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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Update on Aortic Valve Disease Treatments

edited by

Giovanni Concistre

submission deadline 20 Jan 2026 | Viewed by 66 | Submission Open

Keywords: aortic valve disease; minimally invasive surgery; transcatheter procedures; echocardiography; diagnosis; therapy; innovation

(This special issue belongs to the Section Cardiology)

Recent Advances and Future Perspectives of Subarachnoid Hemorrhage

edited by Alexandros Doukas and Athanasios K. Petridis

submission deadline 20 Jan 2026 | Viewed by 66 | Submission Open

Keywords: subarachnoid hemorrhage; neuromonitoring; neurocritical care; neurointerventions; neurointensive care

(This special issue belongs to the Section Clinical Neurology)

Therapeutic Strategies for Obesity and Diabetes in Cardiovascular Disease Patients

edited by Davide D'Andrea

submission deadline 20 Jan 2026 | Viewed by 65 | Submission Open

Keywords: obesity; diabetes; cardiovascular complications; diabetes management; pharmacological treatment; bariatric surgery; regular monitoring

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances, Opportunities, and Challenges in Digestive Diseases of the Foregut

edited by Valentin Mocanu and

Salvador Navarrete

submission deadline 20 Jan 2026 | Viewed by 62 | Submission Open

Keywords: obesity; achalasia; reflux; malrotation; therapeutic endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Chronic Pain Research and Therapy

edited by Elena Makovac

submission deadline 20 Jan 2026 | Viewed by 57 | Submission Open

Keywords: chronic pain; pain perception; brain-body interactions; therapeutic effectiveness; integrated approach

(This special issue belongs to the Section Clinical Rehabilitation)

From Dual Diagnosis to Dual Disorder(s): Bridging Comorbidity and Integrated Clinical Understanding

edited by

Angelo Giovanni Icro Maremmani

submission deadline 20 Jan 2026 | Viewed by 57 | Submission Open

Keywords: dual diagnosis; dual disorder; psychiatric comorbidity; addiction; integrated care; self-medication; substance use; mental illness; treatment models

(This special issue belongs to the Section Mental Health)

Aortic Valve Disease: Current Evolution and Future Opportunities

edited by Gianluigi Perri

submission deadline 20 Jan 2026 | Viewed by 54 | Submission Open

Keywords: aortic valve disease; aortic valve repair; Ross procedure; aortic valve replacement; diagnosis of aortic valve disease

(This special issue belongs to the Section Cardiology)

The Association Between Cancer and Cardiovascular Diseases: Insights After a Quarter of the Century

edited by Tomer Ziv-Baran and Elena Izkhakov

submission deadline 20 Jan 2026 | Viewed by 52 | Submission Open

Keywords: cancer survivors; cardiovascular disease; cardio-oncology; chemotherapy; radiation therapy; immunotherapy; multidisciplinary approach

(This special issue belongs to the Section Epidemiology & Public Health)

Obesity-Related Metabolic and Cardiovascular Disorders

edited by

Lucia Frittitta

and Federica Vinciguerra

submission deadline 20 Jan 2026 | Viewed by 49 | Submission Open

Keywords: obesity; type 2 diabetes mellitus; insulin resistance; metabolic syndrome; cardiovascular disease; lipid disorder; adipose tissue dysfunction; visceral adiposity; cardiometabolic risk; endothelial dysfunction; health disparities; gut microbiota; bariatric surgery; precision medicine

(This special issue belongs to the Section Cardiovascular Medicine)

New Clinical Perception of Cardiac Rehabilitation

edited by

Antonello D’Andrea

and Mario Pacileo

submission deadline 20 Jan 2026 | Viewed by 47 | Submission Open

Keywords: cardiac rehabilitation; digital health; exercise therapy; cardiovascular prevention; chronic disease management; psychosocial support; personalized medicine

(This special issue belongs to the Section Clinical Rehabilitation)

Regional Anesthesia in Pain Management

edited by Jaime L. Baratta

submission deadline 20 Jan 2026 | Viewed by 45 | Submission Open

Keywords: acute pain; perioperative medicine; general anesthesiology; regional anesthesia; orthopedic anesthesia; multimodal analgesia

(This special issue belongs to the Section Anesthesiology)

