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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Care and Rehabilitation for Neuromuscular Diseases

edited by

Hans-Jürgen Gdynia

submission deadline 31 Oct 2025 | Viewed by 714 | Submission Open

Keywords: neuromuscular diseases; myopathy; neuropathy; motor neuron disease; amyotrophic lateral sclerosis; diseases of neuromuscular junction; neurorehabilitation; rehabilitation; clinical care; neuroscience

(This special issue belongs to the Section Clinical Rehabilitation)

Cardiogenic Shock and Cardiac Arrest: Updates, Challenges and Opportunities

edited by Torben K. Becker

submission deadline 31 Oct 2025 | 1 articles | Viewed by 568 | Submission Open

Keywords: cardiac arrest; extracorporeal membrane oxygenation; extracorporeal CPR; cardiopulmonary resuscitation; cardiogenic shock; resuscitation; prognostication

(This special issue belongs to the Section Cardiology)

New Perspective of Oral and Maxillo-Facial Surgery

edited by

Valentino Vellone

Umberto Committeri

and Alessandra Lucchese

submission deadline 31 Oct 2025 | 1 articles | Viewed by 496 | Submission Open

Keywords: maxillofacial surgery; esthetic surgery; orthognatic surgery; TMJ disorders; TMJ surgery; dental implant surgery; 3D imaging; printing applications; tissue engineering; personalized treatment planning; artificial intelligence; squamous cell carcinoma; skin tumors; plastic and reconstructive surgery; head and neck surgery; ENT surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Novel Technologies to Assist Emergency Medical Care

edited by

Sangsoo Han

and Young Soon Cho

submission deadline 31 Oct 2025 | 1 articles | Viewed by 311 | Submission Open

Keywords: emergency medical services; artificial intelligence in emergency medicine; telemedicine and remote patient monitoring; wearable health technologies; point-of-care diagnostics; automated decision support systems; robotics in emergency medicine; pre-hospital care innovations

(This special issue belongs to the Section Emergency Medicine)

Complex Spine Surgery: The Road from Childhood to Adults and Future Directions

edited by Jacob M. Buchowski,

Pawel Grabala

and Michael A. Galgano

submission deadline 31 Oct 2025 | Viewed by 259 | Submission Open

Keywords: complex spine; scoliosis; kyphosis; spinal deformities; spinal tumor; spinal reconstruction; sagittal balance; coronal imbalance

(This special issue belongs to the Section Clinical Neurology)

Interstitial Lung Diseases: New Treatments and Future Directions

edited by Justyna Fijołek

submission deadline 31 Oct 2025 | Viewed by 172 | Submission Open

Keywords: Interstitial Lung Disease (ILD); pulmonary fibrosis; orphan lung disease; AAV-ILD; occupational ILD; rheumatic lung disease; treatment strategies; emerging therapies; precision medicine; future directions

(This special issue belongs to the Section Respiratory Medicine)

Advancing Minimally Invasive Spine Surgery: A Special Edition on Endoscopic Spine Surgery

edited by

Adham M. Khalafallah

and Gregory W. Basil

submission deadline 31 Oct 2025 | Viewed by 161 | Submission Open

Keywords: minimally invasive spine surgery (MIS); endoscopic spine surgery (ESS); spine surgery; percutaneous spine surgery; full-endoscopic spine surgery; biportal endoscopic spine surgery (BESS); unilateral biportal endoscopy (UBE); percutaneous endoscopic lumbar discectomy (PELD); endoscopic decompression; transforaminal endoscopic lumbar discectomy (TELD); interlaminar endoscopic lumbar discectomy (IELD); endoscopic lumbar fusion; endoscopic transforaminal lumbar interbody fusion (Endo-TLIF)

(This special issue belongs to the Section Clinical Neurology)

Current Trends in Hand Surgery

edited by

Alexandre Kaempfen

and Florian Frueh

submission deadline 31 Oct 2025 | Viewed by 142 | Submission Open

Keywords: microsurgery; minimally invasive; arthroscopy; sonography; nerve surgery; joint replacement

(This special issue belongs to the Section Orthopedics)

Current Trends and Future Prospects in Autoantibodies in Liver Diseases

edited by Takashi Himoto

submission deadline 31 Oct 2025 | Viewed by 138 | Submission Open

Keywords: liver-specific autoantibodies; non-organ-specific autoantibodies; autoimmune liver disease; diagnosis; disease activity; treatment outcome; prognosis; virus-induced autoimmunity; drug-induced autoimmunity

