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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Advances in Radiation Therapy for Cancers

edited by

Rodica Maricela Anghel

Liviu Bîlteanu

and

Laura Florentina Rebegea

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1117 | Submission Open

Keywords: radiation oncology; radiotherapy; cancer radiotherapy; cancer radiation therapy; radiobiology; predictive and prognostic biomarkers; cancer treatment; heavy ions radiation oncology; protontherapy; cancer biolology

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Exploring Artificial Intelligence in Precision Medicine for Gastrointestinal Diseases

edited by Vincenzo Davide Palumbo

submission deadline 25 Dec 2025 | 2 articles | Viewed by 937 | Submission Open

Keywords: cholangiocarcinoma; biliary tree stenoses; colorectal cancer; endoscopic image analysis; IBD; gastrointestinal disorders

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Headache: Updates on the Assessment, Diagnosis and Treatment

edited by

Ernesto Anarte-Lazo

and

Carlos Bernal-Utrera

submission deadline 25 Dec 2025 | 2 articles | Viewed by 531 | Submission Open

Keywords: headache; migraine; tension-type headache; cervicogenic headache; therapeutic exercise

(This special issue belongs to the Section Clinical Neurology)

Pulmonary Embolism: Clinical Advances and Future Opportunities

edited by James Horowitz

submission deadline 25 Dec 2025 | Viewed by 395 | Submission Open

Keywords: pulmonary embolism; risk stratification; pulmonary embolism response teams; high risk PE; massive PE; intermediate risk PE; sub massive PE; catheter directed thrombolysis; catheter thrombectomy; catheter directed embolectomy; extra corporeal membrane oxygenation

(This special issue belongs to the Section Respiratory Medicine)

Recent Research Progress in Pediatric Orthopedic Surgery

edited by

Catharina Chiari

and Madeleine Willegger

submission deadline 25 Dec 2025 | 1 articles | Viewed by 364 | Submission Open

Keywords: pediatric orthopedics; deformity correction; pediatric hip; pediatric trauma; basic research in pediatric orthopedics; clubfoot; pediatric foot and ankle deformities; pediatric hand

(This special issue belongs to the Section Clinical Pediatrics)

Kidney Health Under Microscope

edited by

Magdi Yaqoob

submission deadline 25 Dec 2025 | Viewed by 217 | Submission Open

Keywords: complications; IgA nephropathy; glomerulonephritis; atypical haemolytic uraemic syndrome; systemic vasculitis; lupus nephritis; mineral bone disease; anaemia; xenotransplantation; nephrolithiasis

(This special issue belongs to the Section Nephrology & Urology)

Cardiac Imaging Techniques in Heart Failure Care

edited by David Snipelisky

submission deadline 25 Dec 2025 | Viewed by 181 | Submission Open

Keywords: heart failure; advanced imaging; cardiac imaging; echocardiography; cardiomyopathies

(This special issue belongs to the Section Cardiology)

Psychological Pain and Suicidal Behavior: Clinical Implications

edited by Adrián Alacreu-Crespo

submission deadline 25 Dec 2025 | Viewed by 97 | Submission Open

Keywords: suicidal behavior; psychological pain; pain tolerance; therapeutic interventions; clinical outcomes

(This special issue belongs to the Section Mental Health)

State-of-the-Art in Cardiac Surgery: Progress, Challenges and Opportunities

edited by Tomasz Plonek and Sleiman Sebastian Aboul-Hassan

submission deadline 25 Dec 2025 | Viewed by 85 | Submission Open

Keywords: aorta ascendens; minimally invasive surgery; aortic arch surgery; off pump coronary surgery; arterial grafts

(This special issue belongs to the Section Cardiology)

Advances and Innovations in Hand Surgery

edited by

David L. Colen

, Jason Wink and Anthony Archual

submission deadline 25 Dec 2025 | Viewed by 79 | Submission Open

Keywords: hand surgery; peripheral nerve surgery; shared decision making; microsurgery; arthritis; compression neuropathy; carpal tunnel; cubital tunnel

