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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Uterine Fibroids—Quality of Life and Minimally Invasive Therapy Options

edited by

Karolina Chmaj-Wierzchowska

and Maciej Wilczak

submission deadline 20 Oct 2026 | Viewed by 196 | Submission Open

Keywords: uterine fibroids; radiofrequency ablation; pain; quality of life; menstrual bleeding

(This special issue belongs to the Section Obstetrics & Gynecology)

Cutaneous Oncology: Advances in Melanoma, Basal Cell Carcinoma and Other Skin Cancers

edited by Emanuela Passoni,

Nerina Denaro

and

Gianluca Nazzaro

submission deadline 20 Oct 2026 | Viewed by 190 | Submission Open

Keywords: melanoma; basal cell carcinoma; squamous cell carcinoma; nevi; dermoscopy; skin cancers; skin tumors

(This special issue belongs to the Section Dermatology)

Current Concepts in Outcomes and Outcome Assessment in Oculoplastic Care

edited by Yinon Shapira

submission deadline 20 Oct 2026 | Viewed by 189 | Submission Open

Keywords: oculoplastic care; clinical outcomes; outcome assessment; eyelid and orbital disorders; lacrimal disease; anophthalmic rehabilitation; aesthetic and reconstructive ophthalmic plastic surgery

(This special issue belongs to the Section Ophthalmology)

Maternal–Fetal Medicine: Clinical Updates and Perspectives

edited by

Uri Amikam

and Hadas Miremberg

submission deadline 20 Oct 2026 | Viewed by 187 | Submission Open

Keywords: preterm labor; hypertensive disorders of pregnancy; fetal growth restriction; gestational diabetes; multiple pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Acute Coronary Syndrome Management

edited by

Alexandru Dan Costache

Irina Iuliana Costache Enache

and

Minerva Codruta Badescu

submission deadline 20 Oct 2026 | Viewed by 185 | Submission Open

Keywords: acute coronary syndrome; myocardial revascularization; biomarkers; interventional cardiology; cardiac rehabilitation

(This special issue belongs to the Section Cardiology)

Clinical Insights into New Therapeutic Strategies of Atrial Fibrillation

edited by

Giulia Massaro

and

Cristian Martignani

submission deadline 20 Oct 2026 | Viewed by 177 | Submission Open

Keywords: atrial fibrillation; rhythm control; catheter ablation; pulsed field ablation; stroke prevention; anticoagulation strategies; left atrial appendage closure; wearable technologies; artificial intelligence in cardiology; precision medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Highlights and Digital Evolution in Trauma and Orthopedic Surgery

edited by

Francesca Veronesi

and

Deyanira Contartese

submission deadline 20 Oct 2026 | Viewed by 177 | Submission Open

Keywords: trauma surgery; orthopedic surgery; musculoskeletal trauma; joint reconstruction; minimally invasive techniques; surgical innovation; implant technology; sports injuries; evidence-based orthopedics; clinical translational research; digital surgery; research reproducibility

(This special issue belongs to the Section Orthopedics)

Arterial Stiffness: A Key Determinant of Cardiovascular Risk in Clinical Medicine

edited by Hack-Lyoung Kim

submission deadline 20 Oct 2026 | Viewed by 174 | Submission Open

Keywords: cardiology; cardiovascular medicine; arterial stiffness; pulse wave velocity; central hemodynamics; vascular aging; hypertension; atherosclerosis; arteriosclerosis; cardiovascular risk stratification

(This special issue belongs to the Section Cardiology)

Insights into Oral and Maxillofacial Surgery

edited by Gian Battista Bottini and Konstantinos Mitsimponas

submission deadline 20 Oct 2026 | Viewed by 172 | Submission Open

Keywords: oral and maxillofacial surgery; mandibular condyle fractures; reconstructive surgery; dental rehabilitation; dental implant surgery; clinical innovation

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Rheumatoid Arthritis: New Insights and Challenges

edited by

Yoshiro Horai

submission deadline 20 Oct 2026 | Viewed by 170 | Submission Open

Keywords: DMARDs (disease-modifying anti-rheumatic drugs); boDMARDs (biological DMARDs); bsDMARDs (biosimilar DMARDs); csDMARDs (conventional synthetic DMARDs); rheumatoid arthritis; tsDMARDs (targeted synthetic DMARDs)

(This special issue belongs to the Section Immunology & Rheumatology)