Pulmonary Disease and Comorbidities, Clinical and Epidemiological Studies: From Neonates to Adults

edited by

Roxana Maria Nemes

submission deadline 20 Jan 2026 | Viewed by 43 | Submission Open

Keywords: pulmonary disorders; comorbidity; neonatal lung disease; pediatric pulmonology; adult respiratory disease; chronic respiratory conditions; clinical epidemiology; pulmonary function testing; diagnostic imaging; lung biomarkers; risk factors

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Urologic Oncology: 2nd Edition

edited by Saum Ghodoussipour

submission deadline 20 Jan 2026 | Viewed by 40 | Submission Open

Keywords: bladder cancer; kidney cancer; prostate cancer; testis cancer; penile cancer; minimally invasive; cancer treatment

(This special issue belongs to the Section Nephrology & Urology)

Surgical Management of Vascular Diseases: Challenges and Innovations in the 21st Century

edited by Reinhardt T. Grundmann

submission deadline 20 Jan 2026 | Viewed by 39 | Submission Open

Keywords: abdominal aortic aneurysm; carotid stenosis; peripheral vascular disease; endovascular therapy; open surgery; vascular disease and cancer outcomes; clinical trial; meta-analysis; surgical innovation

(This special issue belongs to the Section Cardiovascular Medicine)

Cardiometabolic Insights into Metabolic Dysfunction: From Mechanisms to Therapeutic Strategies

edited by Alessandro Andreis,

Guglielmo Beccuti

and

Angelo Armandi

submission deadline 20 Jan 2026 | Viewed by 35 | Submission Open

Keywords: cardiovascular complications; pharmacological; interventional strategies; cardiology; endocrinology; hepatology

(This special issue belongs to the Section Cardiology)

Current Trends and Future Challenges in Heart Failure

edited by Oren Caspi and Robert Zukermann

submission deadline 20 Jan 2026 | Viewed by 19 | Submission Open

Keywords: heart failure; guideline-directed therapy; digital health; biomarkers; multidisciplinary care; artificial intelligence; cardiorenal syndrome; remote hemodynamic monitoring; cardiac amyloidosis; exercise rehabilitation

(This special issue belongs to the Section Cardiology)

Macular Diseases: From Diagnosis to Treatment

edited by

Gabriella De Salvo

submission deadline 22 Jan 2026 | Viewed by 146 | Submission Open

Keywords: age-related macular degeneration; retinal vascular diseases; intraocular tumours; retinal imaging; OCT; OCT angiography; anti-VEGF; laser therapy; macular surgery; gene therapy; biomarkers; progression; intravitreal injections; biomarkers

(This special issue belongs to the Section Ophthalmology)

Personalized Radiological and Surgical Strategies for Breast Cancer Treatment

edited by Vlad Alexandru Gata, Maximilian Muntean and

Roxana Pintican

submission deadline 22 Jan 2026 | Viewed by 34 | Submission Open

Keywords: breast cancer; targeted and immune therapies; predictive biomarkers; surgical de-escalation; MRI of the breast; breast reconstruction

(This special issue belongs to the Section General Surgery)

Application of Artificial Intelligence in Cardiology

edited by

Matthias Unterhuber

submission deadline 23 Jan 2026 | 1 articles | Viewed by 1007 | Submission Open

Keywords: artificial intelligence; cardiology; clinical practice; valvular heart disease; arrhythmias; device therapy; machine learning

(This special issue belongs to the Section Cardiology)

Clinical Advances and New Challenges in Laparoscopic Surgery

edited by Ionut Bogdan Diaconescu and Matei Bratu

submission deadline 23 Jan 2026 | Viewed by 33 | Submission Open

Keywords: laparoscopic surgery; trauma surgery; surgical oncology; abdominal surgery; colorectal surgery; general surgery; minimally invasive surgery; gastrointestinal surgery; hernia surgery; surgery; advance laparoscopic surgery; cancer surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Glaucoma: Current Status and Prospects

edited by Rubén Sánchez-Jean,

Carmen Dora Méndez-Hernández

and Federico Sáenz-Francés San Baldomero

submission deadline 24 Jan 2026 | 1 articles | Viewed by 1227 | Submission Open

Keywords: glaucoma surgery; new techniques; minimally invasive glaucoma surgery; intraocular pressure; optometry; IOLs designs

(This special issue belongs to the Section Ophthalmology)