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Myocardial Infarction: Clinical Management and Future Options

edited by

Kenichi Sakakura

submission deadline 25 Dec 2025 | Viewed by 73 | Submission Open

Keywords: myocardial infarction; percutaneous coronary intervention; optimal medical therapy; clinical outcomes; cardiogenic shock; mechanical cardiac support device

(This special issue belongs to the Section Cardiology)

Advances in Anterior Segment Surgery: Second Edition

edited by

Mayank A. Nanavaty

submission deadline 25 Dec 2025 | 1 articles | Viewed by 65 | Submission Open

Keywords: lenticule-based surgery; surface ablations; blended vision treatments with laser refractive surgery; corneal inlay procedures; presbyopia management with monovision laser vision correction; refractive lens exchange; premium presbyopia-correcting intraocular lens; refractive solutions for keratoconics; cataract surgery; corneal transplant; biometry

(This special issue belongs to the Section Ophthalmology)

Innovations and Future Directions in Valvular Heart Disease: Imaging, Technology, and Translational Research

edited by

Mohammad Kassar

, Muhammed Gerçek and Felix Rudolph

submission deadline 25 Dec 2025 | Viewed by 63 | Submission Open

Keywords: prosthetic heart valve; heart valve pathophysiology; structural heart valve interventions; echocardiographic assessment; cardiovascular imaging; valvular heart disease; valvular regurgitation; valvular stenosis; minimally invasive surgery; concomitant valve disease

(This special issue belongs to the Section Cardiology)

IgA Nephropathy: Clinical Updates and Prospects

edited by

Meritxell Ibernon

submission deadline 25 Dec 2025 | Viewed by 59 | Submission Open

Keywords: pathogenesis of IgA nephropathy; novel therapies; role of complement system; risk factors for disease progression; proteomic approach; serologic biomarkers; histological classification

(This special issue belongs to the Section Nephrology & Urology)

Clinical Aspects of Cardiac Arrhythmias and Arrhythmogenic Disorders

edited by

Piotr Bienias

and Jakub Baran

submission deadline 25 Dec 2025 | Viewed by 56 | Submission Open

Keywords: non-invasive arrhythmia assessment; electrocardiography; invasive arrhythmia assessment; invasive electrophysiology; catheter ablation; implantable devices; rare diseases and arrhythmias; arrhythmia risk stratification; genetics aspects of arrhythmogenesis; channelopathy

(This special issue belongs to the Section Cardiology)

New Insights in Skin Tumors: From Pathogenesis to Therapy

edited by Loredana Ungureanu and Simona C. Şenilǎ

submission deadline 25 Dec 2025 | Viewed by 46 | Submission Open

Keywords: skin tumors; pathogenesis; diagnosis; personalized medicine; therapeutic strategies; dermato-oncology

(This special issue belongs to the Section Dermatology)

Current Clinical Treatments and Challenges for Cardiovascular Diseases

edited by Georgios Bouras and

Christos Kourek

submission deadline 26 Dec 2025 | 3 articles | Viewed by 3357 | Submission Open

Keywords: heart failure; coronary artery disease; atrial fibrillation; cardiomyopathies; hypertension

(This special issue belongs to the Section Cardiovascular Medicine)

New Advances in Extracorporeal Life Support (ECLS)

edited by Robertas Stasys Samalavičius,

Pranas Šerpytis

and

Holger Thiele

submission deadline 26 Dec 2025 | 2 articles | Viewed by 2631 | Submission Open

Keywords: extracorporeal life support (ECLS); extracorporeal membrane oxygenation (ECMO); innovations in ECLS; respiratory failure; cardiogenic shock; eCPR

(This special issue belongs to the Section Emergency Medicine)

Cardiac Rehabilitation: Clinical Challenges and New Insights

edited by Melissa Tracy

submission deadline 26 Dec 2025 | 2 articles | Viewed by 1360 | Submission Open

Keywords: cardiovascular disease; cardiac rehabilitation; atrial fibrillation

(This special issue belongs to the Section Cardiology)