Endocrine Tumors: Diagnosis, Treatment and Management—2nd Edition

edited by

Jules T. Zhang-Yin

submission deadline 20 Oct 2026 | Viewed by 169 | Submission Open

Keywords: neuroendocrine tumors; thyroid cancer; adrenal gland tumors; pituitary adenomas; parathyroid tumors; pancreatic neuroendocrine tumors; surgical management; radiotherapy

(This special issue belongs to the Section Endocrinology & Metabolism)

New Clinical Advancements in Endodontics

edited by

Mihaela Jana Ţuculinǎ

and Paula Perlea

submission deadline 20 Oct 2026 | Viewed by 169 | Submission Open

Keywords: bioceramic materials; minimally invasive endodontics; regenerative endodontics; laser-activated irrigation; CBCT

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Spinal Cord Injury in Elderly People: Prevention of Complications

edited by Vaidyanathan Subramanian

submission deadline 20 Oct 2026 | Viewed by 168 | Submission Open

Keywords: spinal cord injury; demography; morbidities; complications; spinal injuries; patients; family members; caregivers; general practitioners; discharge; elderly

(This special issue belongs to the Section Geriatric Medicine)

Personalized Medicine in Psychiatry: Precision Approaches to Diagnosis and Treatment

edited by Simran Maggo

submission deadline 20 Oct 2026 | Viewed by 168 | Submission Open

Keywords: pharmacogenomics; precision medicine; precision psychiatry; pharmacogenomic testing; pharmacogenomic bioinfor-matics

(This special issue belongs to the Section Mental Health)

Clinical Advances in Radiation Treatment of Head and Neck Cancers

edited by Daniela Dumitrescu,

Eugen Osiac

and Dragoș-Ovidiu Alexandru

submission deadline 20 Oct 2026 | Viewed by 161 | Submission Open

Keywords: head and neck cancer; radiation therapy; IMRT and VMAT; Image-guided and adaptive radiotherapy; CT; MRI; and PET imaging; post-radiotherapy response assessment; radiation-induced toxicity; skin and mucosal toxicity; dental; maxillofacial; and reconstructive complications; multimodal oncologic treatment

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Advances in Neurocritical Care: Treatment and Patient Outcomes

edited by

Sarkis Morales-Vidal

and Michael Schneck

submission deadline 20 Oct 2026 | Viewed by 159 | Submission Open

Keywords: neurocritical care; stroke; intracerebral hemorrhage; subarachnoid hemorrhage; traumatic brain injury; reperfusion therapy; mechanical thrombectomy; neuromonitoring; continuous EEG; intracranial pressure; neuroimaging; status epilepticus; neuroprotection; targeted temperature management; hemodynamic management; biomarkers; prognostication; neuro‑ICU quality improvement; health disparities; neurorehabilitation; patient outcomes

(This special issue belongs to the Section Clinical Neurology)

Technological Advances and Innovations in Spine Surgery

edited by

Jared D. Ament

submission deadline 20 Oct 2026 | Viewed by 159 | Submission Open

Keywords: neurosurgery; spine surgery; lumbar spine; lumbar spondylolisthesis; artificial disk/artificial facet replacement; motion preservation; patient-specific implants; enabling technologies; use of AI

(This special issue belongs to the Section Clinical Neurology)

Clinical Translational Electrophysiology and Therapeutic Innovation in Cardiovascular Disease

edited by Mena Abdelsayed

submission deadline 20 Oct 2026 | Viewed by 158 | Submission Open

Keywords: cardiac electrophysiology; arrhythmias; translational cardiology; hiPSC-derived cardiomyocytes; lon channels; precision medicine; drug repurposing; computational modeling; neuromodulation; mechanobiology; digital twins

(This special issue belongs to the Section Cardiovascular Medicine)

Recent Updates in Minimally Invasive Surgery

edited by Simona Parisi and

Giovanni Conzo

submission deadline 20 Oct 2026 | Viewed by 158 | Submission Open

Keywords: mini-invasive surgery; robotic surgery; patient compliance; mini-invasive diagnostic procedures; patient comfort

(This special issue belongs to the Section General Surgery)

Optimizing Post-Return of Spontaneous Circulation (Post-ROSC) Management for Out-of-Hospital Cardiac Arrest (OHCA): Strategies to Enhance Survival, Neurological Recovery, and Social Reintegration

edited by

Enrico Baldi

submission deadline 20 Oct 2026 | Viewed by 157 | Submission Open

Keywords: return of spontaneous circulation (ROSC); quality of life; psychological distress; post-ROSC management; return to society