Pediatric Pulmonology: Recent Developments and Emerging Trends

edited by Athina L. Papadopoulou

submission deadline 25 Jan 2026 | 4 articles | Viewed by 10814 | Submission Open

Keywords: definition of breath sounds; lung– gut axis pathophysiology; disease endotypes and phenotypes; asthma management in children; bronchiolitis spectrum; pediatric bronchopulmonary dysplasia; pulmonary function testing in pediatric patients; pediatric sleep-disordered breathing; neonatal respiratory distress syndrome; childhood interstitial lung diseases; pulmonary hypertension in children; biomarkers in pediatric lung diseases; allergy and the lungs; diagnostic and therapeutic challenges in bronchoscopy; gene therapy in cystic fibrosis

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs and Beyond

edited by

Rosalinda Madonna

submission deadline 25 Jan 2026 | 5 articles | Viewed by 10167 | Submission Open

Keywords: cardiotoxicity; vascular toxicity; cardio-oncology; immune checkpoint inhibitors; anthracyclines; tyrosine kinase inhibitors; HER2; proteasome inhibitors; platinum; antimetabolites; microtubule inhibitors

(This special issue belongs to the Section Cardiovascular Medicine)

Personalized Medicine for the Management of Non-Communicable Disease (NCDs)

edited by

Alessandro Mattina

, Giulio Geraci and

Vincenzina Lo Re

submission deadline 25 Jan 2026 | 6 articles | Viewed by 5832 | Submission Open

Keywords: personalized medicine; precision medicine; non-communicable disease; cardiovascular disease; cancer; diabetes; chronic obstructive pulmonary disease; cognitive impairment; atherosclerosis; lipids; inflammation; immunity; therapy

(This special issue belongs to the Section Epidemiology & Public Health)

Male Fertility in the Modern Age: Challenges and Opportunities

edited by

Angelo Marino

submission deadline 25 Jan 2026 | 2 articles | Viewed by 4423 | Submission Open

Keywords: male infertility; semen parameters; sperm selection; IVF/ICSI

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Prevention, Diagnosis and Treatment of Oral Mucosal Diseases

edited by

Masanobu Abe

submission deadline 25 Jan 2026 | 3 articles | Viewed by 3680 | Submission Open

Keywords: oral mucosal diseases; oral mucositis; oral precancerous lesions; oral cancer; oral potentially malignant disorders; OPMDs; oral leukoplakia

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Keratoconus: Current Status and Prospects

edited by

Uxía Regueiro

and Isabel Lema

submission deadline 25 Jan 2026 | 3 articles | Viewed by 3646 | Submission Open

Keywords: keratoconus; prevention; diagnostic; biomarker discovery; genetics; exposome; treatment; personalized medicine; major challenges; technological advances

(This special issue belongs to the Section Ophthalmology)

Clinical Risks and Perinatal Outcomes in Pregnancy and Childbirth: 2nd Edition

edited by Apostolos Mamopoulos and

Ioannis Tsakiridis

submission deadline 25 Jan 2026 | 4 articles | Viewed by 3130 | Submission Open

Keywords: pregnancy complications; perinatal outcomes; childbirth; hypertension; diabetes; fetal growth restriction; stillbirth; preterm delivery

(This special issue belongs to the Section Obstetrics & Gynecology)

Autism Spectrum Disorder: Diagnosis, Treatment, and Management

edited by

Marios Adamou

submission deadline 25 Jan 2026 | 1 articles | Viewed by 2128 | Submission Open

Keywords: adult autism (including autism spectrum disorders); neurodevelopmental disorders; clinical diagnostics; digital diagnostics; artificial intelligence; multimodal treatments

(This special issue belongs to the Section Mental Health)

Clinical Updates in Cardiac Electrophysiology: 2nd Edition

edited by Kenneth C. Bilchick

submission deadline 25 Jan 2026 | 1 articles | Viewed by 1980 | Submission Open

Keywords: arrhythmias; atrial fibrillation; cardiac electrophysiology; heart rhythm disorders; ablation; ventricular tachycardia; remote monitoring; digital health; artificial intelligence; cardiac magnetic resonance

(This special issue belongs to the Section Cardiology)

Interventional Cardiology—Challenges and Solutions

edited by

Yonggu Lee

submission deadline 25 Jan 2026 | 3 articles | Viewed by 1488 | Submission Open

Keywords: chronic total occlusion; highly calcified coronary or lower extremity arteries; stentless percutaneous coronary intervention; chronic limb threatening ischemia; instent restenosis in the extremity artery diseases; endovascular therapy for pulmonary thromboembolism; transcatheter aortic valve replacemment for the bicuspid aortic valve; transcatheter aortic valve replacement for the valve-in-valve procedure; endovascular therapy for tricospid valve regurgitation; transcatheter edge-to-edge repair for mitral valve regurgitation