Current Clinical Advances and Challenges for Endourology

edited by

Carlo Giulioni

and

Daniele Castellani

submission deadline 26 Dec 2025 | 1 articles | Viewed by 552 | Submission Open

Keywords: urolithiasis; upper tract urothelial carcinoma; benign prostatic hyperplasia; minimally invasive surgical therapies

(This special issue belongs to the Section Nephrology & Urology)

Multifactorial Causation and Therapies of Myopia: 2nd Edition

edited by

César Villa Collar

Cristina Alvarez-Peregrina

and

David Piñero

submission deadline 26 Dec 2025 | Viewed by 77 | Submission Open

Keywords: epidemiology; genetics; premyopia; simple and pathological myopia; orthokeratology; lenses for myopia control; blue light and red light; binocular vision and ocular optics; artificial intelligence

(This special issue belongs to the Section Ophthalmology)

Clinical Updates on Metabolic and Bariatric Surgery

edited by Maria-Jose Barahona

submission deadline 27 Dec 2025 | Viewed by 248 | Submission Open

Keywords: obesity; bariatric surgery; metabolic surgery; weight loss; obesity treatment; metabolic disorders

(This special issue belongs to the Section General Surgery)

Atrial Fibrillation Rhythm Management: Outcomes, Innovations, and Future Directions

edited by Roberto Scacciavillani and Gemma Pelargonio

submission deadline 28 Dec 2025 | 2 articles | Viewed by 1087 | Submission Open

Keywords: atrial fibrillation; catheter ablation; radiofrequency; cryoablation; pulsed field ablation; cardioneuroablation; left bundle branch area pacing

(This special issue belongs to the Section Cardiology)

Lung Transplantation: Current Strategies and Future Directions

edited by Omer Senbaklavaci and György Lang

submission deadline 28 Dec 2025 | Viewed by 234 | Submission Open

Keywords: lung transplantation; graft optimization; immunosuppression; artificial lung; xenotransplantation; end-stage lung disease; donor lung preservation; chronic lung allograft dysfunction

(This special issue belongs to the Section Respiratory Medicine)

Imaging and Molecular Biomarkers: The New Approach to Degenerative Retinal Diseases

edited by

Giulia Midena

and

Elisabetta Pilotto

submission deadline 28 Dec 2025 | Viewed by 65 | Submission Open

Keywords: ophthalmology; degenerative retinal diseases; imaging biomarkers; multimodal imaging; OCT; OCT angiography; molecular biomarkers; precision medicine; translational ophthalmic research

(This special issue belongs to the Section Ophthalmology)

Pediatric Neurosurgery: Clinical Advances in Diagnostics and Perioperative Management

edited by Kara Leigh Krajewski and Ulrich-Wilhelm Thomale

submission deadline 29 Dec 2025 | Viewed by 311 | Submission Open

Keywords: rapid sequence MRI; intraoperative MRI; perioperative management; neurocritical care; patient selection; M&M conferences; surgical team; rehabilitation

(This special issue belongs to the Section Clinical Pediatrics)

Current Concepts and Clinical Application of Echocardiography

edited by

Marco Solari

submission deadline 29 Dec 2025 | Viewed by 82 | Submission Open

Keywords: echocardiography; clinical echocardiography; advanced echocardiography; cardiovascular disease; clinical cardiology

(This special issue belongs to the Section Cardiology)

Managements of Venous Thromboembolism

edited by

Anabel Franco Moreno

submission deadline 29 Dec 2025 | Viewed by 44 | Submission Open

Keywords: venous thromboembolism; deep vein thrombosis; pulmonary embolism; anticoagulation therapy; direct oral anticoagulants; risk stratification; bleeding risk; artificial intelligence; personalized medicine

(This special issue belongs to the Section Vascular Medicine)