(This special issue belongs to the Section Cardiology)

Endoscopic Application of Pancreatic and Biliary Diseases: Diagnosis and Treatment

edited by

Lorenzo Fuccio

and

Filippo Antonini

submission deadline 20 Oct 2026 | Viewed by 149 | Submission Open

Keywords: endoscopic retrograde cholangiopancreatography (ERCP); endoscopic ultrasound (EUS); drainage; lumen-apposing metal stent (LAMS); pancreatoscopy; cholangioscopy; pancreatic cancer; pancreatitis; biliary cancer; cholangitis; gallbladder; walled-off necrosis; lithotripsy; radiofrequency ablation (RFA); photodynamic therapy (PDT); necrosectomy; EUS-guided gastroenteroanastomosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

State of the Art: Updates in Preterm Labor and Preterm Birth—2nd Edition

edited by

Eran Bornstein

and Moti Gulersen

submission deadline 20 Oct 2026 | Viewed by 149 | Submission Open

Keywords: prenatal diagnosis; fetal neurosonography; detection of fetal anomalies in the first trimester; preterm birth; antenatal corticosteroids; cerclage; mutiple gestations

(This special issue belongs to the Section Obstetrics & Gynecology)

New Insights into Liver Cirrhosis and Portal Hypertension

edited by Gerond V. Lake-Bakaar

submission deadline 20 Oct 2026 | Viewed by 148 | Submission Open

Keywords: cirrhosis; portal hypertension; liver resection; hepatocellular carcinoma; hepatic blood flow; varices; portosystemic collaterals; hepatic sinusoids

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Best Practices in Kidney Transplantation Across the Continuum: Evaluation to Graft Failure

edited by Sami Alasfar

submission deadline 20 Oct 2026 | Viewed by 145 | Submission Open

Keywords: kidney transplantation; allograft rejection; biomarkers; immunosuppression; failing allograft; retransplantation; transplant outcomes

(This special issue belongs to the Section Nephrology & Urology)

Advances in Mapping and Catheter Ablation of Ventricular Tachycardia

edited by Michele Magnocavallo,

Pietro Rossi

Filippo Maria Cauti

, Antonio Bisignani and Stefano Bianchi

submission deadline 20 Oct 2026 | Viewed by 145 | Submission Open

Keywords: catheter ablation; ventricular tachycardia; sudden cardiac death; structural heart disease

(This special issue belongs to the Section Cardiology)

Current Perspectives and Emerging Insights in Urological Cancer

edited by

Ilias Giannakodimos

and

Konstantinos Stravodimos

submission deadline 20 Oct 2026 | Viewed by 143 | Submission Open

Keywords: prostate cancer; renal cancer; bladder cancer; urogenital cancer; urological cancer; biopsy; diagnosis; therapy

(This special issue belongs to the Section Nephrology & Urology)

State of the Art in Obesity Care: From Pathophysiology to Precision Treatment

edited by

Wissam Ghusn

submission deadline 20 Oct 2026 | Viewed by 141 | Submission Open

Keywords: obesity; obesity management; metabolic disease; cardiometabolic risk; bariatric surgery; endoscopic bariatric therapy; anti-obesity pharmacotherapy; glucagon-like peptide-1 receptor agonists; lifestyle intervention; weight loss outcomes; metabolic surgery; cardiovascular risk reduction

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Advances in Wound Healing and Inflammation Management

edited by Carlotta Scarpa

submission deadline 20 Oct 2026 | Viewed by 139 | Submission Open

Keywords: vascular ulcers; inflammation; traumatic ulcers; burns; regenerative medicine; mononuclear cells; pressure sores; wound technologies

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Physical Therapy in Neurorehabilitation: 2nd Edition

edited by

Marianna Papadopoulou

and

George K. Papadimas

submission deadline 20 Oct 2026 | Viewed by 137 | Submission Open

Keywords: physical therapy; transcutaneous electrical nerve stimulation (TENS); muscle strengthening; balance exercising; pain; quality of life; neurodegenerative disorders; neuromuscular disorders; stroke; demyelinating disorders

(This special issue belongs to the Section Clinical Neurology)

Clinical Aspects of Male Infertility and Azoospermia

edited by

Nikolaos Sofikitis

submission deadline 20 Oct 2026 | Viewed by 136 | Submission Open

Keywords: azoospermia; non obstructive azoospermia; obstructive azoospermia; microdissection testicular sperm extraction; varicocele; hypogonadotropic hypogonadism