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current Updates and Advances in Hemodialysis

edited by Edita Žiginskienė

submission deadline 31 Oct 2025 | Viewed by 126 | Submission Open

Keywords: kidney replacement therapy; hemodialysis; hemodiafiltration; vascular access; dialysis membranes; dialysis complications; dialysis adequacy; outcomes

(This special issue belongs to the Section Nephrology & Urology)

Recent Advances in the Epidemiology of Infectious Diseases: A Clinical Perspective

edited by

Yazan A. Al-Ajlouni

submission deadline 31 Oct 2025 | Viewed by 125 | Submission Open

Keywords: epidemiology of infectious diseases; global health and infectious diseases; hospital-acquired infections (HAIs); infection control; novel treatments; vaccine effectiveness

(This special issue belongs to the Section Epidemiology & Public Health)

Advances in the Diagnosis and Treatment of Skin Cancer

edited by

Konstantinos Lallas

and

Aimilios Lallas

submission deadline 31 Oct 2025 | Viewed by 124 | Submission Open

Keywords: skin cancer; melanoma; keratinocyte carcinoma; basal cell carcinoma; squamous cell carcinoma; biomarkers; immuno-therapy; prognosis

(This special issue belongs to the Section Oncology)

Novel Insights into Neonatal Intensive Care

edited by

Vasilios Giapros

and Maria Baltogianni

submission deadline 31 Oct 2025 | Viewed by 118 | Submission Open

Keywords: neonatology; neonatal intensive care; neonate; sepsis; nutrition; ventilation; hemodynamic; neurodevelopment

(This special issue belongs to the Section Clinical Pediatrics)

Imaging in Diagnosis and Treatment of Musculoskeletal Disorders

edited by Francesco Porta and

Florentin Ananu Vreju

submission deadline 31 Oct 2025 | Viewed by 117 | Submission Open

Keywords: ultrasound; ultrasound-guided injections; imaging-guided procedures

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Immunotherapy of Hematological Malignancies: The State of the Art

edited by

Anca Colita

and

Romeo Gabriel Mihaila

submission deadline 31 Oct 2025 | Viewed by 110 | Submission Open

Keywords: antibody-drug conjugates; bispecific antibodies; chimeric antigen receptor-engineered natural killer cell; chimeric antigen receptor T-cells; cytokine release syndrome; immune checkpoint in-hibitors; immunosuppression; immunotherapy; monoclonal antibodies; neurotoxicities

(This special issue belongs to the Section Hematology)

Current Challenges and Innovations in Spine Deformity: Biomechanics, Imaging and AI-Driven Analysis

edited by Dong-Ho Kang

submission deadline 31 Oct 2025 | Viewed by 107 | Submission Open

Keywords: spinal deformity; cervical deformity; biomechanics; postural alignment; sagittal imbalance; medical imaging; radiographic analysis; artificial intelligence; machine learning; deep learning; phenotyping; computer-assisted diagnosis; predictive modeling; surgical planning

(This special issue belongs to the Section Orthopedics)

Diabetic Retinopathy Screening: Current Advances and Future Options

edited by

Alauddin Bhuiyan

and

Roland Theodore Smith

submission deadline 31 Oct 2025 | Viewed by 99 | Submission Open

Keywords: diabetic retinopathy; diabetic retinopathy screening; retinal imaging; age-related macular degeneration; artificial intelli-gence; image analysis; color fundus photography; optical coherence tomography imaging; telemedicine

(This special issue belongs to the Section Ophthalmology)

Clinical Updates in Pediatric Radiology

edited by

Meriam Koob

and

Farnaz Delavari

submission deadline 31 Oct 2025 | Viewed by 98 | Submission Open

Keywords: pediatric radiology; advances in pediatric imaging; pediatric neuroimaging; artificial in-telligence in pediatric imaging; radiomics and machine learning; low-field MRI techniques; magnetic resonance imaging in pediatrics; computed tomography in pediatrics; radiation dose optimization; patient-centred imaging protocols

(This special issue belongs to the Section Clinical Pediatrics)