Chronic Pain: Non-Pharmacological Treatments and Rehabilitation Strategies

edited by Matteo Ponzano

submission deadline 30 Dec 2025 | 4 articles | Viewed by 3828 | Submission Open

Keywords: pain; neuropathies; musculoskeletal health; biopsychosocial management; physical therapy; cognitive behavioral therapies

(This special issue belongs to the Section Clinical Rehabilitation)

Current Challenges in Inflammatory Bowel Diseases

edited by Wesley M. Raup-Konsavage

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1176 | Submission Open

Keywords: ulcerative colitis; Chron’ s disease; inflammatory bowel disease; colitis-associated cancer; novel pharmaceutics

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Perspectives on Women’s Reproductive Health: Challenges and Management Strategies

edited by

Seok Kyo Seo

submission deadline 30 Dec 2025 | 2 articles | Viewed by 681 | Submission Open

Keywords: endometriosis; ovarian endometrioma; polycystic ovary syndrome; reproductive health; cervical; postmenopausal women; hormone replacement therapy; sarcopenia

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Management for Coronary Artery Disease and Revascularization

edited by Mohammad Reza Movahed

submission deadline 30 Dec 2025 | 1 articles | Viewed by 478 | Submission Open

Keywords: coronary artery disease; coronary syndrome; stenting; revascularization; cardiovascular

(This special issue belongs to the Section Cardiovascular Medicine)

Joint Repair and Replacement: Current Challenges and Opportunities

edited by Bartosz Gonera and Kacper Ruzik

submission deadline 30 Dec 2025 | 1 articles | Viewed by 453 | Submission Open

Keywords: orthopedic biomechanics; knee injuries; joint replacement; anterior cruciate ligament; arthroscopy; sports medicine; prosthetic implants

(This special issue belongs to the Section Orthopedics)

Cerebral Palsy: Recent Advances in Clinical Management

edited by Laurie J. Glader and M. Wade Shrader

submission deadline 30 Dec 2025 | Viewed by 425 | Submission Open

Keywords: cerebral palsy; pediatric; neurology; complex care; clinical management

(This special issue belongs to the Section Clinical Pediatrics)

Augmented and Artificial Intelligence in Ophthalmology

edited by Tina Felfeli, Edsel B. Ing, David Jose Mathew and Michael Balas

submission deadline 30 Dec 2025 | Viewed by 368 | Submission Open

Keywords: artificial intelligence; ophthalmology; eye health; vision; teleophthalmology

(This special issue belongs to the Section Ophthalmology)

Advancements in Emergency Medicine Practices and Protocols

edited by Vincenzo G. Menditto and Beatrice Gasperini

submission deadline 30 Dec 2025 | 1 articles | Viewed by 270 | Submission Open

Keywords: emergency; pulmonary embolism; trauma; management; guidelines; frailty; emergency department observation unit

(This special issue belongs to the Section Emergency Medicine)

Regional Anesthesia and Pain Management: Mastering Clinical Art for Optimal Patient Satisfaction

edited by

Min Suk Chae

submission deadline 30 Dec 2025 | Viewed by 160 | Submission Open

Keywords: regional anesthesia; pain management; ultrasound-guided nerve blocks; fascial plane blocks; multimodal analgesia; postoperative analgesia; chronic pain management; opioid-sparing strategies; non-opioid analgesics; patient satisfaction; anesthesia techniques; perioperative care; pain interventions; nerve block techniques; clinical outcomes

(This special issue belongs to the Section Anesthesiology)

Pulmonary Critical Care: Integrating Bedside Physiology and Advanced Monitoring in the Management of Severe Respiratory Diseases

edited by

Gaetano Scaramuzzo

submission deadline 30 Dec 2025 | Viewed by 86 | Submission Open

Keywords: lung monitoring; ARDS; ARF; biomarkers; lung physiology; pneumonia; lung ultrasound; artificial intelligence; COPD; EIT

(This special issue belongs to the Section Respiratory Medicine)

