This special issue belongs to the Section Emergency Medicine)

Recent Advance in Bariatric Surgery

edited by

Lidia Castagneto Gissey

submission deadline 25 Jul 2026 | Viewed by 20 | Submission Open

Keywords: bariatric surgery; metabolic surgery; minimally invasive surgery; robotic surgery; endoscopic bariatric procedures; obesity management; type 2 diabetes remission; perioperative care; long-term outcomes; enhanced recovery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Sleep Disorders: Current Research and Future Directions—Second Edition

edited by Martina Vendrame

submission deadline 25 Jul 2026 | Viewed by 20 | Submission Open

Keywords: obstructive sleep apnea; parasomnia; idiopathic hypersomnia; periodic limb movement disorder; periodic limb move-ment of sleep

(This special issue belongs to the Section Clinical Neurology)

Interaction Between Systemic Diseases and Oral Diseases: 2nd Edition

edited by

Henk S. Brand

submission deadline 25 Jul 2026 | Viewed by 13 | Submission Open

Keywords: medical dental interaction; saliva; xerostomia; diagnostics; inflammatory bowel disease; cancer survivors; dental erosion; Sjö gren’ s disease; liver transplantation

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Application of Endoscopic Submucosal Dissection in Malignant Gastrointestinal Tumors and Precursors—2nd Edition

edited by

Rainer Schöfl

and

Reinhold Függer

submission deadline 25 Jul 2026 | Viewed by 10 | Submission Open

Keywords: endoscopy; endoscopic submucosal dissection; endoscopic surgery; laparoscopic surgery; minimally invasive surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Hearing Loss Management in Children: Guidelines and Interventions

edited by Lone Percy-Smith

submission deadline 25 Jul 2026 | Viewed by 1 | Submission Open

Keywords: early intervention for populations with HL; emerging new generations of persons with HL; quality assurance of interventions for populations with HL; self-assessments of quality of life

(This special issue belongs to the Section Clinical Pediatrics)

Complications Related to Coronary Artery Disease and Secondary Prevention Strategies

edited by Nazanin Rajai

submission deadline 25 Jul 2026 | Submission Open

Keywords: coronary artery disease; complications; secondary prevention; myocardial infarction; cardiovascular risk; heart failure; arrhythmias; imaging; biomarkers; cardiovascular pharmacotherapy

(This special issue belongs to the Section Cardiovascular Medicine)

Obstructive Sleep Apnea: Advances in Clinical Diagnosis and Management

edited by