Updates in Diabetes and Obesity in Reproductive Health

edited by

Amihai Rottenstreich

and Giulia Barda

submission deadline 31 Oct 2025 | Viewed by 95 | Submission Open

Keywords: obesity; diabetes; reproductive health; childbearing age; pregnancy

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Clinical Management of Pediatric Heart Diseases

edited by Michele Lioncino

submission deadline 31 Oct 2025 | Viewed by 94 | Submission Open

Keywords: pediatric heart diseases; children; pediatric cardiology; congenital heart disease; clinical management; congenital heart surgery; outcome

(This special issue belongs to the Section Clinical Pediatrics)

Rehabilitation Strategies for Neurological Disorders: Advances and Insights

edited by Delia Cinteză and Mihai Berteanu

submission deadline 31 Oct 2025 | Viewed by 93 | Submission Open

Keywords: neurorehabilitation; physical medicine; virtual reality; AI in rehabilitation medicine; robotic rehabilitation; telerehabilitation; advanced technologies; upper neuromotor lesions; peripheral neuropathies; wearable sensor devices; assessment; goal-setting; individual rehabilitation plan

(This special issue belongs to the Section Clinical Rehabilitation)

Takotsubo Syndrome: Insights into Pathophysiology, Diagnosis, and Management

edited by Andreas Mitsis and

Nikolaos Kadoglou

submission deadline 31 Oct 2025 | Viewed by 89 | Submission Open

Keywords: takotsubo syndrome; stress cardiomyopathy; acute heart failure; cardiac imaging; catecholamine surge; myocardial dysfunction; echocardiography; biomarker discovery; cardiovascular risk; clinical management

(This special issue belongs to the Section Cardiology)

Preoperative Optimization in Cardiac Surgery

edited by

Jason M. Ali

submission deadline 31 Oct 2025 | Viewed by 87 | Submission Open

Keywords: preoperative optimization; cardiac surgery; risk assessment; comorbid conditions; multidisciplinary collaboration; perioperative risks; cardiovascular evaluation

(This special issue belongs to the Section Cardiology)

Recent Developments in Reproductive Endocrinology

edited by Birute Žilaitiené and Jonas Čeponis

submission deadline 31 Oct 2025 | Viewed by 86 | Submission Open

Keywords: hypogonadism; infertility; sex hormone deficiency; reproductive endocrinology; sexual health; assisted reproduction

(This special issue belongs to the Section Endocrinology & Metabolism)

New Developments in Coronary Interventional Therapy

edited by

Chadi Alraies

submission deadline 31 Oct 2025 | Viewed by 84 | Submission Open

Keywords: high risk PCI; optical coherence tomography; chronic total occlusions; bifurcation lesions; left main stem disease; multivessel coronary artery disease

(This special issue belongs to the Section Cardiology)

Urologic Neoplasms: Recent Advances and Future Perspectives

edited by

Dorit E. Zilberman

submission deadline 31 Oct 2025 | Viewed by 80 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; immunotherapy; chemotherapy; radiotherapy; prostate cancer; renal cancer; bladder cancer; upper urinary tract neoplasm; testicular cancer; penile cancer

(This special issue belongs to the Section Oncology)

Emerging Diagnostic and Treatment Approaches for Gynecological Cancers

edited by Marco D'Indinosante

submission deadline 31 Oct 2025 | Viewed by 77 | Submission Open

Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma

(This special issue belongs to the Section Obstetrics & Gynecology)

Advanced Hepato-Pancreato-Biliary Surgery: Clinical Innovations and Improved Outcomes

edited by Ahmad Mahamid and Riad Haddad

submission deadline 31 Oct 2025 | Viewed by 75 | Submission Open

Keywords: liver surgery; pancreas surgery; biliary surgery; robotic HPB surgery; single incision surgery; prognostic biomarkers; perioperative clinical care; postoperative complications

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Neuropathic Pain: From Prevention to Diagnosis and Management

edited by Enrico Martin

submission deadline 31 Oct 2025 | Viewed by 73 | Submission Open

Keywords: neuropathic pain; clinical research; TMR; RPNI; preclinical studies; QoL; PROMS; translational medicine; pain mechanisms

(This special issue belongs to the Section Clinical Neurology)

Challenges and Opportunities in Bariatric Surgery

edited by

Francisco Guzman Pruneda

and Umashankkar Kannan

submission deadline 31 Oct 2025 | Viewed by 71 | Submission Open

Keywords: bariatric surgery; DVT/VTE; bleeding; complications; prophylaxis

(This special issue belongs to the Section General Surgery)