(This special issue belongs to the Section Cardiovascular Medicine)

Inflammatory Bowel Diseases: Clinical Advances and Emerging Therapies

edited by

Ewa Malecka-Wojciesko

submission deadline 25 Jan 2026 | 2 articles | Viewed by 1343 | Submission Open

Keywords: inflammatory bowel disease (IBD); ulcerative colitis; Crohn’ s disease; gut inflammation; bowel perforation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Foot and Ankle Surgery: Current Advances and Prospects

edited by

Jaeho Cho

submission deadline 25 Jan 2026 | 2 articles | Viewed by 1176 | Submission Open

Keywords: foot and ankle surgery; foot pathologies; ankle disease and trauma; diabetic foot; epidemiology; clinical anatomy; foot orthoses; weight-bearing CT

(This special issue belongs to the Section Orthopedics)

Ocular Surface Disease: Epidemiology, Diagnosis and Management

edited by

Sandeep K. Dhallu

and

Nicole Carnt

submission deadline 25 Jan 2026 | Viewed by 739 | Submission Open

Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies

(This special issue belongs to the Section Ophthalmology)

Advancements in Individualized Plastic and Reconstructive Surgery: Second Edition

edited by

Paul Immanuel Heidekrueger

, Peter Niclas Broer and Denis C. Ehrl

submission deadline 25 Jan 2026 | 1 articles | Viewed by 611 | Submission Open

Keywords: patient-specific reconstructive procedures; microsurgical precision techniques; autologous tissue transplantation; digital imaging and customization; biomaterials in reconstructive surgery; tissue engineering for plastic reconstruction; flap surgery innovations; personalized cleft surgery; personalized aesthetic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Advances in Treatment for Venous Thromboembolism

edited by

Elisavet Grouzi

and Georgia Kaiafa

submission deadline 25 Jan 2026 | 1 articles | Viewed by 471 | Submission Open

Keywords: venous thromboembolism; anticoagulation; cancer-associated thrombosis; thrombosis in MPNs; thrombosis in multiple myeloma; antiphospholipidic syndrome; thrombosis in PNH; thrombosis in hemoglobinopathies; thrombophilia; pregnancy and thrombophilia; reversal of anticoagulants; thromboprophylaxis

(This special issue belongs to the Section Hematology)

Machine Learning and Artificial Intelligence in Neurosurgery

edited by Jan Oliver Neumann and

Paul Naser

submission deadline 25 Jan 2026 | Viewed by 369 | Submission Open

Keywords: artificial intelligence; neurosurgery; neuro-oncology; spinal neurosurgery; neuro-ICU; stereotactic neurosurgery; pre-operative planning

(This special issue belongs to the Section Clinical Neurology)

Kidney Transplantation: Challenges, Advances and Lessons Learnt

edited by Karim Soliman and

Tibor Fülöp

submission deadline 25 Jan 2026 | Viewed by 268 | Submission Open

Keywords: kidney transplantation; nephrology; transplant medicine; patient selection criteria; immunosuppressive treatment; long-term outcomes; graft survival; complication; multi-organ transplant consideration; innovation

(This special issue belongs to the Section Nephrology & Urology)

Clinical Advances in Hysteroscopic Technology for Gynecological Diseases

edited by Aya Mohr-Sasson and Raanan Meyer

submission deadline 25 Jan 2026 | Viewed by 206 | Submission Open

Keywords: diagnostic hysteroscopy; operative hysteroscopy; uterine sampling; uterine polyp; submucosal fibroid; hysteroscopic dilatation and curettage; hysteroscopic niche repair

(This special issue belongs to the Section Obstetrics & Gynecology)

Shoulder and Elbow Surgery: Clinical Updates and Perspectives

edited by Taku Hatta, Akihiko Hasegawa and Takuma Yuri

submission deadline 25 Jan 2026 | Viewed by 180 | Submission Open

Keywords: rotator cuff injuries; shoulder arthroplasty; elbow surgery; shoulder surgery; shoulder and elbow disease; arthroscopic surgery; orthopedic surgery

(This special issue belongs to the Section Orthopedics)