Interventional Cardiology: Recent Developments and Future Challenges

edited by

Andreas Mitsis

and George Kassimis

submission deadline 30 Dec 2025 | Viewed by 85 | Submission Open

Keywords: percutaneous coronary intervention (PCI); drug-eluting stents (DES); high risk percutaneous coronary intervention (CHIP); chronic total occlusions (CTO); intravascular imaging (IVUS; OCT); coronary physiology (FFR; iFR); antiplatelet therapy; complex coronary interventions; mechanical circulatory support (MCS)

(This special issue belongs to the Section Cardiology)

Plastic and Reconstructive Surgery of the Face: Chances and Challenges

edited by

Cristian Trâmbițaș

and Bogdan Andrei Suciu

submission deadline 30 Dec 2025 | Viewed by 81 | Submission Open

Keywords: facial plastic surgery; facial reconstruction procedures; tissue regeneration; esthetic facial procedures; digital imaging and customization; biomaterials in reconstructive surgery; flap surgery innovations; microsurgical precision techniques

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Autoimmune Diseases and Multisystem Inflammation: Pathophysiology and Therapeutic Strategies

edited by

Tsuyoshi Shirai

submission deadline 30 Dec 2025 | Viewed by 70 | Submission Open

Keywords: autoimmune diseases; cardiovascular diseases; cutaneous diseases; gastrointestinal diseases; pulmonary diseases; renal diseases; systemic manifestation; rheumatoid arthritis; systemic lupus erythematosus; vasculitis

(This special issue belongs to the Section Immunology)

Cardiovascular Magnetic Resonance Imaging: Precise Diagnosis and Therapeutic Guidance

edited by Radu Andy Sascau and

Carina Gabriela Ureche

submission deadline 30 Dec 2025 | Viewed by 65 | Submission Open

Keywords: cardiac magnetic resonance; cardiomyopathy; tissue characterization; stress perfusion; 4D flow; heart failure; ischemic heart disease; multi-modality imaging; valvular heart disease; T1 mapping; T2 mapping; myocarditis

(This special issue belongs to the Section Cardiovascular Medicine)

Advancing Neonatal Seizures and Epilepsy: New Perspectives and Interventions

edited by

Elena Pavlidis

and Gaetano Cantalupo

submission deadline 30 Dec 2025 | Viewed by 62 | Submission Open

Keywords: neonatal seizures; neonatal epilepsy; neonatal EEG; automated EEG analysis; neonatal brain monitoring; genetic; precision medicine; genetic epilepsies; genome; exome

(This special issue belongs to the Section Clinical Pediatrics)

New Developments in Hematopoietic Stem Cell Transplantation in Clinical Practice

edited by Mattia Algeri

submission deadline 30 Dec 2025 | Viewed by 57 | Submission Open

Keywords: hematopoietic stem cell transplantation; graft-versus-host disease (GVHD); conditioning regimens; immune reconstitution; donor selection; post-transplant complications; long-term survivorship

(This special issue belongs to the Section Hematology)

Challenges and Opportunities in Colorectal Cancer

edited by

Naim Abu-Freha

submission deadline 30 Dec 2025 | Viewed by 55 | Submission Open

Keywords: colorectal cancer; screening; staging; treatment of colorectal cancer (CRC); high-risk patients; fecal occult testing; colonoscopy; lynch syndrome

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current and Emerging Treatment Options in Colorectal Cancer

edited by Michael Osseis

submission deadline 30 Dec 2025 | Viewed by 55 | Submission Open

Keywords: colorectal cancer (CRC); emerging treatment options; targeted therapies; new surgical technologies; precision medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Shoulder Arthroplasty: Clinical Advance and Future Perspective

edited by Vani J. Sabesan

submission deadline 30 Dec 2025 | Viewed by 53 | Submission Open

Keywords: shoulder arthroplasty; reverse shoulder arthroplasty; perioperative optimization; multimodal pain management; rehabilitation protocols; outpatient shoulder arthroplasty; implant longevity; complication management; disparities in outcomes

(This special issue belongs to the Section Orthopedics)

Clinical Advances in Antiphospholipid Syndrome (APS)

edited by