Skin Cancers: Update on Clinical Treatment and Management

edited by Nazzaro Gianluca

submission deadline 31 Oct 2025 | Viewed by 70 | Submission Open

Keywords: basal cell carcinoma; squamous cell carcinoma; melanoma; skin cancers; dermoscopy; ultrasonography; immunotherapy; biomarker; prevention; diagnosis; treatment; innovative treatments; prognosis

(This special issue belongs to the Section Dermatology)

Intramedullary Nail of Long Bone Fractures: Treatments, Outcomes, and Staying out of Trouble

edited by Robert D. Zura and Jessica C. Rivera

submission deadline 31 Oct 2025 | Viewed by 70 | Submission Open

Keywords: intramedullary nail; intramedullary fixation; fracture fixation; femur fracture; tibia fracture; orthopedic implant; fracture healing

(This special issue belongs to the Section Orthopedics)

Obstructive Sleep Apnea: Latest Advances and Prospects

edited by

Carlos O’Connor Reina

submission deadline 31 Oct 2025 | Viewed by 62 | Submission Open

Keywords: obstructive sleep apnea; sleep medicine; myofunctional therapy; sleep surgery; neurostimulation; personalized treatment; biomarkers; adherence; home sleep testing

(This special issue belongs to the Section Otolaryngology)

Endometriosis and Endometrial Cancer: Challenge and Clinical Management

edited by

Bogdan Obrzut

, Tomasz Kluz and Bernhard Krämer

submission deadline 31 Oct 2025 | Viewed by 59 | Submission Open

Keywords: endometriosis; endometrial cancer; non-invasive diagnosis; molecular profiling; surgical techniques; medical treatment; alternative therapies

(This special issue belongs to the Section Obstetrics & Gynecology)

Rehabilitation Medicine and Clinical Research: From Diagnosis to Therapeutic Interventions

edited by

Yazan A. Al-Ajlouni

submission deadline 6 Nov 2025 | Viewed by 132 | Submission Open

Keywords: rehabilitation medicine; clinical research; therapeutic interventions; diagnosis; physical therapy; occupational therapy; neurorehabilitation; musculoskeletal rehabilitation; cardiac rehabilitation; functional recovery; assistive technologies; patient-centered care; outcome measures; rehabilitation innovations; multidisciplinary approaches

(This special issue belongs to the Section Clinical Rehabilitation)

Potential Cures of Alzheimer's Dementia

edited by

Jeffrey Fessel

submission deadline 10 Nov 2025 | 4 articles | Viewed by 11020 | Submission Open

Keywords: Alzheimer’ s dementia; cure; therapeutic approaches; clinical assessment; diagnosis; treatment

(This special issue belongs to the Section Mental Health)

Neuro-Psychiatric Disorders: Updates on Diagnosis and Treatment

edited by

Georgios Floros

submission deadline 10 Nov 2025 | 2 articles | Viewed by 5411 | Submission Open

Keywords: neuropsychiatric disorder; diagnosis; treatment; neurobiology; organic psychiatry

(This special issue belongs to the Section Mental Health)

Clinical Advances in Trauma and Emergency Medicine

edited by Viktoria Bogner-Flatz

submission deadline 10 Nov 2025 | 3 articles | Viewed by 1727 | Submission Open

Keywords: resuscitation; trauma emergency management; disaster response; mild traumatic brain injury emergency management; critical emergency care

(This special issue belongs to the Section Emergency Medicine)

Gastroesophageal Cancer: Advances in Clinical Diagnosis and Management

edited by

Tania Triantafyllou

and Maximos Frountzas

submission deadline 10 Nov 2025 | 2 articles | Viewed by 1506 | Submission Open

Keywords: gastroesophageal cancer; endoscopic therapy; minimally invasive surgery; multimodality treatment; immunotherapy

(This special issue belongs to the Section Oncology)

Pediatric Neuromuscular Diseases: Current Concepts, Challenges and Opportunities (Second Edition)

edited by Nina Barišić

submission deadline 10 Nov 2025 | Viewed by 85 | Submission Open

Keywords: neuromuscular disorders (NMD); pediatric; genetic NMD; chronic demyelinating polyneuropathy; juvenile myasthenia gravis; ethics; health economics; next generation sequencing (NGS); diagnosis; prenatal; fetal; disease modifying therapy; immunotherapy; guidelines