Recent Clinical Advances in Reconstructive Urology and Prosthetic Surgery

edited by Elisa Berdondini and

Esaú Fenández-Pascual

submission deadline 25 Jan 2026 | Viewed by 69 | Submission Open

Keywords: reconstructive urology; penile prosthesis; artificial urinary sphincter; urethral stricture; reconstructive surgery; minimally invasive procedures

(This special issue belongs to the Section Nephrology & Urology)

Further Advances in Electrocardiography, Cardiac Arrhythmias, and Arrhythmogenic Disorders: 2nd Edition

edited by

Paweł T. Matusik

submission deadline 25 Jan 2026 | Viewed by 54 | Submission Open

Keywords: electrocardiography; cardiac arrhythmias; genetics; cardiac pacing; implantable cardioverter defibrillators; cardiac resynchronization therapy; magnetic resonance imaging; catheter ablation; arrhythmogenic disorders; channelopathy; cardiomyopathy

(This special issue belongs to the Section Cardiology)

Clinical Updates in the Use of Artificial Intelligence for Radiology

edited by

Martin R. Prince

submission deadline 25 Jan 2026 | Viewed by 52 | Submission Open

Keywords: deep learning; denoising; calculator; nn-UNet; automation; outcomes; quality control; DICE; Halsdorrf; Jaccard

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Diagnostic and Therapeutic Approaches in Cardiac Amyloidosis

edited by Grigorios Giamouzis

submission deadline 25 Jan 2026 | Viewed by 51 | Submission Open

Keywords: cardiac amyloidosis; transthyretin amyloidosis; hypertrophic cardiomyopathy; cardiac imaging; heart failure

(This special issue belongs to the Section Cardiology)

Otologic Disorders and Hearing Impairment: From Diagnosis to Rehabilitation

edited by Andrea Albera and Andrea Canale

submission deadline 25 Jan 2026 | Viewed by 49 | Submission Open

Keywords: otology; hearing loss; cochlear implants; middle ear surgery; otitis media; otosclerosis; auditory rehabilitation; ves-tibular disorders; hearing aid; bone-conduction implants

(This special issue belongs to the Section Otolaryngology)

New Insights into Peritoneal Dialysis and Hemodialysis: 2nd Edition

edited by

Grazia Maria Virzì

submission deadline 26 Jan 2026 | 1 articles | Viewed by 1293 | Submission Open

Keywords: hemodialysis; peritoneal dialysis; end-stage renal disease; kidney replacement therapy (KRT); pathophysiology; di-alysis membranes; dialysis preparation; dialysis modality; cardiovascular events; vascular access; PD-related perito-nitis; unfavorable adverse effects; complications; challenges; inflammation

(This special issue belongs to the Section Nephrology & Urology)

Novel Developments on Diagnosis and Treatment of Atrial Fibrillation

edited by

Elena Bobescu

and Mihaela-Viviana Ivan

submission deadline 26 Jan 2026 | 1 articles | Viewed by 835 | Submission Open

Keywords: atrial fibrillation; supraventricular arrhythmia; cardiovascular risk; oxidative stress; inflammation

(This special issue belongs to the Section Cardiovascular Medicine)

Osteoporotic Fractures of the Pelvis, Hip and Femur: Current Challenges and New Perspectives (2nd Edition)

edited by Andreas Hoch

submission deadline 26 Jan 2026 | Viewed by 41 | Submission Open

Keywords: osteoporosis; fracture management; pelvic fractures; periprosthetic fractures; proximal femoral fractures; non-operative therapies

(This special issue belongs to the Section Orthopedics)

Challenges in Diagnosis and Treatment of Infertility—2nd Edition

edited by Konstantinos A. Zikopoulos

submission deadline 27 Jan 2026 | Viewed by 1423 | Submission Open

Keywords: fertility; regeneration; age-related infertility; preimplantation diagnosis; precision assessment; individualized fertility needs; clinical diagnosis; in vitro fertilization

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Diagnosis and Treatment for Bone Tumor

edited by Antonio Ziranu and Luigi Cianni

submission deadline 27 Jan 2026 | 2 articles | Viewed by 1128 | Submission Open

Keywords: bone tumor; oncology; osteosarcoma; chondrosarcoma; megaprosthesis; bone resection; chemotherapy; radiotherapy; sarcoma; custom-made

(This special issue belongs to the Section Orthopedics)

Displaying special issue 1051-1100 on page 22 of 30.

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