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Clinical Blood Transfusion: History, Development, Need, Demand and Use

edited by

Cees Th Smit Sibinga

submission deadline 20 Oct 2026 | Viewed by 135 | Submission Open

Keywords: clinical blood transfusion; quality management; demands; needs; uses

(This special issue belongs to the Section Hematology)

Cardiogenic Shock: New Insights into Diagnosis, Management and Prognosis

edited by Faisal Rahman

submission deadline 20 Oct 2026 | Viewed by 125 | Submission Open

Keywords: cardiogenic shock; patient outcomes; mechanical circulatory support; hemodynamics; care disparities; healthcare

(This special issue belongs to the Section Cardiology)

From Substrate to Therapy: Integrating Approaches in Arrhythmia Management

edited by

Sara Vázquez-Calvo

and Ivo Roca-Luque

submission deadline 20 Oct 2026 | Viewed by 123 | Submission Open

Keywords: cardiac arrhythmias; substrate characterization; non-invasive mapping; ECGi; cardiac imaging; high-density mapping; emerging ablation technologies; pulsed-field ablation; ultra-cryotherapy; stereotactic body radiotherapy; personalized arrhythmia management

(This special issue belongs to the Section Cardiology)

Musculoskeletal Radiology: Advances and Innovations in Sports Medicine

edited by

Apostolos Karantanas

Michail Klontzas

and Evangelia E. Vassalou

submission deadline 20 Oct 2026 | Viewed by 118 | Submission Open

Keywords: musculoskeletal radiology; sports injury diagnosis and management; quantitative magnetic resonance imaging (MRI); imaging biomarkers in orthopedic medicine; artificial intelligence in sports imaging; image-guided musculoskeletal interventions; post-traumatic osteoarthritis assessment

(This special issue belongs to the Section Sports Medicine)

A New Era of Myalgic Encephalomyelitis (ME) Evolving from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

edited by

Kunihisa Miwa

submission deadline 20 Oct 2026 | Viewed by 102 | Submission Open

Keywords: myalgic encephalomyelitis; chronic fatigue syndrome; post-exertional malaise; central nervous system; neuroinflammation; orthostatic intolerance; disequilibrium; neuroimmune disorder

(This special issue belongs to the Section Clinical Neurology)

Procedural Planning in Congenital Heart Disease

edited by Reza Ashrafi and Sarah Moharem-Elgamal

submission deadline 20 Oct 2026 | Viewed by 99 | Submission Open

Keywords: congenital heart disease; CPEX; echocardiography; CT; MRI; procedural planning

(This special issue belongs to the Section Cardiology)

Oral and Maxillofacial Surgery: Current Trends, Innovations and Techniques

edited by Gabriel Armencea and

Florin Onisor

submission deadline 21 Oct 2026 | 2 articles | Viewed by 3041 | Submission Open

Keywords: maxillofacial; trauma; deformities; cleft lip and palate; OMF surgery; head and neck; head and neck oncology; orthognathic surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

State-of-the-Art Innovations in Oral and Maxillofacial Surgery: 2nd Edition

edited by Marcin Kozakiewicz and

Tomasz Wach

submission deadline 22 Oct 2026 | 2 articles | Viewed by 760 | Submission Open

Keywords: oral surgery; maxillofacial surgery; traumatology; orthognatic surgery; infections; oncology; diagnostics; treatment; implantology; augmentation; imaging; computer-assisted techniques

(This special issue belongs to the Section Otolaryngology)

Advancing Minimally Invasive Spine Surgery: A Special Edition on Endoscopic Spine Surgery

edited by

Adham M. Khalafallah

and Gregory W. Basil

submission deadline 23 Oct 2026 | 7 articles | Viewed by 15597 | Submission Open

Keywords: minimally invasive spine surgery (MIS); endoscopic spine surgery (ESS); spine surgery; percutaneous spine surgery; full-endoscopic spine surgery; biportal endoscopic spine surgery (BESS); unilateral biportal endoscopy (UBE); percutaneous endoscopic lumbar discectomy (PELD); endoscopic decompression; transforaminal endoscopic lumbar discectomy (TELD); interlaminar endoscopic lumbar discectomy (IELD); endoscopic lumbar fusion; endoscopic transforaminal lumbar interbody fusion (Endo-TLIF)