(This special issue belongs to the Section Clinical Pediatrics)

Advances in Catheter Ablation: Current Challenges and Future Perspectives

edited by

Gabriel Cismaru

and Raluca Tomoaia

submission deadline 15 Nov 2025 | 2 articles | Viewed by 1830 | Submission Open

Keywords: catheter ablation; three-dimensional mapping; arrhythmia; wolf– parkinson– white syndrome; atrial fibrillation

(This special issue belongs to the Section Cardiology)

New Advances in Wound Healing and Skin Wound Treatment

edited by Hajime Matsumura

submission deadline 15 Nov 2025 | 2 articles | Viewed by 1390 | Submission Open

Keywords: trauma wound; burns; chronic wound; DFU; VLU; ischemic wound; regenerative medicine in wound care; debridement; biofilm; wound dressing; antimicrobial treatment

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Update in Pulmonary Rehabilitation

edited by Akira Tamaki

submission deadline 15 Nov 2025 | Viewed by 93 | Submission Open

Keywords: pulmonary rehabilitation; chronic obstructive pulmonary disease; interstitial lung disease; sarcopenia; respiratory sarcopenia; respiratory muscle training; nutritional intervention

(This special issue belongs to the Section Respiratory Medicine)

Neuroendocrine Neoplasms: Epidemiology, Clinical Management, and Emerging Therapies

edited by

H. Christian Weber

submission deadline 15 Nov 2025 | Viewed by 91 | Submission Open

Keywords: neuroendocrine neoplasms (NENs); epidemiology; biomarkers for NENs; targeted therapies for NENs; carcinoid syndrome; precision medicine; gastrointestinal NENs; advanced endoscopic approaches to NEN treatment; imaging modalities for NENs; survival risk factors in NENs

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Mechanisms and Management of Intracerebral Hemorrhage

edited by Emanuela Crobeddu

submission deadline 15 Nov 2025 | Viewed by 30 | Submission Open

Keywords: intracerebral hemorrhage; arteriovenous malformation (AVM); dural arteriovenous fistula (DAVF); cavernoma; neuroinflammation; blood– brain barrier; hematoma evacuation; neuroprotection; imaging technologies; vascular lesions

(This special issue belongs to the Section Clinical Neurology)

Complex Orthopedic Trauma: Diagnosis, Treatment, Managing Complications and Rehabilitation

edited by Philip-Christian Nolte and Benedict Swartman

submission deadline 20 Nov 2025 | 4 articles | Viewed by 4659 | Submission Open

Keywords: orthopedic trauma; fracture; complications; infection; bone; rehabilitation

(This special issue belongs to the Section Orthopedics)

Advances in Clinical Practice and Personalized Approaches in Cardiovascular Disease

edited by Joseph B. Selvanayagam and

Sivabaskari Pasupathy

submission deadline 20 Nov 2025 | 6 articles | Viewed by 2798 | Submission Open

Keywords: personalized medicine; cardiovascular innovations; cardiac imaging; risk assessment; multimodal imaging; therapeutic strategies; data-driven decision making; clinical outcomes; translational research

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in the Diagnosis and Treatment of Heart Failure

edited by

Noel Lorenzo-Villalba

and

Manuel Montero-Perez-Barquero

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2587 | Submission Open

Keywords: heart failure; diagnosis; treatment; elderly; pluripathology

(This special issue belongs to the Section Cardiology)

State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy

edited by Marco Mercieri

submission deadline 20 Nov 2025 | Viewed by 319 | Submission Open

Keywords: neuromodulation; spinal cord stimulation; chronic pain management; stimulation waveforms; long-term efficacy; loss of efficacy; outcome prediction; opioid-sparing techniques; neurostimulation mechanisms; psychological predictors; therapeutic targets

(This special issue belongs to the Section Clinical Neurology)

Cardiac Imaging in the Diagnosis and Management of Heart Failure

edited by Mahi Lakshmi Ashwath and Allen S. Anderson

submission deadline 20 Nov 2025 | Viewed by 223 | Submission Open

Keywords: echocardiography; cardiac MRI; myocardial viability; tissue characterization; ischemic and non-ischemic cardiomyopathy; HFpEF; myocardial strain

(This special issue belongs to the Section Cardiology)

Displaying special issue 1051-1100 on page 22 of 27.

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