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates in Physiotherapy for Musculoskeletal Disorders: 2nd Edition

edited by

Santiago Navarro Ledesma

submission deadline 23 Oct 2026 | 1 articles | Viewed by 443 | Submission Open

Keywords: musculoskeletal disorders; physiotherapy interventions; lifestyle; psychoneuroimmunology; chronic pain; inflammation; physical therapy

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Research in Macular Degeneration and Other Retinal Diseases

edited by

Seong Joon Ahn

submission deadline 23 Oct 2026 | 1 articles | Viewed by 424 | Submission Open

Keywords: macular degeneration; retinal diseases; clinical research; retinal imaging; real-world data; drug-induced retinal toxicity; epidemiology; screening strategies

(This special issue belongs to the Section Ophthalmology)

Clinical Advances in Anesthesia and Critical Care

edited by Vincenzo Russotto and

Giuseppe Accurso

submission deadline 23 Oct 2026 | 1 articles | Viewed by 418 | Submission Open

Keywords: anesthesia; critical care; perioperative critical care; emergency medicine; prehospital emergency care; infectious diseases in critical care; antimicrobial stewardship; sepsis

(This special issue belongs to the Section Intensive Care)

Advances in Spine Surgery: Current Innovations and Future Directions

edited by

Gonzalo Mariscal

and Jesús Burgos

submission deadline 24 Oct 2026 | 4 articles | Viewed by 2988 | Submission Open

Keywords: spine; clinical studies; robotics; minimally invasive; complications; patient-reported outcomes; reviews

(This special issue belongs to the Section Orthopedics)

Clinical Management of Oral Healthcare in Diverse Patient Populations: Second Edition

edited by

Antonella Polimeni

and

Iole Vozza

submission deadline 25 Oct 2026 | 14 articles | Viewed by 33408 | Submission Open

Keywords: special needs patients; oral healthcare; pediatric dentistry; dental hygiene; oral pathology; orthodontics; periodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances in Diabetes, Obesity, and Hypertension

edited by

Piotr Matłosz

and

Justyna Wyszyńska

submission deadline 25 Oct 2026 | 9 articles | Viewed by 17625 | Submission Open

Keywords: obesity; hypertension; diabetes; lifestyle; physical activity; risk factors

(This special issue belongs to the Section Endocrinology & Metabolism)

Hand Surgery: Latest Advances and Prospects

edited by

Camillo Fulchignoni

and Lorenzo Rocchi

submission deadline 25 Oct 2026 | 7 articles | Viewed by 13601 | Submission Open

Keywords: hand surgery; musculoskeletal and nerve disorders; innovative surgical procedures; minimally invasive techniques; rehabilitation strategies; robotic surgery

(This special issue belongs to the Section Orthopedics)

Knee Arthroplasty Surgery: Management and Future Opportunities: 2nd Edition

edited by

Joaquín Moya-Angeler

and

Francisco Forriol

submission deadline 25 Oct 2026 | 6 articles | Viewed by 13433 | Submission Open

Keywords: knee; knee replacement; knee arthroplasty; knee alignment technique; robotic knee arthroplasty

(This special issue belongs to the Section Orthopedics)

Autoimmune Skin Diseases: Innovations, Challenges, and Opportunities

edited by Shany Sherman

submission deadline 25 Oct 2026 | 6 articles | Viewed by 10441 | Submission Open

Keywords: healthcare utilization; inflammatory skin diseases; photodermatoses; collagen vascular disease; immunobullous disorders; graft-versus-host disease

(This special issue belongs to the Section Dermatology)

Recent Developments in Reproductive Endocrinology

edited by Birute Žilaitiené and Jonas Čeponis

submission deadline 25 Oct 2026 | 3 articles | Viewed by 10149 | Submission Open

Keywords: hypogonadism; infertility; sex hormone deficiency; reproductive endocrinology; sexual health; assisted reproduction

(This special issue belongs to the Section Endocrinology & Metabolism)

Novel Insights into Neonatal Intensive Care

edited by

Vasilios Giapros

and Maria Baltogianni

submission deadline 25 Oct 2026 | 3 articles | Viewed by 8867 | Submission Open

Keywords: neonatology; neonatal intensive care; neonate; sepsis; nutrition; ventilation; hemodynamic; neurodevelopment

(This special issue belongs to the Section Clinical Pediatrics)

Displaying special issue 1051-1100 on page 22 of 31.

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